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Keywords: G protein-coupled receptor, D2 dopamine receptor, A2A adenosine receptor, heteroreceptor complex, dimerization, dimer interface, allosteric modulation Author: Kjell Fuxe and Jens Carlsson Creator: LaTeX with hyperref package Producer: pdfTeX-1.40.15 CreationDate: Wed Aug 29 07:06:52 2018 CEST ModDate: Wed Aug 29 07:38:50 2018 CEST Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 16 Encrypted: no Page size: 595.276 x 779.528 pts Page rot: 0 File size: 4667960 bytes Optimized: no PDF version: 1.5 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- MPDGBU+MinionPro-Regular Type 1 Custom yes yes no 31 0 BBQODQ+HelveticaNeueLTStd-Bd Type 1 Custom yes yes no 32 0 SOXFBT+HelveticaNeueLTStd-Lt Type 1 Custom yes yes no 33 0 WIQCLD+HelveticaNeueLTStd-BdIt Type 1 Custom yes yes no 34 0 OQZQHU+HelveticaNeueLTStd-LtIt Type 1 Custom yes yes no 35 0 TRPZOU+HelveticaNeueLTStd-MdIt Type 1 Custom yes yes no 37 0 VPXXJP+MinionPro-It Type 1 Custom yes yes no 187 0 RRZGQK+MTSYN Type 1 Builtin yes yes no 205 0 ENYVTH+RBLMI Type 1 Builtin yes yes no 206 0 TZQUGO+MTGU Type 1 Builtin yes yes no 289 0 SNXXHQ+MinionPro-Bold Type 1 Custom yes yes no 389 0 Jhove (Rel. 1.22.1, 2019-04-17) Date: 2023-09-23 02:38:55 CEST RepresentationInformation: pmc_30214407.pdf ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17) LastModified: 2020-03-09 03:39:08 CET Size: 4667960 Format: PDF Version: 1.5 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 1055 FreeObjects: 20 IncrementalUpdates: 2 DocumentCatalog: PageLayout: SinglePage PageMode: UseOutlines Outlines: Item: Title: Mapping the Interface of a GPCR Dimer: A Structural Model of the A2A Adenosine and D2 Dopamine Receptor Heteromer Children: Item: Title: Introduction Item: Title: Materials and Methods Children: Item: Title: Plasmid Constructs Item: Title: Cell Culture and Transfection Item: Title: TM Peptide Treatment Item: Title: BRET1 Assays Item: Title: BRET2 Saturation Assays Item: Title: In situ Proximity Ligation Assay Item: Title: Cell Surface Receptor Expression and Cellular Localization Analysis by Fluorescence Confocal Microscopy Item: Title: [3H]-Raclopride Competition Experiments Item: Title: Statistical Analysis Item: Title: Homology Modeling Item: Title: Protein Protein Docking Item: Title: MD Simulations Item: Title: Results Children: Item: Title: Mapping of the TM Helices Involved in the A2AR D2R Heterodimer Interface Item: Title: Experiment-Guided Modeling of the A2AR D2R Heteroreceptor Complex Item: Title: MD Simulation Refinement of the A2AR D2R Heterodimer Model Item: Title: Experimental Evaluation of D2R Mutations in the Predicted Heteromer Interface Item: Title: Model of the A2AR D2R Complex Based on Crystal Structures of Both Protomers Item: Title: Discussion Item: Title: Author Contributions Item: Title: Funding Item: Title: Supplementary Material Item: Title: References Info: Title: Mapping the Interface of a GPCR Dimer: A Structural Model of the A2A Adenosine and D2 Dopamine Receptor Heteromer Author: Kjell Fuxe and Jens Carlsson Subject: The A2A adenosine (A2AR) and D2 dopamine (D2R) receptors form oligomers in the cell membrane and allosteric interactions across the A2AR D2R heteromer represent a target for development of drugs against central nervous system disorders. 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Link Rect: 415, 527, 494, 536 Annotation: Subtype: Link Rect: 469, 498, 547, 508 Annotation: Subtype: Link Rect: 486, 470, 551, 479 Annotation: Subtype: Link Rect: 312, 462, 339, 469 Annotation: Subtype: Link Rect: 476, 433, 551, 441 Annotation: Subtype: Link Rect: 312, 424, 328, 431 Annotation: Subtype: Link Rect: 341, 376, 452, 384 Annotation: Subtype: Link Rect: 404, 299, 430, 309 Annotation: Subtype: Link Rect: 431, 299, 463, 309 Annotation: Subtype: Link Rect: 463, 299, 498, 309 Annotation: Subtype: Link Rect: 498, 299, 522, 309 Annotation: Subtype: Link Rect: 522, 299, 549, 309 Annotation: Subtype: Link Rect: 43, 29, 124, 38 Annotation: Subtype: Link Rect: 127, 29, 187, 38 Annotation: Subtype: Link Rect: 439, 29, 551, 38 Checksum: a00c1337 Type: CRC32 Checksum: 359bde96dd5e5874b7babbffff951cb7 Type: MD5 Checksum: 61dd01731b4888eaf5071336bcf56f087cbeb08e Type: SHA-1