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Item: Title: Clinical assessment. Item: Title: Pharmacological intervention. Item: Title: Treatment outcome. Item: Title: Genome-wide association study. Item: Title: Identification of candidate causal SNPs. Item: Title: Cis-expression quantitative trait loci analysis. Item: Title: Functional and pathway enrichment analysis. Item: Title: Polygenic risk score analysis. Item: Title: Meta-analysis. Item: Title: Data availability. Item: Title: Results Children: Item: Title: Genome-wide association study in the discovery population. Item: Title: Identification of candidate causal SNPs and cis-expression quantitative trait loci analysis. Item: Title: Functional and pathway enrichment analysis. Item: Title: Polygenic risk score analysis and meta-analysis using the target population. Item: Title: Discussion Item: Title: Acknowledgements Item: Title: Table 1 Cis-associated gene-SNP pairs with a nominal significant effect on methylphenidate response in the GWAS analysis. Item: Title: Table 2 Significantly enriched biological functions and diseases identified by Ingenuity Pathway Analysis within the eGenes associated with methylphenidate response. Item: Title: Table 3 Meta-analysis of the eSNPs nominally associated with methylphenidate response across the discovery and the target population. Info: Title: Integrative genomic analysis of methylphenidate response in attention-deficit/hyperactivity disorder Author: Mireia Pagerols Subject: Scientific Reports, doi:10.1038/s41598-018-20194-7 Keywords: Creator: Springer Producer: iText® 5.3.5 ©2000-2012 1T3XT BVBA (AGPL-version) CreationDate: Fri Jan 19 21:35:01 CET 2018 ModDate: Wed Jan 24 13:56:06 CET 2018 ID: 0x4889366f0f0424db8f9b72e39af93e88, 0xfe000180e33d74deb59b4361d5cb7207 Filters: FilterPipeline: FlateDecode Images: Image: NisoImageMetadata: FormatName: image/png ImageWidth: 1100 ImageHeight: 90 ColorSpace: black is zero BitsPerSample: 1 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric Name: X Fonts: Type0: Font: BaseFont: ERSDLP+Corbel Encoding: Identity-H ToUnicode: true Font: BaseFont: ABQAHX+Corbel-Bold Encoding: Identity-H ToUnicode: true Type1: Font: BaseFont: MinionPro-Bold FirstChar: 0 LastChar: 255 FontDescriptor: FontName: MinionPro-Bold Flags: Serif, Nonsymbolic FontBBox: -319, 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BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true CIDFontType2: Font: BaseFont: ERSDLP+Corbel CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: ERSDLP+Corbel Flags: Symbolic FontBBox: -553, -239, 1110, 952 FontFile2: true Font: BaseFont: ABQAHX+Corbel-Bold CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: ABQAHX+Corbel-Bold Flags: Symbolic FontBBox: -556, -239, 1155, 952 FontFile2: true XMP: application/pdf doi:10.1038/s41598-018-20194-7 Springer US Scientific Reports, doi:10.1038/s41598-018-20194-7 Integrative genomic analysis of methylphenidate response in attention-deficit/hyperactivity disorder Mireia Pagerols Vanesa Richarte Cristina Samp#x000E1;nchez-Mora Paula Rovira Maramp#x000ED;a Soler Artigas Iris Garcia-Martamp#x000ED;nez Eva Calvo-Samp#x000E1;nchez Montse Corrales Bruna Santos da Silva Nina Roth Mota Marcelo Moraes Victor Luis Augusto Rohde Eugenio Horacio Grevet Claiton Henrique Dotto Bau Bru Cormand Miguel Casas Josep Antoni Ramos-Quiroga Marta Ribasamp#x000E9;s 10.1038/s41598-018-20194-7 http://dx.doi.org/10.1038/s41598-018-20194-7 journal Scientific Reports © 2018, The Author(s) 2045-2322 10.1038/s41598-018-20194-7 Springer 2018-01-24T13:56:06+01:00 2018-01-20T01:35:01+05:30 2018-01-24T13:56:06+01:00 True iText® 5.3.5 ©2000-2012 1T3XT BVBA (AGPL-version) VoR uuid:29f4cb45-1541-40cc-a247-78f153868dd2 uuid:8e145e29-3819-4e41-99d6-03622d325232 default 1 converted uuid:ae893baf-3598-4140-be98-039a0846994e converted to PDF/A-2b pdfToolbox 2018-01-20T01:35:46+05:30 2 B http://ns.adobe.com/pdf/1.3/ pdf Adobe PDF Schema internal A name object indicating whether the document has been modified to include trapping information Trapped Text http://ns.adobe.com/pdfx/1.3/ pdfx pdfx internal ID of PDF/X standard GTS_PDFXVersion Text internal Conformance level of PDF/X standard GTS_PDFXConformance Text internal Company creating the PDF Company Text internal Date when 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