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Title:          Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines
Subject:        Journal of Extracellular Vesicles, 2018. doi:10.1080/20013078.2018.1535750
Keywords:       extracellular vesicles; exosomes; ectosomes; microvesicles; minimal information requirements; guidelines; standardization; microparticles; rigor; reproducibility
Author:         Clotilde Théry
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     Item: 
      Title: Abstract
     Item: 
      Title: Table of Contents
     Item: 
      Title: Introduction
     Item: 
      Title: Note on applicability of MISEV2018: species, cells, sample types, and experimental conditions
     Item: 
      Title: Nomenclature
     Item: 
      Title: Collection and pre-processing: pre-analytical variables
      Children: 
       Item: 
        Title: Cell culture conditioned media
        Children: 
         Item: 
          Title: Biological fluids
         Item: 
          Title: Tissue
         Item: 
          Title: Storage
     Item: 
      Title: EV separation and concentration: how MISEV2014 evolves in 2018
     Item: 
      Title: EV characterization: how MISEV2014 evolves in 2018
      Children: 
       Item: 
        Title: Quantification of EVs
        Children: 
         Item: 
          Title: Characterization of EVs by their protein composition
       Item: 
        Title: Single vesicle analysis
        Children: 
         Item: 
          Title: New recommendation: determine the topology of EV-associated components
     Item: 
      Title: Functional studies: how MISEV2014 evolves in 2018
      Children: 
       Item: 
        Title: Determine the specific versus common functions of different types of EVs
        Children: 
         Item: 
          Title: How to normalize amount of EVs used for comparative functional studies
         Item: 
          Title: Demonstrate that the activity is observed in the absence of direct cell-cell contact
         Item: 
          Title: Demonstrate that the activity is predominantly associated with EVs rather than with soluble mediators
         Item: 
          Title: Demonstrate the specific association of the activity with EVs rather than with co-isolated components
         Item: 
          Title: Determine whether afunction is specific to exosomes, as compared with other small EVs
         Item: 
          Title: How to attribute particular effects mediated by EVs to specific EV components
         Item: 
          Title: Consider whether an EV-dependent function is specific to agiven EV source
     Item: 
      Title: General considerations
      Children: 
       Item: 
        Title: Reporting
     Item: 
      Title: Notes
      Children: 
       Item: 
        Title: Exceptions to compliance with MISEV guidelines
     Item: 
      Title: Conclusions
     Item: 
      Title: Acknowledgments
     Item: 
      Title: Disclosure statement
     Item: 
      Title: Funding
     Item: 
      Title: Authors’ contributions
     Item: 
      Title: References
     Item: 
      Title: MISEV2018 Checklist
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               <rdf:li xml:lang="x-default">Journal of Extracellular Vesicles, 2018. doi:10.1080/20013078.2018.1535750</rdf:li>
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               <rdf:li>minimal information requirements</rdf:li>
               <rdf:li>guidelines</rdf:li>
               <rdf:li>standardization</rdf:li>
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         <prism:copyright>© 2018 The Author(s). Published by Informa UK Limited, trading as Taylor &amp; Francis Group on behalf of The International Society for Extracellular Vesicles.</prism:copyright>
         <prism:issn>0000</prism:issn>
         <prism:elssn>2001-3078</prism:elssn>
         <prism:volume>7</prism:volume>
         <prism:number>1</prism:number>
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         <prism:doi>10.1080/20013078.2018.1535750</prism:doi>
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         <pdf:Keywords>extracellular vesicles; exosomes; ectosomes; microvesicles; minimal information requirements; guidelines; standardization; microparticles; rigor; reproducibility</pdf:Keywords>
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