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Title:          Structural insights into positive and negative allosteric regulation of a G protein-coupled receptor through protein-lipid interactions
Subject:        Scientific Reports, doi:10.1038/s41598-018-22735-6
Keywords:       
Author:         Agustamp#x000ED;n Bruzzese
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     Item: 
      Title: Structural insights into positive and negative allosteric regulation of a G protein-coupled receptor through protein-lipid  ...
      Children: 
       Item: 
        Title: Materials and Methods
        Children: 
         Item: 
          Title: β2AR modelling. 
         Item: 
          Title: Molecular dynamics (MD) simulations. 
         Item: 
          Title: MD simulation analysis. 
       Item: 
        Title: Results
        Children: 
         Item: 
          Title: Lipid DOPC partially inactivates β2-adrenergic receptor. 
         Item: 
          Title: Lipid DOPE fully deactivates β2-adrenergic receptor. 
         Item: 
          Title: Lipid DOPG stabilizes active-like state of β2-adrenergic receptor. 
         Item: 
          Title: Membrane characteristics and lipid headgroups facilitate allosteric modulation of β2AR. 
       Item: 
        Title: Discussion
        Children: 
         Item: 
          Title: Associated Content. 
          Children: 
           Item: 
            Title: Supporting Information. 
       Item: 
        Title: Acknowledgements
       Item: 
        Title: Figure 1 Structural comparison of DOPC, DOPE and DOPG unsaturated lipids.
       Item: 
        Title: Figure 2 Partial inactivation of β2AR in a DOPC membrane.
       Item: 
        Title: Figure 3 Partial inactivation of the triad core of β2AR in a DOPC membrane.
       Item: 
        Title: Figure 4 Full deactivation of β2AR in a DOPE membrane.
       Item: 
        Title: Figure 5 Full deactivation of the triad core of β2AR in a DOPE membrane.
       Item: 
        Title: Figure 6 Stabilization of an active-like state of β2AR by protein-lipid allosteric interactions.
       Item: 
        Title: Figure 7 Stabilization of an active-like state of β2AR in a DOPG membrane.
       Item: 
        Title: Figure 8 Stabilization of the triad core in an active-like state of β2AR in DOPG.
       Item: 
        Title: Figure 9 Membrane physical characteristics and effect on β2AR conformation.
       Item: 
        Title: Figure 10 Conformational sampling of β2AR in apo state within DOPC, DOPE and DOPG membranes over respective 4 μs MD simulations.
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The DOI may also be used as the dc:identifier. If used as a dc:identifier, the URI form should be captured, and the bare identifier should also be captured using prism:doi. If an alternate unique identifier is used as the required dc:identifier, then the DOI should be specified as a bare identifier within prism:doi only. 
If the URL associated with a DOI is to be specified, then prism:url may be used in conjunction with prism:doi in order to provide the service endpoint (i.e. the URL). 
</pdfaProperty:description>
                           <pdfaProperty:name>doi</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>ISSN for an electronic version of the issue in which the resource occurs. 
Permits publishers to include a second ISSN, identifying an electronic version of the issue in which the resource occurs (therefore e(lectronic)Issn. If used, prism:eIssn MUST contain the ISSN of the electronic version. See prism:issn. 
</pdfaProperty:description>
                           <pdfaProperty:name>issn</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Title of the magazine, or other publication, in which a resource was/will be published. 
Typically this will be used to provide the name of the magazine an article appeared in as metadata for the article, along with information such as the article title, the publisher, volume, number, and cover date. 

Note: Publication name can be used to differentiate between a print magazine and the online version if the names are different such as “magazine” and “magazine.com.” 
</pdfaProperty:description>
                           <pdfaProperty:name>publicationName</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>This element provides the url for an article or unit of content. 
The attribute platform is optionally allowed for situations in which multiple URLs must be specified. PRISM recommends that a subset of the PCV platform values, namely “mobile” and “web”, be used in conjunction with this element. 
NOTE: PRISM recommends against the use of the #other value allowed in the PRISM Platform controlled vocabulary. In lieu of using #other please reach out to the PRISM group at prism-wg@yahoogroups.com to request addition of your term to the Platform Controlled Vocabulary. 
</pdfaProperty:description>
                           <pdfaProperty:name>url</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
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                  <pdfaSchema:namespaceURI>http://www.niso.org/schemas/jav/1.0/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>jav</pdfaSchema:prefix>
                  <pdfaSchema:schema>NISO</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Values for Journal Article Version are one of the following:
AO = Author’s Original
SMUR = Submitted Manuscript Under Review
AM = Accepted Manuscript
P = Proof
VoR = Version of Record
CVoR = Corrected Version of Record
EVoR = Enhanced Version of Record</pdfaProperty:description>
                           <pdfaProperty:name>journal_article_version</pdfaProperty:name>
                           <pdfaProperty:valueType>Closed Choice of Text</pdfaProperty:valueType>
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