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Title:          Experimental infection of dromedaries with Middle East respiratory syndrome-Coronavirus is accompanied by massive ciliary loss and depletion of the cell surface receptor dipeptidyl peptidase 4
Subject:        Scientific Reports, doi:10.1038/s41598-018-28109-2
Keywords:       
Author:         Ann-Kathrin Haverkamp
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Table 1. Antigen, clonality, species, source, antigen retrieval, dilution and secondary antibodies used for immunohistochemistry and immunofluorescence. Ab, antibody; CD, cluster of differentiation; CEACAM5, carcinoembry:122' cannot be found
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Table 1. Antigen, clonality, species, source, antigen retrieval, dilution and secondary antibodies used for immunohistochemistry and immunofluorescence. Ab, antibody; CD, cluster of differentiation; CEACAM5, carcinoe:128' cannot be found
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      Title: Experimental infection of dromedaries with Middle East respiratory syndrome-Coronavirus is accompanied by massive ciliary l ...
      Children: 
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        Title: Results
        Children: 
         Item: 
          Title: Experimental MERS-CoV infection of dromedaries leads to high virus load in nasal turbinates and trachea accompanied by necr ...
         Item: 
          Title: MERS-CoV infection in dromedaries is accompanied by a strong but transient infiltration of T cells and macrophages. 
         Item: 
          Title: MERS-CoV has a strong tropism for cytokeratin 18 expressing epithelial cells of the upper respiratory tract. 
         Item: 
          Title: Restriction of MERS-CoV infection to apical epithelial cells correlates with the expression of DPP4 by the apical brush bor ...
         Item: 
          Title: MERS-CoV infection in dromedaries is accompanied by massive ciliary loss and concomitant lack of DPP4 expression by the res ...
         Item: 
          Title: MERS-CoV antigen is detectable in macrophages but not in lymphocytes. 
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        Title: Discussion
       Item: 
        Title: Materials and Methods
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          Title: Animals and tissue sampling. 
         Item: 
          Title: Light microscopy, immunohistochemistry, immunofluorescence and TUNEL assay. 
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          Title: Flow cytometry. 
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          Title: Scanning electron microscopy. 
         Item: 
          Title: Evaluation, quantification and statistical analysis. 
       Item: 
        Title: Acknowledgements
       Item: 
        Title: Figure 1 Histological findings in nasal turbinates, trachea, and bronchus of a MERS-Coronavirus (MERS-CoV)-infected, mock-vaccinated dromedary.
       Item: 
        Title: Figure 2 Expression of viral antigen in the nasal turbinates of MERS-Coronavirus (MERS-CoV)-infected, mock-vaccinated and MVA-S-vaccinated dromedaries.
       Item: 
        Title: Figure 3 Immunophenotyping of inflammatory cells in nasal turbinates and trachea of MERS-Coronavirus (MERS-CoV)-infected, MVA-S-vaccinated and MERS-CoV-infected, mock-vaccinated dromedaries.
       Item: 
        Title: Figure 4 Epithelial tropism of MERS-Coronavirus (MERS-CoV) in experimentally infected, mock-vaccinated dromedaries.
       Item: 
        Title: Figure 5 Expression of dipeptidyl peptidase 4 (DPP4) in experimentally infected, mock-vaccinated dromedaries.
       Item: 
        Title: Figure 6 Expression of α-tubulin in MERS-Coronavirus (MERS-CoV)-infected, mock-vaccinated and MVA-S-vaccinated dromedaries.
       Item: 
        Title: Figure 7 Scanning electron microscopy (SEM) of the upper respiratory tract organs of MERS-Coronavirus (MERS-CoV)-infected, mock-vaccinated and MVA-S-vaccinated dromedaries.
       Item: 
        Title: Figure 8 Inflammatory cell tropism of MERS-Coronavirus (MERS-CoV) in experimentally infected, mock-vaccinated dromedaries.
       Item: 
        Title: Figure 9 Expression of dipeptidyl peptidase 4 (DPP4) in lymphoid organs of humans and dromedaries.
       Item: 
        Title: Table 1 Antigen, clonality, species, source, antigen retrieval, dilution and secondary antibodies used for immunohistochemistry and immunofluorescence.
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Comment 
PRISM recommends that the PRISM Aggregation Type Controlled Vocabulary be used to provide values for this element. 
Note: PRISM recommends against the use of the #other value currently allowed in this controlled vocabulary. In lieu of using #other please reach out to the PRISM group at info@prismstandard.org to request addition of your term to the Aggregation Type Controlled Vocabulary. 

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                           <pdfaProperty:description>Copyright </pdfaProperty:description>
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                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
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                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>The Digital Object Identifier for the article.
The DOI may also be used as the dc:identifier. If used as a dc:identifier, the URI form should be captured, and the bare identifier should also be captured using prism:doi. If an alternate unique identifier is used as the required dc:identifier, then the DOI should be specified as a bare identifier within prism:doi only. 
If the URL associated with a DOI is to be specified, then prism:url may be used in conjunction with prism:doi in order to provide the service endpoint (i.e. the URL). 
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                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
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                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>ISSN for an electronic version of the issue in which the resource occurs. 
Permits publishers to include a second ISSN, identifying an electronic version of the issue in which the resource occurs (therefore e(lectronic)Issn. If used, prism:eIssn MUST contain the ISSN of the electronic version. See prism:issn. 
</pdfaProperty:description>
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                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
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                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Title of the magazine, or other publication, in which a resource was/will be published. 
Typically this will be used to provide the name of the magazine an article appeared in as metadata for the article, along with information such as the article title, the publisher, volume, number, and cover date. 

Note: Publication name can be used to differentiate between a print magazine and the online version if the names are different such as “magazine” and “magazine.com.” 
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                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>This element provides the url for an article or unit of content. 
The attribute platform is optionally allowed for situations in which multiple URLs must be specified. PRISM recommends that a subset of the PCV platform values, namely “mobile” and “web”, be used in conjunction with this element. 
NOTE: PRISM recommends against the use of the #other value allowed in the PRISM Platform controlled vocabulary. In lieu of using #other please reach out to the PRISM group at prism-wg@yahoogroups.com to request addition of your term to the Platform Controlled Vocabulary. 
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                           <pdfaProperty:description>Values for Journal Article Version are one of the following:
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SMUR = Submitted Manuscript Under Review
AM = Accepted Manuscript
P = Proof
VoR = Version of Record
CVoR = Corrected Version of Record
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