668086ad9a4ec9746cb079c5fc4b4882  pmc_29347936.pdf
f3c69d5f38d78fe28e75d036a7391ce6b2b9af7b  pmc_29347936.pdf
76df6c0df847e0257b4b8f796261a3466572ce8dfad1d9f605ea0393dc832a1f  pmc_29347936.pdf

Title:          Comparative analysis of COPD associated with tobacco smoking, biomass smoke exposure or both
Subject:        Respiratory Research, 2018, doi:10.1186/s12931-018-0718-y
Keywords:       COPD,Biomass smoke,Immunoglobulin E,Oxygen saturation,Systemic inflammation,Indoor pollution
Author:         Jordi Olloquequi
Creator:        Arbortext Advanced Print Publisher 9.1.440/W Unicode
Producer:       Acrobat Distiller 10.1.5 (Windows); modified using iText® 5.3.5 ©2000-2012 1T3XT BVBA (AGPL-version)
CreationDate:   Thu Jan 18 04:03:03 2018 CET
ModDate:        Thu Jan 18 16:09:39 2018 CET
Tagged:         no
UserProperties: no
Suspects:       no
Form:           none
JavaScript:     no
Pages:          8
Encrypted:      no
Page size:      595.276 x 790.866 pts
Page rot:       0
File size:      490969 bytes
Optimized:      no
PDF version:    1.4


name                                 type              encoding         emb sub uni object ID
------------------------------------ ----------------- ---------------- --- --- --- ---------
LMBEBF+LxpqbbAdvTTaf7f9f4f.B         Type 1C           WinAnsi          yes yes no       8  0
LMBGGI+HfctrrAdvTTe45e47d2           Type 1C           WinAnsi          yes yes no       9  0
LMBGGJ+HxdbgsAdvTTb5929f4c           Type 1C           WinAnsi          yes yes no      85  0
MyriadPro-Regular                    Type 1            Custom           yes no  no      10  0
LMBGJJ+TlrdqsAdvTT99c4c969           Type 1C           WinAnsi          yes yes no      12  0
LMBGKJ+FwxnmkAdvTT1b53b5fb.I         Type 1C           WinAnsi          yes yes no      86  0
LMBGKK+KxnqvfAdvTT86d47313           Type 1C           WinAnsi          yes yes no      13  0
LMBHHH+MshlxxAdvTT7329fd89.I         Type 1C           WinAnsi          yes yes no      14  0
LMBGLL+KddchpAdvTT86d47313+20        Type 1C           WinAnsi          yes yes no      15  0
LMBHKI+YfpnwmAdvTT86d47313+03        Type 1C           Custom           yes yes yes     11  0
LMBHMJ+TckvhrAdvTT86d47313+22        Type 1C           Custom           yes yes yes     60  0
LMBHMK+VbscxnAdvTT4fa15320.B         Type 1C           WinAnsi          yes yes no      61  0
LMBHNK+BdcyymAdvTT8861b38f.I         Type 1C           WinAnsi          yes yes no      62  0
LMBIAK+SwmybxAdvTTb5929f4c+20        Type 1C           WinAnsi          yes yes no      87  0
LMBLOD+GqnfmsAdvTTb5929f4c+03        Type 1C           Custom           yes yes yes     98  0
LMBMFC+NkgjldAdvTT99c4c969+20        Type 1C           WinAnsi          yes yes no     141  0
LMBMFD+WcyhbrAdvTTaf7f9f4f.B+20      Type 1C           WinAnsi          yes yes no     142  0
DvthndOregonLDOBook                  Type 1C           WinAnsi          yes no  no     162  0
GpgkpkOpenSans-Extrabold             Type 1C           WinAnsi          yes no  no     163  0
KywwqtOpenSans-Light                 Type 1C           MacRoman         yes no  no     164  0


Jhove (Rel. 1.28.0, 2023-05-18)
 Date: 2024-01-19 07:03:54 CET
 RepresentationInformation: pmc_29347936.pdf
  ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16)
  LastModified: 2018-03-05 03:50:25 CET
  Size: 490969
  Format: PDF
  Version: 1.4
  Status: Well-Formed and valid
  SignatureMatches:
   PDF-hul
  MIMEtype: application/pdf
  PDFMetadata: 
   Objects: 416
   FreeObjects: 1
   IncrementalUpdates: 0
   DocumentCatalog: 
    PageLayout: SinglePage
    PageMode: UseOutlines
    Outlines: 
     Item: 
      Title: Abstract
      Destination: sectionAbs1
      Children: 
       Item: 
        Title: Background
        Destination: sectionASec1
       Item: 
        Title: Methods
        Destination: sectionASec2
       Item: 
        Title: Results
        Destination: sectionASec3
       Item: 
        Title: Conclusions
        Destination: sectionASec4
     Item: 
      Title: Background
      Destination: sectionSec1
     Item: 
      Title: Methods
      Destination: sectionSec2
      Children: 
       Item: 
        Title: Study population
        Destination: sectionSec3
       Item: 
        Title: Risk factors
        Destination: sectionSec4
       Item: 
        Title: Systemic inflammatory markers
        Destination: sectionSec5
       Item: 
        Title: Statistical analysis
        Destination: sectionSec6
     Item: 
      Title: Results
      Destination: sectionSec7
      Children: 
       Item: 
        Title: Demographic and clinical findings
        Destination: sectionSec8
       Item: 
        Title: Lung function
        Destination: sectionSec9
       Item: 
        Title: Systemic inflammatory markers
        Destination: sectionSec10
       Item: 
        Title: Correlations of interest
        Destination: sectionSec11
     Item: 
      Title: Discussion
      Destination: sectionSec12
      Children: 
       Item: 
        Title: Previous studies
        Destination: sectionSec13
       Item: 
        Title: Interpretation of findings
        Destination: sectionSec14
       Item: 
        Title: Potential limitations
        Destination: sectionSec15
     Item: 
      Title: Conclusions
      Destination: sectionSec16
     Item: 
      Title: Abbreviations
      Destination: sectionabr1
     Item: 
      Title: Funding
      Destination: sectionFPar1
     Item: 
      Title: Availability of data and materials
      Destination: sectionFPar2
     Item: 
      Title: Authors’ contributions
      Destination: sections12931-018-0718-y
     Item: 
      Title: Ethics approval and consent to participate
      Destination: sectionFPar3
     Item: 
      Title: Consent of publication
      Destination: sectionFPar4
     Item: 
      Title: Competing interests
      Destination: sectionFPar5
     Item: 
      Title: Publisher’s Note
      Destination: sectionFPar6
     Item: 
      Title: Author details
      Destination: sectionaunote1
     Item: 
      Title: References
      Destination: sectionBib1
   Info: 
    Title: Comparative analysis of COPD associated with tobacco smoking, biomass smoke exposure or both
    Author: Jordi Olloquequi
    Subject: Respiratory Research, 2018, doi:10.1186/s12931-018-0718-y
    Keywords: COPD,Biomass smoke,Immunoglobulin E,Oxygen saturation,Systemic inflammation,Indoor pollution
    Creator: Arbortext Advanced Print Publisher 9.1.440/W Unicode
    Producer: Acrobat Distiller 10.1.5 (Windows); modified using iText® 5.3.5 ©2000-2012 1T3XT BVBA (AGPL-version)
    CreationDate: Thu Jan 18 04:03:03 CET 2018
    ModDate: Thu Jan 18 16:09:39 CET 2018
   ID: 0xdd2b4386f851a3dc6d80d50c548d76b5, 0xcb1a20bb250fe86ea404a7e656c630f1
   Filters: 
    FilterPipeline: FlateDecode
    FilterPipeline: DCTDecode
   Images: 
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 95
      ImageHeight: 91
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Intent: Perceptual
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 688
      ImageHeight: 126
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 896
      ImageHeight: 2131
      ColorSpace: black is zero
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 1100
      ImageHeight: 90
      ColorSpace: black is zero
      BitsPerSample: 1
      BitsPerSampleUnit: integer
     Filter: FlateDecode
   Fonts: 
    Type1: 
     Font: 
      BaseFont: LMBLOD+GqnfmsAdvTTb5929f4c+03
      FontSubset: true
      FirstChar: 1
      LastChar: 7
      FontDescriptor: 
       FontName: LMBLOD+GqnfmsAdvTTb5929f4c+03
       Flags: Symbolic
       FontBBox: -531, -260, 802, 968
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: DvthndOregonLDOBook
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: DvthndOregonLDOBook
       Flags: Serif, Nonsymbolic
       FontBBox: 1, -308, 1045, 922
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: GpgkpkOpenSans-Extrabold
      FirstChar: 32
      LastChar: 149
      FontDescriptor: 
       FontName: GpgkpkOpenSans-Extrabold
       Flags: Nonsymbolic
       FontBBox: -728, -293, 1407, 1124
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: KywwqtOpenSans-Light
      FirstChar: 32
      LastChar: 222
      FontDescriptor: 
       FontName: KywwqtOpenSans-Light
       Flags: Nonsymbolic
       FontBBox: -521, -269, 1140, 1048
       FontFile3: true
      Encoding: MacRomanEncoding
     Font: 
      BaseFont: LMBEBF+LxpqbbAdvTTaf7f9f4f.B
      FontSubset: true
      FirstChar: 32
      LastChar: 117
      FontDescriptor: 
       FontName: LMBEBF+LxpqbbAdvTTaf7f9f4f.B
       Flags: Nonsymbolic
       FontBBox: -218, -250, 875, 895
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: LMBGGI+HfctrrAdvTTe45e47d2
      FontSubset: true
      FirstChar: 32
      LastChar: 177
      FontDescriptor: 
       FontName: LMBGGI+HfctrrAdvTTe45e47d2
       Flags: Nonsymbolic
       FontBBox: -218, -250, 833, 875
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: MyriadPro-Regular
      FirstChar: 1
      LastChar: 255
      FontDescriptor: 
       FontName: MyriadPro-Regular
       Flags: Nonsymbolic
       FontBBox: -46, -250, 1126, 879
       FontFile: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
     Font: 
      BaseFont: LMBHKI+YfpnwmAdvTT86d47313+03
      FontSubset: true
      FirstChar: 1
      LastChar: 2
      FontDescriptor: 
       FontName: LMBHKI+YfpnwmAdvTT86d47313+03
       Flags: Symbolic
       FontBBox: -281, -250, 906, 822
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: LMBGJJ+TlrdqsAdvTT99c4c969
      FontSubset: true
      FirstChar: 32
      LastChar: 121
      FontDescriptor: 
       FontName: LMBGJJ+TlrdqsAdvTT99c4c969
       Flags: Nonsymbolic
       FontBBox: -41, -250, 854, 885
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: LMBGKK+KxnqvfAdvTT86d47313
      FontSubset: true
      FirstChar: 32
      LastChar: 252
      FontDescriptor: 
       FontName: LMBGKK+KxnqvfAdvTT86d47313
       Flags: Serif, Nonsymbolic
       FontBBox: -218, -239, 1020, 875
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: LMBMFC+NkgjldAdvTT99c4c969+20
      FontSubset: true
      FirstChar: 32
      LastChar: 146
      FontDescriptor: 
       FontName: LMBMFC+NkgjldAdvTT99c4c969+20
       Flags: Nonsymbolic
       FontBBox: -447, -197, 1583, 864
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: LMBHHH+MshlxxAdvTT7329fd89.I
      FontSubset: true
      FirstChar: 32
      LastChar: 121
      FontDescriptor: 
       FontName: LMBHHH+MshlxxAdvTT7329fd89.I
       Flags: Nonsymbolic
       FontBBox: -218, -250, 885, 864
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: LMBMFD+WcyhbrAdvTTaf7f9f4f.B+20
      FontSubset: true
      FirstChar: 32
      LastChar: 146
      FontDescriptor: 
       FontName: LMBMFD+WcyhbrAdvTTaf7f9f4f.B+20
       Flags: Nonsymbolic
       FontBBox: -468, -197, 1656, 864
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: LMBGLL+KddchpAdvTT86d47313+20
      FontSubset: true
      FirstChar: 32
      LastChar: 150
      FontDescriptor: 
       FontName: LMBGLL+KddchpAdvTT86d47313+20
       Flags: Nonsymbolic
       FontBBox: -218, -218, 1291, 812
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: LMBGGJ+HxdbgsAdvTTb5929f4c
      FontSubset: true
      FirstChar: 32
      LastChar: 250
      FontDescriptor: 
       FontName: LMBGGJ+HxdbgsAdvTTb5929f4c
       Flags: Nonsymbolic
       FontBBox: -41, -250, 812, 864
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: LMBGKJ+FwxnmkAdvTT1b53b5fb.I
      FontSubset: true
      FirstChar: 32
      LastChar: 121
      FontDescriptor: 
       FontName: LMBGKJ+FwxnmkAdvTT1b53b5fb.I
       Flags: Nonsymbolic
       FontBBox: -114, -250, 864, 854
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: LMBIAK+SwmybxAdvTTb5929f4c+20
      FontSubset: true
      FirstChar: 32
      LastChar: 150
      FontDescriptor: 
       FontName: LMBIAK+SwmybxAdvTTb5929f4c+20
       Flags: Nonsymbolic
       FontBBox: -447, -208, 1375, 864
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: LMBHMJ+TckvhrAdvTT86d47313+22
      FontSubset: true
      FirstChar: 1
      LastChar: 139
      FontDescriptor: 
       FontName: LMBHMJ+TckvhrAdvTT86d47313+22
       Flags: Symbolic
       FontBBox: -166, -260, 1031, 906
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: LMBHMK+VbscxnAdvTT4fa15320.B
      FontSubset: true
      FirstChar: 32
      LastChar: 46
      FontDescriptor: 
       FontName: LMBHMK+VbscxnAdvTT4fa15320.B
       Flags: Nonsymbolic
       FontBBox: -218, -239, 1052, 885
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: LMBHNK+BdcyymAdvTT8861b38f.I
      FontSubset: true
      FirstChar: 32
      LastChar: 112
      FontDescriptor: 
       FontName: LMBHNK+BdcyymAdvTT8861b38f.I
       Flags: Nonsymbolic
       FontBBox: -187, -239, 1062, 875
       FontFile3: true
      Encoding: WinAnsiEncoding
   XMP: <x:xmpmeta x:xmptk="Adobe XMP Core 4.2.1-c041 52.342996, 2008/05/07-20:48:00        " xmlns:x="adobe:ns:meta/">
   <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
      <rdf:Description rdf:about="" xmlns:pdf="http://ns.adobe.com/pdf/1.3/">
         <pdf:Keywords>COPD,Biomass smoke,Immunoglobulin E,Oxygen saturation,Systemic inflammation,Indoor pollution</pdf:Keywords>
         <pdf:Producer>Acrobat Distiller 10.1.5 (Windows); modified using iText® 5.3.5 ©2000-2012 1T3XT BVBA (AGPL-version)</pdf:Producer>
      </rdf:Description>
      <rdf:Description rdf:about="" xmlns:dc="http://purl.org/dc/elements/1.1/">
         <dc:format>application/pdf</dc:format>
         <dc:identifier>10.1186/s12931-018-0718-y</dc:identifier>
         <dc:publisher>
            <rdf:Bag>
               <rdf:li>Respiratory Research</rdf:li>
            </rdf:Bag>
         </dc:publisher>
         <dc:description>
            <rdf:Alt>
               <rdf:li xml:lang="x-default">Respiratory Research, 2018, doi:10.1186/s12931-018-0718-y</rdf:li>
            </rdf:Alt>
         </dc:description>
         <dc:subject>
            <rdf:Bag>
               <rdf:li>COPD</rdf:li>
               <rdf:li>Biomass smoke</rdf:li>
               <rdf:li>Immunoglobulin E</rdf:li>
               <rdf:li>Oxygen saturation</rdf:li>
               <rdf:li>Systemic inflammation</rdf:li>
               <rdf:li>Indoor pollution</rdf:li>
            </rdf:Bag>
         </dc:subject>
         <dc:title>
            <rdf:Alt>
               <rdf:li xml:lang="x-default">Comparative analysis of COPD associated with tobacco smoking, biomass smoke exposure or both</rdf:li>
            </rdf:Alt>
         </dc:title>
         <dc:creator>
            <rdf:Seq>
               <rdf:li>Jordi Olloquequi</rdf:li>
               <rdf:li>Sergio Jaime</rdf:li>
               <rdf:li>Viviana Parra</rdf:li>
               <rdf:li>Elizabeth Cornejo-Córdova</rdf:li>
               <rdf:li>Gonzalo Valdivia</rdf:li>
               <rdf:li>Àlvar Agustí</rdf:li>
               <rdf:li>Rafael Silva O.</rdf:li>
            </rdf:Seq>
         </dc:creator>
      </rdf:Description>
      <rdf:Description rdf:about="" xmlns:xmp="http://ns.adobe.com/xap/1.0/">
         <xmp:MetadataDate>2018-01-18T16:09:39+01:00</xmp:MetadataDate>
         <xmp:CreateDate>2018-01-18T11:03:03+08:00</xmp:CreateDate>
         <xmp:CreatorTool>Arbortext Advanced Print Publisher 9.1.440/W Unicode</xmp:CreatorTool>
         <xmp:ModifyDate>2018-01-18T16:09:39+01:00</xmp:ModifyDate>
      </rdf:Description>
      <rdf:Description rdf:about="" xmlns:stEvt="http://ns.adobe.com/xap/1.0/sType/ResourceEvent#" xmlns:xmpMM="http://ns.adobe.com/xap/1.0/mm/">
         <xmpMM:DocumentID>uuid:60334ee9-5d74-4076-8036-dbc24b981201</xmpMM:DocumentID>
         <xmpMM:InstanceID>uuid:3f952b85-7c61-4672-a359-9aec76724854</xmpMM:InstanceID>
         <xmpMM:RenditionClass>default</xmpMM:RenditionClass>
         <xmpMM:VersionID>1</xmpMM:VersionID>
         <xmpMM:History>
            <rdf:Seq>
               <rdf:li rdf:parseType="Resource">
                  <stEvt:action>converted</stEvt:action>
                  <stEvt:instanceID>uuid:9ee20126-4160-4017-b09c-3b901804d325</stEvt:instanceID>
                  <stEvt:parameters>converted to PDF/A-2b</stEvt:parameters>
                  <stEvt:softwareAgent>pdfToolbox</stEvt:softwareAgent>
                  <stEvt:when>2018-01-18T11:08:23+08:00</stEvt:when>
               </rdf:li>
            </rdf:Seq>
         </xmpMM:History>
      </rdf:Description>
      <rdf:Description rdf:about="" xmlns:pdfaid="http://www.aiim.org/pdfa/ns/id/">
         <pdfaid:part>2</pdfaid:part>
         <pdfaid:conformance>B</pdfaid:conformance>
      </rdf:Description>
      <rdf:Description rdf:about="" xmlns:author="http://springernature.com/ns/xmpExtensions/2.0/authorInfo/" xmlns:sn="http://springernature.com/ns/xmpExtensions/2.0/">
         <sn:authorInfo>
            <rdf:Bag>
               <rdf:li rdf:parseType="Resource">
                  <author:name>Jordi Olloquequi</author:name>
                  <author:orcid>http://orcid.org/0000-0002-6492-2739</author:orcid>
               </rdf:li>
            </rdf:Bag>
         </sn:authorInfo>
      </rdf:Description>
      <rdf:Description rdf:about="" xmlns:pdfaExtension="http://www.aiim.org/pdfa/ns/extension/" xmlns:pdfaField="http://www.aiim.org/pdfa/ns/field#" xmlns:pdfaProperty="http://www.aiim.org/pdfa/ns/property#" xmlns:pdfaSchema="http://www.aiim.org/pdfa/ns/schema#" xmlns:pdfaType="http://www.aiim.org/pdfa/ns/type#">
         <pdfaExtension:schemas>
            <rdf:Bag>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:schema>Springer Nature ORCID Schema</pdfaSchema:schema>
                  <pdfaSchema:namespaceURI>http://springernature.com/ns/xmpExtensions/2.0/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>sn</pdfaSchema:prefix>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:name>authorInfo</pdfaProperty:name>
                           <pdfaProperty:valueType>Bag AuthorInformation</pdfaProperty:valueType>
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Author information: contains the name of each author and his/her ORCID (ORCiD: Open Researcher and Contributor ID). An ORCID is a persistent identifier (a non-proprietary alphanumeric code) to uniquely identify scientific and other academic authors.</pdfaProperty:description>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:name>editorInfo</pdfaProperty:name>
                           <pdfaProperty:valueType>Bag EditorInformation</pdfaProperty:valueType>
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Editor information: contains the name of each editor and his/her ORCID identifier.</pdfaProperty:description>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:name>seriesEditorInfo</pdfaProperty:name>
                           <pdfaProperty:valueType>Bag SeriesEditorInformation</pdfaProperty:valueType>
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Series editor information: contains the name of each series editor and his/her ORCID identifier.</pdfaProperty:description>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
                  <pdfaSchema:valueType>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaType:type>AuthorInformation</pdfaType:type>
                           <pdfaType:namespaceURI>http://springernature.com/ns/xmpExtensions/2.0/authorInfo/</pdfaType:namespaceURI>
                           <pdfaType:prefix>author</pdfaType:prefix>
                           <pdfaType:description>Specifies the types of author information: name and ORCID of an author.</pdfaType:description>
                           <pdfaType:field>
                              <rdf:Seq>
                                 <rdf:li rdf:parseType="Resource">
                                    <pdfaField:name>name</pdfaField:name>
                                    <pdfaField:valueType>Text</pdfaField:valueType>
                                    <pdfaField:description>Gives the name of an author.</pdfaField:description>
                                 </rdf:li>
                                 <rdf:li rdf:parseType="Resource">
                                    <pdfaField:name>orcid</pdfaField:name>
                                    <pdfaField:valueType>URI</pdfaField:valueType>
                                    <pdfaField:description>Gives the ORCID of an author.</pdfaField:description>
                                 </rdf:li>
                              </rdf:Seq>
                           </pdfaType:field>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaType:type>EditorInformation</pdfaType:type>
                           <pdfaType:namespaceURI>http://springernature.com/ns/xmpExtensions/2.0/editorInfo/</pdfaType:namespaceURI>
                           <pdfaType:prefix>editor</pdfaType:prefix>
                           <pdfaType:description>Specifies the types of editor information: name and ORCID of an editor.</pdfaType:description>
                           <pdfaType:field>
                              <rdf:Seq>
                                 <rdf:li rdf:parseType="Resource">
                                    <pdfaField:name>name</pdfaField:name>
                                    <pdfaField:valueType>Text</pdfaField:valueType>
                                    <pdfaField:description>Gives the name of an editor.</pdfaField:description>
                                 </rdf:li>
                                 <rdf:li rdf:parseType="Resource">
                                    <pdfaField:name>orcid</pdfaField:name>
                                    <pdfaField:valueType>URI</pdfaField:valueType>
                                    <pdfaField:description>Gives the ORCID of an editor.</pdfaField:description>
                                 </rdf:li>
                              </rdf:Seq>
                           </pdfaType:field>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaType:type>SeriesEditorInformation</pdfaType:type>
                           <pdfaType:namespaceURI>http://springernature.com/ns/xmpExtensions/2.0/seriesEditorInfo/</pdfaType:namespaceURI>
                           <pdfaType:prefix>seriesEditor</pdfaType:prefix>
                           <pdfaType:description>Specifies the types of series editor information: name and ORCID of a series editor.</pdfaType:description>
                           <pdfaType:field>
                              <rdf:Seq>
                                 <rdf:li rdf:parseType="Resource">
                                    <pdfaField:name>name</pdfaField:name>
                                    <pdfaField:valueType>Text</pdfaField:valueType>
                                    <pdfaField:description>Gives the name of a series editor.</pdfaField:description>
                                 </rdf:li>
                                 <rdf:li rdf:parseType="Resource">
                                    <pdfaField:name>orcid</pdfaField:name>
                                    <pdfaField:valueType>URI</pdfaField:valueType>
                                    <pdfaField:description>Gives the ORCID of a series editor.</pdfaField:description>
                                 </rdf:li>
                              </rdf:Seq>
                           </pdfaType:field>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:valueType>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://ns.adobe.com/pdf/1.3/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>pdf</pdfaSchema:prefix>
                  <pdfaSchema:schema>Adobe PDF Schema</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>A name object indicating whether the document has been modified to include trapping information</pdfaProperty:description>
                           <pdfaProperty:name>Trapped</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://ns.adobe.com/xap/1.0/mm/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>xmpMM</pdfaSchema:prefix>
                  <pdfaSchema:schema>XMP Media Management Schema</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>UUID based identifier for specific incarnation of a document</pdfaProperty:description>
                           <pdfaProperty:name>InstanceID</pdfaProperty:name>
                           <pdfaProperty:valueType>URI</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>The common identifier for all versions and renditions of a document.</pdfaProperty:description>
                           <pdfaProperty:name>OriginalDocumentID</pdfaProperty:name>
                           <pdfaProperty:valueType>URI</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>A reference to the original document from which this one is derived. It is a minimal reference; missing components can be assumed to be unchanged. For example, a new version might only need to specify the instance ID and version number of the previous version, or a rendition might only need to specify the instance ID and rendition class of the original.</pdfaProperty:description>
                           <pdfaProperty:name>DerivedFrom</pdfaProperty:name>
                           <pdfaProperty:valueType>ResourceRef</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
                  <pdfaSchema:valueType>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaType:description>Identifies a portion of a document. This can be a position at which the document has been changed since the most recent event history (stEvt:changed). For a resource within an xmpMM:Ingredients list, the ResourceRef uses this type to identify both the portion of the containing document that refers to the resource, and the portion of the referenced resource that is referenced.</pdfaType:description>
                           <pdfaType:namespaceURI>http://ns.adobe.com/xap/1.0/sType/Part#</pdfaType:namespaceURI>
                           <pdfaType:prefix>stPart</pdfaType:prefix>
                           <pdfaType:type>Part</pdfaType:type>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:valueType>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://ns.adobe.com/xap/1.0/t/pg/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>xmpTPg</pdfaSchema:prefix>
                  <pdfaSchema:schema>XMP Paged-Text</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>A structure containing the characteristics of a font used in a document</pdfaProperty:description>
                           <pdfaProperty:name>Fonts</pdfaProperty:name>
                           <pdfaProperty:valueType>Bag Font</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>XMP08 Spec: An ordered array of plate names that are needed to print the document (including any in contained documents).</pdfaProperty:description>
                           <pdfaProperty:name>PlateNames</pdfaProperty:name>
                           <pdfaProperty:valueType>Seq Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
                  <pdfaSchema:valueType>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaType:description>A structure containing the characteristics of a font used in a document.</pdfaType:description>
                           <pdfaType:namespaceURI>http://ns.adobe.com/xap/1.0/sType/Font#</pdfaType:namespaceURI>
                           <pdfaType:prefix>stFnt</pdfaType:prefix>
                           <pdfaType:type>Font</pdfaType:type>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:valueType>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://ns.adobe.com/pdfx/1.3/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>pdfx</pdfaSchema:prefix>
                  <pdfaSchema:schema>PDF/X ID Schema</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>ID of PDF/X standard</pdfaProperty:description>
                           <pdfaProperty:name>GTS_PDFXVersion</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Conformance level of PDF/X standard</pdfaProperty:description>
                           <pdfaProperty:name>GTS_PDFXConformance</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Company creating the PDF</pdfaProperty:description>
                           <pdfaProperty:name>Company</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Date when document was last modified</pdfaProperty:description>
                           <pdfaProperty:name>SourceModified</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://www.aiim.org/pdfa/ns/id/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>pdfaid</pdfaSchema:prefix>
                  <pdfaSchema:schema>PDF/A ID Schema</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Part of PDF/A standard</pdfaProperty:description>
                           <pdfaProperty:name>part</pdfaProperty:name>
                           <pdfaProperty:valueType>Integer</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Amendment of PDF/A standard</pdfaProperty:description>
                           <pdfaProperty:name>amd</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Conformance level of PDF/A standard</pdfaProperty:description>
                           <pdfaProperty:name>conformance</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
            </rdf:Bag>
         </pdfaExtension:schemas>
      </rdf:Description>
   </rdf:RDF>
</x:xmpmeta>
   Pages: 
    Page: 
     Sequence: 1
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 484, 657, 538, 679
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 132, 573, 141, 582
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 243, 169, 247, 179
       Flags: Print
       AppearanceDictionary: true
       Destination: 138
      Annotation: 
       Subtype: Link
       Rect: 396, 205, 401, 215
       Flags: Print
       AppearanceDictionary: true
       Destination: 138
      Annotation: 
       Subtype: Link
       Rect: 408, 205, 413, 215
       Flags: Print
       AppearanceDictionary: true
       Destination: 138
      Annotation: 
       Subtype: Link
       Rect: 502, 109, 507, 119
       Flags: Print
       AppearanceDictionary: true
       Destination: 138
      Annotation: 
       Subtype: Link
       Rect: 512, 109, 517, 119
       Flags: Print
       AppearanceDictionary: true
       Destination: 138
      Annotation: 
       Subtype: Link
       Rect: 114, 117, 179, 125
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 239, 65, 357, 72
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 182, 41, 321, 48
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
    Page: 
     Sequence: 2
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 123, 681, 128, 690
       Flags: Print
       AppearanceDictionary: true
       Destination: 138
      Annotation: 
       Subtype: Link
       Rect: 133, 681, 143, 690
       Flags: Print
       AppearanceDictionary: true
       Destination: 138
      Annotation: 
       Subtype: Link
       Rect: 251, 585, 261, 594
       Flags: Print
       AppearanceDictionary: true
       Destination: 138
      Annotation: 
       Subtype: Link
       Rect: 149, 489, 159, 498
       Flags: Print
       AppearanceDictionary: true
       Destination: 138
      Annotation: 
       Subtype: Link
       Rect: 140, 477, 150, 486
       Flags: Print
       AppearanceDictionary: true
       Destination: 138
      Annotation: 
       Subtype: Link
       Rect: 251, 477, 261, 486
       Flags: Print
       AppearanceDictionary: true
       Destination: 138
      Annotation: 
       Subtype: Link
       Rect: 147, 405, 157, 414
       Flags: Print
       AppearanceDictionary: true
       Destination: 138
      Annotation: 
       Subtype: Link
       Rect: 138, 297, 148, 306
       Flags: Print
       AppearanceDictionary: true
       Destination: 138
      Annotation: 
       Subtype: Link
       Rect: 59, 261, 69, 270
       Flags: Print
       AppearanceDictionary: true
       Destination: 138
      Annotation: 
       Subtype: Link
       Rect: 75, 261, 85, 270
       Flags: Print
       AppearanceDictionary: true
       Destination: 138
      Annotation: 
       Subtype: Link
       Rect: 215, 261, 225, 270
       Flags: Print
       AppearanceDictionary: true
       Destination: 138
      Annotation: 
       Subtype: Link
       Rect: 230, 261, 240, 270
       Flags: Print
       AppearanceDictionary: true
       Destination: 152
      Annotation: 
       Subtype: Link
       Rect: 160, 189, 170, 198
       Flags: Print
       AppearanceDictionary: true
       Destination: 152
      Annotation: 
       Subtype: Link
       Rect: 90, 165, 100, 174
       Flags: Print
       AppearanceDictionary: true
       Destination: 152
      Annotation: 
       Subtype: Link
       Rect: 213, 129, 223, 138
       Flags: Print
       AppearanceDictionary: true
       Destination: 152
      Annotation: 
       Subtype: Link
       Rect: 230, 129, 239, 138
       Flags: Print
       AppearanceDictionary: true
       Destination: 152
      Annotation: 
       Subtype: Link
       Rect: 92, 69, 102, 78
       Flags: Print
       AppearanceDictionary: true
       Destination: 152
      Annotation: 
       Subtype: Link
       Rect: 111, 69, 121, 78
       Flags: Print
       AppearanceDictionary: true
       Destination: 152
      Annotation: 
       Subtype: Link
       Rect: 345, 669, 355, 678
       Flags: Print
       AppearanceDictionary: true
       Destination: 152
      Annotation: 
       Subtype: Link
       Rect: 476, 657, 486, 666
       Flags: Print
       AppearanceDictionary: true
       Destination: 152
      Annotation: 
       Subtype: Link
       Rect: 426, 273, 431, 282
       Flags: Print
       AppearanceDictionary: true
       Destination: 138
      Annotation: 
       Subtype: Link
       Rect: 361, 249, 371, 258
       Flags: Print
       AppearanceDictionary: true
       Destination: 152
     Thumb: true
    Page: 
     Sequence: 3
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 191, 533, 200, 542
       Flags: Print
       AppearanceDictionary: true
       Destination: 152
      Annotation: 
       Subtype: Link
       Rect: 102, 389, 107, 398
       Flags: Print
       AppearanceDictionary: true
       Destination: 138
      Annotation: 
       Subtype: Link
       Rect: 329, 669, 334, 678
       Flags: Print
       AppearanceDictionary: true
       Destination: 83
      Annotation: 
       Subtype: Link
       Rect: 304, 417, 309, 426
       Flags: Print
       AppearanceDictionary: true
       Destination: 83
      Annotation: 
       Subtype: Link
       Rect: 463, 285, 468, 294
       Flags: Print
       AppearanceDictionary: true
       Destination: 93
      Annotation: 
       Subtype: Link
       Rect: 389, 237, 398, 246
       Flags: Print
       AppearanceDictionary: true
       Destination: 93
      Annotation: 
       Subtype: Link
       Rect: 523, 201, 533, 210
       Flags: Print
       AppearanceDictionary: true
       Destination: 93
      Annotation: 
       Subtype: Link
       Rect: 465, 117, 474, 126
       Flags: Print
       AppearanceDictionary: true
       Destination: 93
      Annotation: 
       Subtype: Link
       Rect: 398, 81, 403, 90
       Flags: Print
       AppearanceDictionary: true
       Destination: 126
     Thumb: true
    Page: 
     Sequence: 4
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 111, 357, 116, 366
       Flags: Print
       AppearanceDictionary: true
       Destination: 126
      Annotation: 
       Subtype: Link
       Rect: 333, 93, 343, 102
       Flags: Print
       AppearanceDictionary: true
       Destination: 138
     Thumb: true
    Page: 
     Sequence: 5
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 257, 57, 267, 66
       Flags: Print
       AppearanceDictionary: true
       Destination: 138
      Annotation: 
       Subtype: Link
       Rect: 469, 561, 479, 570
       Flags: Print
       AppearanceDictionary: true
       Destination: 152
      Annotation: 
       Subtype: Link
       Rect: 337, 477, 347, 486
       Flags: Print
       AppearanceDictionary: true
       Destination: 152
      Annotation: 
       Subtype: Link
       Rect: 353, 477, 363, 486
       Flags: Print
       AppearanceDictionary: true
       Destination: 152
      Annotation: 
       Subtype: Link
       Rect: 307, 357, 317, 366
       Flags: Print
       AppearanceDictionary: true
       Destination: 152
      Annotation: 
       Subtype: Link
       Rect: 492, 357, 502, 366
       Flags: Print
       AppearanceDictionary: true
       Destination: 152
      Annotation: 
       Subtype: Link
       Rect: 451, 345, 461, 354
       Flags: Print
       AppearanceDictionary: true
       Destination: 152
      Annotation: 
       Subtype: Link
       Rect: 476, 285, 485, 294
       Flags: Print
       AppearanceDictionary: true
       Destination: 152
      Annotation: 
       Subtype: Link
       Rect: 499, 237, 503, 246
       Flags: Print
       AppearanceDictionary: true
       Destination: 138
      Annotation: 
       Subtype: Link
       Rect: 508, 237, 513, 246
       Flags: Print
       AppearanceDictionary: true
       Destination: 138
      Annotation: 
       Subtype: Link
       Rect: 518, 237, 522, 246
       Flags: Print
       AppearanceDictionary: true
       Destination: 138
      Annotation: 
       Subtype: Link
       Rect: 445, 189, 455, 198
       Flags: Print
       AppearanceDictionary: true
       Destination: 152
      Annotation: 
       Subtype: Link
       Rect: 462, 189, 472, 198
       Flags: Print
       AppearanceDictionary: true
       Destination: 152
      Annotation: 
       Subtype: Link
       Rect: 437, 129, 447, 138
       Flags: Print
       AppearanceDictionary: true
       Destination: 152
      Annotation: 
       Subtype: Link
       Rect: 421, 105, 430, 114
       Flags: Print
       AppearanceDictionary: true
       Destination: 152
      Annotation: 
       Subtype: Link
       Rect: 436, 105, 446, 114
       Flags: Print
       AppearanceDictionary: true
       Destination: 152
      Annotation: 
       Subtype: Link
       Rect: 400, 57, 410, 66
       Flags: Print
       AppearanceDictionary: true
       Destination: 152
      Annotation: 
       Subtype: Link
       Rect: 415, 57, 425, 66
       Flags: Print
       AppearanceDictionary: true
       Destination: 152
     Thumb: true
    Page: 
     Sequence: 6
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 87, 429, 97, 438
       Flags: Print
       AppearanceDictionary: true
       Destination: 152
      Annotation: 
       Subtype: Link
       Rect: 103, 429, 112, 438
       Flags: Print
       AppearanceDictionary: true
       Destination: 152
      Annotation: 
       Subtype: Link
       Rect: 187, 333, 197, 342
       Flags: Print
       AppearanceDictionary: true
       Destination: 152
      Annotation: 
       Subtype: Link
       Rect: 75, 249, 79, 258
       Flags: Print
       AppearanceDictionary: true
       Destination: 138
      Annotation: 
       Subtype: Link
       Rect: 277, 189, 287, 198
       Flags: Print
       AppearanceDictionary: true
       Destination: 152
      Annotation: 
       Subtype: Link
       Rect: 277, 153, 287, 162
       Flags: Print
       AppearanceDictionary: true
       Destination: 152
     Thumb: true
    Page: 
     Sequence: 7
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 319, 633, 392, 641
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
    Page: 
     Sequence: 8
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 187, 393, 286, 400
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 71, 384, 276, 391
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
  Checksum: 8f21c581
   Type: CRC32
  Checksum: 668086ad9a4ec9746cb079c5fc4b4882
   Type: MD5
  Checksum: f3c69d5f38d78fe28e75d036a7391ce6b2b9af7b
   Type: SHA-1
  Checksum: 76df6c0df847e0257b4b8f796261a3466572ce8dfad1d9f605ea0393dc832a1f
   Type: SHA-256