46091784a116b47067903d40ce703df5 pmc_30176817.pdf 23dd49007a3d64440ed03dcbce1b31e5a05ce80a pmc_30176817.pdf 6ea81cb26e01d321a6eed5eb03e4acb2d687a5190a8354b9251662538ee2e6d0 pmc_30176817.pdf Title: Pipeline for specific subtype amplification and drug resistance detection in hepatitis C virus Subject: BMC Infectious Diseases, 2018, doi:10.1186/s12879-018-3356-6 Keywords: Next-generation sequencing,Viral quasispecies,Antiviral agents,Viral diagnostics,Treatment planning Author: María Eugenia Soria Creator: Arbortext Advanced Print Publisher 9.1.440/W Unicode Producer: Acrobat Distiller 10.1.5 (Windows); modified using iText® 5.3.5 ©2000-2012 1T3XT BVBA (AGPL-version) CreationDate: Fri Aug 31 13:02:07 2018 CEST ModDate: Mon Sep 3 14:25:45 2018 CEST Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 15 Encrypted: no Page size: 595.276 x 790.866 pts Page rot: 0 File size: 3408557 bytes Optimized: no PDF version: 1.4 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- NNACGC+FmmdycAdvTTaf7f9f4f.B Type 1C WinAnsi yes yes no 8 0 NNACNA+QrwlwxAdvTTe45e47d2 Type 1C WinAnsi yes yes no 9 0 NNACOB+NlhsyxAdvTTb5929f4c Type 1C WinAnsi yes yes no 157 0 NNACOC+GjkqtpAdvTTb5929f4c+20 Type 1C WinAnsi yes yes no 158 0 NNADAC+LwbcsgAdvTT99c4c969 Type 1C WinAnsi yes yes no 12 0 NNADLP+GxtlrvAdvTT7329fd89.I Type 1C WinAnsi yes yes no 13 0 MyriadPro-Regular Type 1 Custom yes no no 10 0 NNADPC+GqfbpxAdvTT86d47313+22 Type 1C Custom yes yes yes 11 0 NNADOB+KvjcbxAdvTT86d47313+20 Type 1C Custom yes yes yes 14 0 NNADOA+VtnjpcAdvTT86d47313 Type 1C WinAnsi yes yes no 15 0 NNAEBC+RdktjbAdvTT86d47313+03 Type 1C Custom yes yes yes 80 0 NNAEBD+SqqsmdAdvTT8861b38f.I Type 1C WinAnsi yes yes no 81 0 NNBGBF+KrslqhAdvTTb5929f4c+22 Type 1C Custom yes yes yes 184 0 NNBNCL+WdltrmAdvTT99c4c969+20 Type 1C WinAnsi yes yes no 285 0 NNBNCM+NjfqgvAdvTTaf7f9f4f.B+20 Type 1C WinAnsi yes yes no 286 0 Jhove (Rel. 1.22.1, 2019-04-17) Date: 2022-06-15 02:28:26 CEST RepresentationInformation: pmc_30176817.pdf ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17) LastModified: 2020-02-05 11:42:57 CET Size: 3408557 Format: PDF Version: 1.4 Status: Well-Formed, but not valid SignatureMatches: PDF-hul ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR1' cannot be found Offset: 3152850 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR2' cannot be found Offset: 3152850 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR3' cannot be found Offset: 3152850 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR4' cannot be found Offset: 3152850 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR5' cannot be found Offset: 3152850 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR6' cannot be found Offset: 3152850 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR7' cannot be found Offset: 3152850 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR8' cannot be found Offset: 3152850 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR9' cannot be found Offset: 3152850 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR14' cannot be found Offset: 3152850 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR15' cannot be found Offset: 3152850 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR17' cannot be found Offset: 3152850 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR18' cannot be found Offset: 3152850 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR19' cannot be found Offset: 3152850 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR9' cannot be found Offset: 3152850 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR10' cannot be found Offset: 3152850 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR14' cannot be found Offset: 3152850 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR20' cannot be found Offset: 3152850 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR24' cannot be found Offset: 3152850 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR25' cannot be found Offset: 3152850 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR6' cannot be found Offset: 3152850 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR26' cannot be found Offset: 3152850 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR27' cannot be found Offset: 3152850 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR2' cannot be found Offset: 3152850 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR28' cannot be found Offset: 3152850 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR30' cannot be found Offset: 3152850 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR5' cannot be found Offset: 3152850 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR31' cannot be found Offset: 3152850 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR32' cannot be found Offset: 3152850 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR33' cannot be found Offset: 3152850 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR31' cannot be found Offset: 3152850 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR34' cannot be found Offset: 3152850 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR34' cannot be found Offset: 3152850 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR35' cannot be found Offset: 3152850 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_MOESM10' cannot be found Offset: 3152850 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_Fig1' cannot be found Offset: 3152850 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_Fig1' cannot be found Offset: 3152850 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_Fig2' cannot be found Offset: 3152850 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR34' cannot be found Offset: 3152850 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_Fig2' cannot be found Offset: 3152850 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR36' cannot be found Offset: 3152850 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR32' cannot be found Offset: 3152850 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_MOESM11' cannot be found Offset: 3152850 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_MOESM12' cannot be found Offset: 3152850 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_MOESM12' cannot be found Offset: 3152850 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_MOESM13' cannot be found Offset: 3152850 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR49' cannot be found Offset: 3152850 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR34' cannot be found Offset: 3152850 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_Fig2' cannot be found Offset: 3152850 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_MOESM14' cannot be found Offset: 3152850 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR9' cannot be found Offset: 3152850 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR10' cannot be found Offset: 3152850 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR14' cannot be found Offset: 3152850 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_MOESM11' cannot be found Offset: 3152850 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_MOESM13' cannot be found Offset: 3152850 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_Fig2' cannot be found Offset: 3152850 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_Fig2' cannot be found Offset: 3152850 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_Fig2' cannot be found Offset: 3152850 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR14' cannot be found Offset: 3152850 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_MOESM15' cannot be found Offset: 3152850 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR9' cannot be found Offset: 3152850 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR10' cannot be found Offset: 3152850 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR14' cannot be found Offset: 3152850 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_MOESM15' cannot be found Offset: 3152850 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR37' cannot be found Offset: 3152850 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR38' cannot be found Offset: 3152850 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR39' cannot be found Offset: 3152850 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR41' cannot be found Offset: 3152850 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR34' cannot be found Offset: 3152850 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR42' cannot be found Offset: 3152850 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR16' cannot be found Offset: 3152850 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR43' cannot be found Offset: 3152850 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR44' cannot be found Offset: 3152850 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR45' cannot be found Offset: 3152850 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR46' cannot be found Offset: 3152850 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR29' cannot be found Offset: 3152850 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR28' cannot be found Offset: 3152850 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR47' cannot be found Offset: 3152850 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR4' cannot be found Offset: 3152850 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR48' cannot be found Offset: 3152850 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR15' cannot be found Offset: 3152850 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR17' cannot be found Offset: 3152850 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_Fig2' cannot be found Offset: 3152850 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_Fig2' cannot be found Offset: 3152850 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_Fig2' cannot be found Offset: 3152850 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_Fig2' cannot be found Offset: 3152850 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_Fig2' cannot be found Offset: 3152850 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_Fig2' cannot be found Offset: 3152850 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR9' cannot be found Offset: 3152850 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR14' cannot be found Offset: 3152850 MIMEtype: application/pdf PDFMetadata: Objects: 597 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseOutlines Outlines: Item: Title: Abstract Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@3aeaafa6 Children: Item: Title: Background Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@76a3e297 Item: Title: Methods Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4d3167f4 Item: Title: Results Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@ed9d034 Item: Title: Conclusion Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6121c9d6 Item: Title: Background Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@87f383f Item: Title: Methods Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4eb7f003 Children: Item: Title: HCV database and primer design Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@eafc191 Item: Title: Production of a triple HCV mutant Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@612fc6eb Item: Title: Control of basal nucleotide sequencing error Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1060b431 Item: Title: Control of PCR recombination Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@612679d6 Item: Title: Deep-sequencing amplification (NGS) Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@11758f2a Item: Title: Amplification of HCV RNA from patient samples Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@e720b71 Item: Title: Comparative analysis using inter- and intra- sequencing platforms Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1b26f7b2 Item: Title: Nucleotide sequence accession numbers Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@491cc5c9 Item: Title: Results Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@74ad1f1f Children: Item: Title: Validation of subtype-specific oligonucleotide primers Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6a1aab78 Item: Title: Limit of detection of individual amino acid substitutions: Experimental and theoretical approaches Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@462d5aee Item: Title: Limit of detection of combined amino acid substitutions Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@69b0fd6f Item: Title: Ultra-deep sequencing data management Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@757942a1 Item: Title: Testing the pipeline: Ultra-deep sequencing of viral RNA from HCV-infected patients Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4a87761d Item: Title: Discussion Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@66d1af89 Item: Title: Conclusions Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@8646db9 Item: Title: Additional files Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@37374a5e Item: Title: Abbreviations Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4671e53b Item: Title: Acknowledgements Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@2db7a79b Item: Title: Funding Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6950e31 Item: Title: Availability of data and materials Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@b7dd107 Item: Title: Authors’ contributions Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@42eca56e Item: Title: Ethics approval and consent to participate Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@52f759d7 Item: Title: Consent for publication Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7cbd213e Item: Title: Competing interests Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@192d3247 Item: Title: Publisher’s Note Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@3ecd23d9 Item: Title: Author details Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@569cfc36 Item: Title: References Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@43bd930a Info: Title: Pipeline for specific subtype amplification and drug resistance detection in hepatitis C virus Author: María Eugenia Soria Subject: BMC Infectious Diseases, 2018, doi:10.1186/s12879-018-3356-6 Keywords: Next-generation sequencing,Viral quasispecies,Antiviral agents,Viral diagnostics,Treatment planning Creator: Arbortext Advanced Print Publisher 9.1.440/W Unicode Producer: Acrobat Distiller 10.1.5 (Windows); modified using iText® 5.3.5 ©2000-2012 1T3XT BVBA (AGPL-version) CreationDate: Fri Aug 31 13:02:07 CEST 2018 ModDate: Mon Sep 03 14:25:45 CEST 2018 ID: 0x75f1154ac2cd418f0131797742ef2510, 0xdfca75579ba371e1524c7b23d54c37a0 Filters: FilterPipeline: FlateDecode FilterPipeline: DCTDecode Images: Image: NisoImageMetadata: FormatName: image/png ImageWidth: 33 ImageHeight: 63 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 95 ImageHeight: 91 BitsPerSample: 8 BitsPerSampleUnit: integer Intent: Perceptual Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 176 ImageHeight: 182 BitsPerSample: 8 BitsPerSampleUnit: integer Intent: Perceptual Image: NisoImageMetadata: FormatName: image/png ImageWidth: 688 ImageHeight: 126 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 1183 ImageHeight: 1280 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: Perceptual Image: NisoImageMetadata: FormatName: image/png ImageWidth: 1183 ImageHeight: 1605 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: Perceptual Image: NisoImageMetadata: FormatName: image/png ImageWidth: 1420 ImageHeight: 1263 ColorSpace: black is zero BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 896 ImageHeight: 1497 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: Perceptual Image: NisoImageMetadata: FormatName: image/png ImageWidth: 1183 ImageHeight: 1729 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: Perceptual Image: NisoImageMetadata: FormatName: image/png ImageWidth: 1100 ImageHeight: 90 ColorSpace: black is zero BitsPerSample: 1 BitsPerSampleUnit: integer Filter: FlateDecode Fonts: Type1: Font: BaseFont: NNACGC+FmmdycAdvTTaf7f9f4f.B FontSubset: true FirstChar: 32 LastChar: 117 FontDescriptor: FontName: NNACGC+FmmdycAdvTTaf7f9f4f.B Flags: Nonsymbolic FontBBox: -218, -250, 875, 895 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: NNACNA+QrwlwxAdvTTe45e47d2 FontSubset: true FirstChar: 32 LastChar: 121 FontDescriptor: FontName: NNACNA+QrwlwxAdvTTe45e47d2 Flags: Nonsymbolic FontBBox: -218, -250, 833, 875 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: MyriadPro-Regular FirstChar: 1 LastChar: 255 FontDescriptor: FontName: MyriadPro-Regular Flags: Nonsymbolic FontBBox: -46, -250, 1126, 879 FontFile: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: NNADPC+GqfbpxAdvTT86d47313+22 FontSubset: true FirstChar: 2 LastChar: 22 FontDescriptor: FontName: NNADPC+GqfbpxAdvTT86d47313+22 Flags: Symbolic FontBBox: -166, -260, 1031, 906 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: NNADAC+LwbcsgAdvTT99c4c969 FontSubset: true FirstChar: 32 LastChar: 121 FontDescriptor: FontName: NNADAC+LwbcsgAdvTT99c4c969 Flags: Nonsymbolic FontBBox: -41, -250, 854, 885 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: NNADLP+GxtlrvAdvTT7329fd89.I FontSubset: true FirstChar: 32 LastChar: 117 FontDescriptor: FontName: NNADLP+GxtlrvAdvTT7329fd89.I Flags: Nonsymbolic FontBBox: -218, -250, 885, 864 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: NNADOB+KvjcbxAdvTT86d47313+20 FontSubset: true FirstChar: 2 LastChar: 151 FontDescriptor: FontName: NNADOB+KvjcbxAdvTT86d47313+20 Flags: Symbolic FontBBox: -218, -218, 1291, 812 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: NNADOA+VtnjpcAdvTT86d47313 FontSubset: true FirstChar: 32 LastChar: 239 FontDescriptor: FontName: NNADOA+VtnjpcAdvTT86d47313 Flags: Serif, Nonsymbolic FontBBox: -218, -239, 1020, 875 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: NNAEBC+RdktjbAdvTT86d47313+03 FontSubset: true FirstChar: 1 LastChar: 5 FontDescriptor: FontName: NNAEBC+RdktjbAdvTT86d47313+03 Flags: Symbolic FontBBox: -281, -250, 906, 885 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: NNAEBD+SqqsmdAdvTT8861b38f.I FontSubset: true FirstChar: 32 LastChar: 121 FontDescriptor: FontName: NNAEBD+SqqsmdAdvTT8861b38f.I Flags: Nonsymbolic FontBBox: -187, -239, 1062, 875 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: NNBGBF+KrslqhAdvTTb5929f4c+22 FontSubset: true FirstChar: 1 LastChar: 2 FontDescriptor: FontName: NNBGBF+KrslqhAdvTTb5929f4c+22 Flags: Symbolic FontBBox: -10, -218, 1083, 906 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: NNACOB+NlhsyxAdvTTb5929f4c FontSubset: true FirstChar: 32 LastChar: 243 FontDescriptor: FontName: NNACOB+NlhsyxAdvTTb5929f4c Flags: Nonsymbolic FontBBox: -41, -250, 812, 864 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: NNBNCL+WdltrmAdvTT99c4c969+20 FontSubset: true FirstChar: 32 LastChar: 146 FontDescriptor: FontName: NNBNCL+WdltrmAdvTT99c4c969+20 Flags: Nonsymbolic FontBBox: -447, -197, 1583, 864 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: NNACOC+GjkqtpAdvTTb5929f4c+20 FontSubset: true FirstChar: 32 LastChar: 151 FontDescriptor: FontName: NNACOC+GjkqtpAdvTTb5929f4c+20 Flags: Nonsymbolic FontBBox: -447, -208, 1375, 864 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: NNBNCM+NjfqgvAdvTTaf7f9f4f.B+20 FontSubset: true FirstChar: 32 LastChar: 146 FontDescriptor: FontName: NNBNCM+NjfqgvAdvTTaf7f9f4f.B+20 Flags: Nonsymbolic FontBBox: -468, -197, 1656, 864 FontFile3: true Encoding: WinAnsiEncoding XMP: Next-generation sequencing,Viral quasispecies,Antiviral agents,Viral diagnostics,Treatment planning Acrobat Distiller 10.1.5 (Windows); modified using iText® 5.3.5 ©2000-2012 1T3XT BVBA (AGPL-version) application/pdf 10.1186/s12879-018-3356-6 BMC Infectious Diseases BMC Infectious Diseases, 2018, doi:10.1186/s12879-018-3356-6 Next-generation sequencing Viral quasispecies Antiviral agents Viral diagnostics Treatment planning Pipeline for specific subtype amplification and drug resistance detection in hepatitis C virus María Eugenia Soria Josep Gregori Qian Chen Damir García-Cehic Meritxell Llorens Ana I. de Ávila Nathan M. Beach Esteban Domingo Francisco Rodríguez-Frías María Buti Rafael Esteban Juan Ignacio Esteban Josep Quer Celia Perales 2018-09-03T14:25:45+02:00 2018-08-31T19:02:07+08:00 Arbortext Advanced Print Publisher 9.1.440/W Unicode 2018-09-03T14:25:45+02:00 uuid:864dea45-49b1-45d1-a6e8-daf6ac21bb0c uuid:54f3bd3d-e853-4612-9cc4-6fdb8bd4a37b default 1 converted uuid:d476a1f9-32b9-4e8c-ac4f-3b6f21625b16 converted to PDF/A-2b pdfToolbox 2018-08-31T19:13:48+08:00 2 B Celia Perales http://orcid.org/0000-0003-1618-1937 Springer Nature ORCID Schema http://springernature.com/ns/xmpExtensions/2.0/ sn authorInfo Bag AuthorInformation external Author information: contains the name of each author and his/her ORCID (ORCiD: Open Researcher and Contributor ID). An ORCID is a persistent identifier (a non-proprietary alphanumeric code) to uniquely identify scientific and other academic authors. editorInfo Bag EditorInformation external Editor information: contains the name of each editor and his/her ORCID identifier. seriesEditorInfo Bag SeriesEditorInformation external Series editor information: contains the name of each series editor and his/her ORCID identifier. AuthorInformation http://springernature.com/ns/xmpExtensions/2.0/authorInfo/ author Specifies the types of author information: name and ORCID of an author. name Text Gives the name of an author. orcid URI Gives the ORCID of an author. EditorInformation http://springernature.com/ns/xmpExtensions/2.0/editorInfo/ editor Specifies the types of editor information: name and ORCID of an editor. name Text Gives the name of an editor. orcid URI Gives the ORCID of an editor. SeriesEditorInformation http://springernature.com/ns/xmpExtensions/2.0/seriesEditorInfo/ seriesEditor Specifies the types of series editor information: name and ORCID of a series editor. name Text Gives the name of a series editor. orcid URI Gives the ORCID of a series editor. http://ns.adobe.com/pdf/1.3/ pdf Adobe PDF Schema internal A name object indicating whether the document has been modified to include trapping information Trapped Text http://ns.adobe.com/xap/1.0/mm/ xmpMM XMP Media Management Schema internal UUID based identifier for specific incarnation of a document InstanceID URI internal The common identifier for all versions and renditions of a document. OriginalDocumentID URI internal A reference to the original document from which this one is derived. It is a minimal reference; missing components can be assumed to be unchanged. For example, a new version might only need to specify the instance ID and version number of the previous version, or a rendition might only need to specify the instance ID and rendition class of the original. DerivedFrom ResourceRef Identifies a portion of a document. This can be a position at which the document has been changed since the most recent event history (stEvt:changed). For a resource within an xmpMM:Ingredients list, the ResourceRef uses this type to identify both the portion of the containing document that refers to the resource, and the portion of the referenced resource that is referenced. http://ns.adobe.com/xap/1.0/sType/Part# stPart Part http://ns.adobe.com/xap/1.0/t/pg/ xmpTPg XMP Paged-Text internal A structure containing the characteristics of a font used in a document Fonts Bag Font internal XMP08 Spec: An ordered array of plate names that are needed to print the document (including any in contained documents). PlateNames Seq Text A structure containing the characteristics of a font used in a document. http://ns.adobe.com/xap/1.0/sType/Font# stFnt Font http://ns.adobe.com/pdfx/1.3/ pdfx PDF/X ID Schema internal ID of PDF/X standard GTS_PDFXVersion Text internal Conformance level of PDF/X standard GTS_PDFXConformance Text internal Company creating the PDF Company Text internal Date when document was last modified SourceModified Text http://www.aiim.org/pdfa/ns/id/ pdfaid PDF/A ID Schema internal Part of PDF/A standard part Integer internal Amendment of PDF/A standard amd Text internal Conformance level of PDF/A standard conformance Text Pages: Page: Sequence: 1 Annotations: Annotation: Subtype: Link Rect: 484, 657, 538, 679 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 316, 545, 325, 554 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 114, 144, 178, 152 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 181, 144, 244, 152 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 239, 65, 357, 72 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 182, 41, 321, 48 Flags: Print AppearanceDictionary: true Thumb: true Page: Sequence: 2 Annotations: Annotation: Subtype: Link Rect: 283, 669, 288, 678 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 56, 657, 61, 666 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 136, 645, 141, 654 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 120, 621, 290, 630 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 56, 609, 214, 618 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 127, 585, 132, 594 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 140, 585, 145, 594 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 149, 537, 154, 546 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 161, 537, 166, 546 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 179, 501, 184, 510 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 169, 417, 174, 426 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 180, 417, 190, 426 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 182, 393, 191, 402 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 197, 393, 207, 402 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 161, 369, 171, 378 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 176, 369, 186, 378 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 251, 321, 256, 330 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 262, 321, 272, 330 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 278, 321, 288, 330 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 56, 309, 66, 318 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 72, 309, 81, 318 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 59, 225, 69, 234 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 280, 141, 285, 150 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 181, 105, 191, 114 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 201, 81, 211, 90 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 408, 657, 412, 666 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 330, 597, 340, 606 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 346, 597, 355, 606 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 381, 273, 538, 282 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 304, 261, 405, 270 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 307, 189, 312, 198 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 459, 153, 463, 162 Flags: Print AppearanceDictionary: true Destination: 247 Annotation: Subtype: Link Rect: 417, 105, 427, 114 Flags: Print AppearanceDictionary: true Destination: null Thumb: true Page: Sequence: 3 Annotations: Annotation: Subtype: Link Rect: 121, 633, 126, 642 Flags: Print AppearanceDictionary: true Destination: 247 Annotation: Subtype: Link Rect: 102, 537, 112, 546 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 243, 489, 253, 498 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 238, 453, 243, 462 Flags: Print AppearanceDictionary: true Destination: 247 Annotation: Subtype: Link Rect: 275, 417, 285, 426 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 283, 105, 288, 114 Flags: Print AppearanceDictionary: true Destination: 247 Annotation: Subtype: Link Rect: 400, 573, 405, 582 Flags: Print AppearanceDictionary: true Destination: 247 Thumb: true Page: Sequence: 4 Annotations: Annotation: Subtype: Link Rect: 219, 633, 224, 642 Flags: Print AppearanceDictionary: true Destination: 247 Annotation: Subtype: Link Rect: 244, 393, 248, 402 Flags: Print AppearanceDictionary: true Destination: 247 Annotation: Subtype: Link Rect: 101, 369, 110, 378 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 363, 693, 372, 702 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 521, 621, 531, 630 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 353, 561, 358, 570 Flags: Print AppearanceDictionary: true Destination: 247 Annotation: Subtype: Link Rect: 470, 561, 475, 570 Flags: Print AppearanceDictionary: true Destination: 247 Annotation: Subtype: Link Rect: 369, 549, 374, 558 Flags: Print AppearanceDictionary: true Destination: 247 Annotation: Subtype: Link Rect: 462, 537, 467, 546 Flags: Print AppearanceDictionary: true Destination: 247 Annotation: Subtype: Link Rect: 351, 525, 356, 534 Flags: Print AppearanceDictionary: true Destination: 247 Annotation: Subtype: Link Rect: 485, 525, 490, 534 Flags: Print AppearanceDictionary: true Destination: 247 Thumb: true Page: Sequence: 5 Annotations: Annotation: Subtype: Link Rect: 230, 681, 240, 690 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 79, 273, 89, 282 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 255, 93, 265, 102 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 122, 57, 126, 66 Flags: Print AppearanceDictionary: true Destination: 247 Annotation: Subtype: Link Rect: 240, 57, 245, 66 Flags: Print AppearanceDictionary: true Destination: 247 Annotation: Subtype: Link Rect: 381, 693, 386, 702 Flags: Print AppearanceDictionary: true Destination: 247 Annotation: Subtype: Link Rect: 531, 633, 536, 642 Flags: Print AppearanceDictionary: true Destination: 247 Annotation: Subtype: Link Rect: 405, 621, 410, 630 Flags: Print AppearanceDictionary: true Destination: 247 Annotation: Subtype: Link Rect: 531, 621, 536, 630 Flags: Print AppearanceDictionary: true Destination: 247 Annotation: Subtype: Link Rect: 427, 609, 432, 618 Flags: Print AppearanceDictionary: true Destination: 247 Annotation: Subtype: Link Rect: 304, 597, 309, 606 Flags: Print AppearanceDictionary: true Destination: 247 Annotation: Subtype: Link Rect: 432, 597, 437, 606 Flags: Print AppearanceDictionary: true Destination: 247 Annotation: Subtype: Link Rect: 349, 561, 353, 570 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 461, 513, 471, 522 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 456, 477, 461, 486 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 437, 429, 442, 438 Flags: Print AppearanceDictionary: true Destination: 172 Annotation: Subtype: Link Rect: 344, 309, 353, 318 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 381, 153, 391, 162 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 526, 105, 536, 114 Flags: Print AppearanceDictionary: true Destination: null Thumb: true Page: Sequence: 6 Annotations: Annotation: Subtype: Link Rect: 370, 237, 380, 246 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 443, 93, 453, 102 Flags: Print AppearanceDictionary: true Destination: null Thumb: true Page: Sequence: 7 Annotations: Annotation: Subtype: Link Rect: 369, 69, 379, 78 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 134, 277, 142, 285 Flags: Print AppearanceDictionary: true Destination: null Thumb: true Page: Sequence: 8 Annotations: Annotation: Subtype: Link Rect: 64, 359, 72, 367 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 348, 329, 351, 337 Flags: Print AppearanceDictionary: true Destination: null Thumb: true Page: Sequence: 9 Annotations: Annotation: Subtype: Link Rect: 122, 657, 131, 666 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 189, 609, 194, 618 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 199, 609, 208, 618 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 213, 609, 223, 618 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 205, 561, 210, 570 Flags: Print AppearanceDictionary: true Destination: 181 Annotation: Subtype: Link Rect: 278, 177, 288, 186 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 175, 165, 185, 174 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 528, 177, 533, 186 Flags: Print AppearanceDictionary: true Destination: 201 Thumb: true Page: Sequence: 10 Annotations: Annotation: Subtype: Link Rect: 415, 141, 419, 150 Flags: Print AppearanceDictionary: true Destination: 201 Annotation: Subtype: Link Rect: 496, 93, 501, 102 Flags: Print AppearanceDictionary: true Destination: 201 Annotation: Subtype: Link Rect: 520, 257, 524, 265 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 163, 247, 167, 255 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 394, 247, 397, 255 Flags: Print AppearanceDictionary: true Destination: null Thumb: true Page: Sequence: 11 Annotations: Annotation: Subtype: Link Rect: 132, 657, 137, 666 Flags: Print AppearanceDictionary: true Destination: 201 Annotation: Subtype: Link Rect: 188, 609, 197, 618 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 209, 549, 218, 558 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 130, 441, 135, 450 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 140, 441, 150, 450 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 156, 441, 165, 450 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 123, 381, 132, 390 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 236, 57, 246, 66 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 253, 57, 263, 66 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 441, 597, 450, 606 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 456, 597, 466, 606 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 368, 573, 378, 582 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 383, 573, 393, 582 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 406, 405, 416, 414 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 377, 345, 387, 354 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 446, 297, 456, 306 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 435, 273, 445, 282 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 307, 189, 317, 198 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 523, 57, 533, 66 Flags: Print AppearanceDictionary: true Destination: null Thumb: true Page: Sequence: 12 Annotations: Annotation: Subtype: Link Rect: 258, 645, 267, 654 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 275, 645, 285, 654 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 148, 537, 153, 546 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 183, 537, 192, 546 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 274, 513, 284, 522 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 56, 501, 66, 510 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 61, 245, 118, 253 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 61, 215, 118, 223 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 61, 185, 118, 193 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 61, 164, 118, 172 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 61, 107, 118, 115 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 309, 690, 366, 697 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 309, 624, 366, 631 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 309, 603, 366, 610 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 309, 582, 366, 589 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 309, 561, 370, 568 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 459, 534, 463, 541 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 322, 523, 326, 531 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 484, 523, 488, 531 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 309, 406, 370, 414 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 309, 295, 370, 303 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 309, 193, 370, 201 Flags: Print AppearanceDictionary: true Thumb: true Page: Sequence: 13 Annotations: Annotation: Subtype: Link Rect: 61, 655, 122, 663 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 61, 544, 122, 552 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 130, 463, 134, 471 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 213, 463, 217, 471 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 156, 454, 159, 462 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 175, 382, 178, 390 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 222, 382, 229, 390 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 494, 156, 529, 164 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 319, 147, 439, 155 Flags: Print AppearanceDictionary: true Thumb: true Page: Sequence: 14 Annotations: Annotation: Subtype: Link Rect: 197, 675, 289, 683 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 220, 566, 290, 573 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 71, 557, 123, 564 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 215, 411, 283, 419 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 71, 402, 124, 410 Flags: Print AppearanceDictionary: true Thumb: true Page: Sequence: 15 Thumb: true Checksum: dab8ea09 Type: CRC32 Checksum: 46091784a116b47067903d40ce703df5 Type: MD5 Checksum: 23dd49007a3d64440ed03dcbce1b31e5a05ce80a Type: SHA-1