ffb2a64fa81a3b7297f3c10851f3c8a8 pmc_29515201.pdf ccd08f8462658f93df99ea88aa66d96d5ea102a5 pmc_29515201.pdf 44d51ab42f159cebeab3d725750d00862d5fbbe1699dd2b024fed5319a57ddab pmc_29515201.pdf Title: Biological Age is a predictor of mortality in Ischemic Stroke Subject: Scientific Reports, doi:10.1038/s41598-018-22579-0 Keywords: Author: Carolina Soriano-Tamp#x000E1;rraga Creator: Springer Producer: iText® 5.3.5 ©2000-2012 1T3XT BVBA (AGPL-version) CreationDate: Thu Mar 1 10:55:56 2018 CET ModDate: Thu Mar 1 17:14:14 2018 CET Tagged: no UserProperties: no Suspects: no Form: AcroForm JavaScript: no Pages: 8 Encrypted: no Page size: 595.276 x 782.362 pts Page rot: 0 File size: 992092 bytes Optimized: no PDF version: 1.4 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- QSJPDS+Corbel CID TrueType Identity-H yes yes yes 282 0 JWORJG+TimesNewRomanPSMT Type 1C WinAnsi yes yes yes 283 0 MinionPro-Regular Type 1C Custom yes no yes 23 0 FDPDQJ+Corbel-Bold2 Type 1C WinAnsi yes yes yes 83 0 MinionPro-It Type 1C Custom yes no yes 84 0 JCCXLH+Corbel2 Type 1C WinAnsi yes yes yes 22 0 VSXOVI+Corbel-Bold CID TrueType Identity-H yes yes yes 149 0 EuclidSymbol-Bold Type 1C Custom yes no yes 18 0 FDPDQJ+Corbel-Bold2 Type 1C WinAnsi yes yes yes 206 0 JCCXLH+Corbel2 Type 1C WinAnsi yes yes yes 215 0 QSJPDS+Corbel CID TrueType Identity-H yes yes yes 320 0 MyriadPro-It Type 1C WinAnsi yes no yes 209 0 EuclidSymbol Type 1C Custom yes no yes 19 0 QVQIDS+STIXGeneral-Regular Type 1C Custom yes yes yes 20 0 MinionPro-Bold Type 1C WinAnsi yes no yes 21 0 JCCXLH+Corbel2 Type 1C WinAnsi yes yes yes 201 0 JCCXLH+Corbel2 Type 1C WinAnsi yes yes yes 207 0 QSJPDS+Corbel CID TrueType Identity-H yes yes yes 208 0 QSJPDS+Corbel CID TrueType Identity-H yes yes yes 216 0 Jhove (Rel. 1.22.1, 2019-04-17) Date: 2023-10-20 02:30:41 CEST RepresentationInformation: pmc_29515201.pdf ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17) LastModified: 2018-03-26 03:48:34 CEST Size: 992092 Format: PDF Version: 1.4 Status: Well-Formed, but not valid SignatureMatches: PDF-hul ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'SpringerNature_SciRep_22579.indd: Table 1. Baseline characteristics of ischemic stroke patients in the discovery and replication cohorts. *Median (Interquartile range). NIHSS, National Institutes of Health Stroke Scale; mRS, modified Rankin Scale.:33' cannot be found Offset: 430568 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'SpringerNature_SciRep_22579.indd: Table 2. Mortality at 3 months after IS. Bivariate analysis. *Median (Interquartile range). †Mean (Standard deviation).:34' cannot be found Offset: 430568 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'SpringerNature_SciRep_22579.indd:Figure 1. Mean age acceleration relates to mortality, p‐value of Student T-test. Age acceleration is the linear regression of biological age adjusted by chronological age, sex, stroke severity, TOAST and p-mRs. By definition, the mean age of par:36' cannot be found Offset: 430568 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'SpringerNature_SciRep_22579.indd: Table 1. Baseline characteristics of ischemic stroke patients in the discovery and replication cohorts. *Median (Interquartile range). NIHSS, National Institutes of Health Stroke Scale; mRS, modified Rankin Scale.:37' cannot be found Offset: 430568 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'SpringerNature_SciRep_22579.indd:Figure 2. Mean age acceleration associated to mortality, stratified by stroke etiology: alive (white bars); deceased (grey bars); and p‐value of Student T-test. Age acceleration was adjusted by chronological age, sex, stroke severity, TOAST and :40' cannot be found Offset: 430568 MIMEtype: application/pdf PDFMetadata: Objects: 360 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: ViewerPreferences: HideToolbar: false HideMenubar: false HideWindowUI: false FitWindow: false CenterWindow: false DisplayDocTitle: false NonFullScreenPageMode: UseNone Direction: L2R ViewArea: CropBox ViewClip: CropBox PrintArea: CropBox PageClip: CropBox PageLayout: SinglePage PageMode: UseOutlines Language: EN Outlines: Item: Title: Biological Age is a predictor of mortality in Ischemic Stroke Children: Item: Title: Results Item: Title: Discussion Item: Title: Materials and Methods Children: Item: Title: Study Participants. Item: Title: Clinical Variables. Item: Title: Array-based DNA Methylation Analysis with Infinium Human Methylation 450 k. Item: Title: Biological Age and Epigenetic Clock. Item: Title: Statistical Analysis. Item: Title: Data availability. Item: Title: Accession number. Item: Title: Acknowledgements Item: Title: Figure 1 Mean age acceleration relates to mortality, p‐value of Student T-test. Item: Title: Figure 2 Mean age acceleration associated to mortality, stratified by stroke etiology: alive (white bars) deceased (grey bars) and p‐value of Student T-test. Item: Title: Table 1 Baseline characteristics of ischemic stroke patients in the discovery and replication cohorts. Item: Title: Table 2 Mortality at 3 months after IS. Item: Title: Table 3 Logistic multivariate regression models of mortality at 3 months after IS. Item: Title: Table 4 Multivariate logistic regression models of mortality at 3 months after IS stratified by TOAST. Info: Title: Biological Age is a predictor of mortality in Ischemic Stroke Author: Carolina Soriano-Tamp#x000E1;rraga Subject: Scientific Reports, doi:10.1038/s41598-018-22579-0 Keywords: Creator: Springer Producer: iText® 5.3.5 ©2000-2012 1T3XT BVBA (AGPL-version) CreationDate: Thu Mar 01 11:25:56 CET 2018 ModDate: Thu Mar 01 17:14:14 CET 2018 ID: 0xd873217576f898191203f31772f18845, 0x7481ece92b2fd4ae5daf7b5becf0a09b Filters: FilterPipeline: FlateDecode FilterPipeline: DCTDecode Images: Image: NisoImageMetadata: FormatName: image/png ImageWidth: 1100 ImageHeight: 90 ColorSpace: black is zero BitsPerSample: 1 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric Name: X Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 850 ImageHeight: 688 ColorSpace: black is zero BitsPerSample: 8 BitsPerSampleUnit: integer Intent: RelativeColorimetric Name: X Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 850 ImageHeight: 847 ColorSpace: black is zero BitsPerSample: 8 BitsPerSampleUnit: integer Intent: RelativeColorimetric Name: X Fonts: Type0: Font: BaseFont: VSXOVI+Corbel-Bold Encoding: Identity-H ToUnicode: true Font: BaseFont: QSJPDS+Corbel Encoding: Identity-H ToUnicode: true Type1: Font: BaseFont: EuclidSymbol-Bold FirstChar: 0 LastChar: 255 FontDescriptor: FontName: EuclidSymbol-Bold Flags: Symbolic FontBBox: -186, -308, 1101, 960 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: FDPDQJ+Corbel-Bold2 FontSubset: true FirstChar: 0 LastChar: 255 FontDescriptor: FontName: FDPDQJ+Corbel-Bold2 Flags: Nonsymbolic FontBBox: -556, -239, 1155, 952 FontFile3: true Encoding: WinAnsiEncoding ToUnicode: true Font: BaseFont: EuclidSymbol FirstChar: 0 LastChar: 255 FontDescriptor: FontName: EuclidSymbol Flags: Symbolic FontBBox: -166, -253, 1090, 950 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: MinionPro-It FirstChar: 0 LastChar: 255 FontDescriptor: FontName: MinionPro-It Flags: Serif, Nonsymbolic, Italic FontBBox: -201, -360, 1684, 1002 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: QVQIDS+STIXGeneral-Regular FontSubset: true FirstChar: 31 LastChar: 31 FontDescriptor: FontName: QVQIDS+STIXGeneral-Regular Flags: Serif, Symbolic FontBBox: -995, -455, 2000, 1055 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: MinionPro-Bold FirstChar: 0 LastChar: 255 FontDescriptor: FontName: MinionPro-Bold Flags: Serif, Nonsymbolic FontBBox: -319, -360, 1684, 1024 FontFile3: true Encoding: WinAnsiEncoding ToUnicode: true Font: BaseFont: JCCXLH+Corbel2 FontSubset: true FirstChar: 0 LastChar: 255 FontDescriptor: FontName: JCCXLH+Corbel2 Flags: Nonsymbolic FontBBox: -553, -239, 1110, 952 FontFile3: true Encoding: WinAnsiEncoding ToUnicode: true Font: BaseFont: MinionPro-Regular FirstChar: 0 LastChar: 255 FontDescriptor: FontName: MinionPro-Regular Flags: Serif, Nonsymbolic FontBBox: -290, -360, 1684, 989 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: JWORJG+TimesNewRomanPSMT FontSubset: true FirstChar: 32 LastChar: 121 FontDescriptor: FontName: JWORJG+TimesNewRomanPSMT Flags: Serif, Nonsymbolic FontBBox: -568, -307, 2000, 1007 FontFile3: true Encoding: WinAnsiEncoding ToUnicode: true CIDFontType2: Font: BaseFont: QSJPDS+Corbel CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: QSJPDS+Corbel Flags: Symbolic FontBBox: -553, -239, 1110, 952 FontFile2: true Font: BaseFont: VSXOVI+Corbel-Bold CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: VSXOVI+Corbel-Bold Flags: Symbolic FontBBox: -556, -239, 1155, 952 FontFile2: true XMP: application/pdf doi:10.1038/s41598-018-22579-0 Springer US Scientific Reports, doi:10.1038/s41598-018-22579-0 Biological Age is a predictor of mortality in Ischemic Stroke Carolina Soriano-Tamp#x000E1;rraga Eva Giralt-Steinhauer Marina Mola-Caminal Angel Ois Ana Rodramp#x000ED;guez-Campello Elisa Cuadrado-Godia Israel Fernamp#x000E1;ndez-Cadenas Natalia Cullell Jaume Roquer Jordi Jimamp#x000E9;nez-Conde 10.1038/s41598-018-22579-0 http://dx.doi.org/10.1038/s41598-018-22579-0 journal Scientific Reports © 2018, The Author(s) 2045-2322 10.1038/s41598-018-22579-0 Springer 2018-03-01T17:14:14+01:00 2018-03-01T15:25:56+05:30 2018-03-01T17:14:14+01:00 True iText® 5.3.5 ©2000-2012 1T3XT BVBA (AGPL-version) VoR uuid:b412a77b-2a17-49b5-8bc6-b0a394a7aa87 uuid:5e32a2b8-fa9c-41a0-8ac5-f231d7c4b4bd default 1 converted uuid:7a37342a-7349-4759-870e-d67ff6e2e987 converted to PDF/A-2b pdfToolbox 2018-03-01T15:26:30+05:30 2 B http://ns.adobe.com/xap/1.0/mm/ xmpMM XMP Media Management Schema internal UUID based identifier for specific incarnation of a document InstanceID URI internal The common identifier for all versions and renditions of a document. OriginalDocumentID URI http://ns.adobe.com/pdf/1.3/ pdf Adobe PDF Schema internal A name object indicating whether the document has been modified to include trapping information Trapped Text http://ns.adobe.com/pdfx/1.3/ pdfx pdfx internal ID of PDF/X standard GTS_PDFXVersion Text internal Conformance level of PDF/X standard GTS_PDFXConformance Text internal Company creating the PDF Company Text internal Date when document was last modified SourceModified Text internal Mirrors crossmark:DOI doi Text http://www.aiim.org/pdfa/ns/id/ pdfaid PDF/A ID Schema internal Part of PDF/A standard part Integer internal Amendment of PDF/A standard amd Text internal Conformance level of PDF/A standard conformance Text http://prismstandard.org/namespaces/basic/2.0/ prism Prism external The aggregation type specifies the unit of aggregation for a content collection. Comment PRISM recommends that the PRISM Aggregation Type Controlled Vocabulary be used to provide values for this element. Note: PRISM recommends against the use of the #other value currently allowed in this controlled vocabulary. In lieu of using #other please reach out to the PRISM group at info@prismstandard.org to request addition of your term to the Aggregation Type Controlled Vocabulary. aggregationType Text external Copyright copyright Text external The Digital Object Identifier for the article. The DOI may also be used as the dc:identifier. If used as a dc:identifier, the URI form should be captured, and the bare identifier should also be captured using prism:doi. If an alternate unique identifier is used as the required dc:identifier, then the DOI should be specified as a bare identifier within prism:doi only. If the URL associated with a DOI is to be specified, then prism:url may be used in conjunction with prism:doi in order to provide the service endpoint (i.e. the URL). doi Text external ISSN for an electronic version of the issue in which the resource occurs. Permits publishers to include a second ISSN, identifying an electronic version of the issue in which the resource occurs (therefore e(lectronic)Issn. If used, prism:eIssn MUST contain the ISSN of the electronic version. See prism:issn. issn Text external Title of the magazine, or other publication, in which a resource was/will be published. Typically this will be used to provide the name of the magazine an article appeared in as metadata for the article, along with information such as the article title, the publisher, volume, number, and cover date. Note: Publication name can be used to differentiate between a print magazine and the online version if the names are different such as “magazine” and “magazine.com.” publicationName Text external This element provides the url for an article or unit of content. The attribute platform is optionally allowed for situations in which multiple URLs must be specified. PRISM recommends that a subset of the PCV platform values, namely “mobile” and “web”, be used in conjunction with this element. NOTE: PRISM recommends against the use of the #other value allowed in the PRISM Platform controlled vocabulary. In lieu of using #other please reach out to the PRISM group at prism-wg@yahoogroups.com to request addition of your term to the Platform Controlled Vocabulary. url Text http://www.niso.org/schemas/jav/1.0/ jav NISO external Values for Journal Article Version are one of the following: AO = Author’s Original SMUR = Submitted Manuscript Under Review AM = Accepted Manuscript P = Proof VoR = Version of Record CVoR = Corrected Version of Record EVoR = Enhanced Version of Record journal_article_version Closed Choice of Text Pages: Page: Sequence: 1 Annotations: Annotation: Subtype: Link Rect: 443, 328, 446, 316 Flags: Print AppearanceDictionary: true Destination: 150 Annotation: Subtype: Link Rect: 449, 328, 452, 316 Flags: Print AppearanceDictionary: true Destination: 150 Annotation: Subtype: Link Rect: 292, 298, 295, 286 Flags: Print AppearanceDictionary: true Destination: 150 Annotation: Subtype: Link Rect: 358, 288, 361, 276 Flags: Print AppearanceDictionary: true Destination: 150 Annotation: Subtype: Link Rect: 364, 288, 367, 276 Flags: Print AppearanceDictionary: true Destination: 150 Annotation: Subtype: Link Rect: 469, 268, 472, 256 Flags: Print AppearanceDictionary: true Destination: 150 Annotation: Subtype: Link Rect: 473, 268, 479, 256 Flags: Print AppearanceDictionary: true Destination: 150 Annotation: Subtype: Link Rect: 246, 258, 249, 246 Flags: Print AppearanceDictionary: true Destination: 150 Annotation: Subtype: Link Rect: 355, 218, 361, 206 Flags: Print AppearanceDictionary: true Destination: 150 Annotation: Subtype: Link Rect: 362, 218, 368, 206 Flags: Print AppearanceDictionary: true Destination: 150 Annotation: Subtype: Link Rect: 398, 198, 404, 186 Flags: Print AppearanceDictionary: true Destination: 150 Annotation: Subtype: Link Rect: 471, 188, 477, 176 Flags: Print AppearanceDictionary: true Destination: 150 Annotation: Subtype: Link Rect: 356, 140, 361, 128 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 382, 63, 491, 53 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 155, 53, 222, 43 Flags: Print AppearanceDictionary: true Thumb: true Page: Sequence: 2 Annotations: Annotation: Subtype: Link Rect: 426, 81, 430, 69 Flags: Print AppearanceDictionary: true Destination: null Thumb: true Page: Sequence: 3 Annotations: Annotation: Subtype: Link Rect: 476, 304, 481, 292 Flags: Print AppearanceDictionary: true Destination: 28 Annotation: Subtype: Link Rect: 309, 224, 313, 212 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 334, 164, 338, 152 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 368, 94, 373, 82 Flags: Print AppearanceDictionary: true Destination: 28 Thumb: true Page: Sequence: 4 Annotations: Annotation: Subtype: Link Rect: 527, 493, 532, 481 Flags: Print AppearanceDictionary: true Destination: 86 Annotation: Subtype: Link Rect: 272, 383, 277, 371 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 458, 311, 463, 299 Flags: Print AppearanceDictionary: true Destination: 150 Annotation: Subtype: Link Rect: 465, 311, 470, 299 Flags: Print AppearanceDictionary: true Destination: 150 Annotation: Subtype: Link Rect: 382, 301, 388, 289 Flags: Print AppearanceDictionary: true Destination: 150 Annotation: Subtype: Link Rect: 523, 291, 528, 279 Flags: Print AppearanceDictionary: true Destination: 150 Annotation: Subtype: Link Rect: 243, 261, 246, 249 Flags: Print AppearanceDictionary: true Destination: 150 Annotation: Subtype: Link Rect: 249, 261, 252, 249 Flags: Print AppearanceDictionary: true Destination: 150 Annotation: Subtype: Link Rect: 175, 231, 181, 219 Flags: Print AppearanceDictionary: true Destination: 150 Annotation: Subtype: Link Rect: 182, 231, 188, 219 Flags: Print AppearanceDictionary: true Destination: 150 Annotation: Subtype: Link Rect: 189, 231, 195, 219 Flags: Print AppearanceDictionary: true Destination: 150 Annotation: Subtype: Link Rect: 188, 201, 194, 189 Flags: Print AppearanceDictionary: true Destination: 150 Annotation: Subtype: Link Rect: 392, 171, 398, 159 Flags: Print AppearanceDictionary: true Destination: 150 Annotation: Subtype: Link Rect: 399, 171, 405, 159 Flags: Print AppearanceDictionary: true Destination: 150 Annotation: Subtype: Link Rect: 296, 151, 299, 139 Flags: Print AppearanceDictionary: true Destination: 150 Annotation: Subtype: Link Rect: 300, 151, 306, 139 Flags: Print AppearanceDictionary: true Destination: 150 Annotation: Subtype: Link Rect: 205, 101, 211, 89 Flags: Print AppearanceDictionary: true Destination: 150 Thumb: true Page: Sequence: 5 Thumb: true Page: Sequence: 6 Annotations: Annotation: Subtype: Link Rect: 518, 694, 523, 682 Flags: Print AppearanceDictionary: true Destination: 150 Annotation: Subtype: Link Rect: 524, 694, 530, 682 Flags: Print AppearanceDictionary: true Destination: 150 Annotation: Subtype: Link Rect: 531, 694, 537, 682 Flags: Print AppearanceDictionary: true Destination: 150 Annotation: Subtype: Link Rect: 183, 654, 189, 642 Flags: Print AppearanceDictionary: true Destination: 150 Annotation: Subtype: Link Rect: 401, 634, 403, 622 Flags: Print AppearanceDictionary: true Destination: 150 Annotation: Subtype: Link Rect: 220, 614, 226, 602 Flags: Print AppearanceDictionary: true Destination: 150 Annotation: Subtype: Link Rect: 227, 614, 233, 602 Flags: Print AppearanceDictionary: true Destination: 150 Annotation: Subtype: Link Rect: 234, 614, 240, 602 Flags: Print AppearanceDictionary: true Destination: 150 Annotation: Subtype: Link Rect: 243, 614, 249, 602 Flags: Print AppearanceDictionary: true Destination: 150 Annotation: Subtype: Link Rect: 330, 534, 335, 522 Flags: Print AppearanceDictionary: true Destination: 150 Annotation: Subtype: Link Rect: 210, 494, 213, 482 Flags: Print AppearanceDictionary: true Destination: 150 Annotation: Subtype: Link Rect: 215, 494, 220, 482 Flags: Print AppearanceDictionary: true Destination: 150 Annotation: Subtype: Link Rect: 222, 494, 227, 482 Flags: Print AppearanceDictionary: true Destination: 176 Annotation: Subtype: Link Rect: 212, 474, 218, 462 Flags: Print AppearanceDictionary: true Destination: 176 Annotation: Subtype: Link Rect: 221, 474, 227, 462 Flags: Print AppearanceDictionary: true Destination: 176 Annotation: Subtype: Link Rect: 239, 464, 242, 452 Flags: Print AppearanceDictionary: true Destination: 150 Annotation: Subtype: Link Rect: 494, 372, 499, 360 Flags: Print AppearanceDictionary: true Destination: 176 Annotation: Subtype: Link Rect: 501, 372, 507, 360 Flags: Print AppearanceDictionary: true Destination: 176 Annotation: Subtype: Link Rect: 437, 342, 443, 330 Flags: Print AppearanceDictionary: true Destination: 176 Annotation: Subtype: Link Rect: 398, 210, 404, 198 Flags: Print AppearanceDictionary: true Destination: 176 Annotation: Subtype: Link Rect: 503, 190, 508, 178 Flags: Print AppearanceDictionary: true Destination: 176 Annotation: Subtype: Link Rect: 357, 102, 363, 90 Flags: Print AppearanceDictionary: true Destination: 176 Annotation: Subtype: Link Rect: 364, 102, 370, 90 Flags: Print AppearanceDictionary: true Destination: 176 Annotation: Subtype: Link Rect: 385, 92, 391, 80 Flags: Print AppearanceDictionary: true Destination: 176 Annotation: Subtype: Link Rect: 368, 82, 374, 70 Flags: Print AppearanceDictionary: true Destination: 150 Annotation: Subtype: Link Rect: 375, 82, 381, 70 Flags: Print AppearanceDictionary: true Destination: 176 Thumb: true Page: Sequence: 7 Annotations: Annotation: Subtype: Link Rect: 215, 714, 220, 702 Flags: Print AppearanceDictionary: true Destination: 150 Annotation: Subtype: Link Rect: 434, 704, 437, 692 Flags: Print AppearanceDictionary: true Destination: 150 Annotation: Subtype: Link Rect: 297, 674, 303, 662 Flags: Print AppearanceDictionary: true Destination: 150 Annotation: Subtype: Link Rect: 467, 556, 472, 544 Flags: Print AppearanceDictionary: true Destination: 150 Annotation: Subtype: Link Rect: 474, 556, 479, 544 Flags: Print AppearanceDictionary: true Destination: 176 Annotation: Subtype: Link Rect: 435, 526, 441, 514 Flags: Print AppearanceDictionary: true Destination: 176 Annotation: Subtype: Link Rect: 216, 487, 338, 475 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 253, 405, 378, 395 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 380, 243, 554, 233 Flags: Print AppearanceDictionary: true Thumb: true Page: Sequence: 8 Annotations: Annotation: Subtype: Link Rect: 167, 556, 243, 546 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 356, 414, 515, 401 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 344, 290, 504, 278 Flags: Print AppearanceDictionary: true Thumb: true Checksum: 46eebc55 Type: CRC32 Checksum: ffb2a64fa81a3b7297f3c10851f3c8a8 Type: MD5 Checksum: ccd08f8462658f93df99ea88aa66d96d5ea102a5 Type: SHA-1