42ee69337a44f4119b6121fde394031d pmc_29354131.pdf 0f7b49539b1717d90b9550954784585ed193a9ad pmc_29354131.pdf 733875e7e7d7c649b4b783a6e9b919ff40c3585672e99fe3423bfda33731e29c pmc_29354131.pdf Title: Dynamics of CD4 and CD8 T-Cell Subsets and Inflammatory Biomarkers during Early and Chronic HIV Infection in Mozambican Adults Subject: During primary HIV infection (PHI), there is a striking cascade response of inflammatory cytokines and many cells of the immune system show altered frequencies and signs of extensive activation. Keywords: AIDS, HIV pathogenesis, T-cell exhaustion, T-cell activation, immunosenescence, cytokines, acute HIV infection, sub-Saharan Africa Author: Lucía Pastor and Julià Blanco Creator: Adobe InDesign CS6 (Windows) Producer: Adobe PDF Library 10.0.1 CreationDate: Thu Dec 28 06:43:33 2017 CET ModDate: Thu Dec 28 10:55:16 2017 CET Tagged: yes UserProperties: no Suspects: no Form: none JavaScript: no Pages: 13 Encrypted: no Page size: 595.276 x 779.528 pts Page rot: 0 File size: 4794162 bytes Optimized: yes PDF version: 1.6 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- EDXYCL+HelveticaNeueLTStd-Lt Type 1C Custom yes yes yes 555 0 XQGIIZ+HelveticaNeueLTStd-Bd Type 1C Custom yes yes yes 556 0 ZGIPKV+HelveticaNeueLTStd-BdIt Type 1C WinAnsi yes yes yes 564 0 PMIHAP+HelveticaNeueLTStd-LtIt Type 1C Custom yes yes yes 565 0 WHSXUB+HelveticaNeueLTStd-MdIt Type 1C WinAnsi yes yes yes 566 0 HIFGSF+STIXGeneral-Regular Type 1C Custom yes yes yes 574 0 PHECAP+MinionPro-Regular Type 1C Custom yes yes yes 575 0 ZECKKV+MinionPro-It Type 1C Custom yes yes yes 491 0 EDXYCL+HelveticaNeueLTStd-Lt Type 1C WinAnsi yes yes yes 498 0 KFPTIZ+MinionPro-Bold Type 1C Custom yes yes yes 505 0 EDXYCL+HelveticaNeueLTStd-Lt Type 1C WinAnsi yes yes yes 504 0 SEOPQJ+STIXGeneral-Bold Type 1C WinAnsi yes yes yes 508 0 Jhove (Rel. 1.22.1, 2019-04-17) Date: 2023-05-31 02:35:37 CEST RepresentationInformation: pmc_29354131.pdf ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17) LastModified: 2018-03-05 03:50:06 CET Size: 4794162 Format: PDF Version: 1.6 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf Profile: Linearized PDF, Tagged PDF PDFMetadata: Objects: 670 FreeObjects: 1 IncrementalUpdates: 1 DocumentCatalog: ViewerPreferences: HideToolbar: false HideMenubar: false HideWindowUI: false FitWindow: false CenterWindow: false DisplayDocTitle: false NonFullScreenPageMode: UseNone Direction: L2R ViewArea: CropBox ViewClip: CropBox PrintArea: CropBox PageClip: CropBox PageLayout: SinglePage PageMode: UseOutlines Outlines: Item: Title: Dynamics of CD4 and CD8 T-Cell Subsets and Inflammatory Biomarkers during Early and Chronic HIV Infection in Mozambican Adults Children: Item: Title: Introduction Item: Title: Materials and Methods Children: Item: Title: Study Population Item: Title: Ethics Statement Item: Title: HIV Diagnosis and Clinical Follow-up Item: Title: Definition of PHI Phases and Quantification of Biomarkers Item: Title: CD4 and CD8 T-Cell Immunophenotyping Item: Title: Statistical Analysis Item: Title: Results Children: Item: Title: Characteristics of the Study Population Item: Title: CD4 Th1Th17 and Treg Changes during the Different Stages of HIV Infection Item: Title: Intensive Loss of Resting CD8 Subsets Early after HIV Infection Item: Title: T-Cell Activation Phenotypes along HIV Infection Item: Title: Dynamics of Soluble Inflammatory Biomarkers and Association with T-Cell Phenotypes in PHI Item: Title: Discussion Item: Title: Ethics Statement Item: Title: Author Contributions Item: Title: Acknowledgments Item: Title: Funding Item: Title: Supplementary Material Item: Title: References Info: Title: Dynamics of CD4 and CD8 T-Cell Subsets and Inflammatory Biomarkers during Early and Chronic HIV Infection in Mozambican Adults Author: Lucía Pastor and Julià Blanco Subject: During primary HIV infection (PHI), there is a striking cascade response of inflammatory cytokines and many cells of the immune system show altered frequencies and signs of extensive activation. Keywords: AIDS, HIV pathogenesis, T-cell exhaustion, T-cell activation, immunosenescence, cytokines, acute HIV infection, sub-Saharan Africa Creator: Adobe InDesign CS6 (Windows) Producer: Adobe PDF Library 10.0.1 CreationDate: Thu Dec 28 07:13:33 CET 2017 ModDate: Thu Dec 28 11:25:16 CET 2017 ID: 0xe7837c0f2b5e3743ab86143eb0638093, 0x8d4c177b1de9c4408eb93b702b4507fc Filters: FilterPipeline: FlateDecode Images: Image: NisoImageMetadata: FormatName: image/png ImageWidth: 2046 ImageHeight: 1997 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric Name: X Image: NisoImageMetadata: FormatName: image/png ImageWidth: 2045 ImageHeight: 1344 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric Name: X Image: NisoImageMetadata: FormatName: image/png ImageWidth: 1424 ImageHeight: 1331 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: 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(PHI), there is a striking cascade response of inflammatory cytokines and many cells of the immune system show altered frequencies and signs of extensive activation. 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