01f242610c30513ab101a50d9a1c00c3 pmc_30544930.pdf bf3ef64a90250f42f70fde0065ba2dea214b5dbe pmc_30544930.pdf 71eb528efe01c4255c7c622e3f4c6baf35ca4c34e5f16cd8f1e0a22e66b39c12 pmc_30544930.pdf Title: An Animal Model for Assessing the Effects of Hydroxyurea Exposure Suggests That the Administration of This Agent to Pregnant Women and Young Infants May Not Be as Safe as We Thought Subject: The cytostatic agent hydroxyurea (HU) has proven to be beneficial for a variety of conditions in the disciplines of oncology, hematology, infectious disease and dermatology. It disrupts the S phase of the cell cycle by inhibiting the ribonucleotide reductase enzyme, thus blocking the transformation of ribonucleotides into deoxyribonucleotides, a rate limiting step in DNA synthesis. HU is listed as an essential medicine by the World Health Organization. Several studies have indicated that HU is well tolerated and safe in pregnant women and very young pediatric patients. To our knowledge, only a few controlled studies on the adverse effects of HU therapy have been done in humans. Despite this, the prevalence of central nervous system abnormalities, including ischemic lesions and stenosis have been reported. This review will summarize and present the effects of HU exposure on the prenatal and perinatal development of the rat cerebellar cortex and deep cerebellar nuclei neurons. Our results call for the necessity to better understand HU effects and define the administration of this drug to gestating women and young pediatric patients. Keywords: hydroxyurea; cerebellum; neuron; immunohistochemistry; electron microscopy; cell death; apoptosis Author: Lucía Rodríguez-Vázquez and Joaquín Martí Creator: LaTeX with hyperref package Producer: pdfTeX-1.40.18 CreationDate: Tue Dec 11 08:41:40 2018 CET ModDate: Tue Dec 11 08:41:40 2018 CET Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 13 Encrypted: no Page size: 595.276 x 841.89 pts (A4) Page rot: 0 File size: 1726418 bytes Optimized: no PDF version: 1.5 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- OQMFWG+URWPalladioL-Ital Type 1 Custom yes yes no 73 0 QZCOYB+URWPalladioL-Bold Type 1 Custom yes yes no 74 0 SSNIUI+VnURWPalladioL-Bold Type 1 Custom yes yes no 75 0 FXYZTF+URWPalladioL-Roma Type 1 Custom yes yes no 76 0 DNNUWA+VnURWPalladioL Type 1 Custom yes yes no 77 0 CKUPDE+TimesNewRomanPS-BoldItalicMT Type 1C WinAnsi yes yes no 82 0 IRWHZX+TimesNewRomanPSMT 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Type 1 Builtin yes yes no 382 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2024-01-19 07:07:36 CET RepresentationInformation: pmc_30544930.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2019-07-08 03:37:46 CEST Size: 1726418 Format: PDF Version: 1.5 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 0 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: ViewerPreferences: HideToolbar: false HideMenubar: false HideWindowUI: false FitWindow: true CenterWindow: false DisplayDocTitle: false NonFullScreenPageMode: UseNone Direction: L2R ViewArea: CropBox ViewClip: CropBox PrintArea: CropBox PageClip: CropBox PageLayout: SinglePage PageMode: UseNone Outlines: Item: Title: ぉのぴひはつふっぴどはの〠 Item: Title: えべつひはへべふひづち〺〠ぁの〠くぶづひぶどづぷ〠 Item: Title: きづっとちのどびねび〠はて〠ぁっぴどはの〠はて〠ぴとづ〠えべつひはへべふひづち〠 Item: Title: ごづひちぴはでづのどっ〠ぅててづっぴび〠はて〠えべつひはへべふひづち〠 Item: Title: 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