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Title:          The Ras-related gene ERAS is involved in human and murine breast cancer
Subject:        Scientific Reports, doi:10.1038/s41598-018-31326-4
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     Item: 
      Title: The Ras-related gene ERAS is involved in human and murine breast cancer
      Children: 
       Item: 
        Title: Results
        Children: 
         Item: 
          Title: SB/T2 mice develop mammary tumors expressing ERAS. 
         Item: 
          Title: ERAS expression induces morphological and proliferative changes to non-tumoral human mammary cells. 
         Item: 
          Title: ERAS induces epithelial-mesenchymal transition and stem cell-like features. 
         Item: 
          Title: Understanding ERAS signaling pathway in mammary gland cells. 
         Item: 
          Title: ERAS modulates the EMT process through downregulation of the miR-200 family. 
         Item: 
          Title: ERAS increases growth rate and invasion, and decreases differentiation in xenograft tumors. 
         Item: 
          Title: ERAS is expressed in some human breast tumors. 
       Item: 
        Title: Discussion
       Item: 
        Title: Methods
        Children: 
         Item: 
          Title: Human tumors. 
         Item: 
          Title: Animals. 
         Item: 
          Title: Cell culture, DNA constructs, transfection and lentiviral production. 
         Item: 
          Title: RNA isolation and quantitative RT-qPCR. 
         Item: 
          Title: Immunohistochemistry and immunofluorescence. 
         Item: 
          Title: Immunoblot analysis. 
         Item: 
          Title: Proliferation and wound-healing assays. 
         Item: 
          Title: Cell cycle and flow cytometry analysis. 
         Item: 
          Title: Orthotopic mammary xenografts assays. 
         Item: 
          Title: Gene expression profiling and analysis. 
         Item: 
          Title: TCGA and cBioPortal data analysis. 
         Item: 
          Title: Statistical analysis. 
         Item: 
          Title: Ethical approval and informed consent. 
       Item: 
        Title: Acknowledgements
       Item: 
        Title: Figure 1 Eras expression in mammary gland tumors with activating transposon insertions in Eras locus.
       Item: 
        Title: Figure 2 Forced expression of ERAS transforms MCF10A cells.
       Item: 
        Title: Figure 3 Increased proliferation and migration in MCF10A cells expressing ERAS.
       Item: 
        Title: Figure 4 Induction of EMT and stem cell-like features by ERAS expression in mammary gland cells.
       Item: 
        Title: Figure 5 ERAS expression in MCF10A cells results in the alteration of multiple signaling pathways.
       Item: 
        Title: Figure 6 Downregulation of miR-200 family induces EMT in MCF10A-ERAS cells.
       Item: 
        Title: Figure 7 ERAS promotes the development of larger and more undifferentiated tumors when expressed in breast cancer cells.
       Item: 
        Title: Figure 8 ERAS is expressed in human breast cancer.
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                           <pdfaProperty:name>doi</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>ISSN for an electronic version of the issue in which the resource occurs. 
Permits publishers to include a second ISSN, identifying an electronic version of the issue in which the resource occurs (therefore e(lectronic)Issn. If used, prism:eIssn MUST contain the ISSN of the electronic version. See prism:issn. 
</pdfaProperty:description>
                           <pdfaProperty:name>issn</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Title of the magazine, or other publication, in which a resource was/will be published. 
Typically this will be used to provide the name of the magazine an article appeared in as metadata for the article, along with information such as the article title, the publisher, volume, number, and cover date. 

Note: Publication name can be used to differentiate between a print magazine and the online version if the names are different such as “magazine” and “magazine.com.” 
</pdfaProperty:description>
                           <pdfaProperty:name>publicationName</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
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                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>This element provides the url for an article or unit of content. 
The attribute platform is optionally allowed for situations in which multiple URLs must be specified. PRISM recommends that a subset of the PCV platform values, namely “mobile” and “web”, be used in conjunction with this element. 
NOTE: PRISM recommends against the use of the #other value allowed in the PRISM Platform controlled vocabulary. In lieu of using #other please reach out to the PRISM group at prism-wg@yahoogroups.com to request addition of your term to the Platform Controlled Vocabulary. 
</pdfaProperty:description>
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                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
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                  <pdfaSchema:namespaceURI>http://www.niso.org/schemas/jav/1.0/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>jav</pdfaSchema:prefix>
                  <pdfaSchema:schema>NISO</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Values for Journal Article Version are one of the following:
AO = Author’s Original
SMUR = Submitted Manuscript Under Review
AM = Accepted Manuscript
P = Proof
VoR = Version of Record
CVoR = Corrected Version of Record
EVoR = Enhanced Version of Record</pdfaProperty:description>
                           <pdfaProperty:name>journal_article_version</pdfaProperty:name>
                           <pdfaProperty:valueType>Closed Choice of Text</pdfaProperty:valueType>
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