de709aaa7883f5c3c10a83ee80e941b5 pmc_29674708.pdf 92e36d13cfd142ef141dd1f4382ec8a81a692059 pmc_29674708.pdf cb9c3932efceccef7fe8bc480440b533da8aa0e150c5c143ca2f176da7a1107f pmc_29674708.pdf Title: Population structure of Environmental and Clinical Legionella pneumophila isolates in Catalonia Subject: Scientific Reports, doi:10.1038/s41598-018-24708-1 Keywords: Author: Sara Quero Creator: Springer Producer: iText® 5.3.5 ©2000-2012 1T3XT BVBA (AGPL-version) CreationDate: Fri Apr 13 07:16:04 2018 CEST ModDate: Fri Apr 13 11:33:41 2018 CEST Tagged: no UserProperties: no Suspects: no Form: AcroForm JavaScript: no Pages: 9 Encrypted: no Page size: 595.276 x 782.362 pts Page rot: 0 File size: 1330864 bytes Optimized: no PDF version: 1.4 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- FHBEVD+Corbel CID TrueType Identity-H yes yes yes 319 0 RJEIFP+Corbel-BoldItalic Type 1C WinAnsi yes yes yes 34 0 MinionPro-Regular Type 1C Custom yes no yes 42 0 XPHTYT+Corbel-Bold2 Type 1C WinAnsi yes yes yes 37 0 XXAUEV+Corbel2 Type 1C WinAnsi yes yes yes 40 0 KHPDNT+Corbel-Bold CID TrueType Identity-H yes yes yes 41 0 MinionPro-It Type 1C Custom yes no yes 36 0 TLXCJB+TimesNewRomanPSMT Type 1C WinAnsi yes yes yes 320 0 XPHTYT+Corbel-Bold2 Type 1C WinAnsi yes yes yes 240 0 XXAUEV+Corbel2 Type 1C WinAnsi yes yes yes 241 0 FHBEVD+Corbel CID TrueType Identity-H yes yes yes 355 0 MyriadPro-It Type 1C WinAnsi yes no yes 243 0 MinionPro-Bold Type 1C WinAnsi yes no yes 35 0 JNMAZV+STIXGeneral-Regular Type 1C Custom yes yes yes 38 0 EuclidSymbol Type 1C Custom yes no yes 39 0 XXAUEV+Corbel2 Type 1C WinAnsi yes yes yes 250 0 FHBEVD+Corbel CID TrueType Identity-H yes yes yes 242 0 XPHTYT+Corbel-Bold2 Type 1C WinAnsi yes yes yes 262 0 XXAUEV+Corbel2 Type 1C WinAnsi yes yes yes 260 0 FHBEVD+Corbel CID TrueType Identity-H yes yes yes 259 0 Jhove (Rel. 1.22.1, 2019-04-17) Date: 2023-03-31 02:32:31 CEST RepresentationInformation: pmc_29674708.pdf ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17) LastModified: 2018-05-07 03:48:51 CEST Size: 1330864 Format: PDF Version: 1.4 Status: Well-Formed, but not valid SignatureMatches: PDF-hul ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'SpringerNature_SciRep_24708.indd:Figure 1. Distribution of the MAb3/1 positive isolates according to acquisition. Statistical differences between groups are shown as *(p⁜琀㰠 ⸀ ㄀ 愀渀搀 ⨀⨀瀠㰠 ⸀  㔀⸀ ＀䇾＀ 䌀䰀㨀 挀氀椀渀椀挀愀氀 椀猀漀氀愀琀攀猀㬀 䔀一刀㨀 攀渀瘀椀爀漀渀洀攀渀琀愀氀 椀猀漀氀愀琀攀猀㬀 ＀䋾＀ 䌀䄀㨀 挀漀洀洀甀渀椀琀礀ⴀ愀挀焀㨀㌀㔩⽂潲摥牛〠〠そ⽓畢瑹灥⽌楮欯䉓㰼⽗‰⽔祰支䉯牤敲⽓⽓㸾⽒散瑛㐰〮㐶㌠㌳㌮㤳㈠㐱ㄮ〴㠠㌲ㄮ㜹ㅝ⽈⽎⽁值㰯丠㈰‰⁒㸾㸾੥湤潢樊ㄲ‰扪਼㰯䘠㐯呹灥⽁湮潴⽄敳琨SpringerNature_SciRep_24708.indd:Figure 1. Distribution of the MAb3/1 positive isolates according to acquisition. Statistical differences between groups are shown as *(p⁜琀㰠 ⸀ ㄀ 愀渀搀 ⨀⨀瀠㰠 ⸀  㔀⸀ ＀䇾＀ 䌀䰀㨀 挀氀椀渀椀挀愀氀 椀猀漀氀愀琀攀猀㬀 䔀一刀㨀 攀渀瘀椀爀漀渀洀攀渀琀愀氀 椀猀漀氀愀琀攀猀㬀 ＀䋾＀ 䌀䄀㨀 挀漀洀洀甀渀椀琀礀ⴀ愀挀㨀㌀㘩⽂潲摥牛〠〠そ⽓畢瑹灥⽌楮欯䉓㰼⽗‰⽔祰支䉯牤敲⽓⽓㸾⽒散瑛㐶㜮㐰㈠㌲㌮㤳㈠㐷㜮〶ㄠ㌱ㄮ㜹ㅝ⽈⽎⽁值㰯丠㈱‰⁒㸾㸾੥湤潢樊ㄳ‰扪਼㰯䘠㐯呹灥⽁湮潴⽄敳琨SpringerNature_SciRep_24708.indd:Figure 1. Distribution of the MAb3/1 positive isolates according to acquisition. Statistical differences between groups are shown as *(p⁜琀㰠 ⸀ ㄀ 愀渀搀 ⨀⨀瀠㰠 ⸀  㔀⸀ ＀䇾＀ 䌀䰀㨀 挀氀椀渀椀挀愀氀 椀猀漀氀愀琀攀猀㬀 䔀一刀㨀 攀渀瘀椀爀漀渀洀攀渀琀愀氀 椀猀漀氀愀琀攀猀㬀 ＀䋾＀ 䌀䄀㨀 挀漀洀洀甀渀椀琀礀ⴀ愀㨀㌀㜩⽂潲摥牛〠〠そ⽓畢瑹灥⽌楮欯䉓㰼⽗‰⽔祰支䉯牤敲⽓⽓㸾⽒散瑛㌸㈮㤸㌠㌰㌮㤳㈠㌹㈮㔹㔠㈹ㄮ㜹ㅝ⽈⽎⽁值㰯丠㈲‰⁒㸾㸾੥湤潢樊ㄴ‰扪਼㰯䘠㐯呹灥⽁湮潴⽄敳琨SpringerNature_SciRep_24708.indd:Figure 1. Distribution of the MAb3/1 positive isolates according to acquisition. Statistical differences between groups are shown as *(p⁜琀㰠 ⸀ ㄀ 愀渀搀 ⨀⨀瀠㰠 ⸀  㔀⸀ ＀䇾＀ 䌀䰀㨀 挀氀椀渀椀挀愀氀 椀猀漀氀愀琀攀猀㬀 䔀一刀㨀 攀渀瘀椀爀漀渀洀攀渀琀愀氀 椀猀漀氀愀琀攀猀㬀 ＀䋾＀ 䌀䄀㨀 挀漀洀洀甀渀椀琀礀ⴀ㨀㌀㠩⽂潲摥牛〠〠そ⽓畢瑹灥⽌楮欯䉓㰼⽗‰⽔祰支䉯牤敲⽓⽓㸾⽒散瑛㔲㠮㄰㘠㈷㌮㤳㈠㔳㜮㜱㠠㈶ㄮ㜹ㅝ⽈⽎⽁值㰯丠㈳‰⁒㸾㸾੥湤潢樊ㄵ‰扪਼㰯䘠㐯呹灥⽁湮潴⽄敳琨SpringerNature_SciRep_24708.indd:Figure 2. Distribution of the most frequent STs according to the origin. (A) CL: clinical isolates; ENR: environmental isolates; (B) CA: community-acquired clinical isolates; HA: hospital-acquired clinical isolates; HOSP: hospital environmen:39' cannot be found Offset: 785379 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'SpringerNature_SciRep_24708.indd:Figure 1. Distribution of the MAb3/1 positive isolates according to acquisition. Statistical differences between groups are shown as *(p⁜琀㰠 ⸀ ㄀ 愀渀搀 ⨀⨀瀠㰠 ⸀  㔀⸀ ＀䇾＀ 䌀䰀㨀 挀氀椀渀椀挀愀氀 椀猀漀氀愀琀攀猀㬀 䔀一刀㨀 攀渀瘀椀爀漀渀洀攀渀琀愀氀 椀猀漀氀愀琀攀猀㬀 ＀䋾＀ 䌀䄀㨀 挀漀洀洀甀渀椀琀礀ⴀ愀挀㨀㌀㘩⽂潲摥牛〠〠そ⽓畢瑹灥⽌楮欯䉓㰼⽗‰⽔祰支䉯牤敲⽓⽓㸾⽒散瑛㐶㜮㐰㈠㌲㌮㤳㈠㐷㜮〶ㄠ㌱ㄮ㜹ㅝ⽈⽎⽁值㰯丠㈱‰⁒㸾㸾੥湤潢樊ㄳ‰扪਼㰯䘠㐯呹灥⽁湮潴⽄敳琨SpringerNature_SciRep_24708.indd:Figure 1. Distribution of the MAb3/1 positive isolates according to acquisition. Statistical differences between groups are shown as *(p⁜琀㰠 ⸀ ㄀ 愀渀搀 ⨀⨀瀠㰠 ⸀  㔀⸀ ＀䇾＀ 䌀䰀㨀 挀氀椀渀椀挀愀氀 椀猀漀氀愀琀攀猀㬀 䔀一刀㨀 攀渀瘀椀爀漀渀洀攀渀琀愀氀 椀猀漀氀愀琀攀猀㬀 ＀䋾＀ 䌀䄀㨀 挀漀洀洀甀渀椀琀礀ⴀ愀㨀㌀㜩⽂潲摥牛〠〠そ⽓畢瑹灥⽌楮欯䉓㰼⽗‰⽔祰支䉯牤敲⽓⽓㸾⽒散瑛㌸㈮㤸㌠㌰㌮㤳㈠㌹㈮㔹㔠㈹ㄮ㜹ㅝ⽈⽎⽁值㰯丠㈲‰⁒㸾㸾੥湤潢樊ㄴ‰扪਼㰯䘠㐯呹灥⽁湮潴⽄敳琨SpringerNature_SciRep_24708.indd:Figure 1. Distribution of the MAb3/1 positive isolates according to acquisition. Statistical differences between groups are shown as *(p⁜琀㰠 ⸀ ㄀ 愀渀搀 ⨀⨀瀠㰠 ⸀  㔀⸀ ＀䇾＀ 䌀䰀㨀 挀氀椀渀椀挀愀氀 椀猀漀氀愀琀攀猀㬀 䔀一刀㨀 攀渀瘀椀爀漀渀洀攀渀琀愀氀 椀猀漀氀愀琀攀猀㬀 ＀䋾＀ 䌀䄀㨀 挀漀洀洀甀渀椀琀礀ⴀ㨀㌀㠩⽂潲摥牛〠〠そ⽓畢瑹灥⽌楮欯䉓㰼⽗‰⽔祰支䉯牤敲⽓⽓㸾⽒散瑛㔲㠮㄰㘠㈷㌮㤳㈠㔳㜮㜱㠠㈶ㄮ㜹ㅝ⽈⽎⽁值㰯丠㈳‰⁒㸾㸾੥湤潢樊ㄵ‰扪਼㰯䘠㐯呹灥⽁湮潴⽄敳琨SpringerNature_SciRep_24708.indd:Figure 2. Distribution of the most frequent STs according to the origin. (A) CL: clinical isolates; ENR: environmental isolates; (B) CA: community-acquired clinical isolates; HA: hospital-acquired clinical isolates; HOSP: hospital environmen:39' cannot be found Offset: 785379 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'SpringerNature_SciRep_24708.indd:Figure 1. Distribution of the MAb3/1 positive isolates according to acquisition. Statistical differences between groups are shown as *(p⁜琀㰠 ⸀ ㄀ 愀渀搀 ⨀⨀瀠㰠 ⸀  㔀⸀ ＀䇾＀ 䌀䰀㨀 挀氀椀渀椀挀愀氀 椀猀漀氀愀琀攀猀㬀 䔀一刀㨀 攀渀瘀椀爀漀渀洀攀渀琀愀氀 椀猀漀氀愀琀攀猀㬀 ＀䋾＀ 䌀䄀㨀 挀漀洀洀甀渀椀琀礀ⴀ愀㨀㌀㜩⽂潲摥牛〠〠そ⽓畢瑹灥⽌楮欯䉓㰼⽗‰⽔祰支䉯牤敲⽓⽓㸾⽒散瑛㌸㈮㤸㌠㌰㌮㤳㈠㌹㈮㔹㔠㈹ㄮ㜹ㅝ⽈⽎⽁值㰯丠㈲‰⁒㸾㸾੥湤潢樊ㄴ‰扪਼㰯䘠㐯呹灥⽁湮潴⽄敳琨SpringerNature_SciRep_24708.indd:Figure 1. Distribution of the MAb3/1 positive isolates according to acquisition. Statistical differences between groups are shown as *(p⁜琀㰠 ⸀ ㄀ 愀渀搀 ⨀⨀瀠㰠 ⸀  㔀⸀ ＀䇾＀ 䌀䰀㨀 挀氀椀渀椀挀愀氀 椀猀漀氀愀琀攀猀㬀 䔀一刀㨀 攀渀瘀椀爀漀渀洀攀渀琀愀氀 椀猀漀氀愀琀攀猀㬀 ＀䋾＀ 䌀䄀㨀 挀漀洀洀甀渀椀琀礀ⴀ㨀㌀㠩⽂潲摥牛〠〠そ⽓畢瑹灥⽌楮欯䉓㰼⽗‰⽔祰支䉯牤敲⽓⽓㸾⽒散瑛㔲㠮㄰㘠㈷㌮㤳㈠㔳㜮㜱㠠㈶ㄮ㜹ㅝ⽈⽎⽁值㰯丠㈳‰⁒㸾㸾੥湤潢樊ㄵ‰扪਼㰯䘠㐯呹灥⽁湮潴⽄敳琨SpringerNature_SciRep_24708.indd:Figure 2. Distribution of the most frequent STs according to the origin. (A) CL: clinical isolates; ENR: environmental isolates; (B) CA: community-acquired clinical isolates; HA: hospital-acquired clinical isolates; HOSP: hospital environmen:39' cannot be found Offset: 785379 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'SpringerNature_SciRep_24708.indd:Figure 1. Distribution of the MAb3/1 positive isolates according to acquisition. Statistical differences between groups are shown as *(p⁜琀㰠 ⸀ ㄀ 愀渀搀 ⨀⨀瀠㰠 ⸀  㔀⸀ ＀䇾＀ 䌀䰀㨀 挀氀椀渀椀挀愀氀 椀猀漀氀愀琀攀猀㬀 䔀一刀㨀 攀渀瘀椀爀漀渀洀攀渀琀愀氀 椀猀漀氀愀琀攀猀㬀 ＀䋾＀ 䌀䄀㨀 挀漀洀洀甀渀椀琀礀ⴀ㨀㌀㠩⽂潲摥牛〠〠そ⽓畢瑹灥⽌楮欯䉓㰼⽗‰⽔祰支䉯牤敲⽓⽓㸾⽒散瑛㔲㠮㄰㘠㈷㌮㤳㈠㔳㜮㜱㠠㈶ㄮ㜹ㅝ⽈⽎⽁值㰯丠㈳‰⁒㸾㸾੥湤潢樊ㄵ‰扪਼㰯䘠㐯呹灥⽁湮潴⽄敳琨SpringerNature_SciRep_24708.indd:Figure 2. Distribution of the most frequent STs according to the origin. (A) CL: clinical isolates; ENR: environmental isolates; (B) CA: community-acquired clinical isolates; HA: hospital-acquired clinical isolates; HOSP: hospital environmen:39' cannot be found Offset: 785379 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'SpringerNature_SciRep_24708.indd:Figure 2. Distribution of the most frequent STs according to the origin. (A) CL: clinical isolates; ENR: environmental isolates; (B) CA: community-acquired clinical isolates; HA: hospital-acquired clinical isolates; HOSP: hospital environmen:39' cannot be found Offset: 785379 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'SpringerNature_SciRep_24708.indd:Figure 2. Distribution of the most frequent STs according to the origin. (A) CL: clinical isolates; ENR: environmental isolates; (B) CA: community-acquired clinical isolates; HA: hospital-acquired clinical isolates; HOSP: hospital environme:40' cannot be found Offset: 785379 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'SpringerNature_SciRep_24708.indd:Figure 2. Distribution of the most frequent STs according to the origin. (A) CL: clinical isolates; ENR: environmental isolates; (B) CA: community-acquired clinical isolates; HA: hospital-acquired clinical isolates; HOSP: hospital environm:41' cannot be found Offset: 785379 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'SpringerNature_SciRep_24708.indd:Figure 2. Distribution of the most frequent STs according to the origin. (A) CL: clinical isolates; ENR: environmental isolates; (B) CA: community-acquired clinical isolates; HA: hospital-acquired clinical isolates; HOSP: hospital environ:42' cannot be found Offset: 785379 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'SpringerNature_SciRep_24708.indd:Figure 2. Distribution of the most frequent STs according to the origin. (A) CL: clinical isolates; ENR: environmental isolates; (B) CA: community-acquired clinical isolates; HA: hospital-acquired clinical isolates; HOSP: hospital enviro:43' cannot be found Offset: 785379 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'SpringerNature_SciRep_24708.indd:Figure 2. Distribution of the most frequent STs according to the origin. (A) CL: clinical isolates; ENR: environmental isolates; (B) CA: community-acquired clinical isolates; HA: hospital-acquired clinical isolates; HOSP: hospital envir:44' cannot be found Offset: 785379 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'SpringerNature_SciRep_24708.indd:Figure 3. Minimum-spanning tree obtained with PhyloViz (A) based  on the SBT allelic profiles of L. pneumophila isolates from Catalonia divided into clinical and environmental isolates. Clonal Complexes (CC) of Single-Locus Variants are sh:45' cannot be found Offset: 785379 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'SpringerNature_SciRep_24708.indd:Figure 3. Minimum-spanning tree obtained with PhyloViz (A) based  on the SBT allelic profiles of L. pneumophila isolates from Catalonia divided into clinical and environmental isolates. Clonal Complexes (CC) of Single-Locus Variants are s:46' cannot be found Offset: 785379 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'SpringerNature_SciRep_24708.indd: 20. Reimer, A. R., Au, S., Schindle, S. & Bernard, K. A. Legionella pneumophila monoclonal antibody subgroups and DNA sequence types isolated in Canada between 1981 and 2009: Laboratory Component of National Surveillance. Eur. J. Clin. M:69' cannot be found Offset: 785379 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'SpringerNature_SciRep_24708.indd: 20. Reimer, A. R., Au, S., Schindle, S. & Bernard, K. A. Legionella pneumophila monoclonal antibody subgroups and DNA sequence types isolated in Canada between 1981 and 2009: Laboratory Component of National Surveillance. Eur. J. Clin. :76' cannot be found Offset: 785379 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'SpringerNature_SciRep_24708.indd: 14. Amemura-Maekawa, J. et al. Distribution of monoclonal antibody subgroups and sequence-based types among Legionella pneumophila serogroup 1 isolates derived from cooling tower water, bathwater, and soil in Japan. Appl. Environ. Micr:77' cannot be found Offset: 785379 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'SpringerNature_SciRep_24708.indd: 20. Reimer, A. R., Au, S., Schindle, S. & Bernard, K. A. Legionella pneumophila monoclonal antibody subgroups and DNA sequence types isolated in Canada between 1981 and 2009: Laboratory Component of National Surveillance. Eur. J. Clin.:78' cannot be found Offset: 785379 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'SpringerNature_SciRep_24708.indd: 15. Kozak-Muiznieks, N. A. et al. Prevalence of sequence types among clinical and environmental isolates of Legionella pneumophila serogroup 1 in the United States from 1982 to 2012. J. Clin. Microbiol. 52, 201–211 (2014). :86' cannot be found Offset: 785379 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'SpringerNature_SciRep_24708.indd: 16. Harrison, T. G., Afshar, B., Doshi, N., Fry, N. K. & Lee, J. V. Distribution of Legionella pneumophila serogroups, monoclonal antibody subgroups and DNA sequence types in recent clinical and environmental isolates from England and Wal:94' cannot be found Offset: 785379 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'SpringerNature_SciRep_24708.indd: 9. Garcia-Nuñez, M. et al. Characterization of unrelated clinical Legionella pneumophila isolates in Catalonia by monoclonal subgrouping and sequence-based typing. Future Microbiol. 11, 865–875 (2016). :106' cannot be found Offset: 785379 MIMEtype: application/pdf PDFMetadata: Objects: 405 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: ViewerPreferences: HideToolbar: false HideMenubar: false HideWindowUI: false FitWindow: false CenterWindow: false DisplayDocTitle: false NonFullScreenPageMode: UseNone Direction: L2R ViewArea: CropBox ViewClip: CropBox PrintArea: CropBox PageClip: CropBox PageLayout: SinglePage PageMode: UseOutlines Language: EN Outlines: Item: Title: Population structure of Environmental and Clinical Legionella pneumophila isolates in Catalonia Children: Item: Title: Results Children: Item: Title: L. pneumophila identification. Item: Title: Reactivity against MAb 3/1. Item: Title: MAb Dresden Panel subgrouping. Item: Title: SBT. Item: Title: ST comparison between groups. Item: Title: Phenons: combinations of SBT and MAb subgrouping. Item: Title: Phylogenetic analysis of ST. Item: Title: Discussion Children: Item: Title: Future perspectives. Item: Title: Methods Children: Item: Title: Bacterial isolates. Children: Item: Title: Clinical isolates. Item: Title: Environmental isolates. Item: Title: L. pneumophila identification, MAb 3/1 reactivity and MAb Dresden Panel subgrouping. Item: Title: SBT. Item: Title: Data interpretation. Item: Title: Statistical analysis. Item: Title: Acknowledgements Item: Title: Figure 1 Distribution of the MAb3/1 positive isolates according to acquisition. Item: Title: Figure 2 Distribution of the most frequent STs according to the origin. Item: Title: Figure 3 Minimum-spanning tree obtained with PhyloViz (A) based  on the SBT allelic profiles of L. Info: Title: Population structure of Environmental and Clinical Legionella pneumophila isolates in Catalonia Author: Sara Quero Subject: Scientific Reports, doi:10.1038/s41598-018-24708-1 Keywords: Creator: Springer Producer: iText® 5.3.5 ©2000-2012 1T3XT BVBA (AGPL-version) CreationDate: Fri Apr 13 07:46:04 CEST 2018 ModDate: Fri Apr 13 11:33:41 CEST 2018 ID: 0x43fd73e60eed1f437a0ff4ef45ef87c6, 0xb4b81f06d9b68bc1151d793c341beb65 Filters: FilterPipeline: FlateDecode FilterPipeline: DCTDecode Images: Image: NisoImageMetadata: FormatName: image/png ImageWidth: 1100 ImageHeight: 90 ColorSpace: black is zero BitsPerSample: 1 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric Name: X Image: NisoImageMetadata: FormatName: image/png ImageWidth: 1500 ImageHeight: 687 ColorSpace: black is zero BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric Name: X Image: NisoImageMetadata: FormatName: image/png ImageWidth: 1000 ImageHeight: 1085 ColorSpace: black is zero BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric Name: X Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1350 ImageHeight: 1393 ColorSpace: black is zero BitsPerSample: 8 BitsPerSampleUnit: integer Intent: RelativeColorimetric Name: X Fonts: Type0: Font: BaseFont: KHPDNT+Corbel-Bold Encoding: Identity-H ToUnicode: true Font: BaseFont: FHBEVD+Corbel Encoding: Identity-H ToUnicode: true Type1: Font: BaseFont: TLXCJB+TimesNewRomanPSMT FontSubset: true FirstChar: 32 LastChar: 120 FontDescriptor: FontName: TLXCJB+TimesNewRomanPSMT Flags: Serif, Nonsymbolic FontBBox: -568, -307, 2000, 1007 FontFile3: true Encoding: WinAnsiEncoding ToUnicode: true Font: BaseFont: RJEIFP+Corbel-BoldItalic FontSubset: true FirstChar: 0 LastChar: 255 FontDescriptor: FontName: RJEIFP+Corbel-BoldItalic Flags: Nonsymbolic, Italic FontBBox: -494, -239, 1194, 952 FontFile3: true Encoding: WinAnsiEncoding ToUnicode: true Font: BaseFont: MinionPro-Bold FirstChar: 0 LastChar: 255 FontDescriptor: FontName: MinionPro-Bold Flags: Serif, Nonsymbolic FontBBox: -319, -360, 1684, 1024 FontFile3: true Encoding: WinAnsiEncoding ToUnicode: true Font: BaseFont: MinionPro-It FirstChar: 0 LastChar: 255 FontDescriptor: FontName: MinionPro-It Flags: Serif, Nonsymbolic, Italic FontBBox: -201, -360, 1684, 1002 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: XPHTYT+Corbel-Bold2 FontSubset: true FirstChar: 0 LastChar: 255 FontDescriptor: FontName: XPHTYT+Corbel-Bold2 Flags: Nonsymbolic FontBBox: -556, -239, 1155, 952 FontFile3: true Encoding: WinAnsiEncoding ToUnicode: true Font: BaseFont: JNMAZV+STIXGeneral-Regular FontSubset: true FirstChar: 31 LastChar: 31 FontDescriptor: FontName: JNMAZV+STIXGeneral-Regular Flags: Serif, Symbolic FontBBox: -995, -455, 2000, 1055 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: EuclidSymbol FirstChar: 0 LastChar: 255 FontDescriptor: FontName: EuclidSymbol Flags: Symbolic FontBBox: -166, -253, 1090, 950 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: XXAUEV+Corbel2 FontSubset: true FirstChar: 0 LastChar: 255 FontDescriptor: FontName: XXAUEV+Corbel2 Flags: Nonsymbolic FontBBox: -553, -239, 1110, 952 FontFile3: true Encoding: WinAnsiEncoding ToUnicode: true Font: BaseFont: MinionPro-Regular FirstChar: 0 LastChar: 255 FontDescriptor: FontName: MinionPro-Regular Flags: Serif, Nonsymbolic FontBBox: -290, -360, 1684, 989 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true CIDFontType2: Font: BaseFont: FHBEVD+Corbel CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: FHBEVD+Corbel Flags: Symbolic FontBBox: -553, -239, 1110, 952 FontFile2: true Font: BaseFont: KHPDNT+Corbel-Bold CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: KHPDNT+Corbel-Bold Flags: Symbolic FontBBox: -556, -239, 1155, 952 FontFile2: true XMP: application/pdf doi:10.1038/s41598-018-24708-1 Springer US Scientific Reports, doi:10.1038/s41598-018-24708-1 Population structure of Environmental and Clinical Legionella pneumophila isolates in Catalonia Sara Quero Noemamp#x000ED; Pamp#x000E1;rraga-Niamp#x000F1;o Irene Barrabeig Maria Rosa Sala M. Luisa Pedro-Botet Eduard Monsamp#x000F3; Mireia Janamp#x000E9; Miquel Sabriamp#x000E0; Marian Garcia-Namp#x000FA;amp#x000F1;ez 10.1038/s41598-018-24708-1 http://dx.doi.org/10.1038/s41598-018-24708-1 journal Scientific Reports © 2018, The Author(s) 2045-2322 10.1038/s41598-018-24708-1 Springer 2018-04-13T11:33:41+02:00 2018-04-13T10:46:04+05:30 2018-04-13T11:33:41+02:00 True iText® 5.3.5 ©2000-2012 1T3XT BVBA (AGPL-version) VoR uuid:f6fdae71-58c2-473a-b350-0e4fd2dd1650 uuid:b3359283-fa30-4f91-bf5f-8bd88a4d6384 default 1 converted uuid:8c525d92-1dd8-4389-8fef-5eb186e3de25 converted to PDF/A-2b pdfToolbox 2018-04-13T10:46:43+05:30 2 B http://ns.adobe.com/xap/1.0/mm/ xmpMM XMP Media Management Schema internal UUID based identifier for specific incarnation of a document InstanceID URI internal The common identifier for all versions and renditions of a document. OriginalDocumentID URI http://ns.adobe.com/pdf/1.3/ pdf Adobe PDF Schema internal A name object indicating whether the document has been modified to include trapping information Trapped Text http://ns.adobe.com/pdfx/1.3/ pdfx pdfx internal ID of PDF/X standard GTS_PDFXVersion Text internal Conformance level of PDF/X standard GTS_PDFXConformance Text internal Company creating the PDF Company Text internal Date when document was last modified SourceModified Text internal Mirrors crossmark:DOI doi Text http://www.aiim.org/pdfa/ns/id/ pdfaid PDF/A ID Schema internal Part of PDF/A standard part Integer internal Amendment of PDF/A standard amd Text internal Conformance level of PDF/A standard conformance Text http://prismstandard.org/namespaces/basic/2.0/ prism Prism external The aggregation type specifies the unit of aggregation for a content collection. Comment PRISM recommends that the PRISM Aggregation Type Controlled Vocabulary be used to provide values for this element. Note: PRISM recommends against the use of the #other value currently allowed in this controlled vocabulary. In lieu of using #other please reach out to the PRISM group at info@prismstandard.org to request addition of your term to the Aggregation Type Controlled Vocabulary. aggregationType Text external Copyright copyright Text external The Digital Object Identifier for the article. The DOI may also be used as the dc:identifier. If used as a dc:identifier, the URI form should be captured, and the bare identifier should also be captured using prism:doi. If an alternate unique identifier is used as the required dc:identifier, then the DOI should be specified as a bare identifier within prism:doi only. If the URL associated with a DOI is to be specified, then prism:url may be used in conjunction with prism:doi in order to provide the service endpoint (i.e. the URL). doi Text external ISSN for an electronic version of the issue in which the resource occurs. Permits publishers to include a second ISSN, identifying an electronic version of the issue in which the resource occurs (therefore e(lectronic)Issn. If used, prism:eIssn MUST contain the ISSN of the electronic version. See prism:issn. issn Text external Title of the magazine, or other publication, in which a resource was/will be published. Typically this will be used to provide the name of the magazine an article appeared in as metadata for the article, along with information such as the article title, the publisher, volume, number, and cover date. Note: Publication name can be used to differentiate between a print magazine and the online version if the names are different such as “magazine” and “magazine.com.” publicationName Text external This element provides the url for an article or unit of content. The attribute platform is optionally allowed for situations in which multiple URLs must be specified. PRISM recommends that a subset of the PCV platform values, namely “mobile” and “web”, be used in conjunction with this element. NOTE: PRISM recommends against the use of the #other value allowed in the PRISM Platform controlled vocabulary. In lieu of using #other please reach out to the PRISM group at prism-wg@yahoogroups.com to request addition of your term to the Platform Controlled Vocabulary. url Text http://www.niso.org/schemas/jav/1.0/ jav NISO external Values for Journal Article Version are one of the following: AO = Author’s Original SMUR = Submitted Manuscript Under Review AM = Accepted Manuscript P = Proof VoR = Version of Record CVoR = Corrected Version of Record EVoR = Enhanced Version of Record journal_article_version Closed Choice of Text Pages: Page: Sequence: 1 Annotations: Annotation: Subtype: Link Rect: 260, 291, 263, 279 Flags: Print AppearanceDictionary: true Destination: 202 Annotation: Subtype: Link Rect: 266, 291, 269, 279 Flags: Print AppearanceDictionary: true Destination: 202 Annotation: Subtype: Link Rect: 190, 261, 193, 249 Flags: Print AppearanceDictionary: true Destination: 202 Annotation: Subtype: Link Rect: 196, 261, 199, 249 Flags: Print AppearanceDictionary: true Destination: 202 Annotation: Subtype: Link Rect: 244, 211, 247, 199 Flags: Print AppearanceDictionary: true Destination: 202 Annotation: Subtype: Link Rect: 357, 191, 362, 179 Flags: Print AppearanceDictionary: true Destination: 202 Annotation: Subtype: Link Rect: 366, 191, 371, 179 Flags: Print AppearanceDictionary: true Destination: 216 Annotation: Subtype: Link Rect: 155, 53, 274, 43 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 342, 53, 406, 43 Flags: Print AppearanceDictionary: true Thumb: true Page: Sequence: 2 Annotations: Annotation: Subtype: Link Rect: 308, 483, 314, 471 Flags: Print AppearanceDictionary: true Destination: 216 Annotation: Subtype: Link Rect: 317, 483, 323, 471 Flags: Print AppearanceDictionary: true Destination: 216 Annotation: Subtype: Link Rect: 407, 94, 417, 82 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 407, 94, 417, 82 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 407, 94, 417, 82 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 407, 94, 417, 82 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 407, 94, 417, 82 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 210, 74, 220, 62 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 466, 64, 475, 52 Flags: Print AppearanceDictionary: true Destination: null Thumb: true Page: Sequence: 3 Annotations: Annotation: Subtype: Link Rect: 424, 399, 434, 387 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 237, 379, 247, 367 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 539, 369, 549, 357 Flags: Print AppearanceDictionary: true Destination: null Thumb: true Page: Sequence: 4 Annotations: Annotation: Subtype: Link Rect: 505, 283, 516, 271 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 391, 243, 401, 231 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 407, 74, 412, 62 Flags: Print AppearanceDictionary: true Destination: 216 Annotation: Subtype: Link Rect: 416, 74, 421, 62 Flags: Print AppearanceDictionary: true Destination: 216 Annotation: Subtype: Link Rect: 190, 54, 193, 42 Flags: Print AppearanceDictionary: true Destination: 202 Annotation: Subtype: Link Rect: 194, 54, 200, 42 Flags: Print AppearanceDictionary: true Destination: 216 Annotation: Subtype: Link Rect: 505, 54, 511, 42 Flags: Print AppearanceDictionary: true Destination: 216 Thumb: true Page: Sequence: 5 Annotations: Annotation: Subtype: Link Rect: 302, 734, 305, 722 Flags: Print AppearanceDictionary: true Destination: 202 Annotation: Subtype: Link Rect: 367, 704, 373, 692 Flags: Print AppearanceDictionary: true Destination: 216 Annotation: Subtype: Link Rect: 178, 674, 183, 662 Flags: Print AppearanceDictionary: true Destination: 216 Annotation: Subtype: Link Rect: 185, 674, 190, 662 Flags: Print AppearanceDictionary: true Destination: 216 Annotation: Subtype: Link Rect: 192, 674, 197, 662 Flags: Print AppearanceDictionary: true Destination: 216 Annotation: Subtype: Link Rect: 443, 664, 448, 652 Flags: Print AppearanceDictionary: true Destination: 216 Annotation: Subtype: Link Rect: 468, 634, 473, 622 Flags: Print AppearanceDictionary: true Destination: 216 Annotation: Subtype: Link Rect: 475, 634, 480, 622 Flags: Print AppearanceDictionary: true Destination: 216 Annotation: Subtype: Link Rect: 482, 634, 488, 622 Flags: Print AppearanceDictionary: true Destination: 216 Annotation: Subtype: Link Rect: 259, 614, 264, 602 Flags: Print AppearanceDictionary: true Destination: 216 Annotation: Subtype: Link Rect: 391, 564, 393, 552 Flags: Print AppearanceDictionary: true Destination: 202 Annotation: Subtype: Link Rect: 215, 544, 221, 532 Flags: Print AppearanceDictionary: true Destination: 216 Annotation: Subtype: Link Rect: 222, 544, 228, 532 Flags: Print AppearanceDictionary: true Destination: 216 Annotation: Subtype: Link Rect: 381, 514, 387, 502 Flags: Print AppearanceDictionary: true Destination: 216 Annotation: Subtype: Link Rect: 388, 514, 394, 502 Flags: Print AppearanceDictionary: true Destination: 216 Annotation: Subtype: Link Rect: 395, 514, 401, 502 Flags: Print AppearanceDictionary: true Destination: 216 Annotation: Subtype: Link Rect: 337, 494, 343, 482 Flags: Print AppearanceDictionary: true Destination: 216 Annotation: Subtype: Link Rect: 344, 494, 350, 482 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 524, 484, 529, 472 Flags: Print AppearanceDictionary: true Destination: 216 Annotation: Subtype: Link Rect: 531, 484, 536, 472 Flags: Print AppearanceDictionary: true Destination: 216 Annotation: Subtype: Link Rect: 540, 414, 545, 402 Flags: Print AppearanceDictionary: true Destination: 216 Annotation: Subtype: Link Rect: 547, 414, 552, 402 Flags: Print AppearanceDictionary: true Destination: 216 Annotation: Subtype: Link Rect: 297, 354, 303, 342 Flags: Print AppearanceDictionary: true Destination: 216 Annotation: Subtype: Link Rect: 410, 324, 416, 312 Flags: Print AppearanceDictionary: true Destination: 216 Annotation: Subtype: Link Rect: 417, 324, 423, 312 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 303, 314, 309, 302 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 310, 314, 315, 302 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 317, 314, 322, 302 Flags: Print AppearanceDictionary: true Destination: 216 Annotation: Subtype: Link Rect: 324, 314, 329, 302 Flags: Print AppearanceDictionary: true Destination: 216 Annotation: Subtype: Link Rect: 332, 314, 338, 302 Flags: Print AppearanceDictionary: true Destination: 216 Annotation: Subtype: Link Rect: 317, 294, 323, 282 Flags: Print AppearanceDictionary: true Destination: 216 Annotation: Subtype: Link Rect: 548, 244, 554, 232 Flags: Print AppearanceDictionary: true Destination: 216 Annotation: Subtype: Link Rect: 345, 204, 351, 192 Flags: Print AppearanceDictionary: true Destination: 216 Annotation: Subtype: Link Rect: 352, 204, 357, 192 Flags: Print AppearanceDictionary: true Destination: 216 Annotation: Subtype: Link Rect: 166, 134, 172, 122 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 546, 134, 552, 122 Flags: Print AppearanceDictionary: true Destination: 216 Annotation: Subtype: Link Rect: 380, 124, 386, 112 Flags: Print AppearanceDictionary: true Destination: 216 Annotation: Subtype: Link Rect: 205, 114, 210, 102 Flags: Print AppearanceDictionary: true Destination: 216 Thumb: true Page: Sequence: 6 Annotations: Annotation: Subtype: Link Rect: 306, 654, 312, 642 Flags: Print AppearanceDictionary: true Destination: 216 Annotation: Subtype: Link Rect: 313, 654, 319, 642 Flags: Print AppearanceDictionary: true Destination: 216 Annotation: Subtype: Link Rect: 321, 654, 326, 642 Flags: Print AppearanceDictionary: true Destination: 216 Annotation: Subtype: Link Rect: 369, 644, 375, 632 Flags: Print AppearanceDictionary: true Destination: 216 Annotation: Subtype: Link Rect: 443, 604, 449, 592 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 380, 424, 386, 412 Flags: Print AppearanceDictionary: true Destination: 216 Annotation: Subtype: Link Rect: 389, 424, 395, 412 Flags: Print AppearanceDictionary: true Destination: 216 Annotation: Subtype: Link Rect: 514, 404, 519, 392 Flags: Print AppearanceDictionary: true Destination: 216 Annotation: Subtype: Link Rect: 522, 404, 528, 392 Flags: Print AppearanceDictionary: true Destination: 216 Annotation: Subtype: Link Rect: 504, 354, 510, 342 Flags: Print AppearanceDictionary: true Destination: 216 Annotation: Subtype: Link Rect: 511, 354, 517, 342 Flags: Print AppearanceDictionary: true Destination: 216 Annotation: Subtype: Link Rect: 465, 224, 471, 212 Flags: Print AppearanceDictionary: true Destination: 216 Annotation: Subtype: Link Rect: 474, 224, 480, 212 Flags: Print AppearanceDictionary: true Destination: 216 Annotation: Subtype: Link Rect: 492, 204, 497, 192 Flags: Print AppearanceDictionary: true Destination: 216 Annotation: Subtype: Link Rect: 499, 204, 504, 192 Flags: Print AppearanceDictionary: true Destination: 216 Annotation: Subtype: Link Rect: 469, 194, 475, 182 Flags: Print AppearanceDictionary: true Destination: 216 Thumb: true Page: Sequence: 7 Annotations: Annotation: Subtype: Link Rect: 353, 684, 356, 672 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 420, 482, 425, 470 Flags: Print AppearanceDictionary: true Destination: 216 Annotation: Subtype: Link Rect: 281, 373, 499, 361 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 489, 363, 494, 351 Flags: Print AppearanceDictionary: true Destination: 216 Thumb: true Page: Sequence: 8 Annotations: Annotation: Subtype: Link Rect: 424, 267, 489, 257 Flags: Print AppearanceDictionary: true Thumb: true Page: Sequence: 9 Annotations: Annotation: Subtype: Link Rect: 356, 479, 515, 466 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 344, 355, 504, 343 Flags: Print AppearanceDictionary: true Thumb: true Checksum: e72a0378 Type: CRC32 Checksum: de709aaa7883f5c3c10a83ee80e941b5 Type: MD5 Checksum: 92e36d13cfd142ef141dd1f4382ec8a81a692059 Type: SHA-1