2a7dbb8a72ef248d78b1d217c4783512  pmc_29991677.pdf
7b5e3ca5a7d879294da851994e3d57637552b30d  pmc_29991677.pdf
4f50a65a01929dc4deb79abd0b06fd42816eab81b2338d03f60838833882ee87  pmc_29991677.pdf

Title:          Nintedanib decreases muscle fibrosis and improves muscle function in a murine model of dystrophinopathy
Subject:        Cell Death and Disease, doi:10.1038/s41419-018-0792-6
Keywords:       
Author:         Patricia Piñol-Jurado
Creator:        Springer
Producer:       iText® 5.3.5 ©2000-2012 1T3XT BVBA (AGPL-version)
CreationDate:   Mon Jul  9 14:18:37 2018 CEST
ModDate:        Tue Jul 10 11:51:57 2018 CEST
Tagged:         no
UserProperties: no
Suspects:       no
Form:           AcroForm
JavaScript:     no
Pages:          15
Encrypted:      no
Page size:      595.276 x 790.866 pts
Page rot:       0
File size:      3105867 bytes
Optimized:      no
PDF version:    1.4


name                                 type              encoding         emb sub uni object ID
------------------------------------ ----------------- ---------------- --- --- --- ---------
DGPFBP+AdvOT0d9ab1db.I               Type 1C           WinAnsi          yes yes no      87  0
DGPFBO+AdvOT07517017+fb              Type 1C           Custom           yes yes yes     74  0
DGPEMA+AdvOT07517017                 Type 1C           WinAnsi          yes yes no      76  0
DGPEFM+AdvOT46dcae81                 Type 1C           WinAnsi          yes yes no     269  0
DGPEGN+AdvOT65f8a23b.I               Type 1C           WinAnsi          yes yes no     477  0
DGPFDA+AdvOTa9103878                 Type 1C           WinAnsi          yes yes no      70  0
DGPEGO+AdvMyriad_R                   Type 1C           WinAnsi          yes yes no     478  0
DGPFDB+AdvOTf0bf83d5.I               Type 1C           WinAnsi          yes yes no      71  0
MyriadPro-Regular                    Type 1C           WinAnsi          yes no  no     479  0
DGPEKO+AdvOT3b30f6db.B               Type 1C           WinAnsi          yes yes no      72  0
DGPELP+AdvOT46dcae81+fb              Type 1C           Custom           yes yes yes    480  0
DGPFGD+AdvOTce3d9a73                 Type 1C           WinAnsi          yes yes no      73  0
DGPFHE+AdvOT07517017+20              Type 1C           WinAnsi          yes yes no     270  0
DGPFDC+AdvOTa9103878+20              Type 1C           WinAnsi          yes yes no      75  0
DGPFED+AdvOTa9103878+fb              Type 1C           Custom           yes yes yes     77  0
DGPFKD+AdvAGaramond-R                Type 1C           WinAnsi          yes yes no      80  0
DGPFOE+AdvOTce3d9a73+fb              Type 1C           Custom           yes yes yes     78  0
DGPFOF+AdvTTab7e17fd                 Type 1C           WinAnsi          yes yes no      79  0
DGPFND+AdvOTa9103878+03              Type 1C           Custom           yes yes yes     81  0
DHACLH+AdvOTce3d9a73+20              Type 1C           WinAnsi          yes yes no      88  0
DHACLI+AdvOT07517017+03              Type 1C           Custom           yes yes yes     89  0
DHACMJ+AdvOT0d9ab1db.I+03            Type 1C           Custom           yes yes yes     90  0
DHALKD+AdvOT56309c18.I               Type 1C           WinAnsi          yes yes no     104  0
DHALLE+AdvTTab7e17fd+22              Type 1C           Custom           yes yes no     132  0
DHCKCK+AdvOT07517017+22              Type 1C           Custom           yes yes yes    195  0
DHCKKI+AdvTT7b515deb                 Type 1C           WinAnsi          yes yes no     257  0


Jhove (Rel. 1.22.1, 2019-04-17)
 Date: 2022-05-05 02:34:28 CEST
 RepresentationInformation: pmc_29991677.pdf
  ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17)
  LastModified: 2020-03-09 03:39:47 CET
  Size: 3105867
  Format: PDF
  Version: 1.4
  Status: Well-Formed, but not valid
  SignatureMatches:
   PDF-hul
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR4' cannot be found
   Offset: 2831281
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR10' cannot be found
   Offset: 2831281
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR11' cannot be found
   Offset: 2831281
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR12' cannot be found
   Offset: 2831281
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR13' cannot be found
   Offset: 2831281
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR14' cannot be found
   Offset: 2831281
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR15' cannot be found
   Offset: 2831281
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR17' cannot be found
   Offset: 2831281
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR18' cannot be found
   Offset: 2831281
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR19' cannot be found
   Offset: 2831281
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR20' cannot be found
   Offset: 2831281
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR21' cannot be found
   Offset: 2831281
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR22' cannot be found
   Offset: 2831281
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR23' cannot be found
   Offset: 2831281
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR24' cannot be found
   Offset: 2831281
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR25' cannot be found
   Offset: 2831281
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR25' cannot be found
   Offset: 2831281
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR26' cannot be found
   Offset: 2831281
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR27' cannot be found
   Offset: 2831281
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR28' cannot be found
   Offset: 2831281
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR29' cannot be found
   Offset: 2831281
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR30' cannot be found
   Offset: 2831281
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR31' cannot be found
   Offset: 2831281
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR32' cannot be found
   Offset: 2831281
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR33' cannot be found
   Offset: 2831281
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR34' cannot be found
   Offset: 2831281
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR22' cannot be found
   Offset: 2831281
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR35' cannot be found
   Offset: 2831281
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR35' cannot be found
   Offset: 2831281
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR39' cannot be found
   Offset: 2831281
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR40' cannot be found
   Offset: 2831281
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR41' cannot be found
   Offset: 2831281
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR42' cannot be found
   Offset: 2831281
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR25' cannot be found
   Offset: 2831281
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR26' cannot be found
   Offset: 2831281
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR31' cannot be found
   Offset: 2831281
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR36' cannot be found
   Offset: 2831281
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR43' cannot be found
   Offset: 2831281
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR21' cannot be found
   Offset: 2831281
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR40' cannot be found
   Offset: 2831281
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR50' cannot be found
   Offset: 2831281
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR51' cannot be found
   Offset: 2831281
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR53' cannot be found
   Offset: 2831281
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR43' cannot be found
   Offset: 2831281
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR54' cannot be found
   Offset: 2831281
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR55' cannot be found
   Offset: 2831281
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR56' cannot be found
   Offset: 2831281
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR57' cannot be found
   Offset: 2831281
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR58' cannot be found
   Offset: 2831281
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR59' cannot be found
   Offset: 2831281
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR24' cannot be found
   Offset: 2831281
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR25' cannot be found
   Offset: 2831281
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR60' cannot be found
   Offset: 2831281
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR61' cannot be found
   Offset: 2831281
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR50' cannot be found
   Offset: 2831281
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR62' cannot be found
   Offset: 2831281
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR63' cannot be found
   Offset: 2831281
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR64' cannot be found
   Offset: 2831281
  MIMEtype: application/pdf
  PDFMetadata: 
   Objects: 567
   FreeObjects: 1
   IncrementalUpdates: 0
   DocumentCatalog: 
    PageLayout: SinglePage
    PageMode: UseOutlines
    Language: EN
    Outlines: 
     Item: 
      Title: Nintedanib decreases muscle fibrosis and improves muscle function in a murine model of dystrophinopathy
      Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@612fc6eb
      Children: 
       Item: 
        Title: Introduction
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1060b431
       Item: 
        Title: Results
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@612679d6
        Children: 
         Item: 
          Title: Nintedanib reduced proliferation, migration, and mRNA expression of fibrotic markers in human fibroblasts
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@11758f2a
         Item: 
          Title: Nintedanib had no effect on myoblast differentiation to myotubes in’vitro
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@e720b71
         Item: 
          Title: Nintedanib treatment improves electrophysiological tests in mdx mice
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1b26f7b2
         Item: 
          Title: Nintedanib treatment reduces muscle fibrosis in mdx mice
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@491cc5c9
         Item: 
          Title: Effect of nintedanib in heart fibrosis of the mdx mouse
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@74ad1f1f
       Item: 
        Title: Discussion
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6a1aab78
       Item: 
        Title: Material and methods
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@462d5aee
        Children: 
         Item: 
          Title: Muscle biopsies
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@69b0fd6f
         Item: 
          Title: Isolation and culture of myoblasts and fibroblasts from human muscle biopsies
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@757942a1
         Item: 
          Title: Differentiation and repair assay of human myotubes
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4a87761d
         Item: 
          Title: Cell proliferation, viability, and cell death
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@66d1af89
         Item: 
          Title: Scratch and transwell assays
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@8646db9
         Item: 
          Title: Fibroblast gene expression
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@37374a5e
         Item: 
          Title: Mouse model
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4671e53b
         Item: 
          Title: Motor functional analysis: Digigait assay
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@2db7a79b
         Item: 
          Title: Motor nerve conduction studies
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6950e31
         Item: 
          Title: Electromyography
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@b7dd107
         Item: 
          Title: Immunostaining
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@42eca56e
         Item: 
          Title: Collagen content quantification and muscle fibers geometric features extraction
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@52f759d7
         Item: 
          Title: RNA extraction and reverse transcription
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7cbd213e
         Item: 
          Title: Real-time quantitative PCR (TaqMan) analysis
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@192d3247
         Item: 
          Title: Western blot
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@3ecd23d9
         Item: 
          Title: Statistics
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@569cfc36
       Item: 
        Title: ACKNOWLEDGMENTS
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@43bd930a
   Info: 
    Title: Nintedanib decreases muscle fibrosis and improves muscle function in a murine model of dystrophinopathy
    Author: Patricia Piñol-Jurado
    Subject: Cell Death and Disease, doi:10.1038/s41419-018-0792-6
    Keywords: 
    Creator: Springer
    Producer: iText® 5.3.5 ©2000-2012 1T3XT BVBA (AGPL-version)
    CreationDate: Mon Jul 09 14:48:37 CEST 2018
    ModDate: Tue Jul 10 11:51:57 CEST 2018
   ID: 0xae52f637cf99391987269721d98f47ba, 0xab4acb3966f734b6fc3a08a9b24dd8ca
   Filters: 
    FilterPipeline: FlateDecode
    FilterPipeline: DCTDecode
   Images: 
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 245
      ImageHeight: 46
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Intent: Perceptual
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 1950
      ImageHeight: 1646
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Intent: Perceptual
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 1800
      ImageHeight: 1173
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     Intent: Perceptual
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 1950
      ImageHeight: 878
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Intent: Perceptual
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 1950
      ImageHeight: 1066
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Intent: Perceptual
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 1900
      ImageHeight: 1087
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Intent: Perceptual
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 1950
      ImageHeight: 2398
      ColorSpace: black is zero
      BitsPerSample: 8
      BitsPerSampleUnit: integer
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 1600
      ImageHeight: 1244
      ColorSpace: black is zero
      BitsPerSample: 8
      BitsPerSampleUnit: integer
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 1100
      ImageHeight: 90
      ColorSpace: black is zero
      BitsPerSample: 1
      BitsPerSampleUnit: integer
     Filter: FlateDecode
   Fonts: 
    Type1: 
     Font: 
      BaseFont: DHCKKI+AdvTT7b515deb
      FontSubset: true
      FirstChar: 174
      LastChar: 174
      FontDescriptor: 
       FontName: DHCKKI+AdvTT7b515deb
       Flags: Nonsymbolic
       FontBBox: -93, -187, 854, 843
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: DHCKCK+AdvOT07517017+22
      FontSubset: true
      FirstChar: 1
      LastChar: 1
      FontDescriptor: 
       FontName: DHCKCK+AdvOT07517017+22
       Flags: Symbolic
       FontBBox: 0, -135, 666, 812
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: DHALLE+AdvTTab7e17fd+22
      FontSubset: true
      FirstChar: 21
      LastChar: 21
      FontDescriptor: 
       FontName: DHALLE+AdvTTab7e17fd+22
       Flags: Nonsymbolic
       FontBBox: -156, -218, 937, 947
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
     Font: 
      BaseFont: DGPFDA+AdvOTa9103878
      FontSubset: true
      FirstChar: 37
      LastChar: 242
      FontDescriptor: 
       FontName: DGPFDA+AdvOTa9103878
       Flags: Serif, Nonsymbolic
       FontBBox: -20, -239, 1020, 875
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: DGPFDB+AdvOTf0bf83d5.I
      FontSubset: true
      FirstChar: 40
      LastChar: 121
      FontDescriptor: 
       FontName: DGPFDB+AdvOTf0bf83d5.I
       Flags: Nonsymbolic
       FontBBox: -187, -239, 1062, 875
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: DGPEKO+AdvOT3b30f6db.B
      FontSubset: true
      FirstChar: 65
      LastChar: 117
      FontDescriptor: 
       FontName: DGPEKO+AdvOT3b30f6db.B
       Flags: Nonsymbolic
       FontBBox: -31, -250, 875, 895
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: DGPFGD+AdvOTce3d9a73
      FontSubset: true
      FirstChar: 39
      LastChar: 121
      FontDescriptor: 
       FontName: DGPFGD+AdvOTce3d9a73
       Flags: Nonsymbolic
       FontBBox: -41, -250, 854, 885
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: DGPFBO+AdvOT07517017+fb
      FontSubset: true
      FirstChar: 1
      LastChar: 3
      FontDescriptor: 
       FontName: DGPFBO+AdvOT07517017+fb
       Flags: Symbolic
       FontBBox: 0, 0, 677, 718
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: DGPFDC+AdvOTa9103878+20
      FontSubset: true
      FirstChar: 146
      LastChar: 150
      FontDescriptor: 
       FontName: DGPFDC+AdvOTa9103878+20
       Flags: Nonsymbolic
       FontBBox: -166, -218, 968, 812
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: DGPEMA+AdvOT07517017
      FontSubset: true
      FirstChar: 37
      LastChar: 243
      FontDescriptor: 
       FontName: DGPEMA+AdvOT07517017
       Flags: Nonsymbolic
       FontBBox: -41, -250, 812, 864
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: DGPFED+AdvOTa9103878+fb
      FontSubset: true
      FirstChar: 1
      LastChar: 3
      FontDescriptor: 
       FontName: DGPFED+AdvOTa9103878+fb
       Flags: Symbolic
       FontBBox: 0, -10, 812, 708
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: DGPEFM+AdvOT46dcae81
      FontSubset: true
      FirstChar: 40
      LastChar: 241
      FontDescriptor: 
       FontName: DGPEFM+AdvOT46dcae81
       Flags: Nonsymbolic
       FontBBox: -41, -250, 833, 875
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: DGPFHE+AdvOT07517017+20
      FontSubset: true
      FirstChar: 146
      LastChar: 150
      FontDescriptor: 
       FontName: DGPFHE+AdvOT07517017+20
       Flags: Nonsymbolic
       FontBBox: 0, -208, 1041, 864
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: DGPFOE+AdvOTce3d9a73+fb
      FontSubset: true
      FirstChar: 1
      LastChar: 3
      FontDescriptor: 
       FontName: DGPFOE+AdvOTce3d9a73+fb
       Flags: Symbolic
       FontBBox: 0, 0, 791, 718
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: DGPFOF+AdvTTab7e17fd
      FontSubset: true
      FirstChar: 43
      LastChar: 61
      FontDescriptor: 
       FontName: DGPFOF+AdvTTab7e17fd
       Flags: Nonsymbolic
       FontBBox: -156, -250, 1072, 947
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: DGPFKD+AdvAGaramond-R
      FontSubset: true
      FirstChar: 35
      LastChar: 95
      FontDescriptor: 
       FontName: DGPFKD+AdvAGaramond-R
       Flags: Nonsymbolic
       FontBBox: -177, -260, 1093, 750
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: DGPFND+AdvOTa9103878+03
      FontSubset: true
      FirstChar: 1
      LastChar: 4
      FontDescriptor: 
       FontName: DGPFND+AdvOTa9103878+03
       Flags: Symbolic
       FontBBox: -135, -250, 906, 822
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: DGPFBP+AdvOT0d9ab1db.I
      FontSubset: true
      FirstChar: 38
      LastChar: 121
      FontDescriptor: 
       FontName: DGPFBP+AdvOT0d9ab1db.I
       Flags: Nonsymbolic
       FontBBox: -114, -250, 864, 854
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: DHACLH+AdvOTce3d9a73+20
      FontSubset: true
      FirstChar: 150
      LastChar: 150
      FontDescriptor: 
       FontName: DHACLH+AdvOTce3d9a73+20
       Flags: Nonsymbolic
       FontBBox: -156, -197, 1197, 864
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: DHACLI+AdvOT07517017+03
      FontSubset: true
      FirstChar: 1
      LastChar: 3
      FontDescriptor: 
       FontName: DHACLI+AdvOT07517017+03
       Flags: Symbolic
       FontBBox: -20, -197, 708, 781
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: DHACMJ+AdvOT0d9ab1db.I+03
      FontSubset: true
      FirstChar: 1
      LastChar: 1
      FontDescriptor: 
       FontName: DHACMJ+AdvOT0d9ab1db.I+03
       Flags: Symbolic
       FontBBox: -62, -197, 729, 781
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: DGPEGN+AdvOT65f8a23b.I
      FontSubset: true
      FirstChar: 67
      LastChar: 116
      FontDescriptor: 
       FontName: DGPEGN+AdvOT65f8a23b.I
       Flags: Nonsymbolic
       FontBBox: -104, -250, 885, 864
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: DGPEGO+AdvMyriad_R
      FontSubset: true
      FirstChar: 35
      LastChar: 95
      FontDescriptor: 
       FontName: DGPEGO+AdvMyriad_R
       Flags: Nonsymbolic
       FontBBox: -41, -239, 1125, 750
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: MyriadPro-Regular
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: MyriadPro-Regular
       Flags: Nonsymbolic
       FontBBox: -157, -250, 1126, 952
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: DGPELP+AdvOT46dcae81+fb
      FontSubset: true
      FirstChar: 1
      LastChar: 1
      FontDescriptor: 
       FontName: DGPELP+AdvOT46dcae81+fb
       Flags: Symbolic
       FontBBox: 0, 0, 739, 718
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: DHALKD+AdvOT56309c18.I
      FontSubset: true
      FirstChar: 100
      LastChar: 120
      FontDescriptor: 
       FontName: DHALKD+AdvOT56309c18.I
       Flags: Nonsymbolic
       FontBBox: -93, -250, 906, 875
       FontFile3: true
      Encoding: WinAnsiEncoding
   XMP: <x:xmpmeta x:xmptk="Adobe XMP Core 5.2-c001 63.143651, 2012/04/05-09:01:49        " xmlns:x="adobe:ns:meta/">
   <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
      <rdf:Description rdf:about="" xmlns:dc="http://purl.org/dc/elements/1.1/">
         <dc:format>application/pdf</dc:format>
         <dc:identifier>doi:10.1038/s41419-018-0792-6</dc:identifier>
         <dc:title>
            <rdf:Alt>
               <rdf:li xml:lang="x-default">Nintedanib decreases muscle fibrosis and improves muscle function in a murine model of dystrophinopathy</rdf:li>
            </rdf:Alt>
         </dc:title>
         <dc:creator>
            <rdf:Seq>
               <rdf:li>Patricia Piñol-Jurado</rdf:li>
               <rdf:li>Xavier Suárez-Calvet</rdf:li>
               <rdf:li>Esther Fernández-Simón</rdf:li>
               <rdf:li>Eduard Gallardo</rdf:li>
               <rdf:li>Natalia de la Oliva</rdf:li>
               <rdf:li>Anna Martínez-Muriana</rdf:li>
               <rdf:li>Pedro Gómez-Gálvez</rdf:li>
               <rdf:li>Luis M. Escudero</rdf:li>
               <rdf:li>María Pérez-Peiró</rdf:li>
               <rdf:li>Lutz Wollin</rdf:li>
               <rdf:li>Noemi de Luna</rdf:li>
               <rdf:li>Xavier Navarro</rdf:li>
               <rdf:li>Isabel Illa</rdf:li>
               <rdf:li>Jordi Díaz-Manera</rdf:li>
            </rdf:Seq>
         </dc:creator>
         <dc:publisher>
            <rdf:Bag>
               <rdf:li>Springer US</rdf:li>
            </rdf:Bag>
         </dc:publisher>
         <dc:subject>
            <rdf:Bag></rdf:Bag>
         </dc:subject>
         <dc:description>
            <rdf:Alt>
               <rdf:li xml:lang="x-default">Cell Death and Disease, doi:10.1038/s41419-018-0792-6</rdf:li>
            </rdf:Alt>
         </dc:description>
      </rdf:Description>
      <rdf:Description rdf:about="" xmlns:prism="http://prismstandard.org/namespaces/basic/2.0/">
         <prism:doi>10.1038/s41419-018-0792-6</prism:doi>
         <prism:url>http://dx.doi.org/10.1038/s41419-018-0792-6</prism:url>
         <prism:aggregationType>journal</prism:aggregationType>
         <prism:publicationName>Cell Death and Disease</prism:publicationName>
         <prism:copyright>© 2018, The Author(s)</prism:copyright>
         <prism:issn>2041-4889</prism:issn>
      </rdf:Description>
      <rdf:Description rdf:about="" xmlns:pdfx="http://ns.adobe.com/pdfx/1.3/">
         <pdfx:doi>10.1038/s41419-018-0792-6</pdfx:doi>
         <pdfx:CrossMarkDomains>
            <rdf:Seq>
               <rdf:li>springer.com</rdf:li>
               <rdf:li>springerlink.com</rdf:li>
            </rdf:Seq>
         </pdfx:CrossMarkDomains>
      </rdf:Description>
      <rdf:Description rdf:about="" xmlns:crossmark="http://crossref.org/crossmark/1.0/">
         <crossmark:MajorVersionDate>2010-04-23</crossmark:MajorVersionDate>
         <crossmark:CrossmarkDomainExclusive>True</crossmark:CrossmarkDomainExclusive>
         <crossmark:DOI>10.1038/s41419-018-0792-6</crossmark:DOI>
         <crossmark:CrossMarkDomains>
            <rdf:Seq>
               <rdf:li>springer.com</rdf:li>
               <rdf:li>springerlink.com</rdf:li>
            </rdf:Seq>
         </crossmark:CrossMarkDomains>
      </rdf:Description>
      <rdf:Description rdf:about="" xmlns:xmp="http://ns.adobe.com/xap/1.0/">
         <xmp:CreatorTool>Springer</xmp:CreatorTool>
         <xmp:ModifyDate>2018-07-10T11:51:57+02:00</xmp:ModifyDate>
         <xmp:CreateDate>2018-07-09T17:48:37+05:30</xmp:CreateDate>
         <xmp:MetadataDate>2018-07-10T11:51:57+02:00</xmp:MetadataDate>
      </rdf:Description>
      <rdf:Description rdf:about="" xmlns:xmpRights="http://ns.adobe.com/xap/1.0/rights/">
         <xmpRights:Marked>True</xmpRights:Marked>
      </rdf:Description>
      <rdf:Description rdf:about="" xmlns:pdf="http://ns.adobe.com/pdf/1.3/">
         <pdf:Keywords></pdf:Keywords>
      <pdf:Producer>iText® 5.3.5 ©2000-2012 1T3XT BVBA (AGPL-version)</pdf:Producer></rdf:Description>
      <rdf:Description rdf:about="" xmlns:jav="http://www.niso.org/schemas/jav/1.0/">
         <jav:journal_article_version>VoR</jav:journal_article_version>
      </rdf:Description>
      <rdf:Description rdf:about="" xmlns:stEvt="http://ns.adobe.com/xap/1.0/sType/ResourceEvent#" xmlns:xmpMM="http://ns.adobe.com/xap/1.0/mm/">
         <xmpMM:DocumentID>uuid:d20bbd1b-2184-451c-8cf8-213f7baaf4ea</xmpMM:DocumentID>
         <xmpMM:InstanceID>uuid:93d89d22-fbdb-4672-825b-a83fb1736ae1</xmpMM:InstanceID>
         <xmpMM:RenditionClass>default</xmpMM:RenditionClass>
         <xmpMM:VersionID>1</xmpMM:VersionID>
         <xmpMM:History>
            <rdf:Seq>
               <rdf:li rdf:parseType="Resource">
                  <stEvt:action>converted</stEvt:action>
                  <stEvt:instanceID>uuid:730444d6-33ad-4306-ada3-a09f8618ba03</stEvt:instanceID>
                  <stEvt:parameters>converted to PDF/A-2b</stEvt:parameters>
                  <stEvt:softwareAgent>pdfToolbox</stEvt:softwareAgent>
                  <stEvt:when>2018-07-09T17:49:19+05:30</stEvt:when>
               </rdf:li>
            </rdf:Seq>
         </xmpMM:History>
      </rdf:Description>
      <rdf:Description rdf:about="" xmlns:pdfaid="http://www.aiim.org/pdfa/ns/id/">
         <pdfaid:part>2</pdfaid:part>
         <pdfaid:conformance>B</pdfaid:conformance>
      </rdf:Description>
      <rdf:Description rdf:about="" xmlns:author="http://springernature.com/ns/xmpExtensions/2.0/authorInfo/" xmlns:sn="http://springernature.com/ns/xmpExtensions/2.0/">
         <sn:authorInfo>
            <rdf:Bag>
               <rdf:li rdf:parseType="Resource">
                  <author:name>Xavier Suárez-Calvet</author:name>
                  <author:orcid>http://orcid.org/0000-0002-5314-6607</author:orcid>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <author:name>Xavier Navarro</author:name>
                  <author:orcid>http://orcid.org/0000-0001-9849-902X</author:orcid>
               </rdf:li>
            </rdf:Bag>
         </sn:authorInfo>
      </rdf:Description>
      <rdf:Description rdf:about="" xmlns:pdfaExtension="http://www.aiim.org/pdfa/ns/extension/" xmlns:pdfaField="http://www.aiim.org/pdfa/ns/field#" xmlns:pdfaProperty="http://www.aiim.org/pdfa/ns/property#" xmlns:pdfaSchema="http://www.aiim.org/pdfa/ns/schema#" xmlns:pdfaType="http://www.aiim.org/pdfa/ns/type#">
         <pdfaExtension:schemas>
            <rdf:Bag>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://ns.adobe.com/pdf/1.3/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>pdf</pdfaSchema:prefix>
                  <pdfaSchema:schema>Adobe PDF Schema</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>A name object indicating whether the document has been modified to include trapping information</pdfaProperty:description>
                           <pdfaProperty:name>Trapped</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://ns.adobe.com/pdfx/1.3/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>pdfx</pdfaSchema:prefix>
                  <pdfaSchema:schema>pdfx</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>ID of PDF/X standard</pdfaProperty:description>
                           <pdfaProperty:name>GTS_PDFXVersion</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Conformance level of PDF/X standard</pdfaProperty:description>
                           <pdfaProperty:name>GTS_PDFXConformance</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Company creating the PDF</pdfaProperty:description>
                           <pdfaProperty:name>Company</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Date when document was last modified</pdfaProperty:description>
                           <pdfaProperty:name>SourceModified</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Mirrors crossmark:CrosMarkDomains</pdfaProperty:description>
                           <pdfaProperty:name>CrossMarkDomains</pdfaProperty:name>
                           <pdfaProperty:valueType>Seq Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Mirrors crossmark:DOI</pdfaProperty:description>
                           <pdfaProperty:name>doi</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://ns.adobe.com/xap/1.0/mm/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>xmpMM</pdfaSchema:prefix>
                  <pdfaSchema:schema>XMP Media Management Schema</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>UUID based identifier for specific incarnation of a document</pdfaProperty:description>
                           <pdfaProperty:name>InstanceID</pdfaProperty:name>
                           <pdfaProperty:valueType>URI</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>The common identifier for all versions and renditions of a document.</pdfaProperty:description>
                           <pdfaProperty:name>OriginalDocumentID</pdfaProperty:name>
                           <pdfaProperty:valueType>URI</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://www.aiim.org/pdfa/ns/id/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>pdfaid</pdfaSchema:prefix>
                  <pdfaSchema:schema>PDF/A ID Schema</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Part of PDF/A standard</pdfaProperty:description>
                           <pdfaProperty:name>part</pdfaProperty:name>
                           <pdfaProperty:valueType>Integer</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Amendment of PDF/A standard</pdfaProperty:description>
                           <pdfaProperty:name>amd</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Conformance level of PDF/A standard</pdfaProperty:description>
                           <pdfaProperty:name>conformance</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://crossref.org/crossmark/1.0/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>crossmark</pdfaSchema:prefix>
                  <pdfaSchema:schema>crossmark</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>CrossMarkDomains</pdfaProperty:description>
                           <pdfaProperty:name>CrossMarkDomains</pdfaProperty:name>
                           <pdfaProperty:valueType>Seq Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>CrossmarkDomainExclusive</pdfaProperty:description>
                           <pdfaProperty:name>CrossmarkDomainExclusive</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Usual same as prism:doi</pdfaProperty:description>
                           <pdfaProperty:name>DOI</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>The date when a publication was published.</pdfaProperty:description>
                           <pdfaProperty:name>MajorVersionDate</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://prismstandard.org/namespaces/basic/2.0/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>prism</pdfaSchema:prefix>
                  <pdfaSchema:schema>Prism</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>The aggregation type specifies the unit of aggregation for a content collection. 
Comment 
PRISM recommends that the PRISM Aggregation Type Controlled Vocabulary be used to provide values for this element. 
Note: PRISM recommends against the use of the #other value currently allowed in this controlled vocabulary. In lieu of using #other please reach out to the PRISM group at info@prismstandard.org to request addition of your term to the Aggregation Type Controlled Vocabulary. 

</pdfaProperty:description>
                           <pdfaProperty:name>aggregationType</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Copyright </pdfaProperty:description>
                           <pdfaProperty:name>copyright</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>The Digital Object Identifier for the article.
The DOI may also be used as the dc:identifier. If used as a dc:identifier, the URI form should be captured, and the bare identifier should also be captured using prism:doi. If an alternate unique identifier is used as the required dc:identifier, then the DOI should be specified as a bare identifier within prism:doi only. 
If the URL associated with a DOI is to be specified, then prism:url may be used in conjunction with prism:doi in order to provide the service endpoint (i.e. the URL). 
</pdfaProperty:description>
                           <pdfaProperty:name>doi</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>ISSN for an electronic version of the issue in which the resource occurs. 
Permits publishers to include a second ISSN, identifying an electronic version of the issue in which the resource occurs (therefore e(lectronic)Issn. If used, prism:eIssn MUST contain the ISSN of the electronic version. See prism:issn. 
</pdfaProperty:description>
                           <pdfaProperty:name>issn</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Title of the magazine, or other publication, in which a resource was/will be published. 
Typically this will be used to provide the name of the magazine an article appeared in as metadata for the article, along with information such as the article title, the publisher, volume, number, and cover date. 

Note: Publication name can be used to differentiate between a print magazine and the online version if the names are different such as “magazine” and “magazine.com.” 
</pdfaProperty:description>
                           <pdfaProperty:name>publicationName</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>This element provides the url for an article or unit of content. 
The attribute platform is optionally allowed for situations in which multiple URLs must be specified. PRISM recommends that a subset of the PCV platform values, namely “mobile” and “web”, be used in conjunction with this element. 
NOTE: PRISM recommends against the use of the #other value allowed in the PRISM Platform controlled vocabulary. In lieu of using #other please reach out to the PRISM group at prism-wg@yahoogroups.com to request addition of your term to the Platform Controlled Vocabulary. 
</pdfaProperty:description>
                           <pdfaProperty:name>url</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://springernature.com/ns/xmpExtensions/2.0/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>sn</pdfaSchema:prefix>
                  <pdfaSchema:schema>Springer Nature ORCID Schema</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Author information: contains the name of each author and his/her ORCID (ORCiD: Open Researcher and Contributor ID). An ORCID is a persistent identifier (a non-proprietary alphanumeric code) to uniquely identify scientific and other academic authors.</pdfaProperty:description>
                           <pdfaProperty:name>authorInfo</pdfaProperty:name>
                           <pdfaProperty:valueType>Bag AuthorInformation</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
                  <pdfaSchema:valueType>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaType:description>Specifies the types of author information: name and ORCID of an author.</pdfaType:description>
                           <pdfaType:namespaceURI>http://springernature.com/ns/xmpExtensions/2.0/authorInfo/</pdfaType:namespaceURI>
                           <pdfaType:prefix>author</pdfaType:prefix>
                           <pdfaType:type>AuthorInformation</pdfaType:type>
                           <pdfaType:field>
                              <rdf:Seq>
                                 <rdf:li rdf:parseType="Resource">
                                    <pdfaField:description>Gives the name of an author.</pdfaField:description>
                                    <pdfaField:name>name</pdfaField:name>
                                    <pdfaField:valueType>Text</pdfaField:valueType>
                                 </rdf:li>
                                 <rdf:li rdf:parseType="Resource">
                                    <pdfaField:description>Gives the ORCID of an author.</pdfaField:description>
                                    <pdfaField:name>orcid</pdfaField:name>
                                    <pdfaField:valueType>URI</pdfaField:valueType>
                                 </rdf:li>
                              </rdf:Seq>
                           </pdfaType:field>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:valueType>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://www.niso.org/schemas/jav/1.0/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>jav</pdfaSchema:prefix>
                  <pdfaSchema:schema>NISO</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Values for Journal Article Version are one of the following:
AO = Author’s Original
SMUR = Submitted Manuscript Under Review
AM = Accepted Manuscript
P = Proof
VoR = Version of Record
CVoR = Corrected Version of Record
EVoR = Enhanced Version of Record</pdfaProperty:description>
                           <pdfaProperty:name>journal_article_version</pdfaProperty:name>
                           <pdfaProperty:valueType>Closed Choice of Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
            </rdf:Bag>
         </pdfaExtension:schemas>
      </rdf:Description>
   </rdf:RDF>
</x:xmpmeta>
   Pages: 
    Page: 
     Label: 1
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 231, 577, 232, 588
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 231, 577, 232, 588
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 241, 577, 242, 588
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 232, 577, 241, 588
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 240, 577, 241, 588
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 116, 549, 117, 560
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 116, 549, 117, 560
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 126, 549, 127, 560
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 117, 549, 126, 560
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 125, 549, 126, 560
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 244, 218, 248, 228
       Flags: Print
       AppearanceDictionary: true
       Destination: 260
      Annotation: 
       Subtype: Link
       Rect: 249, 218, 253, 228
       Flags: Print
       AppearanceDictionary: true
       Destination: 260
      Annotation: 
       Subtype: Link
       Rect: 451, 302, 455, 311
       Flags: Print
       AppearanceDictionary: true
       Destination: 260
      Annotation: 
       Subtype: Link
       Rect: 532, 278, 536, 287
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 475, 242, 479, 252
       Flags: Print
       AppearanceDictionary: true
       Destination: 260
      Annotation: 
       Subtype: Link
       Rect: 480, 242, 484, 252
       Flags: Print
       AppearanceDictionary: true
       Destination: 260
      Annotation: 
       Subtype: Link
       Rect: 336, 194, 340, 204
       Flags: Print
       AppearanceDictionary: true
       Destination: 260
      Annotation: 
       Subtype: Link
       Rect: 341, 194, 345, 204
       Flags: Print
       AppearanceDictionary: true
       Destination: 260
      Annotation: 
       Subtype: Link
       Rect: 464, 158, 467, 168
       Flags: Print
       AppearanceDictionary: true
       Destination: 260
      Annotation: 
       Subtype: Link
       Rect: 469, 158, 476, 168
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 269, 59, 385, 66
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 168, 182, 226, 190
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
    Page: 
     Label: 2
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 149, 684, 157, 694
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 158, 684, 166, 694
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 97, 612, 104, 622
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 281, 601, 288, 610
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 187, 553, 195, 562
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 199, 553, 206, 562
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 272, 517, 279, 527
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 281, 517, 288, 527
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 201, 457, 208, 467
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 170, 397, 178, 407
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 179, 397, 187, 407
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 93, 349, 100, 359
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 83, 314, 91, 323
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 92, 314, 100, 323
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 128, 278, 135, 287
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 137, 278, 144, 287
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 210, 146, 217, 156
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 219, 146, 226, 156
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 78, 82, 83, 92
       Flags: Print
       AppearanceDictionary: true
       Destination: 82
      Annotation: 
       Subtype: Link
       Rect: 405, 584, 410, 594
       Flags: Print
       AppearanceDictionary: true
       Destination: 82
      Annotation: 
       Subtype: Link
       Rect: 460, 536, 464, 546
       Flags: Print
       AppearanceDictionary: true
       Destination: 82
      Annotation: 
       Subtype: Link
       Rect: 362, 524, 367, 534
       Flags: Print
       AppearanceDictionary: true
       Destination: 82
      Annotation: 
       Subtype: Link
       Rect: 489, 512, 494, 522
       Flags: Print
       AppearanceDictionary: true
       Destination: 82
      Annotation: 
       Subtype: Link
       Rect: 328, 481, 335, 491
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 337, 481, 344, 491
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 325, 441, 330, 450
       Flags: Print
       AppearanceDictionary: true
       Destination: 82
      Annotation: 
       Subtype: Link
       Rect: 355, 417, 360, 427
       Flags: Print
       AppearanceDictionary: true
       Destination: 82
      Annotation: 
       Subtype: Link
       Rect: 462, 321, 467, 331
       Flags: Print
       AppearanceDictionary: true
       Destination: 82
      Annotation: 
       Subtype: Link
       Rect: 370, 273, 375, 283
       Flags: Print
       AppearanceDictionary: true
       Destination: 82
      Annotation: 
       Subtype: Link
       Rect: 523, 166, 528, 176
       Flags: Print
       AppearanceDictionary: true
       Destination: 82
     Thumb: true
    Page: 
     Label: 3
     Thumb: true
    Page: 
     Label: 4
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 193, 82, 198, 92
       Flags: Print
       AppearanceDictionary: true
       Destination: 91
      Annotation: 
       Subtype: Link
       Rect: 403, 285, 407, 295
       Flags: Print
       AppearanceDictionary: true
       Destination: 91
      Annotation: 
       Subtype: Link
       Rect: 390, 166, 395, 176
       Flags: Print
       AppearanceDictionary: true
       Destination: 91
      Annotation: 
       Subtype: Link
       Rect: 529, 74, 536, 84
       Flags: Print
       AppearanceDictionary: true
       Destination: null
     Thumb: true
    Page: 
     Label: 5
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 102, 321, 106, 331
       Flags: Print
       AppearanceDictionary: true
       Destination: 105
      Annotation: 
       Subtype: Link
       Rect: 238, 190, 243, 199
       Flags: Print
       AppearanceDictionary: true
       Destination: 133
      Annotation: 
       Subtype: Link
       Rect: 280, 166, 285, 176
       Flags: Print
       AppearanceDictionary: true
       Destination: 162
      Annotation: 
       Subtype: Link
       Rect: 121, 106, 126, 116
       Flags: Print
       AppearanceDictionary: true
       Destination: 162
      Annotation: 
       Subtype: Link
       Rect: 350, 333, 355, 343
       Flags: Print
       AppearanceDictionary: true
       Destination: 181
      Annotation: 
       Subtype: Link
       Rect: 509, 321, 514, 331
       Flags: Print
       AppearanceDictionary: true
       Destination: 181
      Annotation: 
       Subtype: Link
       Rect: 378, 309, 383, 319
       Flags: Print
       AppearanceDictionary: true
       Destination: 181
      Annotation: 
       Subtype: Link
       Rect: 326, 297, 330, 307
       Flags: Print
       AppearanceDictionary: true
       Destination: 181
      Annotation: 
       Subtype: Link
       Rect: 389, 261, 394, 271
       Flags: Print
       AppearanceDictionary: true
       Destination: 181
      Annotation: 
       Subtype: Link
       Rect: 418, 226, 423, 235
       Flags: Print
       AppearanceDictionary: true
       Destination: 181
      Annotation: 
       Subtype: Link
       Rect: 434, 154, 438, 164
       Flags: Print
       AppearanceDictionary: true
       Destination: 186
     Thumb: true
    Page: 
     Label: 6
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 200, 74, 208, 84
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 339, 361, 347, 371
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 348, 361, 355, 371
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 460, 302, 467, 311
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 469, 302, 476, 311
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 394, 254, 401, 264
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 406, 254, 413, 264
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 407, 230, 415, 240
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 492, 182, 499, 192
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 501, 182, 508, 192
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 499, 146, 506, 156
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 508, 146, 515, 156
       Flags: Print
       AppearanceDictionary: true
       Destination: null
     Thumb: true
    Page: 
     Label: 7
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 202, 302, 210, 311
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 211, 302, 219, 311
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 220, 302, 228, 311
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 229, 302, 237, 311
       Flags: Print
       AppearanceDictionary: true
       Destination: 260
      Annotation: 
       Subtype: Link
       Rect: 529, 302, 536, 311
       Flags: Print
       AppearanceDictionary: true
       Destination: 260
      Annotation: 
       Subtype: Link
       Rect: 395, 194, 402, 204
       Flags: Print
       AppearanceDictionary: true
       Destination: 260
      Annotation: 
       Subtype: Link
       Rect: 469, 62, 476, 72
       Flags: Print
       AppearanceDictionary: true
       Destination: 260
     Thumb: true
    Page: 
     Label: 8
     Thumb: true
    Page: 
     Label: 9
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 85, 146, 92, 156
       Flags: Print
       AppearanceDictionary: true
       Destination: 260
      Annotation: 
       Subtype: Link
       Rect: 94, 146, 101, 156
       Flags: Print
       AppearanceDictionary: true
       Destination: 260
     Thumb: true
    Page: 
     Label: 10
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 217, 660, 225, 670
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 226, 660, 233, 670
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 235, 660, 242, 670
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 229, 624, 237, 634
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 241, 624, 248, 634
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 240, 589, 248, 598
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 119, 553, 127, 562
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 128, 553, 136, 562
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 162, 529, 169, 539
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 221, 529, 229, 539
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 130, 517, 137, 527
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 237, 493, 244, 503
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 231, 409, 239, 419
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 240, 409, 248, 419
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 90, 326, 97, 335
       Flags: Print
       AppearanceDictionary: true
       Destination: null
     Thumb: true
    Page: 
     Label: 11
     Thumb: true
    Page: 
     Label: 12
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 141, 612, 148, 622
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 216, 553, 223, 562
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 240, 361, 247, 371
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 185, 266, 192, 275
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 354, 182, 361, 192
       Flags: Print
       AppearanceDictionary: true
       Destination: null
     Thumb: true
    Page: 
     Label: 13
     Thumb: true
    Page: 
     Label: 14
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 233, 658, 279, 665
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 56, 649, 137, 657
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
    Page: 
     Label: 15
     Thumb: true
  Checksum: a85bd285
   Type: CRC32
  Checksum: 2a7dbb8a72ef248d78b1d217c4783512
   Type: MD5
  Checksum: 7b5e3ca5a7d879294da851994e3d57637552b30d
   Type: SHA-1