158860ed8cc514acd1f0bffb566c808c pmc_29358916.pdf 9d25ce1b0289857cb6524fa899d715092abfe22e pmc_29358916.pdf 45843712e78862f25639493a964d1604dffa3dc170aa147da1bd439966d81c4d pmc_29358916.pdf Title: Reducing the Levels of Akt Activation by PDK1 Knock-in Mutation Protects Neuronal Cultures against Synthetic Amyloid-Beta Peptides Subject: The Akt kinase has been widely assumed for years as a key downstream effector of the PI3K signaling pathway in promoting neuronal survival. Keywords: PDK1/Akt, knock-in mouse, Alzheimer disease, TACE α-secretase, unfolding protein response Author: Jose R. Bayascas Creator: LaTeX with hyperref package + hypdvips Producer: dvips + MiKTeX GPL Ghostscript 9.0 CreationDate: Fri Jan 5 07:55:50 2018 CET ModDate: Fri Jan 5 07:59:17 2018 CET Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 19 Encrypted: no Page size: 595.26 x 779.52 pts Page rot: 0 File size: 7849636 bytes Optimized: no PDF version: 1.5 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- UQJOEK+MinionPro-Regular Type 1C Custom yes yes no 83 0 WBCJEU+MTGUB Type 1C Custom yes yes no 81 0 KRXKRG+MTGU Type 1C Custom yes yes no 79 0 OLSJKN+HelveticaNeueLTStd-MdIt Type 1C WinAnsi yes yes no 72 0 TGEXUW+HelveticaNeueLTStd-LtIt Type 1C Custom yes yes no 67 0 FZSBHM+HelveticaNeueLTStd-BdIt Type 1C WinAnsi yes yes no 65 0 SWTNLV+HelveticaNeueLTStd-Lt Type 1C Custom yes yes no 48 0 PXKXHX+HelveticaNeueLTStd-Bd Type 1C Custom yes yes no 43 0 AEOMKV+RMTMI Type 1C Custom yes yes no 147 0 EVVQGU+MTSY Type 1C Custom yes yes yes 181 0 YNOYNR+MinionPro-It Type 1C Custom yes yes no 175 0 NIFUBG+MinionPro-Bold Type 1C Custom yes yes no 196 0 MAFHMF+CMR6 Type 1C WinAnsi yes yes no 232 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2024-01-19 07:03:46 CET RepresentationInformation: pmc_29358916.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2020-08-10 03:39:19 CEST Size: 7849636 Format: PDF Version: 1.5 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 613 FreeObjects: 1 IncrementalUpdates: 1 DocumentCatalog: ViewerPreferences: HideToolbar: false HideMenubar: false HideWindowUI: false FitWindow: true CenterWindow: false DisplayDocTitle: false NonFullScreenPageMode: UseNone Direction: L2R ViewArea: CropBox ViewClip: CropBox PrintArea: CropBox PageClip: CropBox PageLayout: SinglePage PageMode: UseOutlines Language: en Outlines: Item: Title: げづつふっどので〠ぴとづ〠がづぶづぬび〠はて〠ぁにぴ〠ぁっぴどぶちぴどはの〠ぢべ〠ぐいか〱〠かのはっに〭どの〠きふぴちぴどはの〠ぐひはぴづっぴび〠ぎづふひはのちぬ〠ぃふぬぴふひづび〠ちでちどのびぴ〠こべのぴとづぴどっ〠ぁねべぬはどつ〭あづぴち〠ぐづばぴどつづび Destination: ariclecounter.1 Children: Item: Title: ぉのぴひはつふっぴどはの Destination: section*.2 Item: Title: きちぴづひどちぬび〠ちのつ〠きづぴとはつび Destination: section*.3 Children: Item: Title: きどっづ Destination: section*.4 Item: Title: ぐひどねちひべ〠ぃふぬぴふひづび〠はて〠ぅねぢひべはのどっ〠ぎづふひはのび〠ちのつ〠ぃづぬぬ〠ぁびびちべび Destination: section*.5 Item: Title: ぇづのづひちぴどはの〠はて〠ぐひはぴづどの〠ぅへぴひちっぴび〠ちのつ〠しづびぴづひの〠あぬはぴ〠ぁのちぬべびどび Destination: section*.6 Item: Title: きづねぢひちのづ〠ちのつ〠ぃべぴはびはぬ〠ぐひづばちひちぴどはの Destination: section*.7 Item: Title: ぐひづばちひちぴどはの〠はて〠ぁねべぬはどつ〭あづぴち〠くぬどではねづひび Destination: section*.8 Item: Title: ごちっづ〠ぉねねふのはばひづっどばどぴちぴどはの〠ちのつ〠ごちっづ〠ぁっぴどぶどぴべ Destination: section*.9 Item: Title: けふちのぴどてどっちぴどはの〠はて〠あいぎう〠ちのつ〠びごぎうげ〱 Destination: section*.10 Item: Title: きはふびづ〠ぃべぴはにどのづ〯ぃとづねはにどのづ〠ぁびびちべび Destination: section*.11 Item: Title: あひちどの〠ぉねねふのはとどびぴはっとづねどびぴひべ Destination: section*.12 Item: Title: ぉねねふのはっべぴはっとづねどびぴひべ Destination: section*.13 Item: Title: ぁのぴどぢはつどづび Destination: section*.14 Item: Title: こぴちぴどびぴどっちぬ〠ぁのちぬべびどび Destination: section*.15 Item: Title: げづびふぬぴび Destination: section*.16 Children: Item: Title: えべばづひちっぴどぶちぴどはの〠はて〠ぴとづ〠ぐいか〱〯ぁにぴ〠こどでのちぬどので〠ぁへどび〠どの〠ぁい〠ごひちのびでづのどっ〠きどっづ〠きはつづぬび Destination: section*.17 Item: Title: ぉのっひづちびづつ〠ごちっづ〠ぁっぴどぶどぴべ〠ちのつ〠ぅぬづぶちぴづつ〠こはぬふぢぬづ〠ごぎうげ〱〠がづぶづぬび〠どの〠ぴとづ〠ぁでづつ〠ぐいか〱か〴〶〵ぅ〯か〴〶〵ぅ〠かのはっに〭どの〠きどっづ〠ぃはひぴづへ〠ちのつ〠えどばばはっちねばふび Destination: section*.18 Item: Title: ぉのっひづちびづつ〠がづぶづぬび〠はて〠ごちっづ〠ぷどぴと〠いづっひづちびづつ〠ごぎうげ〱〠がづぶづぬび〠どの〠ぴとづ〠ぐぬちびねち〠きづねぢひちのづ〠はて〠ぴとづ〠ぐいか〱か〴〶〵ぅ〯か〴〶〵ぅ〠かのはっに〭どの〠きどっづ〠ぎづふひはのび Destination: section*.19 Item: Title: げづつふっづつ〠ざふぬのづひちぢどぬどぴべ〠はて〠ぴとづ〠ぐいか〱か〴〶〵ぅ〯か〴〶〵ぅ〠ぐひどねちひべ〠ぃはひぴどっちぬ〠ぎづふひはのび〠ぴは〠ごぎう㎱–ぉのつふっづつ〠ごはへどっどぴべ Destination: section*.20 Item: Title: ぁでづ〭いづばづのつづのぴ〠ぁぴぴづのふちぴどはの〠はて〠ぴとづ〠ぐぅげか〯ぅぉう〲ぁ〠ぁへどび〠ぷどぴとどの〠ぴとづ〠さのてはぬつどので〠ぐひはぴづどの〠げづびばはのびづ〠どの〠ぴとづ〠ぐいか〱か〴〶〵ぅ〯か〴〶〵ぅ〠きどっづ Destination: section*.21 Item: Title: ぁぴぴづのふちぴづつ〠さぐげ〠こどでのちぬどので〠どの〠ぴとづ〠ぐいか〱か〴〶〵ぅ〯か〴〶〵ぅ〠ぐひどねちひべ〠ぃはひぴどっちぬ〠ぎづふひはのび〠ぃはのてづひび〠げづびどびぴちのっづ〠ぴは〠ぅげ〠こぴひづびび Destination: section*.22 Item: Title: げづつふっづつ〠ぁっぴどぶちぴどはの〠はて〠ぁにぴ〠ぐひはぴづっぴづつ〠ぴとづ〠ぐいか〱か〴〶〵ぅ〯か〴〶〵ぅ〠ぎづふひはのび〠ちでちどのびぴ〠ぁ㎲–ぉのつふっづつ〠ぃづぬぬ〠いづちぴと Destination: section*.23 Item: Title: いどびっふびびどはの Destination: section*.24 Item: Title: ぃはのっぬふびどはの Destination: section*.25 Item: Title: ぁふぴとはひ〠ぃはのぴひどぢふぴどはのび Destination: section*.26 Item: Title: うふのつどので Destination: section*.27 Item: Title: ぁっにのはぷぬづつでねづのぴび Destination: section*.28 Item: Title: こふばばぬづねづのぴちひべ〠きちぴづひどちぬ Destination: section*.29 Item: Title: げづてづひづのっづび Destination: section*.30 Info: Title: Reducing the Levels of Akt Activation by PDK1 Knock-in Mutation Protects Neuronal Cultures against Synthetic Amyloid-Beta Peptides Author: Jose R. Bayascas Subject: The Akt kinase has been widely assumed for years as a key downstream effector of the PI3K signaling pathway in promoting neuronal survival. Keywords: PDK1/Akt, knock-in mouse, Alzheimer disease, TACE α-secretase, unfolding protein response Creator: LaTeX with hyperref package + hypdvips Producer: dvips + MiKTeX GPL Ghostscript 9.0 CreationDate: Fri Jan 05 08:25:50 CET 2018 ModDate: Fri Jan 05 08:29:17 CET 2018 ID: 0x0bb7b88085105359eb6e13af11e51033, 0xff9e92eb0c13204496e6577886607bd1 Filters: FilterPipeline: FlateDecode FilterPipeline: DCTDecode Images: Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 3246 ImageHeight: 4131 ColorSpace: black is zero BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 2217 ImageHeight: 2663 ColorSpace: black is zero BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 2353 ImageHeight: 2671 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg 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Bayascas The Akt kinase has been widely assumed for years as a key downstream effector of the PI3K signaling pathway in promoting neuronal survival. The Akt kinase has been widely assumed for years as a key downstream effector of the PI3K signaling pathway in promoting neuronal survival. 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Subtype: Link Rect: 47, 111, 81, 122 Destination: External Annotation: Subtype: Link Rect: 493, 88, 546, 99 Destination: External Annotation: Subtype: Link Rect: 43, 29, 140, 37 Annotation: Subtype: Link Rect: 144, 29, 204, 37 Annotation: Subtype: Link Rect: 437, 29, 551, 38 Page: Label: 〹 Sequence: 9 Annotations: Annotation: Subtype: Link Rect: 47, 695, 99, 705 Destination: External Annotation: Subtype: Link Rect: 256, 610, 67, 610 Destination: External Annotation: Subtype: Link Rect: 73, 598, 93, 610 Destination: External Annotation: Subtype: Link Rect: 88, 575, 110, 587 Destination: External Annotation: Subtype: Link Rect: 112, 575, 132, 587 Destination: External Annotation: Subtype: Link Rect: 268, 564, 66, 564 Destination: External Annotation: Subtype: Link Rect: 71, 552, 91, 564 Destination: External Annotation: Subtype: Link Rect: 203, 458, 244, 469 Destination: External Annotation: Subtype: Link Rect: 47, 401, 88, 412 Destination: External Annotation: Subtype: Link Rect: 118, 332, 158, 343 Destination: External Annotation: Subtype: Link Rect: 164, 156, 206, 166 Destination: External Annotation: Subtype: Link Rect: 186, 110, 239, 121 Destination: External Annotation: Subtype: Link Rect: 206, 87, 248, 98 Destination: External Annotation: Subtype: Link Rect: 307, 708, 368, 720 Destination: External Annotation: Subtype: Link Rect: 370, 708, 390, 720 Destination: External Annotation: Subtype: Link Rect: 413, 518, 469, 529 Destination: External Annotation: Subtype: Link Rect: 472, 518, 492, 529 Destination: External Annotation: Subtype: Link Rect: 382, 390, 423, 400 Destination: External Annotation: Subtype: Link Rect: 367, 355, 408, 366 Destination: External Annotation: Subtype: Link Rect: 359, 64, 400, 75 Destination: External Annotation: Subtype: Link Rect: 43, 29, 140, 37 Annotation: Subtype: Link Rect: 144, 29, 204, 37 Annotation: Subtype: Link Rect: 437, 29, 551, 38 Page: Label: 〱〰 Sequence: 10 Annotations: Annotation: Subtype: Link Rect: 47, 74, 87, 84 Destination: External Annotation: Subtype: Link Rect: 43, 29, 140, 37 Annotation: Subtype: Link Rect: 144, 29, 204, 37 Annotation: Subtype: Link Rect: 437, 29, 551, 38 Page: Label: 〱〱 Sequence: 11 Annotations: Annotation: Subtype: Link Rect: 376, 135, 417, 145 Destination: External Annotation: Subtype: Link Rect: 505, 66, 546, 76 Destination: External Annotation: Subtype: Link Rect: 43, 29, 140, 37 Annotation: Subtype: Link Rect: 144, 29, 204, 37 Annotation: Subtype: Link Rect: 437, 29, 551, 38 Page: Label: 〱〲 Sequence: 12 Annotations: Annotation: Subtype: Link Rect: 47, 107, 88, 117 Destination: External Annotation: Subtype: Link Rect: 307, 164, 360, 174 Destination: External Annotation: Subtype: Link Rect: 376, 152, 416, 163 Destination: External Annotation: Subtype: Link Rect: 435, 141, 476, 151 Destination: External Annotation: Subtype: Link Rect: 43, 29, 140, 37 Annotation: Subtype: Link Rect: 144, 29, 204, 37 Annotation: Subtype: Link Rect: 437, 29, 551, 38 Page: Label: 〱〳 Sequence: 13 Annotations: Annotation: Subtype: Link Rect: 241, 134, 276, 144 Destination: External Annotation: Subtype: Link Rect: 391, 159, 427, 170 Destination: External Annotation: Subtype: Link Rect: 431, 159, 451, 170 Destination: External Annotation: Subtype: Link Rect: 416, 113, 472, 124 Destination: External Annotation: Subtype: Link Rect: 477, 113, 497, 124 Destination: External Annotation: Subtype: Link Rect: 502, 113, 549, 124 Destination: External Annotation: Subtype: Link Rect: 304, 102, 324, 113 Destination: External Annotation: Subtype: Link Rect: 43, 29, 140, 37 Annotation: Subtype: Link Rect: 144, 29, 204, 37 Annotation: Subtype: Link Rect: 437, 29, 551, 38 Page: Label: 〱〴 Sequence: 14 Annotations: Annotation: Subtype: Link Rect: 43, 29, 140, 37 Annotation: Subtype: Link Rect: 144, 29, 204, 37 Annotation: Subtype: Link Rect: 437, 29, 551, 38 Page: Label: 〱〵 Sequence: 15 Annotations: Annotation: Subtype: Link Rect: 243, 583, 289, 594 Destination: External Annotation: Subtype: Link Rect: 43, 571, 64, 583 Destination: External Annotation: Subtype: Link Rect: 131, 537, 191, 549 Destination: External Annotation: Subtype: Link Rect: 193, 537, 214, 549 Destination: External Annotation: Subtype: Link Rect: 121, 491, 167, 503 Destination: External Annotation: Subtype: Link Rect: 171, 491, 191, 503 Destination: External Annotation: Subtype: Link Rect: 185, 468, 263, 480 Destination: External Annotation: Subtype: Link Rect: 265, 468, 285, 480 Destination: External Annotation: Subtype: Link Rect: 126, 331, 199, 342 Destination: External Annotation: Subtype: Link Rect: 203, 331, 223, 342 Destination: External Annotation: Subtype: Link Rect: 226, 331, 264, 342 Destination: External Annotation: Subtype: Link Rect: 267, 331, 287, 342 Destination: External Annotation: Subtype: Link Rect: 100, 319, 168, 331 Destination: External Annotation: Subtype: Link Rect: 173, 319, 193, 331 Destination: External Annotation: Subtype: Link Rect: 78, 285, 142, 296 Destination: External Annotation: Subtype: Link Rect: 148, 285, 168, 296 Destination: External Annotation: Subtype: Link Rect: 175, 285, 232, 296 Destination: External Annotation: Subtype: Link Rect: 238, 285, 258, 296 Destination: External Annotation: Subtype: Link Rect: 265, 285, 64, 285 Destination: External Annotation: Subtype: Link Rect: 68, 274, 88, 285 Destination: External Annotation: Subtype: Link Rect: 88, 228, 150, 239 Destination: External Annotation: Subtype: Link Rect: 153, 228, 174, 239 Destination: External Annotation: Subtype: Link Rect: 178, 228, 264, 239 Destination: External Annotation: Subtype: Link Rect: 268, 228, 289, 239 Destination: External Annotation: Subtype: Link Rect: 43, 216, 127, 228 Destination: External Annotation: Subtype: Link Rect: 133, 216, 153, 228 Destination: External Annotation: Subtype: Link Rect: 190, 182, 232, 193 Destination: External Annotation: Subtype: Link Rect: 236, 182, 256, 193 Destination: External Annotation: Subtype: Link Rect: 259, 182, 289, 193 Destination: External Annotation: Subtype: Link Rect: 43, 170, 64, 182 Destination: External Annotation: Subtype: Link Rect: 307, 606, 370, 617 Destination: External Annotation: Subtype: Link Rect: 375, 606, 395, 617 Destination: External Annotation: Subtype: Link Rect: 393, 549, 453, 560 Destination: External Annotation: Subtype: Link Rect: 457, 549, 477, 560 Destination: External Annotation: Subtype: Link Rect: 460, 514, 506, 526 Destination: External Annotation: Subtype: Link Rect: 509, 514, 529, 526 Destination: External Annotation: Subtype: Link Rect: 393, 468, 447, 480 Destination: External Annotation: Subtype: Link Rect: 451, 468, 471, 480 Destination: External Annotation: Subtype: Link Rect: 475, 468, 549, 480 Destination: External Annotation: Subtype: Link Rect: 304, 457, 324, 468 Destination: External Annotation: Subtype: Link Rect: 482, 445, 549, 457 Destination: External Annotation: Subtype: Link Rect: 304, 434, 324, 445 Destination: External Annotation: Subtype: Link Rect: 358, 388, 380, 400 Destination: External Annotation: Subtype: Link Rect: 384, 388, 404, 400 Destination: External Annotation: Subtype: Link Rect: 307, 365, 366, 377 Destination: External Annotation: Subtype: Link Rect: 369, 365, 389, 377 Destination: External Annotation: Subtype: Link Rect: 307, 331, 364, 342 Destination: External Annotation: Subtype: Link Rect: 369, 331, 389, 342 Destination: External Annotation: Subtype: Link Rect: 394, 331, 434, 342 Destination: External Annotation: Subtype: Link Rect: 439, 331, 459, 342 Destination: External Annotation: Subtype: Link Rect: 307, 285, 356, 296 Destination: External Annotation: Subtype: Link Rect: 361, 285, 381, 296 Destination: External Annotation: Subtype: Link Rect: 43, 29, 140, 37 Annotation: Subtype: Link Rect: 144, 29, 204, 37 Annotation: Subtype: Link Rect: 437, 29, 551, 38 Page: Label: 〱〶 Sequence: 16 Annotations: Annotation: Subtype: Link Rect: 474, 674, 525, 685 Destination: External Annotation: Subtype: Link Rect: 529, 674, 549, 685 Destination: External Annotation: Subtype: Link Rect: 304, 662, 362, 674 Destination: External Annotation: Subtype: Link Rect: 365, 662, 385, 674 Destination: External Annotation: Subtype: Link Rect: 350, 651, 409, 662 Destination: External Annotation: Subtype: Link Rect: 411, 651, 432, 662 Destination: External Annotation: Subtype: Link Rect: 434, 651, 473, 662 Destination: External Annotation: Subtype: Link Rect: 475, 651, 495, 662 Destination: External Annotation: Subtype: Link Rect: 498, 651, 549, 662 Destination: External Annotation: Subtype: Link Rect: 304, 640, 324, 651 Destination: External Annotation: Subtype: Link Rect: 374, 628, 418, 640 Destination: External Annotation: Subtype: Link Rect: 422, 628, 442, 640 Destination: External Annotation: Subtype: Link Rect: 491, 617, 522, 628 Destination: External Annotation: Subtype: Link Rect: 525, 617, 546, 628 Destination: External Annotation: Subtype: Link Rect: 491, 605, 523, 617 Destination: External Annotation: Subtype: Link Rect: 525, 605, 546, 617 Destination: External Annotation: Subtype: Link Rect: 307, 491, 394, 502 Destination: External Annotation: Subtype: Link Rect: 397, 491, 417, 502 Destination: External Annotation: Subtype: Link Rect: 391, 468, 470, 479 Destination: External Annotation: Subtype: Link Rect: 473, 468, 493, 479 Destination: External Annotation: Subtype: Link Rect: 436, 422, 470, 433 Destination: External Annotation: Subtype: Link Rect: 473, 422, 493, 433 Destination: External Annotation: Subtype: Link Rect: 524, 296, 326, 296 Destination: External Annotation: Subtype: Link Rect: 331, 284, 351, 296 Destination: External Annotation: Subtype: Link Rect: 356, 284, 434, 296 Destination: External Annotation: Subtype: Link Rect: 439, 284, 459, 296 Destination: External Annotation: Subtype: Link Rect: 332, 135, 388, 147 Destination: External Annotation: Subtype: Link Rect: 393, 135, 413, 147 Destination: External Annotation: Subtype: Link Rect: 464, 67, 499, 78 Destination: External Annotation: Subtype: Link Rect: 502, 67, 522, 78 Destination: External Annotation: Subtype: Link Rect: 43, 29, 140, 37 Annotation: Subtype: Link Rect: 144, 29, 204, 37 Annotation: Subtype: Link Rect: 437, 29, 551, 38 Page: Label: 〱〷 Sequence: 17 Annotations: Annotation: Subtype: Link Rect: 104, 674, 167, 685 Destination: External Annotation: Subtype: Link Rect: 172, 674, 192, 685 Destination: External Annotation: Subtype: Link Rect: 110, 651, 150, 662 Destination: External Annotation: Subtype: Link Rect: 155, 651, 176, 662 Destination: External Annotation: Subtype: Link Rect: 47, 548, 83, 559 Destination: External Annotation: Subtype: Link Rect: 86, 548, 106, 559 Destination: External Annotation: Subtype: Link Rect: 175, 534, 244, 545 Annotation: Subtype: Link Rect: 242, 535, 247, 545 Destination: External Annotation: Subtype: Link Rect: 552, 304, 303, 329 Annotation: Subtype: Link Rect: 95, 224, 194, 233 Annotation: Subtype: Link Rect: 66, 187, 131, 194 Annotation: Subtype: Link Rect: 111, 147, 190, 157 Annotation: Subtype: Link Rect: 66, 119, 170, 128 Annotation: Subtype: Link Rect: 66, 92, 131, 100 Annotation: Subtype: Link Rect: 177, 73, 241, 81 Annotation: Subtype: Link Rect: 405, 252, 482, 261 Annotation: Subtype: Link Rect: 363, 215, 436, 223 Annotation: Subtype: Link Rect: 492, 196, 545, 204 Annotation: Subtype: Link Rect: 379, 157, 448, 166 Annotation: Subtype: Link Rect: 369, 119, 451, 128 Annotation: Subtype: Link Rect: 552, 71, 313, 92 Annotation: Subtype: Link Rect: 43, 28, 140, 36 Annotation: Subtype: Link Rect: 144, 28, 204, 36 Annotation: Subtype: Link Rect: 437, 28, 551, 37 Page: Label: 〱〸 Sequence: 18 Annotations: Annotation: Subtype: Link Rect: 117, 678, 196, 687 Annotation: Subtype: Link Rect: 66, 641, 162, 649 Annotation: Subtype: Link Rect: 130, 612, 209, 621 Annotation: Subtype: Link Rect: 141, 583, 211, 593 Annotation: Subtype: Link Rect: 102, 528, 176, 536 Annotation: Subtype: Link Rect: 66, 462, 152, 469 Annotation: Subtype: Link Rect: 102, 424, 152, 431 Annotation: Subtype: Link Rect: 182, 404, 254, 413 Annotation: Subtype: Link Rect: 205, 367, 265, 375 Annotation: Subtype: Link Rect: 204, 347, 275, 356 Annotation: Subtype: Link Rect: 292, 317, 52, 338 Annotation: Subtype: Link Rect: 137, 290, 190, 299 Annotation: Subtype: Link Rect: 201, 273, 277, 280 Annotation: Subtype: Link Rect: 66, 244, 130, 252 Annotation: Subtype: Link Rect: 95, 214, 179, 223 Annotation: Subtype: Link Rect: 66, 178, 178, 185 Annotation: Subtype: Link Rect: 121, 159, 210, 166 Annotation: Subtype: Link Rect: 66, 121, 125, 129 Annotation: Subtype: Link Rect: 66, 72, 170, 81 Annotation: Subtype: Link Rect: 416, 689, 475, 696 Annotation: Subtype: Link Rect: 356, 650, 426, 659 Annotation: Subtype: Link Rect: 327, 623, 380, 630 Annotation: Subtype: Link Rect: 359, 585, 425, 592 Annotation: Subtype: Link Rect: 421, 564, 500, 574 Annotation: Subtype: Link Rect: 394, 538, 475, 545 Annotation: Subtype: Link Rect: 327, 500, 407, 507 Annotation: Subtype: Link Rect: 473, 480, 536, 488 Annotation: Subtype: Link Rect: 327, 442, 435, 450 Annotation: Subtype: Link Rect: 348, 413, 411, 422 Annotation: Subtype: Link Rect: 438, 394, 546, 403 Annotation: Subtype: Link Rect: 327, 347, 410, 356 Annotation: Subtype: Link Rect: 482, 320, 534, 327 Annotation: Subtype: Link Rect: 349, 281, 412, 289 Annotation: Subtype: Link Rect: 472, 252, 549, 261 Annotation: Subtype: Link Rect: 445, 233, 539, 243 Annotation: Subtype: Link Rect: 385, 195, 500, 205 Annotation: Subtype: Link Rect: 356, 167, 447, 176 Annotation: Subtype: Link Rect: 327, 129, 407, 138 Annotation: Subtype: Link Rect: 457, 101, 520, 110 Annotation: Subtype: Link Rect: 327, 72, 412, 81 Annotation: Subtype: Link Rect: 43, 29, 140, 37 Annotation: Subtype: Link Rect: 144, 29, 204, 37 Annotation: Subtype: Link Rect: 437, 29, 551, 38 Page: Label: 〱〹 Sequence: 19 Annotations: Annotation: Subtype: Link Rect: 292, 679, 52, 697 Annotation: Subtype: Link Rect: 66, 641, 166, 649 Annotation: Subtype: Link Rect: 110, 593, 218, 602 Annotation: Subtype: Link Rect: 66, 555, 150, 564 Annotation: Subtype: Link Rect: 150, 527, 235, 536 Annotation: Subtype: Link Rect: 66, 489, 162, 498 Annotation: Subtype: Link Rect: 144, 452, 198, 460 Annotation: Subtype: Link Rect: 176, 424, 288, 431 Annotation: Subtype: Link Rect: 142, 394, 229, 403 Annotation: Subtype: Link Rect: 209, 366, 291, 375 Annotation: Subtype: Link Rect: 66, 328, 166, 337 Annotation: Subtype: Link Rect: 66, 290, 146, 299 Annotation: Subtype: Link Rect: 159, 215, 215, 223 Annotation: Subtype: Link Rect: 292, 175, 52, 196 Annotation: Subtype: Link Rect: 407, 669, 464, 678 Annotation: Subtype: Link Rect: 409, 642, 516, 649 Annotation: Subtype: Link Rect: 355, 613, 440, 621 Annotation: Subtype: Link Rect: 346, 583, 456, 592 Annotation: Subtype: Link Rect: 327, 555, 406, 564 Annotation: Subtype: Link Rect: 327, 519, 394, 526 Annotation: Subtype: Link Rect: 363, 442, 425, 450 Annotation: Subtype: Link Rect: 327, 404, 408, 413 Annotation: Subtype: Link Rect: 327, 377, 386, 384 Annotation: Subtype: Link Rect: 391, 348, 486, 356 Annotation: Subtype: Link Rect: 353, 311, 427, 318 Annotation: Subtype: Link Rect: 339, 216, 365, 223 Annotation: Subtype: Link Rect: 365, 216, 397, 223 Annotation: Subtype: Link Rect: 396, 216, 431, 224 Annotation: Subtype: Link Rect: 431, 216, 454, 223 Annotation: Subtype: Link Rect: 453, 215, 480, 224 Annotation: Subtype: Link Rect: 43, 29, 140, 37 Annotation: Subtype: Link Rect: 144, 29, 204, 37 Annotation: Subtype: Link Rect: 437, 29, 551, 38 Checksum: 47e20621 Type: CRC32 Checksum: 158860ed8cc514acd1f0bffb566c808c Type: MD5 Checksum: 9d25ce1b0289857cb6524fa899d715092abfe22e Type: SHA-1 Checksum: 45843712e78862f25639493a964d1604dffa3dc170aa147da1bd439966d81c4d Type: SHA-256