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Title:          Phosphatidylserine-Liposomes Promote Tolerogenic Features on Dendritic Cells in Human Type 1 Diabetes by Apoptotic Mimicry
Subject:        Type 1 diabetes (T1D) is a metabolic disease caused by the autoimmune destruction of insulin-producing β-cells.
Keywords:       immunotherapy, autoimmunity, human type 1 diabetes, liposomes, tolerance, dendritic cells
Author:         Marta Vives-Pi
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     Item: 
      Title: Phosphatidylserine-Liposomes Promote Tolerogenic Features on Dendritic Cells in Human Type 1 Diabetes by Apoptotic Mimicry
      Children: 
       Item: 
        Title: Introduction
       Item: 
        Title: Materials and Methods
        Children: 
         Item: 
          Title: Patients
         Item: 
          Title: Cell Separation and Generation of DCs
         Item: 
          Title: Peptide Selection and Preparation of Liposomes
         Item: 
          Title: Phagocytosis Assay
         Item: 
          Title: Assessment of DCs Phenotype after Liposome Uptake
         Item: 
          Title: T Cell Proliferation Assays
         Item: 
          Title: Cytokine Production
         Item: 
          Title: RNA-Seq of DCs before and after Liposome Phagocytosis
         Item: 
          Title: Quantitative RT-PCR
         Item: 
          Title: Statistical Analysis
       Item: 
        Title: Results
        Children: 
         Item: 
          Title: Patients with T1D and Control Subjects Display Similar Features
         Item: 
          Title: DC Differentiation Efficiency Is Similar in Patients with T1D and Control Subjects
         Item: 
          Title: PS-Liposomes Show Multivesicular Vesicle Morphology and Encapsulate Insulin Peptides
         Item: 
          Title: Human DCs Display Optimal Kinetics of PS-Liposomes Phagocytosis without Affecting Viability
         Item: 
          Title: PS-Liposomes Uptake Regulates the Phenotypic Maturation of Human DCs
         Item: 
          Title: PS-Liposomes Uptake Impairs DCs Ability to Stimulate Autologous T Cell Proliferation
         Item: 
          Title: Transcriptional Changes in DCs from Patients with T1D after PS-Liposomes Phagocytosis Point to an Immunoregulatory Prolife
       Item: 
        Title: Discussion
       Item: 
        Title: Ethics Statement
       Item: 
        Title: Author Contributions
       Item: 
        Title: Acknowledgments
       Item: 
        Title: Funding
       Item: 
        Title: Supplementary Material
       Item: 
        Title: References
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    Title: Phosphatidylserine-Liposomes Promote Tolerogenic Features on Dendritic Cells in Human Type 1 Diabetes by Apoptotic Mimicry
    Author: Marta Vives-Pi
    Subject: Type 1 diabetes (T1D) is a metabolic disease caused by the autoimmune destruction of insulin-producing β-cells.
    Keywords: immunotherapy, autoimmunity, human type 1 diabetes, liposomes, tolerance, dendritic cells
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