a5f8461c6fc3acf70f3a81f734b8c98d pmc_29615708.pdf 22233a658f21b0c995cb4339a40d7d7edd98633f pmc_29615708.pdf 16d4e513aa6ba6320b269e9d566912ff848ecda48a57f5a3767a1b5c8c6fa469 pmc_29615708.pdf Title: Genomic diversity in ochratoxigenic and non ochratoxigenic strains of Aspergillus carbonarius Subject: Scientific Reports, doi:10.1038/s41598-018-23802-8 Keywords: Author: Gemma Castellamp#x000E1; Creator: Springer Producer: iText® 5.3.5 ©2000-2012 1T3XT BVBA (AGPL-version) CreationDate: Fri Mar 23 19:10:03 2018 CET ModDate: Mon Mar 26 13:26:03 2018 CEST Tagged: no UserProperties: no Suspects: no Form: AcroForm JavaScript: no Pages: 11 Encrypted: no Page size: 595.276 x 782.362 pts Page rot: 0 File size: 1809518 bytes Optimized: no PDF version: 1.4 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- NQNCBI+Corbel CID TrueType Identity-H yes yes yes 406 0 SPDEXN+Corbel-BoldItalic Type 1C WinAnsi yes yes yes 40 0 MinionPro-It Type 1C Custom yes no yes 42 0 PURUFG+Corbel-Bold2 Type 1C WinAnsi yes yes yes 43 0 SCIJOJ+Corbel2 Type 1C WinAnsi yes yes yes 46 0 SQBBTY+Corbel-Bold CID TrueType Identity-H yes yes yes 407 0 MinionPro-Regular Type 1C Custom yes no yes 48 0 UKRFVU+TimesNewRomanPSMT Type 1C WinAnsi yes yes yes 408 0 PURUFG+Corbel-Bold2 Type 1C WinAnsi yes yes yes 283 0 SCIJOJ+Corbel2 Type 1C WinAnsi yes yes yes 284 0 NQNCBI+Corbel CID TrueType Identity-H yes yes yes 444 0 MyriadPro-It Type 1C WinAnsi yes no yes 285 0 MinionPro-Bold Type 1C Custom yes no yes 41 0 STIXGeneral-Bold Type 1C Custom yes no yes 44 0 EuclidSymbol Type 1C Custom yes no yes 45 0 JLQNXQ+STIXGeneral-Regular Type 1C Custom yes yes yes 47 0 SCIJOJ+Corbel2 Type 1C WinAnsi yes yes yes 265 0 NQNCBI+Corbel CID TrueType Identity-H yes yes yes 278 0 PURUFG+Corbel-Bold2 Type 1C WinAnsi yes yes yes 288 0 SCIJOJ+Corbel2 Type 1C WinAnsi yes yes yes 289 0 NQNCBI+Corbel CID TrueType Identity-H yes yes yes 290 0 MyriadPro-It Type 1C WinAnsi yes no yes 291 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2024-01-19 06:59:20 CET RepresentationInformation: pmc_29615708.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2018-04-16 03:48:51 CEST Size: 1809518 Format: PDF Version: 1.4 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 502 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: ViewerPreferences: HideToolbar: false HideMenubar: false HideWindowUI: false FitWindow: false CenterWindow: false DisplayDocTitle: false NonFullScreenPageMode: UseNone Direction: L2R ViewArea: CropBox ViewClip: CropBox PrintArea: CropBox PageClip: CropBox PageLayout: SinglePage PageMode: UseOutlines Language: EN Outlines: Item: Title: Genomic diversity in ochratoxigenic and non ochratoxigenic strains of Aspergillus carbonarius Children: Item: Title: Results Children: Item: Title: OTA production in the A. carbonarius strains studied. Item: Title: Resequencing study. Item: Title: SNPs and DIPs analysis. Item: Title: CNV and SV analysis. Item: Title: Expression analysis of OTA genes in A. carbonarius. Item: Title: Discussion Item: Title: Methods Children: Item: Title: OTA production ability detection. Item: Title: Genomic DNA extraction. Item: Title: Genomic DNA sequencing and alignment. Item: Title: SNPs and DIPs. Item: Title: CNV and SV analysis. Item: Title: Variant association with previous studies. Item: Title: RNA extraction and cDNA synthesis. Item: Title: Analysis of gene expression by RT-qPCR. Item: Title: Accession codes. Item: Title: Acknowledgements Item: Title: Figure 1 HPLC-FLD chromatograms and mass spectra of (a) the OTA producing strain A. Item: Title: Figure 2 Relative expression analysis by real time PCR of AcOTApks, AcOTAnrps, AcOTAhal, AcOTAbZIP and AcOTAp450 genes in A. Item: Title: Figure 3 Schematic representation of the putative OTA biosynthetic gene cluster 38, located on scaffold 12 (931076-971429 nt). Item: Title: Table 1 Ochratoxin A concentration (mean value in µg/g) detected in the 5 strains of A. Item: Title: Table 2 Statistics of resequencing results. Item: Title: Table 3 Summary of SNP and DIP analysis. Item: Title: Table 4 Summary of SNP and DIP analysis in selected genes. Item: Title: Table 5 Genes with common variants in atoxigenic strains. Info: Title: Genomic diversity in ochratoxigenic and non ochratoxigenic strains of Aspergillus carbonarius Author: Gemma Castellamp#x000E1; Subject: Scientific Reports, doi:10.1038/s41598-018-23802-8 Keywords: Creator: Springer Producer: iText® 5.3.5 ©2000-2012 1T3XT BVBA (AGPL-version) CreationDate: Fri Mar 23 19:40:03 CET 2018 ModDate: Mon Mar 26 13:26:03 CEST 2018 ID: 0xe7a4b8b1bcd6f8cb24e9ef274355532a, 0xf3ea7f36f09e2d92ea25f7543054054a Filters: FilterPipeline: FlateDecode Images: Image: NisoImageMetadata: FormatName: image/png ImageWidth: 1100 ImageHeight: 90 ColorSpace: black is zero BitsPerSample: 1 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric Name: X Image: NisoImageMetadata: FormatName: image/png ImageWidth: 1500 ImageHeight: 2316 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric Name: X Image: NisoImageMetadata: FormatName: image/png ImageWidth: 1250 ImageHeight: 739 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric Name: X Image: NisoImageMetadata: FormatName: image/png ImageWidth: 1650 ImageHeight: 319 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric Name: X Fonts: Type0: Font: BaseFont: NQNCBI+Corbel Encoding: Identity-H ToUnicode: true Font: BaseFont: SQBBTY+Corbel-Bold Encoding: Identity-H ToUnicode: true Type1: Font: BaseFont: MinionPro-Regular FirstChar: 0 LastChar: 255 FontDescriptor: FontName: MinionPro-Regular Flags: Serif, Nonsymbolic FontBBox: -290, -360, 1684, 989 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: UKRFVU+TimesNewRomanPSMT FontSubset: true FirstChar: 32 LastChar: 121 FontDescriptor: FontName: UKRFVU+TimesNewRomanPSMT Flags: Serif, Nonsymbolic FontBBox: -568, -307, 2000, 1007 FontFile3: true Encoding: WinAnsiEncoding ToUnicode: true Font: BaseFont: SPDEXN+Corbel-BoldItalic FontSubset: true FirstChar: 0 LastChar: 255 FontDescriptor: FontName: SPDEXN+Corbel-BoldItalic Flags: Nonsymbolic, Italic FontBBox: -494, -239, 1194, 952 FontFile3: true Encoding: WinAnsiEncoding ToUnicode: true Font: BaseFont: MinionPro-Bold FirstChar: 0 LastChar: 255 FontDescriptor: FontName: MinionPro-Bold Flags: Serif, Nonsymbolic FontBBox: -319, -360, 1684, 1024 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: MinionPro-It FirstChar: 0 LastChar: 255 FontDescriptor: FontName: MinionPro-It Flags: Serif, Nonsymbolic, Italic FontBBox: -201, -360, 1684, 1002 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: PURUFG+Corbel-Bold2 FontSubset: true FirstChar: 0 LastChar: 255 FontDescriptor: FontName: PURUFG+Corbel-Bold2 Flags: Nonsymbolic FontBBox: -556, -239, 1155, 952 FontFile3: true Encoding: WinAnsiEncoding ToUnicode: true Font: BaseFont: STIXGeneral-Bold FirstChar: 0 LastChar: 255 FontDescriptor: FontName: STIXGeneral-Bold Flags: Serif, Symbolic FontBBox: -1030, -455, 2000, 1055 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: EuclidSymbol FirstChar: 0 LastChar: 255 FontDescriptor: FontName: EuclidSymbol Flags: Symbolic FontBBox: -166, -253, 1090, 950 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: SCIJOJ+Corbel2 FontSubset: true FirstChar: 0 LastChar: 255 FontDescriptor: FontName: SCIJOJ+Corbel2 Flags: Nonsymbolic FontBBox: -553, -239, 1110, 952 FontFile3: true Encoding: WinAnsiEncoding ToUnicode: true Font: BaseFont: JLQNXQ+STIXGeneral-Regular FontSubset: true FirstChar: 30 LastChar: 31 FontDescriptor: FontName: JLQNXQ+STIXGeneral-Regular Flags: Serif, Symbolic FontBBox: -995, -455, 2000, 1055 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true CIDFontType2: Font: BaseFont: SQBBTY+Corbel-Bold CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: SQBBTY+Corbel-Bold Flags: Symbolic FontBBox: -556, -239, 1155, 952 FontFile2: true Font: BaseFont: NQNCBI+Corbel CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: NQNCBI+Corbel Flags: Symbolic FontBBox: -553, -239, 1110, 952 FontFile2: true XMP: application/pdf doi:10.1038/s41598-018-23802-8 Springer US Scientific Reports, doi:10.1038/s41598-018-23802-8 Genomic diversity in ochratoxigenic and non ochratoxigenic strains of Aspergillus carbonarius Gemma Castellamp#x000E1; M. Rosa Bragulat Laura Puig Walter Sanseverino F. Javier Cabaamp#x000F1;es 10.1038/s41598-018-23802-8 http://dx.doi.org/10.1038/s41598-018-23802-8 journal Scientific Reports © 2018, The Author(s) 2045-2322 10.1038/s41598-018-23802-8 Springer 2018-03-26T13:26:03+02:00 2018-03-23T23:40:03+05:30 2018-03-26T13:26:03+02:00 True iText® 5.3.5 ©2000-2012 1T3XT BVBA (AGPL-version) VoR uuid:d33d6bec-621d-438b-89d2-a1123938412d uuid:d4a3622c-e840-4076-a20d-41c0b1624cab default 1 converted uuid:57efa32d-1659-41d5-a225-4ca560bb03cb converted to PDF/A-2b pdfToolbox 2018-03-23T23:40:15+05:30 2 B http://ns.adobe.com/xap/1.0/mm/ xmpMM XMP Media Management Schema internal UUID based identifier for specific incarnation of a document InstanceID URI internal The common identifier for all versions and renditions of a document. 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