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Title:          High Antigen Dose Is Detrimental to Post-Exposure Vaccine Protection against Tuberculosis
Subject:        Mycobacterium tuberculosis (Mtb), the etiologic agent of tuberculosis (TB), causes 1.8M deaths annually.
Keywords:       tuberculosis, post-exposure vaccination, vaccine dose, T cell quality, functional avidity, CAF01, H56, adjuvant
Author:         Rolf Billeskov and Peter Andersen
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ModDate:        Fri Jan 12 11:13:57 2018 CET
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     Item: 
      Title: High Antigen Dose Is Detrimental to Post-Exposure Vaccine Protection against Tuberculosis
      Children: 
       Item: 
        Title: Introduction
       Item: 
        Title: Materials and Methods
        Children: 
         Item: 
          Title: Animal Handling
         Item: 
          Title: Bacteria
         Item: 
          Title: Antigens and Vaccines
         Item: 
          Title: Experimental Infections and the Preventive and Post-Exposure TB Models
         Item: 
          Title: Immunizations
         Item: 
          Title: Cell Cultures and Immunological Readouts
         Item: 
          Title: Normalization of CFU to Compare Protection
         Item: 
          Title: Histopathological Assessment
         Item: 
          Title: Adoptive Transfer Experiment and 
ESAT-64–17 Tetramer
         Item: 
          Title: Statistical Methods
       Item: 
        Title: Results
        Children: 
         Item: 
          Title: High Antigen Dose Abrogates Vaccine Protection against TB in the Post-Exposure Setting
         Item: 
          Title: Only Low Dose Vaccination Reduce TB-Related Pathology in the Post-Exposure Model
         Item: 
          Title: High Antigen Dose Given Post-Exposure Leads to a More Effector-Driven T Cell Phenotype
         Item: 
          Title: High Antigen Dose Given Post-Exposure Leads to a Decrease in T Cell Functional Avidity
         Item: 
          Title: High Dose Post-Exposure Vaccination Reduces Lung Parenchymal Homing Ability of Vaccine-Specific T Cells
       Item: 
        Title: Discussion
       Item: 
        Title: Ethics Statement
       Item: 
        Title: Author Contributions
       Item: 
        Title: Acknowledgments
       Item: 
        Title: Supplementary Material
       Item: 
        Title: References
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    Author: Rolf Billeskov and Peter Andersen
    Subject: Mycobacterium tuberculosis (Mtb), the etiologic agent of tuberculosis (TB), causes 1.8M deaths annually.
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   Type: CRC32
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   Type: MD5
  Checksum: f27db11410216688baf98ef35c8ea296494b8ed4
   Type: SHA-1