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Introduction Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@ed9d034 Item: Title: 2. Methods Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6121c9d6 Children: Item: Title: 2.1. Subjects Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@87f383f Item: Title: 2.2. Joint Mobility Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4eb7f003 Item: Title: 2.3. Metabolic Control and Microvascular Complications Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@eafc191 Item: Title: 2.4. Statistical Analysis Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@612fc6eb Item: Title: 3. Results Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1060b431 Item: Title: 4. Discussion Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@612679d6 Item: Title: Conflicts of Interest Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@11758f2a Item: Title: Acknowledgments Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@e720b71 Info: Title: HDIJE_1897058 1..5 Creator: Aspose Ltd. Producer: Aspose.Pdf for .NET 10.1.0; modified using iTextSharp™ 5.4.0 ©2000-2012 1T3XT BVBA (AGPL-version) CreationDate: Tue May 01 00:36:16 CEST 2018 ModDate: Wed May 16 11:44:17 CEST 2018 ID: 0x837ba4585317bd47eb3487db73d45cb8, 0x61fb1ba82a23e7e024cb5b4bba7cb896 Filters: FilterPipeline: FlateDecode Fonts: Type0: Font: BaseFont: MinionPro-Regular Encoding: Identity-H ToUnicode: true Font: BaseFont: OZFHUQ+MinionPro-Regular Encoding: Identity-H ToUnicode: true Type1: Font: BaseFont: DBAAGP+Minion-Black FontSubset: true FirstChar: 32 LastChar: 122 FontDescriptor: FontName: DBAAGP+Minion-Black Flags: Serif, Nonsymbolic, ForceBold FontBBox: -133, -250, 1120, 827 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: DBABNB+MinionMath-Regular+20 FontSubset: true FirstChar: 32 LastChar: 134 FontDescriptor: FontName: DBABNB+MinionMath-Regular+20 Flags: Nonsymbolic FontBBox: -1187, -427, 1541, 1072 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: DBAAGO+MinionProIt FontSubset: true FirstChar: 32 LastChar: 243 FontDescriptor: FontName: DBAAGO+MinionProIt Flags: Serif, Nonsymbolic FontBBox: -135, -250, 1000, 854 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: DBABHA+MinionMathItalic FontSubset: true FirstChar: 32 LastChar: 112 FontDescriptor: FontName: DBABHA+MinionMathItalic Flags: Nonsymbolic, Italic FontBBox: -333, -260, 1000, 854 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: DBABGP+MinionMath-Regular FontSubset: true FirstChar: 32 LastChar: 177 FontDescriptor: FontName: DBABGP+MinionMath-Regular Flags: Nonsymbolic FontBBox: -20, -427, 1541, 1072 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: DBABKB+MinionScUnic FontSubset: true FirstChar: 32 LastChar: 117 FontDescriptor: FontName: DBABKB+MinionScUnic Flags: Serif, Nonsymbolic FontBBox: -218, -250, 937, 802 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: DBAAMN+MinionProBold FontSubset: true FirstChar: 32 LastChar: 54 FontDescriptor: FontName: DBAAMN+MinionProBold Flags: Nonsymbolic FontBBox: -20, -239, 968, 854 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: DBABEL+MinionProIt+20 FontSubset: true FirstChar: 32 LastChar: 146 FontDescriptor: FontName: DBABEL+MinionProIt+20 Flags: Nonsymbolic FontBBox: -1187, -260, 1312, 822 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: DBABEM+MinionProRegular FontSubset: true FirstChar: 32 LastChar: 246 FontDescriptor: FontName: DBABEM+MinionProRegular Flags: Serif, Nonsymbolic FontBBox: -20, -250, 947, 854 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: MinionPro-Regular2 FirstChar: 2 LastChar: 138 FontDescriptor: FontName: MinionPro-Regular2 Flags: Symbolic FontBBox: -290, -360, 1684, 989 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: DBABFO+MinionProRegular+20 FontSubset: true FirstChar: 32 LastChar: 151 FontDescriptor: FontName: DBABFO+MinionProRegular+20 Flags: Nonsymbolic FontBBox: -1187, -260, 1333, 833 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: DBACFA+MinionMath-Regular-Graphic FontSubset: true FirstChar: 2 LastChar: 3 FontDescriptor: FontName: DBACFA+MinionMath-Regular-Graphic Flags: Symbolic FontBBox: 67, -171, 433, 239 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: DBABFN+MinionProRegular+fb FontSubset: true FirstChar: 1 LastChar: 6 FontDescriptor: FontName: DBABFN+MinionProRegular+fb Flags: Symbolic FontBBox: 0, -10, 781, 708 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: DBABMB+MinionMath-Regular+22 FontSubset: true FirstChar: 2 LastChar: 22 FontDescriptor: FontName: DBABMB+MinionMath-Regular+22 Flags: Symbolic FontBBox: -135, -385, 1333, 895 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true CIDFontType0: Font: BaseFont: MinionPro-Regular CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: MinionPro-Regular Flags: Nonsymbolic FontBBox: -290, -360, 1684, 989 FontFile3: true CIDFontType2: Font: BaseFont: OZFHUQ+MinionPro-Regular CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: OZFHUQ+MinionPro-Regular Flags: Nonsymbolic FontBBox: -289, -360, 1684, 917 FontFile2: true XMP: application/pdfLimited Joint Mobility Progression in Type 1 Diabetes: A 15-Year Follow-Up StudyLabad, JavierRozadilla, AntoniGarcia-Sancho, PaulaNolla, Joan M.Montanya, EduardObjective. To assess the evolution of joint mobility over a period of 15 years in type 1 diabetic patients and healthy controls and to determine whether microalbuminuria is associated with a different evolution of joint mobility. Methods. Joint mobility of hand and wrist was determined in 63 patients with type 1 diabetes and 63 healthy subjects. Fifteen years later, 37 (58.7%) diabetic patients and 16 (25.4%) healthy subjects were studied again. Joint mobility was assessed with the Prayer sign and by measuring the angle of maximal flexion of the fifth and third metacarpophalangeal (MCP) joints and wrist. Patients with diabetes were visited 2–4 times every year with regular assessment of glycated hemoglobin (HbA1c), urinary albumin excretion (UAE), and ophthalmoscopy. Results. Fifteen years after the initial exam, diabetic patients showed reduced flexion of the fifth MCP joint (82.6 ± 5.8 versus 76.0 ± 6.4 degrees, p<0.001) and wrist (75.9 ± 8.1 versus 73.2 ± 7.4 degrees, p=0.015) compared to baseline examination. Joint mobility did not change significantly in healthy subjects. Patients with microalbuminuria showed greater reduction in hand joint mobility than diabetic patients with normal UAE or than healthy subjects (p<0.001). Conclusions. In type 1 diabetic patients, the severity of LJM progresses with time, and the progression is enhanced in patients with microalbuminuria.International Journal of EndocrinologyHindawi2018/05/02Research articledoi:10.1155/2018/1897058en Pages: Page: Label: 1 Annotations: Annotation: Subtype: Link Rect: 151, 557, 161, 567 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 383, 557, 393, 567 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 201, 543, 211, 553 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 91, 135, 96, 145 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 101, 135, 105, 145 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 53, 78, 58, 88 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 63, 78, 68, 88 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 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