12a306b3cdfe7bc2fbe472236bbcb0e6 pmc_30158879.pdf bd886f2f208d768a84830e3fe8023f05fc19d06e pmc_30158879.pdf 10654b5a9dfe58e03f6c79c7e1eff27b3c9b8e213df59553b23c15e91f15f3c2 pmc_30158879.pdf Title: Intermittent Hypoxia Mimicking Sleep Apnea Increases Passive Stiffness of Myocardial Extracellular Matrix. A Multiscale Study Subject: Background: Tissue hypoxia-reoxygenation characterizes obstructive sleep apnea (OSA), a very prevalent respiratory disease associated with increased cardiovascular morbidity and mortality. Keywords: atomic force microscopy, tensile test, heart mechanics, myocardial stiffness, ventricular strain, obstructive sleep apnea Author: Daniel Navajas Creator: LaTeX with hyperref package Producer: pdfTeX-1.40.15 CreationDate: Mon Aug 13 15:26:56 2018 CEST ModDate: Mon Aug 13 16:11:49 2018 CEST Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 10 Encrypted: no Page size: 595.276 x 779.528 pts Page rot: 0 File size: 892244 bytes Optimized: no PDF version: 1.5 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- WDEHFG+MinionPro-Regular Type 1 Custom yes yes no 54 0 OWNNIJ+HelveticaNeueLTStd-Bd Type 1 Custom yes yes no 55 0 ZNJNWF+HelveticaNeueLTStd-Lt Type 1 Custom yes yes no 56 0 CCVXXJ+HelveticaNeueLTStd-BdIt Type 1 Custom yes yes no 57 0 DGTPGY+HelveticaNeueLTStd-LtIt Type 1 Custom yes yes no 58 0 LZGOMY+HelveticaNeueLTStd-MdIt Type 1 Custom yes yes no 60 0 RSJEBB+MTSYN Type 1 Builtin yes yes no 61 0 QBKTLL+MTGU Type 1 Builtin yes yes no 62 0 EHTHXU+RBLMI Type 1 Builtin yes yes no 63 0 HEMVLW+MinionPro-It Type 1 Custom yes yes no 215 0 ZXELRP+BLEX Type 1 Custom yes yes no 252 0 TDIRTD+MinionPro-Bold Type 1 Custom yes yes no 265 0 Jhove (Rel. 1.22.1, 2019-04-17) Date: 2023-09-02 02:32:18 CEST RepresentationInformation: pmc_30158879.pdf ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17) LastModified: 2020-02-05 11:43:19 CET Size: 892244 Format: PDF Version: 1.5 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 780 FreeObjects: 3 IncrementalUpdates: 1 DocumentCatalog: PageLayout: SinglePage PageMode: UseOutlines Outlines: Item: Title: Intermittent Hypoxia Mimicking Sleep Apnea Increases Passive Stiffness of Myocardial Extracellular Matrix. A Multiscale Study Children: Item: Title: Introduction Item: Title: Materials and Methods Children: Item: Title: Animals and Exposures of Intermittent Hypoxia Item: Title: Measurement of Macroscale Stiffness by Tensile Stretching Item: Title: Measurement of Microscale Stiffness by Atomic Force Microscopy Item: Title: Collagen Assessment Item: Title: Statistical Analysis Item: Title: Results Children: Item: Title: Tensile Stretch Measurements Item: Title: AFM Measurements Item: Title: Collagen Content Item: Title: Discussion Item: Title: Conclusion Item: Title: Ethics Statement Item: Title: Author Contributions Item: Title: Funding Item: Title: Acknowledgments Item: Title: References Info: Title: Intermittent Hypoxia Mimicking Sleep Apnea Increases Passive Stiffness of Myocardial Extracellular Matrix. A Multiscale Study Author: Daniel Navajas Subject: Background: Tissue hypoxia-reoxygenation characterizes obstructive sleep apnea (OSA), a very prevalent respiratory disease associated with increased cardiovascular morbidity and mortality. Keywords: atomic force microscopy, tensile test, heart mechanics, myocardial stiffness, ventricular strain, obstructive sleep apnea Creator: LaTeX with hyperref package Producer: pdfTeX-1.40.15 CreationDate: Mon Aug 13 15:56:56 CEST 2018 ModDate: Mon Aug 13 16:41:49 CEST 2018 ID: 0xe083c8b348503f08604f13ac9efc9ea8, 0x9d3dadebb9c0b04ea1e648817fa1d616 Filters: FilterPipeline: FlateDecode Fonts: Type1: Font: BaseFont: WDEHFG+MinionPro-Regular FontSubset: true FirstChar: 2 LastChar: 250 FontDescriptor: FontName: WDEHFG+MinionPro-Regular Flags: Symbolic FontBBox: -289, -360, 1684, 917 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: OWNNIJ+HelveticaNeueLTStd-Bd FontSubset: true FirstChar: 40 LastChar: 124 FontDescriptor: FontName: OWNNIJ+HelveticaNeueLTStd-Bd Flags: Symbolic FontBBox: -166, -218, 1078, 975 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: HEMVLW+MinionPro-It FontSubset: true FirstChar: 40 LastChar: 233 FontDescriptor: FontName: HEMVLW+MinionPro-It Flags: Symbolic FontBBox: -201, -360, 1684, 919 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: ZNJNWF+HelveticaNeueLTStd-Lt FontSubset: true FirstChar: 2 LastChar: 233 FontDescriptor: FontName: ZNJNWF+HelveticaNeueLTStd-Lt Flags: Symbolic FontBBox: -166, -214, 1050, 967 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: CCVXXJ+HelveticaNeueLTStd-BdIt FontSubset: true FirstChar: 42 LastChar: 121 FontDescriptor: FontName: CCVXXJ+HelveticaNeueLTStd-BdIt Flags: Symbolic FontBBox: -166, -218, 1129, 975 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: TDIRTD+MinionPro-Bold FontSubset: true FirstChar: 3 LastChar: 117 FontDescriptor: FontName: TDIRTD+MinionPro-Bold Flags: Symbolic FontBBox: -318, -360, 1684, 917 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: DGTPGY+HelveticaNeueLTStd-LtIt FontSubset: true FirstChar: 2 LastChar: 242 FontDescriptor: FontName: DGTPGY+HelveticaNeueLTStd-LtIt Flags: Symbolic FontBBox: -165, -214, 1099, 951 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: LZGOMY+HelveticaNeueLTStd-MdIt FontSubset: true FirstChar: 42 LastChar: 250 FontDescriptor: FontName: LZGOMY+HelveticaNeueLTStd-MdIt Flags: Symbolic FontBBox: -165, -218, 1125, 947 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: ZXELRP+BLEX FontSubset: true FirstChar: 0 LastChar: 1 FontDescriptor: FontName: ZXELRP+BLEX Flags: Symbolic FontBBox: -23, -2954, 1454, 762 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: RSJEBB+MTSYN FontSubset: true FirstChar: 0 LastChar: 112 FontDescriptor: FontName: RSJEBB+MTSYN Flags: Symbolic FontBBox: 0, -954, 1043, 900 FontFile: true Font: BaseFont: QBKTLL+MTGU FontSubset: true FirstChar: 43 LastChar: 115 FontDescriptor: FontName: QBKTLL+MTGU Flags: Symbolic FontBBox: 25, -213, 839, 683 FontFile: true Font: BaseFont: EHTHXU+RBLMI FontSubset: true FirstChar: 29 LastChar: 62 FontDescriptor: FontName: EHTHXU+RBLMI Flags: Symbolic FontBBox: -11, -230, 987, 750 FontFile: true XMP: application/pdf Daniel Navajas Background: Tissue hypoxia-reoxygenation characterizes obstructive sleep apnea (OSA), a very prevalent respiratory disease associated with increased cardiovascular morbidity and mortality. Intermittent Hypoxia Mimicking Sleep Apnea Increases Passive Stiffness of Myocardial Extracellular Matrix. A Multiscale Study atomic force microscopy tensile test heart mechanics myocardial stiffness ventricular strain obstructive sleep apnea 2018-08-13T18:56:56+05:30 LaTeX with hyperref package 2018-08-13T19:41:49+05:30 2018-08-13T19:41:49+05:30 atomic force microscopy, tensile test, heart mechanics, myocardial stiffness, ventricular strain, obstructive sleep apnea pdfTeX-1.40.15 False This is MiKTeX-pdfTeX 2.9.5496 (1.40.15) uuid:e6ac2150-b68d-4865-a070-efa8fda6660a uuid:da9be9d3-11ee-4deb-88d4-1c567e175c98 Pages: Page: Sequence: 1 Annotations: Annotation: Subtype: Link Rect: 43, 718, 147, 754 Annotation: Subtype: Link Rect: 474, 736, 551, 745 Annotation: Subtype: Link Rect: 467, 727, 551, 737 Annotation: Subtype: Link Rect: 453, 718, 551, 729 Annotation: Subtype: Link Rect: 86, 425, 160, 435 Annotation: Subtype: Link Rect: 75, 65, 160, 74 Annotation: Subtype: Link Rect: 521, 677, 551, 707 Annotation: Subtype: Link Rect: 176, 518, 551, 608 Annotation: Subtype: Link Rect: 176, 497, 225, 507 Annotation: Subtype: Link Rect: 309, 497, 375, 507 Annotation: Subtype: Link Rect: 386, 497, 441, 507 Annotation: Subtype: Link Rect: 452, 497, 506, 507 Annotation: Subtype: Link Rect: 176, 486, 228, 498 Annotation: Subtype: Link Rect: 235, 486, 306, 498 Annotation: Subtype: Link Rect: 322, 486, 378, 498 Annotation: Subtype: Link Rect: 409, 486, 472, 498 Annotation: Subtype: Link Rect: 43, 29, 113, 38 Annotation: Subtype: Link Rect: 116, 29, 176, 38 Annotation: Subtype: Link Rect: 435, 29, 551, 38 Page: Sequence: 2 Annotations: Annotation: Subtype: Link Rect: 166, 546, 228, 557 ActionDest: 593 Annotation: Subtype: Link Rect: 233, 546, 254, 557 ActionDest: 593 Annotation: Subtype: Link Rect: 260, 546, 292, 557 ActionDest: 593 Annotation: Subtype: Link Rect: 43, 534, 66, 546 ActionDest: 593 Annotation: Subtype: Link Rect: 71, 534, 91, 546 ActionDest: 593 Annotation: Subtype: Link Rect: 215, 454, 261, 465 ActionDest: 593 Annotation: Subtype: Link Rect: 267, 454, 287, 465 ActionDest: 593 Annotation: Subtype: Link Rect: 47, 421, 112, 431 ActionDest: 529 Annotation: Subtype: Link Rect: 115, 421, 135, 431 ActionDest: 529 Annotation: Subtype: Link Rect: 137, 421, 158, 431 ActionDest: 529 Annotation: Subtype: Link Rect: 160, 421, 180, 431 ActionDest: 529 Annotation: Subtype: Link Rect: 183, 421, 231, 431 ActionDest: 633 Annotation: Subtype: Link Rect: 233, 421, 253, 431 ActionDest: 633 Annotation: Subtype: Link Rect: 256, 421, 292, 431 ActionDest: 593 Annotation: Subtype: Link Rect: 43, 409, 93, 420 ActionDest: 593 Annotation: Subtype: Link Rect: 98, 409, 118, 420 ActionDest: 593 Annotation: Subtype: Link Rect: 199, 385, 264, 397 ActionDest: 593 Annotation: Subtype: Link Rect: 270, 385, 290, 397 ActionDest: 593 Annotation: Subtype: Link Rect: 43, 374, 97, 385 ActionDest: 593 Annotation: Subtype: Link Rect: 99, 374, 120, 385 ActionDest: 593 Annotation: Subtype: Link Rect: 238, 317, 290, 328 ActionDest: 633 Annotation: Subtype: Link Rect: 43, 305, 64, 316 ActionDest: 633 Annotation: Subtype: Link Rect: 194, 225, 251, 236 ActionDest: 633 Annotation: Subtype: Link Rect: 253, 225, 273, 236 ActionDest: 633 Annotation: Subtype: Link Rect: 205, 156, 260, 167 ActionDest: 593 Annotation: Subtype: Link Rect: 267, 156, 287, 167 ActionDest: 593 Annotation: Subtype: Link Rect: 94, 122, 181, 133 ActionDest: 529 Annotation: Subtype: Link Rect: 185, 122, 205, 133 ActionDest: 529 Annotation: Subtype: Link Rect: 383, 580, 431, 591 ActionDest: 529 Annotation: Subtype: Link Rect: 435, 580, 456, 591 ActionDest: 529 Annotation: Subtype: Link Rect: 460, 580, 521, 591 ActionDest: 593 Annotation: Subtype: Link Rect: 525, 580, 545, 591 ActionDest: 593 Annotation: Subtype: Link Rect: 478, 534, 549, 546 ActionDest: 529 Annotation: Subtype: Link Rect: 302, 524, 322, 534 ActionDest: 529 Annotation: Subtype: Link Rect: 325, 524, 371, 534 ActionDest: 593 Annotation: Subtype: Link Rect: 373, 524, 394, 534 ActionDest: 593 Annotation: Subtype: Link Rect: 474, 443, 523, 454 ActionDest: 529 Annotation: Subtype: Link Rect: 528, 443, 549, 454 ActionDest: 529 Annotation: Subtype: Link Rect: 302, 432, 366, 442 ActionDest: 633 Annotation: Subtype: Link Rect: 371, 432, 391, 442 ActionDest: 633 Annotation: Subtype: Link Rect: 396, 432, 454, 442 ActionDest: 593 Annotation: Subtype: Link Rect: 459, 432, 479, 442 ActionDest: 593 Annotation: Subtype: Link Rect: 484, 432, 524, 442 ActionDest: 593 Annotation: Subtype: Link Rect: 528, 432, 549, 442 ActionDest: 593 Annotation: Subtype: Link Rect: 302, 421, 349, 431 ActionDest: 593 Annotation: Subtype: Link Rect: 353, 421, 373, 431 ActionDest: 593 Annotation: Subtype: Link Rect: 376, 421, 437, 431 ActionDest: 593 Annotation: Subtype: Link Rect: 440, 421, 460, 431 ActionDest: 593 Annotation: Subtype: Link Rect: 464, 421, 502, 431 ActionDest: 633 Annotation: Subtype: Link Rect: 505, 421, 526, 431 ActionDest: 633 Annotation: Subtype: Link Rect: 529, 421, 551, 431 ActionDest: 633 Annotation: Subtype: Link Rect: 302, 408, 323, 420 ActionDest: 633 Annotation: Subtype: Link Rect: 326, 408, 346, 420 ActionDest: 633 Annotation: Subtype: Link Rect: 362, 351, 446, 362 ActionDest: 529 Annotation: Subtype: Link Rect: 449, 351, 469, 362 ActionDest: 529 Annotation: Subtype: Link Rect: 472, 351, 494, 362 ActionDest: 593 Annotation: Subtype: Link Rect: 497, 351, 517, 362 ActionDest: 593 Annotation: Subtype: Link Rect: 520, 351, 551, 362 ActionDest: 529 Annotation: Subtype: Link Rect: 302, 339, 322, 351 ActionDest: 529 Annotation: Subtype: Link Rect: 325, 339, 346, 351 ActionDest: 529 Annotation: Subtype: Link Rect: 520, 283, 551, 293 ActionDest: 529 Annotation: Subtype: Link Rect: 302, 271, 345, 282 ActionDest: 529 Annotation: Subtype: Link Rect: 348, 271, 368, 282 ActionDest: 529 Annotation: Subtype: Link Rect: 370, 271, 454, 282 ActionDest: 529 Annotation: Subtype: Link Rect: 456, 271, 477, 282 ActionDest: 529 Annotation: Subtype: Link Rect: 305, 202, 355, 213 ActionDest: 593 Annotation: Subtype: Link Rect: 357, 202, 377, 213 ActionDest: 593 Annotation: Subtype: Link Rect: 380, 202, 424, 213 ActionDest: 633 Annotation: Subtype: Link Rect: 426, 202, 446, 213 ActionDest: 633 Annotation: Subtype: Link Rect: 449, 202, 523, 213 ActionDest: 529 Annotation: Subtype: Link Rect: 525, 202, 545, 213 ActionDest: 529 Annotation: Subtype: Link Rect: 494, 179, 551, 190 ActionDest: 593 Annotation: Subtype: Link Rect: 302, 168, 348, 179 ActionDest: 593 Annotation: Subtype: Link Rect: 353, 168, 374, 179 ActionDest: 593 Annotation: Subtype: Link Rect: 378, 168, 436, 179 ActionDest: 529 Annotation: Subtype: Link Rect: 441, 168, 461, 179 ActionDest: 529 Annotation: Subtype: Link Rect: 481, 110, 549, 122 ActionDest: 633 Annotation: Subtype: Link Rect: 302, 99, 322, 110 ActionDest: 633 Annotation: Subtype: Link Rect: 325, 99, 375, 110 ActionDest: 593 Annotation: Subtype: Link Rect: 377, 99, 397, 110 ActionDest: 593 Annotation: Subtype: Link Rect: 498, 76, 549, 87 ActionDest: 529 Annotation: Subtype: Link Rect: 302, 65, 322, 76 ActionDest: 529 Annotation: Subtype: Link Rect: 326, 65, 411, 76 ActionDest: 593 Annotation: Subtype: Link Rect: 415, 65, 435, 76 ActionDest: 593 Annotation: Subtype: Link Rect: 43, 29, 113, 38 Annotation: Subtype: Link Rect: 116, 29, 176, 38 Annotation: Subtype: Link Rect: 435, 29, 551, 38 Page: Sequence: 3 Annotations: Annotation: Subtype: Link Rect: 180, 614, 263, 626 ActionDest: 593 Annotation: Subtype: Link Rect: 270, 614, 290, 626 ActionDest: 593 Annotation: Subtype: Link Rect: 43, 604, 103, 614 ActionDest: 593 Annotation: Subtype: Link Rect: 105, 604, 125, 614 ActionDest: 593 Annotation: Subtype: Link Rect: 247, 356, 292, 367 ActionDest: 529 Annotation: Subtype: Link Rect: 43, 345, 63, 356 ActionDest: 529 Annotation: Subtype: Link Rect: 65, 345, 86, 356 ActionDest: 529 Annotation: Subtype: Link Rect: 501, 410, 523, 421 ActionDest: 529 Annotation: Subtype: Link Rect: 527, 410, 548, 421 ActionDest: 529 Annotation: Subtype: Link Rect: 524, 241, 551, 251 ActionDest: 593 Annotation: Subtype: Link Rect: 302, 228, 337, 240 ActionDest: 593 Annotation: Subtype: Link Rect: 340, 228, 360, 240 ActionDest: 593 Annotation: Subtype: Link Rect: 363, 228, 383, 240 ActionDest: 593 Annotation: Subtype: Link Rect: 43, 29, 113, 38 Annotation: Subtype: Link Rect: 116, 29, 176, 38 Annotation: Subtype: Link Rect: 435, 29, 551, 38 Page: Sequence: 4 Annotations: Annotation: Subtype: Link Rect: 411, 501, 450, 512 ActionDest: 319 Annotation: Subtype: Link Rect: 406, 443, 450, 455 ActionDest: 319 Annotation: Subtype: Link Rect: 334, 432, 376, 443 ActionDest: 319 Annotation: Subtype: Link Rect: 447, 168, 483, 179 ActionDest: 406 Annotation: Subtype: Link Rect: 470, 64, 506, 76 ActionDest: 406 Annotation: Subtype: Link Rect: 43, 29, 113, 38 Annotation: Subtype: Link Rect: 116, 29, 176, 38 Annotation: Subtype: Link Rect: 435, 29, 551, 38 Page: Sequence: 5 Annotations: Annotation: Subtype: Link Rect: 81, 202, 131, 213 ActionDest: 633 Annotation: Subtype: Link Rect: 134, 202, 154, 213 ActionDest: 633 Annotation: Subtype: Link Rect: 208, 156, 267, 167 ActionDest: 593 Annotation: Subtype: Link Rect: 270, 156, 290, 167 ActionDest: 593 Annotation: Subtype: Link Rect: 43, 144, 98, 156 ActionDest: 593 Annotation: Subtype: Link Rect: 101, 144, 121, 156 ActionDest: 593 Annotation: Subtype: Link Rect: 127, 122, 176, 133 ActionDest: 593 Annotation: Subtype: Link Rect: 179, 122, 199, 133 ActionDest: 593 Annotation: Subtype: Link Rect: 268, 122, 292, 133 ActionDest: 529 Annotation: Subtype: Link Rect: 43, 110, 63, 121 ActionDest: 529 Annotation: Subtype: Link Rect: 65, 110, 86, 121 ActionDest: 529 Annotation: Subtype: Link Rect: 134, 110, 213, 121 ActionDest: 593 Annotation: Subtype: Link Rect: 216, 110, 236, 121 ActionDest: 593 Annotation: Subtype: Link Rect: 47, 99, 97, 110 ActionDest: 633 Annotation: Subtype: Link Rect: 101, 99, 121, 110 ActionDest: 633 Annotation: Subtype: Link Rect: 202, 99, 263, 110 ActionDest: 529 Annotation: Subtype: Link Rect: 267, 99, 287, 110 ActionDest: 529 Annotation: Subtype: Link Rect: 353, 236, 404, 247 ActionDest: 529 Annotation: Subtype: Link Rect: 407, 236, 427, 247 ActionDest: 529 Annotation: Subtype: Link Rect: 511, 213, 551, 225 ActionDest: 593 Annotation: Subtype: Link Rect: 302, 203, 324, 213 ActionDest: 593 Annotation: Subtype: Link Rect: 327, 203, 347, 213 ActionDest: 593 Annotation: Subtype: Link Rect: 342, 167, 404, 179 ActionDest: 593 Annotation: Subtype: Link Rect: 407, 167, 428, 179 ActionDest: 593 Annotation: Subtype: Link Rect: 478, 122, 522, 133 ActionDest: 633 Annotation: Subtype: Link Rect: 528, 122, 549, 133 ActionDest: 633 Annotation: Subtype: Link Rect: 302, 111, 363, 121 ActionDest: 593 Annotation: Subtype: Link Rect: 368, 111, 388, 121 ActionDest: 593 Annotation: Subtype: Link Rect: 433, 76, 486, 87 ActionDest: 529 Annotation: Subtype: Link Rect: 490, 76, 510, 87 ActionDest: 529 Annotation: Subtype: Link Rect: 513, 76, 549, 87 ActionDest: 593 Annotation: Subtype: Link Rect: 302, 64, 322, 76 ActionDest: 593 Annotation: Subtype: Link Rect: 324, 64, 361, 76 ActionDest: 633 Annotation: Subtype: Link Rect: 363, 64, 383, 76 ActionDest: 633 Annotation: Subtype: Link Rect: 385, 64, 467, 76 ActionDest: 593 Annotation: Subtype: Link Rect: 469, 64, 489, 76 ActionDest: 593 Annotation: Subtype: Link Rect: 43, 29, 113, 38 Annotation: Subtype: Link Rect: 116, 29, 176, 38 Annotation: Subtype: Link Rect: 435, 29, 551, 38 Page: Sequence: 6 Annotations: Annotation: Subtype: Link Rect: 226, 145, 290, 156 ActionDest: 593 Annotation: Subtype: Link Rect: 43, 133, 64, 144 ActionDest: 593 Annotation: Subtype: Link Rect: 68, 133, 89, 144 ActionDest: 593 Annotation: Subtype: Link Rect: 412, 671, 494, 683 ActionDest: 633 Annotation: Subtype: Link Rect: 500, 671, 521, 683 ActionDest: 633 Annotation: Subtype: Link Rect: 364, 603, 459, 614 ActionDest: 529 Annotation: Subtype: Link Rect: 464, 603, 485, 614 ActionDest: 529 Annotation: Subtype: Link Rect: 490, 603, 549, 614 ActionDest: 593 Annotation: Subtype: Link Rect: 302, 591, 322, 603 ActionDest: 593 Annotation: Subtype: Link Rect: 345, 511, 401, 522 ActionDest: 593 Annotation: Subtype: Link Rect: 408, 511, 429, 522 ActionDest: 593 Annotation: Subtype: Link Rect: 459, 500, 495, 511 ActionDest: 319 Annotation: Subtype: Link Rect: 399, 454, 443, 465 ActionDest: 593 Annotation: Subtype: Link Rect: 448, 454, 468, 465 ActionDest: 593 Annotation: Subtype: Link Rect: 332, 420, 397, 431 ActionDest: 593 Annotation: Subtype: Link Rect: 402, 420, 422, 431 ActionDest: 593 Annotation: Subtype: Link Rect: 415, 374, 472, 385 ActionDest: 529 Annotation: Subtype: Link Rect: 477, 374, 497, 385 ActionDest: 529 Annotation: Subtype: Link Rect: 520, 351, 551, 362 ActionDest: 529 Annotation: Subtype: Link Rect: 302, 340, 326, 351 ActionDest: 529 Annotation: Subtype: Link Rect: 332, 340, 352, 351 ActionDest: 529 Annotation: Subtype: Link Rect: 359, 340, 425, 351 ActionDest: 593 Annotation: Subtype: Link Rect: 431, 340, 451, 351 ActionDest: 593 Annotation: Subtype: Link Rect: 510, 305, 548, 316 ActionDest: 406 Annotation: Subtype: Link Rect: 406, 282, 443, 293 ActionDest: 319 Annotation: Subtype: Link Rect: 339, 203, 388, 213 ActionDest: 593 Annotation: Subtype: Link Rect: 390, 203, 411, 213 ActionDest: 593 Annotation: Subtype: Link Rect: 500, 168, 539, 179 ActionDest: 319 Annotation: Subtype: Link Rect: 541, 168, 548, 179 ActionDest: 406 Annotation: Subtype: Link Rect: 369, 110, 414, 121 ActionDest: 593 Annotation: Subtype: Link Rect: 418, 110, 438, 121 ActionDest: 593 Annotation: Subtype: Link Rect: 467, 99, 520, 110 ActionDest: 633 Annotation: Subtype: Link Rect: 525, 99, 545, 110 ActionDest: 633 Annotation: Subtype: Link Rect: 43, 29, 113, 38 Annotation: Subtype: Link Rect: 116, 29, 176, 38 Annotation: Subtype: Link Rect: 435, 29, 551, 38 Page: Sequence: 7 Annotations: Annotation: Subtype: Link Rect: 232, 706, 290, 717 ActionDest: 593 Annotation: Subtype: Link Rect: 43, 694, 64, 706 ActionDest: 593 Annotation: Subtype: Link Rect: 68, 694, 124, 706 ActionDest: 529 Annotation: Subtype: Link Rect: 128, 694, 148, 706 ActionDest: 529 Annotation: Subtype: Link Rect: 108, 649, 181, 660 ActionDest: 529 Annotation: Subtype: Link Rect: 186, 649, 206, 660 ActionDest: 529 Annotation: Subtype: Link Rect: 211, 649, 262, 660 ActionDest: 529 Annotation: Subtype: Link Rect: 267, 649, 287, 660 ActionDest: 529 Annotation: Subtype: Link Rect: 198, 603, 262, 614 ActionDest: 593 Annotation: Subtype: Link Rect: 267, 603, 287, 614 ActionDest: 593 Annotation: Subtype: Link Rect: 158, 581, 209, 591 ActionDest: 593 Annotation: Subtype: Link Rect: 213, 581, 233, 591 ActionDest: 593 Annotation: Subtype: Link Rect: 216, 534, 266, 545 ActionDest: 529 Annotation: Subtype: Link Rect: 270, 534, 290, 545 ActionDest: 529 Annotation: Subtype: Link Rect: 43, 523, 95, 534 ActionDest: 593 Annotation: Subtype: Link Rect: 100, 523, 121, 534 ActionDest: 593 Annotation: Subtype: Link Rect: 67, 442, 118, 454 ActionDest: 593 Annotation: Subtype: Link Rect: 120, 442, 141, 454 ActionDest: 593 Annotation: Subtype: Link Rect: 216, 397, 267, 408 ActionDest: 529 Annotation: Subtype: Link Rect: 270, 397, 290, 408 ActionDest: 529 Annotation: Subtype: Link Rect: 43, 385, 91, 396 ActionDest: 529 Annotation: Subtype: Link Rect: 94, 385, 114, 396 ActionDest: 529 Annotation: Subtype: Link Rect: 118, 385, 170, 396 ActionDest: 633 Annotation: Subtype: Link Rect: 173, 385, 194, 396 ActionDest: 633 Annotation: Subtype: Link Rect: 47, 363, 102, 373 ActionDest: 593 Annotation: Subtype: Link Rect: 104, 363, 124, 373 ActionDest: 593 Annotation: Subtype: Link Rect: 47, 305, 98, 316 ActionDest: 529 Annotation: Subtype: Link Rect: 102, 305, 122, 316 ActionDest: 529 Annotation: Subtype: Link Rect: 63, 293, 114, 305 ActionDest: 633 Annotation: Subtype: Link Rect: 118, 293, 138, 305 ActionDest: 633 Annotation: Subtype: Link Rect: 93, 282, 145, 293 ActionDest: 633 Annotation: Subtype: Link Rect: 149, 282, 169, 293 ActionDest: 633 Annotation: Subtype: Link Rect: 187, 259, 245, 270 ActionDest: 593 Annotation: Subtype: Link Rect: 250, 259, 270, 270 ActionDest: 593 Annotation: Subtype: Link Rect: 274, 236, 292, 247 ActionDest: 633 Annotation: Subtype: Link Rect: 43, 225, 66, 236 ActionDest: 633 Annotation: Subtype: Link Rect: 72, 225, 92, 236 ActionDest: 633 Annotation: Subtype: Link Rect: 264, 179, 292, 190 ActionDest: 529 Annotation: Subtype: Link Rect: 43, 167, 66, 179 ActionDest: 529 Annotation: Subtype: Link Rect: 71, 167, 91, 179 ActionDest: 529 Annotation: Subtype: Link Rect: 96, 167, 144, 179 ActionDest: 529 Annotation: Subtype: Link Rect: 149, 167, 169, 179 ActionDest: 529 Annotation: Subtype: Link Rect: 69, 122, 133, 133 ActionDest: 593 Annotation: Subtype: Link Rect: 138, 122, 158, 133 ActionDest: 593 Annotation: Subtype: Link Rect: 119, 87, 151, 99 ActionDest: 529 Annotation: Subtype: Link Rect: 156, 87, 176, 99 ActionDest: 529 Annotation: Subtype: Link Rect: 133, 76, 174, 87 ActionDest: 633 Annotation: Subtype: Link Rect: 178, 76, 198, 87 ActionDest: 633 Annotation: Subtype: Link Rect: 203, 76, 262, 87 ActionDest: 593 Annotation: Subtype: Link Rect: 267, 76, 287, 87 ActionDest: 593 Annotation: Subtype: Link Rect: 328, 649, 384, 660 ActionDest: 529 Annotation: Subtype: Link Rect: 390, 649, 411, 660 ActionDest: 529 Annotation: Subtype: Link Rect: 339, 637, 407, 648 ActionDest: 529 Annotation: Subtype: Link Rect: 413, 637, 434, 648 ActionDest: 529 Annotation: Subtype: Link Rect: 43, 29, 113, 38 Annotation: Subtype: Link Rect: 116, 29, 176, 38 Annotation: Subtype: Link Rect: 435, 29, 551, 38 Page: Sequence: 8 Annotations: Annotation: Subtype: Link Rect: 171, 551, 285, 560 Annotation: Subtype: Link Rect: 100, 514, 178, 522 Annotation: Subtype: Link Rect: 251, 485, 293, 494 Annotation: Subtype: Link Rect: 53, 477, 115, 484 Annotation: Subtype: Link Rect: 130, 437, 224, 447 Annotation: Subtype: Link Rect: 169, 409, 259, 418 Annotation: Subtype: Link Rect: 90, 381, 190, 390 Annotation: Subtype: Link Rect: 247, 352, 293, 362 Annotation: Subtype: Link Rect: 53, 345, 111, 352 Annotation: Subtype: Link Rect: 115, 315, 211, 324 Annotation: Subtype: Link Rect: 175, 296, 266, 305 Annotation: Subtype: Link Rect: 248, 267, 293, 276 Annotation: Subtype: Link Rect: 53, 259, 162, 267 Annotation: Subtype: Link Rect: 53, 220, 125, 229 Annotation: Subtype: Link Rect: 104, 182, 201, 191 Annotation: Subtype: Link Rect: 279, 153, 293, 163 Annotation: Subtype: Link Rect: 53, 146, 114, 153 Annotation: Subtype: Link Rect: 252, 125, 293, 134 Annotation: Subtype: Link Rect: 53, 116, 114, 125 Annotation: Subtype: Link Rect: 82, 89, 192, 97 Annotation: Subtype: Link Rect: 487, 589, 551, 598 Annotation: Subtype: Link Rect: 312, 581, 350, 588 Annotation: Subtype: Link Rect: 508, 551, 551, 560 Annotation: Subtype: Link Rect: 312, 543, 354, 550 Annotation: Subtype: Link Rect: 413, 523, 507, 532 Annotation: Subtype: Link Rect: 312, 486, 439, 494 Annotation: Subtype: Link Rect: 355, 456, 482, 466 Annotation: Subtype: Link Rect: 464, 428, 551, 437 Annotation: Subtype: Link Rect: 312, 420, 334, 427 Annotation: Subtype: Link Rect: 410, 390, 510, 399 Annotation: Subtype: Link Rect: 312, 352, 384, 362 Annotation: Subtype: Link Rect: 432, 333, 530, 343 Annotation: Subtype: Link Rect: 509, 305, 551, 314 Annotation: Subtype: Link Rect: 312, 296, 373, 304 Annotation: Subtype: Link Rect: 348, 239, 466, 248 Annotation: Subtype: Link Rect: 503, 210, 551, 220 Annotation: Subtype: Link Rect: 312, 203, 356, 209 Annotation: Subtype: Link Rect: 403, 164, 508, 172 Annotation: Subtype: Link Rect: 312, 136, 377, 144 Annotation: Subtype: Link Rect: 492, 116, 551, 125 Annotation: Subtype: Link Rect: 312, 108, 328, 115 Annotation: Subtype: Link Rect: 458, 78, 551, 87 Annotation: Subtype: Link Rect: 312, 70, 328, 77 Annotation: Subtype: Link Rect: 43, 29, 113, 38 Annotation: Subtype: Link Rect: 116, 29, 176, 38 Annotation: Subtype: Link Rect: 435, 29, 551, 38 Page: Sequence: 9 Annotations: Annotation: Subtype: Link Rect: 115, 678, 217, 687 Annotation: Subtype: Link Rect: 229, 650, 293, 659 Annotation: Subtype: Link Rect: 53, 641, 107, 649 Annotation: Subtype: Link Rect: 53, 612, 153, 621 Annotation: Subtype: Link Rect: 53, 574, 146, 583 Annotation: Subtype: Link Rect: 143, 555, 257, 564 Annotation: Subtype: Link Rect: 251, 527, 293, 536 Annotation: Subtype: Link Rect: 53, 519, 96, 526 Annotation: Subtype: Link Rect: 134, 489, 231, 498 Annotation: Subtype: Link Rect: 214, 470, 293, 479 Annotation: Subtype: Link Rect: 53, 462, 95, 469 Annotation: Subtype: Link Rect: 53, 434, 163, 441 Annotation: Subtype: Link Rect: 184, 404, 293, 413 Annotation: Subtype: Link Rect: 53, 396, 90, 403 Annotation: Subtype: Link Rect: 53, 366, 134, 375 Annotation: Subtype: Link Rect: 227, 337, 293, 347 Annotation: Subtype: Link Rect: 53, 330, 91, 336 Annotation: Subtype: Link Rect: 179, 290, 293, 299 Annotation: Subtype: Link Rect: 53, 282, 90, 289 Annotation: Subtype: Link Rect: 121, 244, 215, 252 Annotation: Subtype: Link Rect: 279, 214, 293, 224 Annotation: Subtype: Link Rect: 53, 205, 142, 214 Annotation: Subtype: Link Rect: 128, 177, 222, 186 Annotation: Subtype: Link Rect: 151, 138, 251, 148 Annotation: Subtype: Link Rect: 251, 110, 293, 119 Annotation: Subtype: Link Rect: 53, 101, 87, 110 Annotation: Subtype: Link Rect: 53, 73, 153, 82 Annotation: Subtype: Link Rect: 312, 687, 414, 697 Annotation: Subtype: Link Rect: 480, 659, 551, 668 Annotation: Subtype: Link Rect: 312, 650, 349, 658 Annotation: Subtype: Link Rect: 348, 613, 448, 621 Annotation: Subtype: Link Rect: 537, 583, 551, 593 Annotation: Subtype: Link Rect: 312, 574, 412, 583 Annotation: Subtype: Link Rect: 341, 547, 419, 555 Annotation: Subtype: Link Rect: 429, 517, 513, 526 Annotation: Subtype: Link Rect: 506, 489, 551, 498 Annotation: Subtype: Link Rect: 312, 481, 370, 489 Annotation: Subtype: Link Rect: 312, 452, 404, 460 Annotation: Subtype: Link Rect: 429, 413, 522, 422 Annotation: Subtype: Link Rect: 396, 385, 470, 394 Annotation: Subtype: Link Rect: 385, 347, 489, 356 Annotation: Subtype: Link Rect: 312, 271, 383, 280 Annotation: Subtype: Link Rect: 312, 234, 406, 243 Annotation: Subtype: Link Rect: 442, 205, 551, 214 Annotation: Subtype: Link Rect: 312, 197, 348, 204 Annotation: Subtype: Link Rect: 359, 157, 452, 167 Annotation: Subtype: Link Rect: 509, 101, 551, 110 Annotation: Subtype: Link Rect: 312, 92, 373, 100 Annotation: Subtype: Link Rect: 43, 29, 113, 38 Annotation: Subtype: Link Rect: 116, 29, 176, 38 Annotation: Subtype: Link Rect: 435, 29, 551, 38 Page: Sequence: 10 Annotations: Annotation: Subtype: Link Rect: 228, 706, 293, 716 Annotation: Subtype: Link Rect: 53, 699, 91, 706 Annotation: Subtype: Link Rect: 220, 678, 293, 687 Annotation: Subtype: Link Rect: 53, 670, 84, 677 Annotation: Subtype: Link Rect: 122, 631, 229, 640 Annotation: Subtype: Link Rect: 220, 602, 293, 612 Annotation: Subtype: Link Rect: 53, 595, 84, 601 Annotation: Subtype: Link Rect: 138, 564, 244, 574 Annotation: Subtype: Link Rect: 213, 508, 285, 517 Annotation: Subtype: Link Rect: 252, 479, 293, 489 Annotation: Subtype: Link Rect: 53, 470, 128, 479 Annotation: Subtype: Link Rect: 190, 441, 290, 451 Annotation: Subtype: Link Rect: 211, 422, 293, 432 Annotation: Subtype: Link Rect: 53, 415, 75, 422 Annotation: Subtype: Link Rect: 131, 375, 229, 384 Annotation: Subtype: Link Rect: 380, 697, 462, 706 Annotation: Subtype: Link Rect: 496, 669, 551, 678 Annotation: Subtype: Link Rect: 312, 661, 352, 668 Annotation: Subtype: Link Rect: 439, 621, 551, 631 Annotation: Subtype: Link Rect: 312, 612, 329, 621 Annotation: Subtype: Link Rect: 312, 583, 414, 593 Annotation: Subtype: Link Rect: 356, 555, 462, 564 Annotation: Subtype: Link Rect: 462, 527, 551, 536 Annotation: Subtype: Link Rect: 312, 519, 334, 526 Annotation: Subtype: Link Rect: 410, 489, 499, 498 Annotation: Subtype: Link Rect: 524, 422, 551, 432 Annotation: Subtype: Link Rect: 302, 413, 334, 422 Annotation: Subtype: Link Rect: 335, 413, 370, 422 Annotation: Subtype: Link Rect: 371, 413, 395, 422 Annotation: Subtype: Link Rect: 396, 413, 424, 422 Annotation: Subtype: Link Rect: 43, 29, 113, 38 Annotation: Subtype: Link Rect: 116, 29, 176, 38 Annotation: Subtype: Link Rect: 435, 29, 551, 38 Checksum: 890524e9 Type: CRC32 Checksum: 12a306b3cdfe7bc2fbe472236bbcb0e6 Type: MD5 Checksum: bd886f2f208d768a84830e3fe8023f05fc19d06e Type: SHA-1