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Producer: Aspose.Pdf for .NET 10.1.0 PDF Creator http://www.pdf-tools.com; modified using iTextSharp™ 5.4.0 ©2000-2012 1T3XT BVBA (AGPL-version) CreationDate: Fri Oct 12 06:26:22 2018 CEST ModDate: Sun Oct 28 12:33:34 2018 CET Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 7 Encrypted: no Page size: 600.04 x 800.05 pts Page rot: 0 File size: 1120360 bytes Optimized: no PDF version: 1.4 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- MinionPro-Regular CID Type 0C Identity-H yes no yes 22 0 FGGJIK+MinionPro-It Type 1C Custom yes yes yes 23 0 QGKUVF+MinionStd-Black Type 1C Custom yes yes yes 24 0 BNHJUV+MinionPro-Regular2 Type 1C Custom yes yes yes 25 0 YSAGYS+MinionMath-Regular Type 1C Custom yes yes yes 26 0 SYYRFE+minionMathItalic Type 1C Builtin yes yes yes 27 0 BLBYUY+MinionMathSymbols Type 1C Builtin yes yes yes 28 0 HCLVQQ+MinionPro-Regular CID TrueType Identity-H yes yes yes 1 0 BIVWFI+Minion-RegularSC Type 1C Custom yes yes yes 212 0 MinionPro-Regular22 Type 1C WinAnsi yes no no 247 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2024-02-03 02:39:58 CET RepresentationInformation: 287921.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2024-02-02 10:02:41 CET Size: 1120360 Format: PDF Version: 1.4 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 387 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseNone Language: en Info: Creator: Aspose Ltd. Producer: Aspose.Pdf for .NET 10.1.0 PDF Creator http://www.pdf-tools.com; modified using iTextSharp™ 5.4.0 ©2000-2012 1T3XT BVBA (AGPL-version) CreationDate: Fri Oct 12 06:26:22 CEST 2018 ModDate: Sun Oct 28 12:33:34 CET 2018 ID: 0x03bebd77841cb0b2501cde81a533ae8f, 0xc813738811fc6bfa927aa290a40f4c7a Filters: FilterPipeline: FlateDecode Fonts: Type0: Font: BaseFont: HCLVQQ+MinionPro-Regular Encoding: Identity-H ToUnicode: true Font: BaseFont: MinionPro-Regular Encoding: Identity-H ToUnicode: true Type1: Font: BaseFont: BIVWFI+Minion-RegularSC FontSubset: true FirstChar: 1 LastChar: 12 FontDescriptor: FontName: BIVWFI+Minion-RegularSC Flags: Nonsymbolic, SmallCap FontBBox: -141, -250, 1104, 812 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: FGGJIK+MinionPro-It FontSubset: true FirstChar: 1 LastChar: 73 FontDescriptor: FontName: FGGJIK+MinionPro-It Flags: Nonsymbolic, Italic FontBBox: -201, -360, 1684, 919 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: QGKUVF+MinionStd-Black FontSubset: true FirstChar: 1 LastChar: 64 FontDescriptor: FontName: QGKUVF+MinionStd-Black Flags: Nonsymbolic, ForceBold FontBBox: -173, -250, 1120, 827 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: BNHJUV+MinionPro-Regular2 FontSubset: true FirstChar: 1 LastChar: 93 FontDescriptor: FontName: BNHJUV+MinionPro-Regular2 Flags: Nonsymbolic FontBBox: -289, -360, 1684, 917 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: YSAGYS+MinionMath-Regular FontSubset: true FirstChar: 1 LastChar: 9 FontDescriptor: FontName: YSAGYS+MinionMath-Regular Flags: Nonsymbolic FontBBox: -1196, -2876, 2350, 3473 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: SYYRFE+minionMathItalic FontSubset: true FirstChar: 1 LastChar: 130 FontDescriptor: FontName: SYYRFE+minionMathItalic Flags: Symbolic FontBBox: -50, -180, 1000, 720 FontFile3: true ToUnicode: true Font: BaseFont: BLBYUY+MinionMathSymbols FontSubset: true FirstChar: 1 LastChar: 151 FontDescriptor: FontName: BLBYUY+MinionMathSymbols Flags: Symbolic FontBBox: -50, -180, 1000, 720 FontFile3: true ToUnicode: true CIDFontType0: Font: BaseFont: MinionPro-Regular CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: MinionPro-Regular Flags: Nonsymbolic FontBBox: -290, -360, 1684, 989 FontFile3: true CIDFontType2: Font: BaseFont: HCLVQQ+MinionPro-Regular CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: HCLVQQ+MinionPro-Regular Flags: Nonsymbolic FontBBox: -289, -360, 1684, 917 FontFile2: true XMP: application/pdfEfficacy and Safety of an Aflibercept Treat-and-Extend Regimen in Treatment-Naïve Patients with Macular Oedema Secondary to Central Retinal Vein Occlusion (CRVO): A Prospective 12-Month, Single-Arm, Multicentre TrialGarcia-Arumi, JoseGómez-Ulla, FranciscoAmparo, NaveaCervera, EnriqueFonollosa, AlexArias, LuisAraiz, JavierDonate, JuanFigueroa, Marta Suárez deManzanas, LuciaCrespí, JaumeGallego, RobertoObjectives. To evaluate efficacy and safety of an aflibercept treat-and-extend (TAE) regimen in patients with macular oedema (MO) secondary to central retinal vein occlusion (CRVO). Design, Setting, and Patients. Phase IV, prospective, open-label, single-arm trial in 11 Spanish hospitals. Treatment-naïve patients with <6 month diagnosis of MO secondary to CRVO and best-corrected visual acuity (BCVA) of 73-24 ETDRS letters were included between 23 January 2015 and 17 March 2016. Intervention. Intravitreal aflibercept 2 mg monthly (3 months) followed by proactive individualized dosing. Main Outcomes. Mean change in BCVA after 12 months. Results. 24 eyes (24 patients) were included; mean (SD) age: 62.8 (15.0) years; 54.2% male; median (IQR) time since diagnosis: 7.6 (3.0, 15.2) days. Mean BCVA scores significantly improved between baseline (56.0 (16.5)) and Month 12 (74.1 (17.6)); mean (95% CI) change: 14.8 (8.2, 21.4); P=0.0001. Twelve (50.0%) patients gained ≥15 ETDRS letters. Foveal thickness improved between baseline (mean: 569.4 (216.8) µm) and Month 12 (mean 257.4 (48.4) µm); P<0.0001. At Month 12, 8.3% patients had MO. The mean (SD) number of injections: 8.3 (3.0). No treatment-related AEs were reported. Five (20.8%) patients experienced ocular AEs. Two nonocular serious AEs were reported. Conclusions. An aflibercept TAE regimen improves visual acuity in patients with MO secondary to CRVO over 12 months with good tolerability.Journal of OphthalmologyHindawi2018/10/14Research articledoi:10.1155/2018/8310350en Pages: Page: Sequence: 1 Annotations: Annotation: Subtype: Link Rect: 307, 319, 401, 328 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 183, 517, 193, 527 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 404, 517, 414, 527 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 225, 503, 235, 513 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 433, 261, 549, 271 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 86, 250, 113, 260 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 50, 713, 168, 721 Page: Sequence: 2 Annotations: Annotation: Subtype: Link Rect: 135, 672, 139, 682 Flags: Print AppearanceDictionary: true Destination: 20 Annotation: 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