e647cb7288733a495828c54614346eec pmc_30045853.pdf 7fcdef6701c8df44442070834b0144b2a9b66220 pmc_30045853.pdf ec4fefdc720e9c03971bb4893bad763209522f1b8de229737023cc4675710abe pmc_30045853.pdf Creator: Adobe InDesign CS6 (Windows) Producer: Adobe PDF Library 10.0.1 CreationDate: Wed Oct 10 10:33:05 2018 CEST ModDate: Wed Oct 10 10:33:06 2018 CEST Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 9 Encrypted: no Page size: 595.276 x 793.701 pts Page rot: 0 File size: 268896 bytes Optimized: yes PDF version: 1.4 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- CTDHCP+ArialMT CID TrueType Identity-H yes yes yes 467 0 ZUMYMV+FrutigerLTPro-LightCn Type 1C Custom yes yes yes 444 0 ZUMYMV+FrutigerLTPro-BoldCn Type 1C Custom yes yes yes 445 0 CTDHCP+FrutigerLTPro-Condensed Type 1C Custom yes yes yes 446 0 ZUMYMV+FrutigerLTPro-LightCnIta Type 1C Custom yes yes yes 460 0 ZUMYMV+FrutigerLTPro-LightCn Type 1C WinAnsi yes yes yes 497 0 ZUMYMV+FrutigerLTPro-LightCnIta Type 1C Custom yes yes yes 499 0 ZUMYMV+FrutigerLTPro-BoldCn Type 1C WinAnsi yes yes yes 501 0 CTDHCP+ClassicalGaramondBT-Roman CID TrueType Identity-H yes yes yes 287 0 CTDHCP+ClassicalGaramondBT-Roman TrueType WinAnsi yes yes yes 283 0 MVGPMV+ClassicalGaramondBT-Italic TrueType WinAnsi yes yes yes 282 0 ZUMYMV+FrutigerLTPro-LightCn Type 1C WinAnsi yes yes yes 280 0 ZUMYMV+FrutigerLTPro-LightCnIta Type 1C Custom yes yes yes 278 0 ZUMYMV+FrutigerLTPro-BoldCn Type 1C WinAnsi yes yes yes 276 0 MVGPMV+FrutigerLTPro-CondensedIta Type 1C Custom yes yes yes 302 0 ZUMYMV+FrutigerLTPro-LightCn Type 1C WinAnsi yes yes yes 300 0 ZUMYMV+FrutigerLTPro-LightCnIta Type 1C Custom yes yes yes 298 0 ZUMYMV+FrutigerLTPro-BoldCn Type 1C WinAnsi yes yes yes 296 0 MVGPMV+FrutigerLTStd-BoldCn Type 1C WinAnsi yes yes yes 309 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2024-01-19 07:09:21 CET RepresentationInformation: pmc_30045853.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2020-02-05 11:45:52 CET Size: 268896 Format: PDF Version: 1.4 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf Profile: Linearized PDF PDFMetadata: Objects: 507 FreeObjects: 1 IncrementalUpdates: 1 DocumentCatalog: ViewerPreferences: HideToolbar: false HideMenubar: false HideWindowUI: false FitWindow: false CenterWindow: false DisplayDocTitle: false NonFullScreenPageMode: UseNone Direction: L2R ViewArea: CropBox ViewClip: CropBox PrintArea: CropBox PageClip: CropBox PageLayout: SinglePage PageMode: UseNone Outlines: Item: Title: First Latin American clinical practice guidelines for the treatment of systemic lupus erythematosus: Latin American Group for the Study of Lupus (GLADEL, Grupo Latino Americano de Estudio del Lupus)–Pan-American League of Associations of Rheumatology (P Children: Item: Title: Abstract Item: Title: Introduction Item: Title: Methods Item: Title: Results Children: Item: Title: Musculoskeletal manifestations Children: Item: Title: Interventions considered Item: Title: Benefits and harms Item: Title: Recommendation Item: Title: Cutaneous manifestations Children: Item: Title: Interventions considered Item: Title: Benefits and harms Item: Title: Recommendation Item: Title: Adult kidney manifestations Children: Item: Title: Interventions considered Item: Title: Benefits and harms Item: Title: Recommendation Item: Title: Interventions considered Item: Title: Benefits and harms Item: Title: Recommendation Item: Title: Childhood-onset lupus nephritis Children: Item: Title: Interventions considered Item: Title: Benefits and harms Item: Title: Recommendation Item: Title: Interventions considered Item: Title: Benefits and harms Item: Title: Recommendation Item: Title: Cardiac manifestations Children: Item: Title: Interventions considered Item: Title: Benefits and harms Item: Title: Recommendation Item: Title: Pulmonary manifestations Children: Item: Title: Interventions considered Item: Title: Benefits and harms Item: Title: Recommendation Item: Title: Neuropsychiatric manifestations Children: Item: Title: Interventions considered Item: Title: Benefits and harms Item: Title: Recommendation Item: Title: Haematological manifestations Children: Item: Title: Interventions considered Item: Title: Benefits and harms Item: Title: Recommendation Item: Title: Interventions considered Item: Title: Benefits and harms Item: Title: Recommendations Item: Title: Antiphospholipid syndrome Children: Item: Title: Interventions considered Item: Title: Benefits and harms Item: Title: Recommendation Item: Title: Interventions considered Item: Title: Benefits and harms Item: Title: Recommendation Item: Title: Interventions considered Item: Title: Benefits and harms Item: Title: Recommendation Item: Title: Discussion Item: Title: References Info: Creator: Adobe InDesign CS6 (Windows) Producer: Adobe PDF Library 10.0.1 CreationDate: Wed Oct 10 10:33:05 CEST 2018 ModDate: Wed Oct 10 10:33:06 CEST 2018 ID: 0x962d069690552a4da1c3562cd2cb6218, 0x840c9da1c771824ba8f53d7c1a3fc879 Filters: FilterPipeline: FlateDecode Fonts: Type0: Font: BaseFont: CTDHCP+ArialMT Encoding: Identity-H ToUnicode: true Font: BaseFont: CTDHCP+ClassicalGaramondBT-Roman Encoding: Identity-H ToUnicode: true Type1: Font: BaseFont: MVGPMV+FrutigerLTStd-BoldCn FontSubset: true FirstChar: 67 LastChar: 83 FontDescriptor: FontName: MVGPMV+FrutigerLTStd-BoldCn Flags: Nonsymbolic FontBBox: -112, -250, 1000, 940 FontFile3: true Encoding: WinAnsiEncoding ToUnicode: true Font: BaseFont: ZUMYMV+FrutigerLTPro-LightCnIta FontSubset: true FirstChar: 31 LastChar: 121 FontDescriptor: FontName: ZUMYMV+FrutigerLTPro-LightCnIta Flags: Nonsymbolic FontBBox: -161, -250, 991, 919 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: ZUMYMV+FrutigerLTPro-LightCn FontSubset: true FirstChar: 29 LastChar: 250 FontDescriptor: FontName: ZUMYMV+FrutigerLTPro-LightCn Flags: Nonsymbolic FontBBox: -100, -250, 1000, 919 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: ZUMYMV+FrutigerLTPro-BoldCn FontSubset: true FirstChar: 30 LastChar: 150 FontDescriptor: FontName: ZUMYMV+FrutigerLTPro-BoldCn Flags: Nonsymbolic FontBBox: -112, -250, 1000, 940 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: CTDHCP+FrutigerLTPro-Condensed FontSubset: true FirstChar: 29 LastChar: 150 FontDescriptor: FontName: CTDHCP+FrutigerLTPro-Condensed Flags: Nonsymbolic FontBBox: -105, -250, 1000, 929 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: MVGPMV+FrutigerLTPro-CondensedIta FontSubset: true FirstChar: 30 LastChar: 121 FontDescriptor: FontName: MVGPMV+FrutigerLTPro-CondensedIta Flags: Nonsymbolic, Italic FontBBox: -166, -250, 992, 929 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true TrueType: Font: BaseFont: MVGPMV+ClassicalGaramondBT-Italic FontSubset: true FirstChar: 32 LastChar: 117 FontDescriptor: FontName: MVGPMV+ClassicalGaramondBT-Italic Flags: Serif, Nonsymbolic FontBBox: -167, -237, 1275, 963 FontFile2: true Encoding: WinAnsiEncoding ToUnicode: true Font: BaseFont: CTDHCP+ClassicalGaramondBT-Roman FontSubset: true FirstChar: 32 LastChar: 150 FontDescriptor: FontName: CTDHCP+ClassicalGaramondBT-Roman Flags: Serif, Nonsymbolic FontBBox: -166, -237, 1261, 963 FontFile2: true Encoding: WinAnsiEncoding ToUnicode: true CIDFontType2: Font: BaseFont: CTDHCP+ArialMT CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: CTDHCP+ArialMT Flags: Symbolic FontBBox: -665, -325, 2000, 1006 FontFile2: true Font: BaseFont: CTDHCP+ClassicalGaramondBT-Roman CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: CTDHCP+ClassicalGaramondBT-Roman Flags: Serif, Symbolic FontBBox: -166, -237, 1261, 963 FontFile2: true XMP: doi:annrheumdis-2018-213512 application/pdf 2018-10-10T09:33:05+01:00 2018-10-10T09:33:06+01:00 2018-10-10T09:33:06+01:00 Adobe InDesign CS6 (Windows) uuid:56875b59-7e8a-44c4-8eda-e5d97f2d90df xmp.did:B2C59A163194E611BD009A7CB80B8EC7 xmp.id:BCB41A1B67CCE811AB40F8A539E7064D proof:pdf xmp.iid:BBB41A1B67CCE811AB40F8A539E7064D xmp.did:F55F4D56162068118C14CF26067AF65C xmp.did:B2C59A163194E611BD009A7CB80B8EC7 default converted from application/x-indesign to application/pdf Adobe InDesign CS6 (Windows) / 2018-10-10T09:33:05+01:00 29c21d74-50e3-47b4-bf7f-8f1b193fc3b4 Adobe PDF Library 10.0.1 False Pages: Page: Label: 1549 Sequence: 1 Annotations: Annotation: Subtype: Link Rect: 481, 38, 527, 20 Annotation: Subtype: Link Rect: 40, 34, 65, 18 Annotation: Subtype: Link Rect: 40, 171, 136, 148 Page: Label: 1550 Sequence: 2 Annotations: Annotation: Subtype: Link Rect: 64, 464, 73, 453 ActionDest: 160 Annotation: Subtype: Link Rect: 116, 453, 126, 442 ActionDest: 160 Annotation: Subtype: Link Rect: 132, 431, 152, 420 ActionDest: 160 Annotation: Subtype: Link Rect: 122, 365, 137, 354 ActionDest: 160 Annotation: Subtype: Link Rect: 285, 365, 288, 354 ActionDest: 160 Annotation: Subtype: Link Rect: 97, 343, 101, 332 ActionDest: 160 Annotation: Subtype: Link Rect: 215, 343, 218, 332 ActionDest: 160 Annotation: Subtype: Link Rect: 102, 332, 105, 321 ActionDest: 160 Annotation: Subtype: Link Rect: 81, 321, 108, 310 ActionDest: 160 Annotation: Subtype: Link Rect: 136, 288, 153, 277 ActionDest: 160 Annotation: Subtype: Link Rect: 196, 277, 228, 266 ActionDest: 160 Annotation: Subtype: Link Rect: 265, 277, 274, 266 ActionDest: 160 Annotation: Subtype: Link Rect: 208, 266, 224, 255 ActionDest: 160 Annotation: Subtype: Link Rect: 91, 233, 108, 222 ActionDest: 160 Annotation: Subtype: Link Rect: 108, 211, 115, 200 ActionDest: 160 Annotation: Subtype: Link Rect: 264, 65, 288, 54 Annotation: Subtype: Link Rect: 42, 54, 155, 43 Annotation: Subtype: Link Rect: 346, 432, 352, 421 ActionDest: 160 Annotation: Subtype: Link Rect: 363, 272, 369, 261 ActionDest: 160 Annotation: Subtype: Link Rect: 430, 239, 453, 228 ActionDest: 1 Annotation: Subtype: Link Rect: 306, 217, 387, 206 Annotation: Subtype: Link Rect: 399, 217, 550, 206 Annotation: Subtype: Link Rect: 370, 87, 553, 76 Annotation: Subtype: Link Rect: 306, 76, 553, 65 Annotation: Subtype: Link Rect: 306, 65, 553, 54 Annotation: Subtype: Link Rect: 306, 54, 413, 43 Page: Label: 1551 Sequence: 3 Annotations: Annotation: Subtype: Link Rect: 141, 302, 167, 291 ActionDest: 59 Annotation: Subtype: Link Rect: 231, 189, 288, 178 Annotation: Subtype: Link Rect: 42, 178, 288, 167 Annotation: Subtype: Link Rect: 42, 167, 100, 156 Annotation: Subtype: Link Rect: 444, 714, 470, 703 ActionDest: 59 Annotation: Subtype: Link Rect: 496, 606, 553, 595 Annotation: Subtype: Link Rect: 306, 595, 553, 584 Annotation: Subtype: Link Rect: 306, 584, 442, 573 Annotation: Subtype: Link Rect: 484, 305, 511, 294 ActionDest: 86 Annotation: Subtype: Link Rect: 508, 194, 553, 183 Annotation: Subtype: Link Rect: 306, 183, 553, 172 Annotation: Subtype: Link Rect: 306, 172, 390, 161 Page: Label: 1552 Sequence: 4 Annotations: Annotation: Subtype: Link Rect: 93, 414, 119, 403 ActionDest: 86 Annotation: Subtype: Link Rect: 260, 334, 288, 323 Annotation: Subtype: Link Rect: 42, 323, 121, 312 Annotation: Subtype: Link Rect: 135, 222, 141, 211 ActionDest: 160 Annotation: Subtype: Link Rect: 76, 122, 102, 111 ActionDest: 86 Annotation: Subtype: Link Rect: 231, 65, 288, 54 Annotation: Subtype: Link Rect: 42, 54, 87, 43 Annotation: Subtype: Link Rect: 398, 692, 404, 681 ActionDest: 160 Annotation: Subtype: Link Rect: 499, 618, 525, 607 ActionDest: 86 Annotation: Subtype: Link Rect: 336, 499, 488, 488 Annotation: Subtype: Link Rect: 309, 341, 335, 330 ActionDest: 86 Page: Label: 1553 Sequence: 5 Annotations: Annotation: Subtype: Link Rect: 42, 703, 193, 692 Annotation: Subtype: Link Rect: 172, 528, 198, 517 ActionDest: 86 Annotation: Subtype: Link Rect: 149, 433, 288, 423 Annotation: Subtype: Link Rect: 42, 422, 288, 412 Annotation: Subtype: Link Rect: 42, 411, 96, 401 Annotation: Subtype: Link Rect: 44, 160, 71, 149 ActionDest: 111 Annotation: Subtype: Link Rect: 231, 65, 288, 54 Annotation: Subtype: Link Rect: 42, 54, 144, 43 Annotation: Subtype: Link Rect: 309, 277, 335, 266 ActionDest: 111 Annotation: Subtype: Link Rect: 435, 188, 553, 177 Annotation: Subtype: Link Rect: 306, 177, 370, 166 Page: Label: 1554 Sequence: 6 Annotations: Annotation: Subtype: Link Rect: 208, 637, 234, 626 ActionDest: 111 Annotation: Subtype: Link Rect: 176, 512, 288, 502 Annotation: Subtype: Link Rect: 42, 501, 88, 491 Annotation: Subtype: Link Rect: 42, 133, 203, 122 Annotation: Subtype: Link Rect: 429, 567, 553, 556 Annotation: Subtype: Link Rect: 306, 556, 543, 545 Annotation: Subtype: Link Rect: 409, 254, 436, 243 ActionDest: 155 Annotation: Subtype: Link Rect: 335, 197, 352, 186 ActionDest: 160 Page: Label: 1555 Sequence: 7 Annotations: Annotation: Subtype: Link Rect: 213, 357, 274, 346 ActionDest: 160 Page: Label: 1556 Sequence: 8 Annotations: Annotation: Subtype: Link Rect: 111, 420, 247, 411 Annotation: Subtype: Link Rect: 245, 370, 270, 361 Annotation: Subtype: Link Rect: 188, 343, 230, 334 Annotation: Subtype: Link Rect: 136, 316, 179, 307 Annotation: Subtype: Link Rect: 188, 288, 231, 280 Annotation: Subtype: Link Rect: 190, 270, 251, 262 Annotation: Subtype: Link Rect: 163, 234, 206, 225 Annotation: Subtype: Link Rect: 165, 207, 218, 198 Annotation: Subtype: Link Rect: 213, 189, 255, 180 Annotation: Subtype: Link Rect: 275, 161, 279, 153 Annotation: Subtype: Link Rect: 54, 152, 97, 144 Annotation: Subtype: Link Rect: 122, 125, 161, 116 Annotation: Subtype: Link Rect: 252, 107, 268, 98 Annotation: Subtype: Link Rect: 97, 71, 136, 62 Annotation: Subtype: Link Rect: 54, 52, 97, 44 Annotation: Subtype: Link Rect: 362, 728, 407, 720 Annotation: Subtype: Link Rect: 458, 710, 491, 702 Annotation: Subtype: Link Rect: 342, 674, 370, 666 Annotation: Subtype: Link Rect: 503, 647, 545, 639 Annotation: Subtype: Link Rect: 516, 620, 553, 612 Annotation: Subtype: Link Rect: 319, 611, 328, 603 Annotation: Subtype: Link Rect: 537, 593, 548, 585 Annotation: Subtype: Link Rect: 319, 584, 343, 576 Annotation: Subtype: Link Rect: 539, 566, 550, 558 Annotation: Subtype: Link Rect: 319, 557, 358, 548 Annotation: Subtype: Link Rect: 428, 503, 470, 494 Annotation: Subtype: Link Rect: 415, 476, 431, 467 Annotation: Subtype: Link Rect: 402, 449, 441, 440 Annotation: Subtype: Link Rect: 436, 431, 475, 422 Annotation: Subtype: Link Rect: 423, 413, 459, 404 Annotation: Subtype: Link Rect: 439, 395, 486, 386 Annotation: Subtype: Link Rect: 336, 368, 404, 359 Annotation: Subtype: Link Rect: 401, 350, 446, 341 Annotation: Subtype: Link Rect: 477, 323, 538, 314 Annotation: Subtype: Link Rect: 491, 287, 531, 278 Annotation: Subtype: Link Rect: 409, 251, 451, 242 Annotation: Subtype: Link Rect: 366, 224, 409, 215 Annotation: Subtype: Link Rect: 373, 197, 415, 188 Annotation: Subtype: Link Rect: 341, 170, 383, 161 Annotation: Subtype: Link Rect: 319, 143, 361, 134 Annotation: Subtype: Link Rect: 405, 116, 453, 107 Annotation: Subtype: Link Rect: 367, 89, 406, 80 Annotation: Subtype: Link Rect: 491, 62, 551, 53 Page: Label: 1557 Sequence: 9 Annotations: Annotation: Subtype: Link Rect: 54, 727, 115, 718 Annotation: Subtype: Link Rect: 75, 698, 91, 690 Annotation: Subtype: Link Rect: 191, 679, 207, 670 Annotation: Subtype: Link Rect: 117, 650, 133, 641 Annotation: Subtype: Link Rect: 125, 612, 142, 603 Annotation: Subtype: Link Rect: 429, 737, 445, 729 Annotation: Subtype: Link Rect: 506, 710, 551, 702 Annotation: Subtype: Link Rect: 319, 674, 335, 666 Annotation: Subtype: Link Rect: 417, 647, 433, 639 Annotation: Subtype: Link Rect: 500, 620, 542, 612 Checksum: 24b92c7d Type: CRC32 Checksum: e647cb7288733a495828c54614346eec Type: MD5 Checksum: 7fcdef6701c8df44442070834b0144b2a9b66220 Type: SHA-1 Checksum: ec4fefdc720e9c03971bb4893bad763209522f1b8de229737023cc4675710abe Type: SHA-256