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Title:          DUSP5 is methylated in CIMP-high colorectal cancer but is not a major regulator of intestinal cell proliferation and tumorigenesis
Subject:        Scientific Reports, doi:10.1038/s41598-018-20176-9
Keywords:       
Author:         Lars Tamp#x000F6;gel
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     Item: 
      Title: DUSP5 is methylated in CIMP-high colorectal cancer but is not a major regulator of intestinal cell proliferation and tumori ...
      Children: 
       Item: 
        Title: Results
        Children: 
         Item: 
          Title: DUSP5 is downregulated in colorectal cancers (CRCs). 
         Item: 
          Title: DUSP5 is induced by ERK signalling in CRC cell lines. 
         Item: 
          Title: The DUSP5 promoter is methylated in a subset of CRCs. 
         Item: 
          Title: DUSP5 is not a major regulator of ERK signalling in CRC cells. 
         Item: 
          Title: DUSP5 overexpression in the mouse intestinal epithelium does not alter ERK signalling, intestinal homeostasis or adenoma fo ...
       Item: 
        Title: Discussion
       Item: 
        Title: Methods
        Children: 
         Item: 
          Title: Cell lines and treatments. 
         Item: 
          Title: Quantitative real-time PCR. 
         Item: 
          Title: Bisulfite sequencing. 
         Item: 
          Title: High-resolution melting methylation analysis. 
         Item: 
          Title: Western blotting. 
         Item: 
          Title: Generation of Vil1-DUSP5Tg mice. 
         Item: 
          Title: Immunohistochemistry. 
         Item: 
          Title: Statistical methods. 
         Item: 
          Title: Data availability. 
       Item: 
        Title: Acknowledgements
       Item: 
        Title: Figure 1 Downregulation of DUSP5 mRNA expression in CRC.
       Item: 
        Title: Figure 2 Induction of DUSP5 by EGFR-ERK signalling in CRC cells.
       Item: 
        Title: Figure 3 DUSP5 promoter methylation in CRC cell lines and tumours.
       Item: 
        Title: Figure 4 DUSP5 regulation of basal ERK signaling in CRC cells.
       Item: 
        Title: Figure 5 DUSP5 regulation of EGF-induced ERK signalling in CRC cells.
       Item: 
        Title: Figure 6 Impact of DUSP5 overexpression on ERK signaling in the mouse intestine.
       Item: 
        Title: Figure 7 Impact of DUSP5 overexpression on intestinal phenotype.
       Item: 
        Title: Figure 8 Impact of DUSP5 overexpression on intestinal adenoma formation.
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               <rdf:li>Anderly C. Champ#x000FC;eh</rdf:li>
               <rdf:li>Sheren Al-Obaidi</rdf:li>
               <rdf:li>Ian Luk</rdf:li>
               <rdf:li>Mercedes Damp#x000E1;valos-Salas</rdf:li>
               <rdf:li>Fiona Chionh</rdf:li>
               <rdf:li>Carmel Murone</rdf:li>
               <rdf:li>Daniel D. Buchanan</rdf:li>
               <rdf:li>Zac Chatterton</rdf:li>
               <rdf:li>Oliver M. Sieber</rdf:li>
               <rdf:li>Diego Arango</rdf:li>
               <rdf:li>Niall C. Tebbutt</rdf:li>
               <rdf:li>David Williams</rdf:li>
               <rdf:li>Amardeep S. Dhillon</rdf:li>
               <rdf:li>John M. Mariadason</rdf:li>
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         <prism:publicationName>Scientific Reports</prism:publicationName>
         <prism:copyright>© 2018, The Author(s)</prism:copyright>
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                           <pdfaProperty:description>The common identifier for all versions and renditions of a document.</pdfaProperty:description>
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                        <rdf:li rdf:parseType="Resource">
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                           <pdfaProperty:description>The aggregation type specifies the unit of aggregation for a content collection. 
Comment 
PRISM recommends that the PRISM Aggregation Type Controlled Vocabulary be used to provide values for this element. 
Note: PRISM recommends against the use of the #other value currently allowed in this controlled vocabulary. In lieu of using #other please reach out to the PRISM group at info@prismstandard.org to request addition of your term to the Aggregation Type Controlled Vocabulary. 

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                           <pdfaProperty:description>Copyright </pdfaProperty:description>
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                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>The Digital Object Identifier for the article.
The DOI may also be used as the dc:identifier. If used as a dc:identifier, the URI form should be captured, and the bare identifier should also be captured using prism:doi. If an alternate unique identifier is used as the required dc:identifier, then the DOI should be specified as a bare identifier within prism:doi only. 
If the URL associated with a DOI is to be specified, then prism:url may be used in conjunction with prism:doi in order to provide the service endpoint (i.e. the URL). 
</pdfaProperty:description>
                           <pdfaProperty:name>doi</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>ISSN for an electronic version of the issue in which the resource occurs. 
Permits publishers to include a second ISSN, identifying an electronic version of the issue in which the resource occurs (therefore e(lectronic)Issn. If used, prism:eIssn MUST contain the ISSN of the electronic version. See prism:issn. 
</pdfaProperty:description>
                           <pdfaProperty:name>issn</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Title of the magazine, or other publication, in which a resource was/will be published. 
Typically this will be used to provide the name of the magazine an article appeared in as metadata for the article, along with information such as the article title, the publisher, volume, number, and cover date. 

Note: Publication name can be used to differentiate between a print magazine and the online version if the names are different such as “magazine” and “magazine.com.” 
</pdfaProperty:description>
                           <pdfaProperty:name>publicationName</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>This element provides the url for an article or unit of content. 
The attribute platform is optionally allowed for situations in which multiple URLs must be specified. PRISM recommends that a subset of the PCV platform values, namely “mobile” and “web”, be used in conjunction with this element. 
NOTE: PRISM recommends against the use of the #other value allowed in the PRISM Platform controlled vocabulary. In lieu of using #other please reach out to the PRISM group at prism-wg@yahoogroups.com to request addition of your term to the Platform Controlled Vocabulary. 
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                           <pdfaProperty:name>url</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
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                  <pdfaSchema:schema>NISO</pdfaSchema:schema>
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                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Values for Journal Article Version are one of the following:
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SMUR = Submitted Manuscript Under Review
AM = Accepted Manuscript
P = Proof
VoR = Version of Record
CVoR = Corrected Version of Record
EVoR = Enhanced Version of Record</pdfaProperty:description>
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