bcd0e6c05b2ad65357dd541ef9a99e30 pmc_29511289.pdf 2d61215cc4ff0cfdee2314d4eab2cc1ca58b6914 pmc_29511289.pdf 6cb7bfaae1f4e484dd3c0123308d4215adc3478967356d2b6f5141921164fb97 pmc_29511289.pdf Title: Novel phosphorylated TAK1 species with functional impact on NF-κB and β-catenin signaling in human Cutaneous T-cell lymphoma Subject: Leukemia, doi:10.1038/s41375-018-0066-4 Keywords: Author: Fernando Gallardo Creator: Springer CreationDate: Sat Sep 22 12:02:13 2018 CEST ModDate: Sat Sep 22 12:10:47 2018 CEST Tagged: no UserProperties: no Suspects: no Form: AcroForm JavaScript: no Pages: 13 Encrypted: no Page size: 595.276 x 790.866 pts Page rot: 0 File size: 3280188 bytes Optimized: yes PDF version: 1.4 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- NBAKCI+AdvOT5fcf1b24 Type 1C WinAnsi yes yes no 464 0 NBAKPM+AdvOTf9433e2d+fb Type 1C Custom yes yes yes 487 0 NBAKPN+AdvOTf9433e2d+20 Type 1C WinAnsi yes yes no 492 0 NBALAO+AdvTTab7e17fd Type 1C WinAnsi yes yes no 493 0 NBALAP+AdvTT4ff65459 Type 1C WinAnsi yes yes no 498 0 NBALBA+AdvOT9d60b855.B Type 1C WinAnsi yes yes no 497 0 NBAKDJ+AdvOT5fcf1b24+20 Type 1C WinAnsi yes yes no 468 0 NBAKDK+AdvOTce3d9a73 Type 1C WinAnsi yes yes no 469 0 NBAKJJ+AdvOTc20ddc96 Type 1C WinAnsi yes yes no 472 0 NBAKJK+AdvOTc20ddc96+03 Type 1C Custom yes yes yes 473 0 NBAKKK+AdvOT8608a8d1+25 Type 1C Custom yes yes yes 474 0 NBAKOK+AdvOT3b30f6db.B Type 1C WinAnsi yes yes no 477 0 NBAKPK+AdvOTf9433e2d Type 1C WinAnsi yes yes no 478 0 NBAKPL+AdvOT8608a8d1+03 Type 1C Custom yes yes yes 485 0 NBALHO+AdvOT35387326.B Type 1C WinAnsi yes yes no 233 0 NBALIP+AdvOTb4af3d5d.I Type 1C WinAnsi yes yes no 234 0 NBALNO+AdvOT35387326.B+fb Type 1C Custom yes yes yes 249 0 NBALNP+AdvOTf9433e2d+03 Type 1C Custom yes yes yes 245 0 NBALPP+AdvOT35387326.B+03 Type 1C Custom yes yes yes 246 0 NBAPEM+ArialMT Type 1C WinAnsi yes yes no 271 0 NBCMPH+AdvOT35387326.B+20 Type 1C WinAnsi yes yes no 294 0 NBEJFK+Arial-BoldMT Type 1C WinAnsi yes yes no 305 0 Calibri-Bold Type 1C WinAnsi yes no no 304 0 NBFACC+AdvOTc20ddc96+fb Type 1C Custom yes yes yes 307 0 Jhove (Rel. 1.22.1, 2019-04-17) Date: 2021-06-03 02:39:49 CEST RepresentationInformation: pmc_29511289.pdf ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17) LastModified: 2020-02-24 03:46:29 CET Size: 3280188 Format: PDF Version: 1.4 Status: Well-Formed, but not valid SignatureMatches: PDF-hul ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR11' cannot be found Offset: 3234860 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR12' cannot be found Offset: 3234860 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR18' cannot be found Offset: 3234860 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR19' cannot be found Offset: 3234860 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR20' cannot be found Offset: 3234860 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR21' cannot be found Offset: 3234860 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR23' cannot be found Offset: 3234860 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR24' cannot be found Offset: 3234860 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR26' cannot be found Offset: 3234860 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR27' cannot be found Offset: 3234860 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR28' cannot be found Offset: 3234860 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR29' cannot be found Offset: 3234860 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR30' cannot be found Offset: 3234860 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR31' cannot be found Offset: 3234860 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR32' cannot be found Offset: 3234860 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR33' cannot be found Offset: 3234860 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR10' cannot be found Offset: 3234860 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR34' cannot be found Offset: 3234860 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR35' cannot be found Offset: 3234860 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR38' cannot be found Offset: 3234860 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR39' cannot be found Offset: 3234860 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR35' cannot be found Offset: 3234860 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR37' cannot be found Offset: 3234860 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR40' cannot be found Offset: 3234860 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR42' cannot be found Offset: 3234860 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR43' cannot be found Offset: 3234860 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR45' cannot be found Offset: 3234860 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR46' cannot be found Offset: 3234860 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR47' cannot be found Offset: 3234860 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR38' cannot be found Offset: 3234860 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR20' cannot be found Offset: 3234860 MIMEtype: application/pdf Profile: Linearized PDF PDFMetadata: Objects: 566 FreeObjects: 1 IncrementalUpdates: 1 DocumentCatalog: PageLayout: SinglePage PageMode: UseOutlines Language: EN Outlines: Item: Title: Novel phosphorylated TAK1’species with functional impact on NF-κB and β-catenin signaling in human Cutaneous T-cell lymphoma Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@11758f2a Children: Item: Title: Abstract Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@e720b71 Item: Title: Introduction Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1b26f7b2 Item: Title: Materials and Methods Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@491cc5c9 Children: Item: Title: Cell cultures and cell lines Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@74ad1f1f Item: Title: SeAx tumor model in NSG mouse Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6a1aab78 Item: Title: Antibodies against active TAK1 Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@462d5aee Item: Title: Generation of TAK1 point mutants and cell transfection Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@69b0fd6f Item: Title: Gel filtration assay on Superdex200 columns Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@757942a1 Item: Title: Mass spectrometry analysis Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4a87761d Item: Title: Tissue samples and sample preparation Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@66d1af89 Item: Title: Statistical methods for biomarker correlations Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@8646db9 Item: Title: Image analysis Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@37374a5e Item: Title: Results and discussion Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4671e53b Children: Item: Title: PP1 activity counteracts the TAK1-dependent activation of NF-κB signaling in CTCL cells Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@2db7a79b Item: Title: Regulation of canonical NF-κB by PP1 in CTCL lays downstream of the ROCK/MYPT1 pathway Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6950e31 Item: Title: PP1 regulates TAK1 phosphorylation at non-canonical regulatory sites Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@b7dd107 Item: Title: Functional impact of phosphorylation at T344, S389, T444, and T511 on TAK1 activity Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@42eca56e Item: Title: Inhibition of TAK1 reduces CTCL tumors in’vivo Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@52f759d7 Item: Title: The MYPT1–nobreakTAK1 pathway is activated in human CTCL Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7cbd213e Item: Title: Compliance with ethical standards Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@192d3247 Item: Title: ACKNOWLEDGMENTS Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@3ecd23d9 Item: Title: References Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@569cfc36 Info: Title: Novel phosphorylated TAK1 species with functional impact on NF-κB and β-catenin signaling in human Cutaneous T-cell lymphoma Author: Fernando Gallardo Subject: Leukemia, doi:10.1038/s41375-018-0066-4 Keywords: Creator: Springer CreationDate: Sat Sep 22 12:32:13 CEST 2018 ModDate: Sat Sep 22 12:40:47 CEST 2018 ID: 0xca23face574fc1e5b6d59d47f9812446, 0xd32cb3098636744fa9f6861a7a374c9b Filters: FilterPipeline: FlateDecode FilterPipeline: DCTDecode Images: Image: NisoImageMetadata: FormatName: image/png ImageWidth: 96 ImageHeight: 96 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1408 ImageHeight: 1906 BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1680 ImageHeight: 2268 ColorSpace: CMYK BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1594 ImageHeight: 914 BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1329 ImageHeight: 1104 BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 973 ImageHeight: 1170 ColorSpace: CMYK BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1682 ImageHeight: 2141 ColorSpace: CMYK BitsPerSample: 8 BitsPerSampleUnit: integer Fonts: Type1: Font: BaseFont: NBAKPL+AdvOT8608a8d1+03 FontSubset: true FirstChar: 1 LastChar: 6 FontDescriptor: FontName: NBAKPL+AdvOT8608a8d1+03 Flags: Symbolic FontBBox: -479, -364, 854, 927 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: NBCMPH+AdvOT35387326.B+20 FontSubset: true FirstChar: 150 LastChar: 150 FontDescriptor: FontName: NBCMPH+AdvOT35387326.B+20 Flags: Nonsymbolic FontBBox: -125, -197, 1156, 854 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: NBAKPM+AdvOTf9433e2d+fb FontSubset: true FirstChar: 1 LastChar: 3 FontDescriptor: FontName: NBAKPM+AdvOTf9433e2d+fb Flags: Symbolic FontBBox: 0, 0, 520, 697 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: NBALHO+AdvOT35387326.B FontSubset: true FirstChar: 44 LastChar: 121 FontDescriptor: FontName: NBALHO+AdvOT35387326.B Flags: Nonsymbolic FontBBox: -31, -250, 802, 885 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: NBALIP+AdvOTb4af3d5d.I FontSubset: true FirstChar: 45 LastChar: 121 FontDescriptor: FontName: NBALIP+AdvOTb4af3d5d.I Flags: Nonsymbolic FontBBox: -166, -208, 906, 875 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: NBAKPN+AdvOTf9433e2d+20 FontSubset: true FirstChar: 146 LastChar: 150 FontDescriptor: FontName: NBAKPN+AdvOTf9433e2d+20 Flags: Nonsymbolic FontBBox: -166, -145, 1000, 708 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: NBALAO+AdvTTab7e17fd FontSubset: true FirstChar: 43 LastChar: 61 FontDescriptor: FontName: NBALAO+AdvTTab7e17fd Flags: Nonsymbolic FontBBox: -156, -250, 1072, 947 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: NBAPEM+ArialMT FontSubset: true FirstChar: 32 LastChar: 181 FontDescriptor: FontName: NBAPEM+ArialMT Flags: Nonsymbolic FontBBox: -665, -325, 2000, 1006 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: NBAKCI+AdvOT5fcf1b24 FontSubset: true FirstChar: 40 LastChar: 169 FontDescriptor: FontName: NBAKCI+AdvOT5fcf1b24 Flags: Nonsymbolic FontBBox: -31, -250, 770, 875 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: Calibri-Bold FirstChar: 0 LastChar: 255 FontDescriptor: FontName: Calibri-Bold Flags: Nonsymbolic FontBBox: -519, -306, 1240, 971 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: NBALBA+AdvOT9d60b855.B FontSubset: true FirstChar: 69 LastChar: 121 FontDescriptor: FontName: NBALBA+AdvOT9d60b855.B Flags: Serif, Nonsymbolic FontBBox: -62, -208, 979, 927 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: NBEJFK+Arial-BoldMT FontSubset: true FirstChar: 32 LastChar: 117 FontDescriptor: FontName: NBEJFK+Arial-BoldMT Flags: Nonsymbolic FontBBox: -628, -376, 2000, 1018 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: NBALAP+AdvTT4ff65459 FontSubset: true FirstChar: 42 LastChar: 42 FontDescriptor: FontName: NBALAP+AdvTT4ff65459 Flags: Nonsymbolic FontBBox: 0, -208, 1354, 895 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: NBFACC+AdvOTc20ddc96+fb FontSubset: true FirstChar: 1 LastChar: 1 FontDescriptor: FontName: NBFACC+AdvOTc20ddc96+fb Flags: Symbolic FontBBox: 0, 0, 750, 708 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: NBAKDJ+AdvOT5fcf1b24+20 FontSubset: true FirstChar: 150 LastChar: 150 FontDescriptor: FontName: NBAKDJ+AdvOT5fcf1b24+20 Flags: Nonsymbolic FontBBox: -125, -197, 1052, 854 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: NBAKDK+AdvOTce3d9a73 FontSubset: true FirstChar: 45 LastChar: 243 FontDescriptor: FontName: NBAKDK+AdvOTce3d9a73 Flags: Nonsymbolic FontBBox: -41, -250, 854, 885 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: NBALNP+AdvOTf9433e2d+03 FontSubset: true FirstChar: 1 LastChar: 1 FontDescriptor: FontName: NBALNP+AdvOTf9433e2d+03 Flags: Symbolic FontBBox: 0, -208, 614, 697 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: NBALPP+AdvOT35387326.B+03 FontSubset: true FirstChar: 1 LastChar: 1 FontDescriptor: FontName: NBALPP+AdvOT35387326.B+03 Flags: Symbolic FontBBox: -52, -218, 729, 843 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: NBAKJJ+AdvOTc20ddc96 FontSubset: true FirstChar: 45 LastChar: 121 FontDescriptor: FontName: NBAKJJ+AdvOTc20ddc96 Flags: Nonsymbolic FontBBox: -31, -250, 791, 885 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: NBAKJK+AdvOTc20ddc96+03 FontSubset: true FirstChar: 1 LastChar: 3 FontDescriptor: FontName: NBAKJK+AdvOTc20ddc96+03 Flags: Symbolic FontBBox: -41, -208, 708, 822 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: NBALNO+AdvOT35387326.B+fb FontSubset: true FirstChar: 1 LastChar: 1 FontDescriptor: FontName: NBALNO+AdvOT35387326.B+fb Flags: Symbolic FontBBox: 0, 0, 791, 708 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: NBAKKK+AdvOT8608a8d1+25 FontSubset: true FirstChar: 1 LastChar: 1 FontDescriptor: FontName: NBAKKK+AdvOT8608a8d1+25 Flags: Symbolic FontBBox: -10, -302, 1208, 906 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: NBAKOK+AdvOT3b30f6db.B FontSubset: true FirstChar: 65 LastChar: 117 FontDescriptor: FontName: NBAKOK+AdvOT3b30f6db.B Flags: Nonsymbolic FontBBox: -31, -250, 875, 895 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: NBAKPK+AdvOTf9433e2d FontSubset: true FirstChar: 35 LastChar: 243 FontDescriptor: FontName: NBAKPK+AdvOTf9433e2d Flags: Serif, Nonsymbolic FontBBox: -62, -208, 927, 895 FontFile3: true Encoding: WinAnsiEncoding XMP: application/pdf doi:10.1038/s41375-018-0066-4 Novel phosphorylated TAK1 species with functional impact on NF-κB and β-catenin signaling in human Cutaneous T-cell lymphoma Fernando Gallardo Joan Bertran Erika López-Arribillaga Jéssica González Silvia Menéndez Ignacio Sánchez Luis Colomo Mar Iglesias Marta Garrido Luis Francisco Santamaría-Babí Ferran Torres Ramon M Pujol Anna Bigas Lluís Espinosa Springer US Leukemia, doi:10.1038/s41375-018-0066-4 10.1038/s41375-018-0066-4 http://dx.doi.org/10.1038/s41375-018-0066-4 journal Leukemia © 2018, The Author(s) 1476-5551 10.1038/s41375-018-0066-4 springer.com springerlink.com 2010-04-23 True 10.1038/s41375-018-0066-4 springer.com springerlink.com Springer 2018-09-22T15:40:47+05:30 2018-09-22T15:32:13+05:30 2018-09-22T15:40:47+05:30 True VoR uuid:dc00f267-f27a-4dba-841b-4a8c4393ddeb uuid:b1460af4-3d79-4230-b481-8d507766db6c default 1 converted uuid:364e2803-a0a8-4e57-8d47-6e302fe9210f converted to PDF/A-2b pdfToolbox 2018-09-22T15:40:47+05:30 2 B Ferran Torres http://orcid.org/0000-0002-7355-7913 http://ns.adobe.com/pdf/1.3/ pdf Adobe PDF Schema internal A name object indicating whether the document has been modified to include trapping information Trapped Text http://ns.adobe.com/pdfx/1.3/ pdfx pdfx internal ID of PDF/X standard GTS_PDFXVersion Text internal Conformance level of PDF/X standard GTS_PDFXConformance Text internal Company creating the PDF Company Text internal Date when document was last modified SourceModified Text external Mirrors crossmark:CrosMarkDomains CrossMarkDomains Seq Text internal Mirrors crossmark:DOI doi Text http://ns.adobe.com/xap/1.0/mm/ xmpMM XMP Media Management Schema internal UUID based identifier for specific incarnation of a document InstanceID URI internal The common identifier for all versions and renditions of a document. OriginalDocumentID URI http://www.aiim.org/pdfa/ns/id/ pdfaid PDF/A ID Schema internal Part of PDF/A standard part Integer internal Amendment of PDF/A standard amd Text internal Conformance level of PDF/A standard conformance Text http://crossref.org/crossmark/1.0/ crossmark crossmark internal CrossMarkDomains CrossMarkDomains Seq Text internal CrossmarkDomainExclusive CrossmarkDomainExclusive Text internal Usual same as prism:doi DOI Text external The date when a publication was published. MajorVersionDate Text http://prismstandard.org/namespaces/basic/2.0/ prism Prism external The aggregation type specifies the unit of aggregation for a content collection. Comment PRISM recommends that the PRISM Aggregation Type Controlled Vocabulary be used to provide values for this element. Note: PRISM recommends against the use of the #other value currently allowed in this controlled vocabulary. In lieu of using #other please reach out to the PRISM group at info@prismstandard.org to request addition of your term to the Aggregation Type Controlled Vocabulary. aggregationType Text external Copyright copyright Text external The Digital Object Identifier for the article. The DOI may also be used as the dc:identifier. If used as a dc:identifier, the URI form should be captured, and the bare identifier should also be captured using prism:doi. If an alternate unique identifier is used as the required dc:identifier, then the DOI should be specified as a bare identifier within prism:doi only. If the URL associated with a DOI is to be specified, then prism:url may be used in conjunction with prism:doi in order to provide the service endpoint (i.e. the URL). doi Text external ISSN for an electronic version of the issue in which the resource occurs. Permits publishers to include a second ISSN, identifying an electronic version of the issue in which the resource occurs (therefore e(lectronic)Issn. If used, prism:eIssn MUST contain the ISSN of the electronic version. See prism:issn. issn Text external Title of the magazine, or other publication, in which a resource was/will be published. Typically this will be used to provide the name of the magazine an article appeared in as metadata for the article, along with information such as the article title, the publisher, volume, number, and cover date. Note: Publication name can be used to differentiate between a print magazine and the online version if the names are different such as “magazine” and “magazine.com.” publicationName Text external This element provides the url for an article or unit of content. The attribute platform is optionally allowed for situations in which multiple URLs must be specified. PRISM recommends that a subset of the PCV platform values, namely “mobile” and “web”, be used in conjunction with this element. NOTE: PRISM recommends against the use of the #other value allowed in the PRISM Platform controlled vocabulary. In lieu of using #other please reach out to the PRISM group at prism-wg@yahoogroups.com to request addition of your term to the Platform Controlled Vocabulary. url Text http://springernature.com/ns/xmpExtensions/2.0/ sn Springer Nature ORCID Schema external Author information: contains the name of each author and his/her ORCID (ORCiD: Open Researcher and Contributor ID). An ORCID is a persistent identifier (a non-proprietary alphanumeric code) to uniquely identify scientific and other academic authors. authorInfo Bag AuthorInformation Specifies the types of author information: name and ORCID of an author. http://springernature.com/ns/xmpExtensions/2.0/authorInfo/ author AuthorInformation Gives the name of an author. name Text Gives the ORCID of an author. orcid URI http://www.niso.org/schemas/jav/1.0/ jav NISO external Values for Journal Article Version are one of the following: AO = Author’s Original SMUR = Submitted Manuscript Under Review AM = Accepted Manuscript P = Proof VoR = Version of Record CVoR = Corrected Version of Record EVoR = Enhanced Version of Record journal_article_version Closed Choice of Text Pages: Page: Label: 2211 Sequence: 1 Annotations: Annotation: Subtype: Link Rect: 515, 694, 517, 721 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 515, 698, 534, 725 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 534, 715, 544, 725 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 109, 603, 110, 613 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 109, 603, 110, 613 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 119, 603, 120, 613 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 110, 603, 119, 613 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 119, 603, 119, 613 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 65, 195, 121, 203 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 65, 171, 130, 180 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 53, 234, 199, 242 Flags: Print AppearanceDictionary: true Thumb: true Page: Label: 2212 Sequence: 2 Annotations: Annotation: Subtype: Link Rect: 108, 672, 112, 682 Flags: Print AppearanceDictionary: true Destination: 188 Annotation: Subtype: Link Rect: 268, 622, 273, 632 Flags: Print AppearanceDictionary: true Destination: 188 Annotation: Subtype: Link Rect: 278, 622, 283, 632 Flags: Print AppearanceDictionary: true Destination: 188 Annotation: Subtype: Link Rect: 149, 560, 154, 570 Flags: Print AppearanceDictionary: true Destination: 188 Annotation: Subtype: Link Rect: 159, 560, 169, 570 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 235, 547, 245, 557 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 250, 547, 260, 557 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 245, 522, 256, 532 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 261, 522, 271, 532 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 160, 498, 170, 508 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 175, 498, 185, 508 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 260, 473, 270, 483 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 275, 473, 285, 483 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 215, 448, 225, 458 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 257, 361, 268, 371 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 273, 361, 283, 371 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 275, 286, 285, 296 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 113, 273, 124, 283 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 182, 248, 192, 258 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 198, 236, 209, 246 Flags: Print AppearanceDictionary: true Destination: null Thumb: true Page: Label: 2213 Sequence: 3 Annotations: Annotation: Subtype: Link Rect: 405, 373, 410, 383 Flags: Print AppearanceDictionary: true Destination: 188 Annotation: Subtype: Link Rect: 417, 373, 427, 383 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 490, 373, 495, 383 Flags: Print AppearanceDictionary: true Destination: 188 Annotation: Subtype: Link Rect: 511, 286, 516, 296 Flags: Print AppearanceDictionary: true Destination: 48 Annotation: Subtype: Link Rect: 404, 211, 409, 221 Flags: Print AppearanceDictionary: true Destination: 72 Thumb: true Page: Label: 2214 Sequence: 4 Annotations: Annotation: Subtype: Link Rect: 257, 435, 262, 445 Flags: Print AppearanceDictionary: true Destination: 72 Annotation: Subtype: Link Rect: 189, 423, 199, 433 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 228, 423, 233, 433 Flags: Print AppearanceDictionary: true Destination: 72 Annotation: Subtype: Link Rect: 273, 323, 278, 333 Flags: Print AppearanceDictionary: true Destination: 72 Annotation: Subtype: Link Rect: 274, 298, 279, 308 Flags: Print AppearanceDictionary: true Destination: 72 Annotation: Subtype: Link Rect: 177, 273, 182, 283 Flags: Print AppearanceDictionary: true Destination: 72 Annotation: Subtype: Link Rect: 72, 199, 77, 209 Flags: Print AppearanceDictionary: true Destination: 72 Annotation: Subtype: Link Rect: 370, 448, 375, 458 Flags: Print AppearanceDictionary: true Destination: 72 Annotation: Subtype: Link Rect: 507, 410, 512, 420 Flags: Print AppearanceDictionary: true Destination: 72 Annotation: Subtype: Link Rect: 469, 311, 474, 321 Flags: Print AppearanceDictionary: true Destination: 188 Annotation: Subtype: Link Rect: 480, 311, 490, 321 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 495, 311, 505, 321 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 451, 298, 461, 308 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 373, 273, 383, 283 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 388, 273, 398, 283 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 488, 124, 497, 134 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 502, 124, 513, 134 Flags: Print AppearanceDictionary: true Destination: null Thumb: true Page: Label: 2215 Sequence: 5 Thumb: true Page: Label: 2216 Sequence: 6 Thumb: true Page: Label: 2217 Sequence: 7 Annotations: Annotation: Subtype: Link Rect: 263, 697, 268, 707 Flags: Print AppearanceDictionary: true Destination: 84 Annotation: Subtype: Link Rect: 243, 635, 248, 644 Flags: Print AppearanceDictionary: true Destination: 84 Annotation: Subtype: Link Rect: 240, 585, 250, 595 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 255, 585, 265, 595 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 116, 498, 121, 508 Flags: Print AppearanceDictionary: true Destination: 84 Annotation: Subtype: Link Rect: 76, 435, 81, 445 Flags: Print AppearanceDictionary: true Destination: 84 Annotation: Subtype: Link Rect: 275, 410, 280, 420 Flags: Print AppearanceDictionary: true Destination: 84 Annotation: Subtype: Link Rect: 190, 224, 200, 234 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 359, 684, 363, 694 Flags: Print AppearanceDictionary: true Destination: 117 Annotation: Subtype: Link Rect: 327, 659, 332, 669 Flags: Print AppearanceDictionary: true Destination: 117 Annotation: Subtype: Link Rect: 447, 635, 451, 644 Flags: Print AppearanceDictionary: true Destination: 72 Annotation: Subtype: Link Rect: 470, 585, 475, 595 Flags: Print AppearanceDictionary: true Destination: 117 Annotation: Subtype: Link Rect: 453, 448, 457, 458 Flags: Print AppearanceDictionary: true Destination: 48 Annotation: Subtype: Link Rect: 523, 286, 528, 296 Flags: Print AppearanceDictionary: true Destination: 137 Thumb: true Page: Label: 2218 Sequence: 8 Annotations: Annotation: Subtype: Link Rect: 127, 361, 132, 371 Flags: Print AppearanceDictionary: true Destination: 137 Annotation: Subtype: Link Rect: 225, 361, 230, 371 Flags: Print AppearanceDictionary: true Destination: 137 Annotation: Subtype: Link Rect: 97, 236, 102, 246 Flags: Print AppearanceDictionary: true Destination: 137 Annotation: Subtype: Link Rect: 137, 199, 142, 209 Flags: Print AppearanceDictionary: true Destination: 137 Annotation: Subtype: Link Rect: 82, 87, 92, 97 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 120, 87, 125, 97 Flags: Print AppearanceDictionary: true Destination: 155 Annotation: Subtype: Link Rect: 330, 286, 335, 296 Flags: Print AppearanceDictionary: true Destination: 155 Annotation: Subtype: Link Rect: 529, 87, 534, 97 Flags: Print AppearanceDictionary: true Destination: 155 Thumb: true Page: Label: 2219 Sequence: 9 Annotations: Annotation: Subtype: Link Rect: 208, 99, 213, 109 Flags: Print AppearanceDictionary: true Destination: 188 Annotation: Subtype: Link Rect: 170, 74, 175, 84 Flags: Print AppearanceDictionary: true Destination: 188 Annotation: Subtype: Link Rect: 329, 311, 334, 321 Flags: Print AppearanceDictionary: true Destination: 188 Annotation: Subtype: Link Rect: 345, 186, 355, 196 Flags: Print AppearanceDictionary: true Destination: null Thumb: true Page: Label: 2220 Sequence: 10 Annotations: Annotation: Subtype: Link Rect: 156, 186, 161, 196 Flags: Print AppearanceDictionary: true Destination: 188 Annotation: Subtype: Link Rect: 242, 149, 252, 159 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 104, 112, 114, 122 Flags: Print AppearanceDictionary: true Destination: 204 Annotation: Subtype: Link Rect: 91, 99, 101, 109 Flags: Print AppearanceDictionary: true Destination: 204 Annotation: Subtype: Link Rect: 499, 124, 504, 134 Flags: Print AppearanceDictionary: true Destination: 188 Thumb: true Page: Label: 2221 Sequence: 11 Thumb: true Page: Label: 2222 Sequence: 12 Annotations: Annotation: Subtype: Link Rect: 118, 85, 287, 93 Flags: Print AppearanceDictionary: true Thumb: true Page: Label: 2223 Sequence: 13 Thumb: true Checksum: 1d78de52 Type: CRC32 Checksum: bcd0e6c05b2ad65357dd541ef9a99e30 Type: MD5 Checksum: 2d61215cc4ff0cfdee2314d4eab2cc1ca58b6914 Type: SHA-1