1f00a154c3d061a3b033039333eb22f5 pmc_30245864.pdf 6215ca8c99a62e219b67ba0912c2e70817a81ccc pmc_30245864.pdf 9bd82eb37265bf58ae0916c4340cffba25ec13ab8721a5000598018ceae626aa pmc_30245864.pdf Creator: Adobe InDesign CS6 (Windows) Producer: Adobe PDF Library 10.0.1 CreationDate: Wed Sep 5 11:38:42 2018 CEST ModDate: Wed Sep 5 11:38:43 2018 CEST Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 8 Encrypted: no Page size: 595.276 x 793.701 pts Page rot: 0 File size: 609219 bytes Optimized: yes PDF version: 1.4 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- LHVMCW+HelveticaNeueLTStd-BdCn Type 1C WinAnsi yes yes yes 245 0 YNOIXW+HelveticaNeueLTStd-Bd Type 1C WinAnsi yes yes yes 246 0 YNOIXW+HelveticaNeueLTStd-Roman Type 1C Custom yes yes yes 254 0 TDBEFG+HelveticaLTStd-BoldCond Type 1C WinAnsi yes yes yes 255 0 LHVMCW+HelveticaNeueLTStd-Cn Type 1C Custom yes yes yes 256 0 LHVMCW+HelveticaNeueLTStd-CnO Type 1C Custom yes yes yes 257 0 OYOANQ+Helvetica-Condensed-Bold Type 1C WinAnsi yes yes yes 258 0 OYOANQ+NewBaskerville-Roman Type 1C WinAnsi yes yes yes 272 0 YNOIXW+BookAntiqua-Bold TrueType WinAnsi yes yes yes 260 0 LHVMCW+HelveticaNeueLTStd-Cn Type 1C Custom yes yes yes 301 0 LHVMCW+HelveticaNeueLTStd-CnO Type 1C Custom yes yes yes 303 0 LHVMCW+HelveticaNeueLTStd-BdCn Type 1C WinAnsi yes yes yes 305 0 OYOANQ+Symbol Type 1C Custom yes yes yes 187 0 JOBWVA+ArialMT CID TrueType Identity-H yes yes yes 194 0 JOBWVA+FrutigerLTStd-Bold Type 1C WinAnsi yes yes yes 199 0 JOBWVA+HelveticaNeueLTStd-It Type 1C Custom yes yes yes 195 0 Jhove (Rel. 1.22.1, 2019-04-17) Date: 2022-06-14 02:28:55 CEST RepresentationInformation: pmc_30245864.pdf ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17) LastModified: 2020-02-24 03:40:02 CET Size: 609219 Format: PDF Version: 1.4 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf Profile: Linearized PDF PDFMetadata: Objects: 318 FreeObjects: 1 IncrementalUpdates: 1 DocumentCatalog: ViewerPreferences: HideToolbar: false HideMenubar: false HideWindowUI: false FitWindow: false CenterWindow: false DisplayDocTitle: false NonFullScreenPageMode: UseNone Direction: L2R ViewArea: CropBox ViewClip: CropBox PrintArea: CropBox PageClip: CropBox PageLayout: SinglePage PageMode: UseNone Outlines: Item: Title: Preparing for the incoming wave of biosimilars in oncology Children: Item: Title: Abstract Item: Title: Introduction Item: Title: Clinician’s perspective: building confidence for prescribing biosimilars Item: Title: Improving biosimilar use in the clinic: the crucial role of specialist nurses Item: Title: The patient’s perspective: what have we learnt and what can be improved? Item: Title: Providing regulatory transparency for biosimilars Item: Title: Impact of oncology biosimilars on the sustainability of healthcare systems Item: Title: The Scandinavian experience: a real-life experiment introducing a biosimilar Item: Title: Lessons learnt Item: Title: References Info: Creator: Adobe InDesign CS6 (Windows) Producer: Adobe PDF Library 10.0.1 CreationDate: Wed Sep 05 11:38:42 CEST 2018 ModDate: Wed Sep 05 11:38:43 CEST 2018 ID: 0x83cd5ec1c7a4c64d904aaaaf7a156228, 0x97cfb2653ff1e74a98d7fc8451d88cf8 Filters: FilterPipeline: FlateDecode FilterPipeline: DCTDecode Images: Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 391 ImageHeight: 109 ColorSpace: CMYK BitsPerSample: 8 BitsPerSampleUnit: integer Intent: RelativeColorimetric Name: X Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 2008 ImageHeight: 876 ColorSpace: CMYK BitsPerSample: 8 BitsPerSampleUnit: integer Intent: RelativeColorimetric Name: X Fonts: Type0: Font: BaseFont: JOBWVA+ArialMT Encoding: Identity-H ToUnicode: true Type1: Font: BaseFont: OYOANQ+NewBaskerville-Roman FontSubset: true FirstChar: 32 LastChar: 239 FontDescriptor: FontName: OYOANQ+NewBaskerville-Roman Flags: Serif, Nonsymbolic FontBBox: -205, -272, 1207, 906 FontFile3: true Encoding: WinAnsiEncoding ToUnicode: true Font: BaseFont: LHVMCW+HelveticaNeueLTStd-Cn FontSubset: true FirstChar: 30 LastChar: 242 FontDescriptor: FontName: LHVMCW+HelveticaNeueLTStd-Cn Flags: Nonsymbolic FontBBox: -164, -212, 1000, 932 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: LHVMCW+HelveticaNeueLTStd-CnO FontSubset: true FirstChar: 31 LastChar: 116 FontDescriptor: FontName: LHVMCW+HelveticaNeueLTStd-CnO Flags: Nonsymbolic, Italic FontBBox: -171, -272, 1068, 932 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: OYOANQ+Helvetica-Condensed-Bold FontSubset: true FirstChar: 32 LastChar: 120 FontDescriptor: FontName: OYOANQ+Helvetica-Condensed-Bold Flags: Nonsymbolic FontBBox: -169, -250, 1091, 991 FontFile3: true Encoding: WinAnsiEncoding ToUnicode: true Font: BaseFont: JOBWVA+HelveticaNeueLTStd-It FontSubset: true FirstChar: 31 LastChar: 121 FontDescriptor: FontName: JOBWVA+HelveticaNeueLTStd-It Flags: Nonsymbolic, Italic FontBBox: -166, -214, 1106, 957 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: LHVMCW+HelveticaNeueLTStd-BdCn FontSubset: true FirstChar: 32 LastChar: 146 FontDescriptor: FontName: LHVMCW+HelveticaNeueLTStd-BdCn Flags: Nonsymbolic FontBBox: -164, -224, 1066, 961 FontFile3: true Encoding: WinAnsiEncoding ToUnicode: true Font: BaseFont: YNOIXW+HelveticaNeueLTStd-Bd FontSubset: true FirstChar: 32 LastChar: 119 FontDescriptor: FontName: YNOIXW+HelveticaNeueLTStd-Bd Flags: Nonsymbolic FontBBox: -166, -218, 1078, 975 FontFile3: true Encoding: WinAnsiEncoding ToUnicode: true Font: BaseFont: JOBWVA+FrutigerLTStd-Bold FontSubset: true FirstChar: 67 LastChar: 83 FontDescriptor: FontName: JOBWVA+FrutigerLTStd-Bold Flags: Nonsymbolic FontBBox: -166, -250, 1000, 935 FontFile3: true Encoding: WinAnsiEncoding ToUnicode: true Font: BaseFont: OYOANQ+Symbol FontSubset: true FirstChar: 30 LastChar: 31 FontDescriptor: FontName: OYOANQ+Symbol Flags: Symbolic FontBBox: -180, -293, 1090, 1010 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: YNOIXW+HelveticaNeueLTStd-Roman FontSubset: true FirstChar: 30 LastChar: 252 FontDescriptor: FontName: YNOIXW+HelveticaNeueLTStd-Roman Flags: Nonsymbolic FontBBox: -166, -214, 1076, 952 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: TDBEFG+HelveticaLTStd-BoldCond FontSubset: true FirstChar: 32 LastChar: 116 FontDescriptor: FontName: TDBEFG+HelveticaLTStd-BoldCond Flags: Nonsymbolic FontBBox: -169, -250, 1091, 991 FontFile3: true Encoding: WinAnsiEncoding ToUnicode: true TrueType: Font: BaseFont: YNOIXW+BookAntiqua-Bold FontSubset: true FirstChar: 32 LastChar: 121 FontDescriptor: FontName: YNOIXW+BookAntiqua-Bold Flags: Serif, Nonsymbolic FontBBox: -134, -337, 1193, 1021 FontFile2: true Encoding: WinAnsiEncoding ToUnicode: true CIDFontType2: Font: BaseFont: JOBWVA+ArialMT CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: JOBWVA+ArialMT Flags: Symbolic FontBBox: -665, -325, 2000, 1006 FontFile2: true XMP: doi:esmoopen-2018-000420 application/pdf 2018-09-05T10:38:42+01:00 2018-09-05T10:38:43+01:00 2018-09-05T10:38:43+01:00 Adobe InDesign CS6 (Windows) uuid:13bc193e-fc50-4339-9bfc-3d9e06982c25 xmp.did:B2C59A163194E611BD009A7CB80B8EC7 xmp.id:EE4B1A7AEFB0E811A6ECC4B28D9A851A proof:pdf xmp.iid:60D81379EFB0E811A6ECC4B28D9A851A xmp.did:3CADEA59182068118C14CF26067AF65C xmp.did:B2C59A163194E611BD009A7CB80B8EC7 default converted from application/x-indesign to application/pdf Adobe InDesign CS6 (Windows) / 2018-09-05T10:38:42+01:00 e94a067b-c937-4678-b700-087a40e9c0a9 Adobe PDF Library 10.0.1 False Pages: Page: Sequence: 1 Annotations: Annotation: Subtype: Link Rect: 474, 38, 539, 18 Annotation: Subtype: Link Rect: 38, 34, 63, 18 Annotation: Subtype: Link Rect: 40, 706, 139, 662 Annotation: Subtype: Link Rect: 301, 266, 304, 254 ActionDest: 80 Annotation: Subtype: Link Rect: 395, 547, 399, 536 ActionDest: 80 Annotation: Subtype: Link Rect: 415, 475, 450, 463 ActionDest: 1 Annotation: Subtype: Link Rect: 427, 402, 430, 390 ActionDest: 80 Annotation: Subtype: Link Rect: 529, 256, 533, 245 ActionDest: 80 Annotation: Subtype: Link Rect: 551, 184, 554, 172 ActionDest: 80 Page: Sequence: 2 Annotations: Annotation: Subtype: Link Rect: 167, 416, 171, 404 ActionDest: 80 Annotation: Subtype: Link Rect: 214, 380, 218, 368 ActionDest: 80 Annotation: Subtype: Link Rect: 499, 367, 503, 355 ActionDest: 80 Page: Sequence: 3 Annotations: Annotation: Subtype: Link Rect: 277, 746, 288, 734 ActionDest: 80 Annotation: Subtype: Link Rect: 136, 578, 153, 566 ActionDest: 80 Annotation: Subtype: Link Rect: 213, 530, 220, 518 ActionDest: 80 Annotation: Subtype: Link Rect: 398, 494, 405, 482 ActionDest: 80 Annotation: Subtype: Link Rect: 381, 296, 398, 284 ActionDest: 80 Annotation: Subtype: Link Rect: 406, 224, 421, 212 ActionDest: 80 Annotation: Subtype: Link Rect: 454, 176, 469, 164 ActionDest: 80 Page: Sequence: 4 Annotations: Annotation: Subtype: Link Rect: 269, 734, 275, 722 ActionDest: 80 Annotation: Subtype: Link Rect: 145, 698, 152, 686 ActionDest: 80 Annotation: Subtype: Link Rect: 209, 506, 215, 494 ActionDest: 80 Annotation: Subtype: Link Rect: 500, 674, 504, 662 ActionDest: 80 Annotation: Subtype: Link Rect: 428, 662, 445, 650 ActionDest: 80 Annotation: Subtype: Link Rect: 533, 74, 540, 62 ActionDest: 80 Page: Sequence: 5 Annotations: Annotation: Subtype: Link Rect: 241, 727, 248, 715 ActionDest: 80 Annotation: Subtype: Link Rect: 209, 464, 235, 452 ActionDest: 47 Annotation: Subtype: Link Rect: 67, 170, 70, 158 ActionDest: 80 Annotation: Subtype: Link Rect: 436, 494, 443, 482 ActionDest: 80 Page: Sequence: 6 Annotations: Annotation: Subtype: Link Rect: 94, 206, 101, 194 ActionDest: 80 Annotation: Subtype: Link Rect: 94, 146, 101, 134 ActionDest: 80 Annotation: Subtype: Link Rect: 256, 74, 263, 62 ActionDest: 172 Annotation: Subtype: Link Rect: 547, 206, 554, 194 ActionDest: 172 Annotation: Subtype: Link Rect: 438, 158, 445, 146 ActionDest: 172 Annotation: Subtype: Link Rect: 453, 74, 460, 62 ActionDest: 172 Page: Sequence: 7 Annotations: Annotation: Subtype: Link Rect: 102, 698, 120, 686 ActionDest: 172 Annotation: Subtype: Link Rect: 104, 614, 111, 602 ActionDest: 172 Annotation: Subtype: Link Rect: 192, 226, 276, 217 Annotation: Subtype: Link Rect: 40, 217, 95, 208 Annotation: Subtype: Link Rect: 84, 154, 244, 145 Annotation: Subtype: Link Rect: 56, 145, 258, 136 Annotation: Subtype: Link Rect: 56, 137, 246, 128 Annotation: Subtype: Link Rect: 56, 128, 257, 119 Annotation: Subtype: Link Rect: 56, 120, 272, 111 Annotation: Subtype: Link Rect: 56, 111, 277, 102 Annotation: Subtype: Link Rect: 56, 103, 103, 94 Annotation: Subtype: Link Rect: 139, 77, 181, 68 Annotation: Subtype: Link Rect: 460, 737, 491, 728 Annotation: Subtype: Link Rect: 480, 711, 544, 702 Annotation: Subtype: Link Rect: 458, 685, 536, 676 Annotation: Subtype: Link Rect: 322, 676, 553, 667 Annotation: Subtype: Link Rect: 322, 667, 352, 659 Annotation: Subtype: Link Rect: 442, 641, 540, 633 Annotation: Subtype: Link Rect: 322, 633, 540, 624 Annotation: Subtype: Link Rect: 322, 624, 507, 615 Annotation: Subtype: Link Rect: 447, 607, 477, 598 Annotation: Subtype: Link Rect: 469, 572, 538, 563 Annotation: Subtype: Link Rect: 490, 537, 543, 529 Annotation: Subtype: Link Rect: 322, 503, 461, 494 Annotation: Subtype: Link Rect: 526, 485, 548, 477 Annotation: Subtype: Link Rect: 322, 477, 385, 468 Annotation: Subtype: Link Rect: 380, 451, 433, 442 Annotation: Subtype: Link Rect: 344, 407, 396, 399 Annotation: Subtype: Link Rect: 411, 381, 459, 373 Annotation: Subtype: Link Rect: 528, 364, 543, 355 Annotation: Subtype: Link Rect: 322, 355, 396, 347 Annotation: Subtype: Link Rect: 391, 303, 527, 295 Annotation: Subtype: Link Rect: 322, 295, 529, 286 Annotation: Subtype: Link Rect: 322, 286, 413, 277 Annotation: Subtype: Link Rect: 428, 260, 481, 251 Annotation: Subtype: Link Rect: 463, 243, 554, 234 Annotation: Subtype: Link Rect: 322, 234, 553, 225 Annotation: Subtype: Link Rect: 322, 225, 331, 217 Annotation: Subtype: Link Rect: 394, 199, 531, 191 Annotation: Subtype: Link Rect: 322, 191, 501, 182 Annotation: Subtype: Link Rect: 455, 95, 552, 86 Annotation: Subtype: Link Rect: 541, 69, 547, 60 Annotation: Subtype: Link Rect: 322, 61, 369, 52 Page: Sequence: 8 Annotations: Annotation: Subtype: Link Rect: 177, 737, 284, 728 Annotation: Subtype: Link Rect: 56, 728, 117, 720 Annotation: Subtype: Link Rect: 141, 703, 183, 694 Annotation: Subtype: Link Rect: 244, 669, 267, 660 Annotation: Subtype: Link Rect: 322, 643, 541, 635 Annotation: Subtype: Link Rect: 322, 635, 466, 626 Checksum: 4aad6cb2 Type: CRC32 Checksum: 1f00a154c3d061a3b033039333eb22f5 Type: MD5 Checksum: 6215ca8c99a62e219b67ba0912c2e70817a81ccc Type: SHA-1