4921f633dd17ca533e69e7c29718c3d3 pmc_29625589.pdf 1600dc1bf398af92277dec2e73649263c5178064 pmc_29625589.pdf 2b196a120d3e7d9048a3d8fc3d0a85aa9938c9975458294a3d361562ca283cd3 pmc_29625589.pdf Title: Intramuscular transplantation of bone marrow cells prolongs the lifespan of SOD1G93A mice and modulates expression of prognosis biomarkers of the disease Subject: Stem Cell Research & Therapy, 2018, doi:10.1186/s13287-018-0843-z Keywords: Author: Amaya Rando Creator: Arbortext Advanced Print Publisher 9.1.440/W Unicode Producer: Acrobat Distiller 10.1.5 (Windows); modified using iText® 5.3.5 ©2000-2012 1T3XT BVBA (AGPL-version) CreationDate: Thu Mar 29 23:43:44 2018 CEST ModDate: Fri Apr 6 16:05:36 2018 CEST Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 12 Encrypted: no Page size: 595.276 x 790.866 pts Page rot: 0 File size: 3401789 bytes Optimized: no PDF version: 1.5 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- DEKEIM+JjylxmAdvTTaf7f9f4f.B Type 1C WinAnsi yes yes no 8 0 DEKEMM+CrxkrrAdvTTe45e47d2 Type 1C WinAnsi yes yes no 9 0 DEKEMN+YpvsltAdvTTb5929f4c Type 1C WinAnsi yes yes no 57 0 DEKGAM+WmvrbrAdvTT7329fd89.I Type 1C WinAnsi yes yes no 11 0 DEKEMO+XmwprgAdvTTb5929f4c+20 Type 1C Custom yes yes yes 58 0 DEKFAN+LmfvlvAdvTT99c4c969 Type 1C WinAnsi yes yes no 12 0 DEKFAO+SpldqnAdvTT1b53b5fb.I Type 1C WinAnsi yes yes no 59 0 DEKFCB+DwxtltAdvTT8861b38f.I Type 1C WinAnsi yes yes no 13 0 DEKFCA+MvlmrvAdvTT86d47313+20 Type 1C Custom yes yes yes 14 0 MyriadPro-Regular Type 1 Custom yes no no 10 0 DEKFAP+PqgxrrAdvTT86d47313 Type 1C WinAnsi yes yes no 16 0 DEKGEN+HnwsjxAdvTT86d47313+03 Type 1C Custom yes yes yes 15 0 DEKGHO+VmlxmnAdvTTb5929f4c+21 Type 1C Custom yes yes yes 60 0 DEKGHP+DrtyqhAdvTT1b53b5fb.I+03 Type 1C Custom yes yes yes 61 0 DEKGGN+BbyscyAdvTT8861b38f.I+03 Type 1C Custom yes yes yes 62 0 DEKGJP+FxymfhAdvTT83913201.I Type 1C WinAnsi yes yes no 86 0 DENLFN+JkvtqkAdvTTaf7f9f4f.B+20 Type 1C WinAnsi yes yes no 270 0 DENLEM+WmhqwkAdvTT99c4c969+20 Type 1C WinAnsi yes yes no 271 0 DENLML+GtgmvpAdvTTb5929f4c+22 Type 1C Custom yes yes no 286 0 CydkjgOpenSans-Extrabold Type 1C WinAnsi yes no no 301 0 NdqmjnOpenSans-Light Type 1C MacRoman yes no no 302 0 BtwwnqOregonLDOBook Type 1C WinAnsi yes no no 303 0 Jhove (Rel. 1.6, 2011-01-04) Date: 2019-02-14 17:23:38 CET RepresentationInformation: pmc_29625589.pdf ReportingModule: PDF-hul, Rel. 1.8 (2009-05-22) LastModified: 2018-04-16 03:48:34 CEST Size: 3401789 Format: PDF Version: 1.5 Status: Well-Formed, but not valid SignatureMatches: PDF-hul ErrorMessage: Invalid destination object Offset: 3114233 ErrorMessage: Invalid destination object Offset: 3114233 ErrorMessage: Invalid destination object Offset: 3114233 ErrorMessage: Invalid destination object Offset: 3114233 ErrorMessage: Invalid destination object Offset: 3112658 ErrorMessage: Invalid destination object Offset: 3114233 ErrorMessage: Invalid destination object Offset: 3114233 ErrorMessage: Invalid destination object Offset: 3114233 ErrorMessage: Invalid destination object Offset: 3114233 ErrorMessage: Invalid destination object Offset: 3114233 ErrorMessage: Invalid destination object Offset: 3114233 ErrorMessage: Invalid destination object Offset: 3114233 ErrorMessage: Invalid destination object Offset: 3114233 ErrorMessage: Invalid destination object Offset: 3114233 ErrorMessage: Invalid destination object Offset: 3114233 ErrorMessage: Invalid destination object Offset: 3114233 ErrorMessage: Invalid destination object Offset: 3114233 ErrorMessage: Invalid destination object Offset: 3114233 ErrorMessage: Invalid destination object Offset: 3114233 ErrorMessage: Invalid destination object Offset: 3114233 ErrorMessage: Invalid destination object Offset: 3114233 ErrorMessage: Invalid destination object Offset: 3114233 ErrorMessage: Invalid destination object Offset: 3114233 ErrorMessage: Invalid destination object Offset: 3114233 ErrorMessage: Invalid destination object Offset: 3114233 ErrorMessage: Invalid destination object Offset: 3114233 ErrorMessage: Invalid destination object Offset: 3114233 ErrorMessage: Invalid destination object Offset: 3114233 ErrorMessage: Invalid destination object Offset: 3114233 ErrorMessage: Invalid destination object Offset: 3114233 ErrorMessage: Invalid destination object Offset: 3114233 ErrorMessage: Invalid destination object Offset: 3114233 ErrorMessage: Invalid destination object Offset: 3114233 ErrorMessage: Invalid destination object Offset: 3114233 ErrorMessage: Invalid destination object Offset: 3114233 ErrorMessage: Invalid destination object Offset: 3114233 ErrorMessage: Invalid destination object Offset: 3114233 ErrorMessage: Invalid destination object Offset: 3114233 ErrorMessage: Invalid destination object Offset: 3114233 ErrorMessage: Invalid destination object Offset: 3114233 ErrorMessage: Invalid destination object Offset: 3114233 ErrorMessage: Invalid destination object Offset: 3114233 ErrorMessage: Invalid destination object Offset: 3114233 ErrorMessage: Invalid destination object Offset: 3114233 ErrorMessage: Invalid destination object Offset: 3114233 ErrorMessage: Invalid destination object Offset: 3114233 ErrorMessage: Invalid destination object Offset: 3114233 ErrorMessage: Invalid destination object Offset: 3114233 ErrorMessage: Invalid destination object Offset: 3114233 ErrorMessage: Invalid destination object Offset: 3114233 ErrorMessage: Invalid destination object Offset: 3114233 ErrorMessage: Invalid destination object Offset: 3114233 ErrorMessage: Invalid destination object Offset: 3114233 ErrorMessage: Invalid destination object Offset: 3114233 ErrorMessage: Invalid destination object Offset: 3114233 ErrorMessage: Invalid destination object Offset: 3114233 ErrorMessage: Invalid destination object Offset: 3114233 ErrorMessage: Invalid destination object Offset: 3114233 ErrorMessage: Invalid destination object Offset: 3114233 ErrorMessage: Invalid destination object Offset: 3114233 ErrorMessage: Invalid destination object Offset: 3114233 ErrorMessage: Invalid destination object Offset: 3114233 ErrorMessage: Invalid destination object Offset: 3114233 ErrorMessage: Invalid destination object Offset: 3114233 ErrorMessage: Invalid destination object Offset: 3114233 ErrorMessage: Invalid destination object Offset: 3114233 ErrorMessage: Invalid destination object Offset: 3114233 ErrorMessage: Invalid destination object Offset: 3112658 ErrorMessage: Invalid destination object Offset: 3114233 ErrorMessage: Invalid destination object Offset: 3112658 ErrorMessage: Invalid destination object Offset: 3112658 ErrorMessage: Invalid destination object Offset: 3114233 ErrorMessage: Invalid destination object Offset: 3114233 ErrorMessage: Invalid destination object Offset: 3112658 ErrorMessage: Invalid destination object Offset: 3112658 ErrorMessage: Invalid destination object Offset: 3112658 ErrorMessage: Invalid destination object Offset: 3112658 ErrorMessage: Invalid destination object Offset: 3112658 ErrorMessage: Invalid destination object Offset: 3112658 ErrorMessage: Invalid destination object Offset: 3112658 ErrorMessage: Invalid destination object Offset: 3112658 ErrorMessage: Invalid destination object Offset: 3114233 ErrorMessage: Invalid destination object Offset: 3114233 ErrorMessage: Invalid destination object Offset: 3114233 ErrorMessage: Invalid destination object Offset: 3114233 ErrorMessage: Invalid destination object Offset: 3112658 ErrorMessage: Invalid destination object Offset: 3114233 ErrorMessage: Invalid destination object Offset: 3114233 ErrorMessage: Invalid destination object Offset: 3112658 ErrorMessage: Invalid destination object Offset: 3114233 ErrorMessage: Invalid destination object Offset: 3112658 ErrorMessage: Invalid destination object Offset: 3114233 ErrorMessage: Invalid destination object Offset: 3114233 ErrorMessage: Invalid destination object Offset: 3114233 ErrorMessage: Invalid destination object Offset: 3114233 ErrorMessage: Invalid destination object Offset: 3114233 ErrorMessage: Invalid destination object Offset: 3114233 ErrorMessage: Invalid destination object Offset: 3112658 ErrorMessage: Invalid destination object Offset: 3112658 ErrorMessage: Invalid destination object Offset: 3112658 ErrorMessage: Invalid destination object Offset: 3112658 ErrorMessage: Invalid destination object Offset: 3112658 ErrorMessage: Invalid destination object Offset: 3112658 ErrorMessage: Invalid destination object Offset: 3112658 ErrorMessage: Invalid destination object Offset: 3114233 MIMEtype: application/pdf PDFMetadata: Objects: 639 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseOutlines Outlines: Item: Title: Abstract Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@16f65612 Children: Item: Title: Background Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@311d617d Item: Title: Methods Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7c53a9eb Item: Title: Results Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@ed17bee Item: Title: Conclusions Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@2a33fae0 Item: Title: Background Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@707f7052 Item: Title: Methods Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@11028347 Children: Item: Title: Animal care Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@14899482 Item: Title: Locomotor behavioral assays Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@21588809 Item: Title: Lifespan analysis method Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@2aae9190 Item: Title: Separation method of BMCs from GFP mice Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@2f333739 Item: Title: Cell transplantation Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@77468bd9 Item: Title: Tissue preparation and immunohistofluorescence Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@12bb4df8 Item: Title: Motoneuron counting Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4cc77c2e Item: Title: Gene expression Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7a7b0070 Item: Title: Western blot assay Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@39a054a5 Item: Title: Statistical analysis Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@71bc1ae4 Item: Title: Results Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6ed3ef1 Children: Item: Title: Bone marrow transplant improved evolution and prolonged survival of SOD1G93A mice and downregulated the expression of genetic markers of ALS Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@2437c6dc Children: Item: Title: Immunofluorescence and RT-PCR revealed the presence of GFP-positive cells in the skeletal muscle of SOD1G93A mice 35 days after transplantation Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1f89ab83 Item: Title: Bone marrow grafts significantly improved disease clinical outcomes and prolonged survival of SOD1G93A mice Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@e73f9ac Item: Title: Bone marrow grafts induced downregulation of genetic biomarkers of ALS Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@61064425 Item: Title: BMC graft improved maintenance of NMJs and increased survival of motoneurons in the spinal cord in SOD1G93A mice, and these effects are mediated by neurotrophic factor release Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7b1d7fff Children: Item: Title: BMC transplant increased the survival of motoneurons in the spinal cord of SOD1G93A mice Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@299a06ac Item: Title: BMC grafts improved maintenance of NMJs Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@383534aa Item: Title: The therapeutic effect of BMC grafts was mediated by neurotrophic factor release Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6bc168e5 Item: Title: Discussion Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7b3300e5 Item: Title: Conclusions Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@2e5c649 Item: Title: Abbreviations Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@136432db Item: Title: Funding Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7382f612 Item: Title: Availability of data and materials Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1055e4af Item: Title: Authors’ contributions Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@3caeaf62 Item: Title: Ethics approval Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@e6ea0c6 Item: Title: Consent for publication Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6a38e57f Item: Title: Competing interests Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@5577140b Item: Title: Publisher’s Note Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1c6b6478 Item: Title: Author details Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@67f89fa3 Item: Title: References Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4ac68d3e Info: Title: Intramuscular transplantation of bone marrow cells prolongs the lifespan of SOD1G93A mice and modulates expression of prognosis biomarkers of the disease Author: Amaya Rando Subject: Stem Cell Research & Therapy, 2018, doi:10.1186/s13287-018-0843-z Keywords: Creator: Arbortext Advanced Print Publisher 9.1.440/W Unicode Producer: Acrobat Distiller 10.1.5 (Windows); modified using iText® 5.3.5 ©2000-2012 1T3XT BVBA (AGPL-version) CreationDate: Thu Mar 29 23:43:44 CEST 2018 ModDate: Fri Apr 06 16:05:36 CEST 2018 ID: 0x17e39206f3b4b94c670e8be578d07953, 0xee6f44d4c0ae635674761c4c198b5218 Filters: FilterPipeline: FlateDecode FilterPipeline: DCTDecode Images: Image: NisoImageMetadata: CompressionScheme: JPEG ImageWidth: 95 ImageHeight: 91 BitsPerSample: 8 BitsPerSampleUnit: integer Intent: Perceptual Image: NisoImageMetadata: ImageWidth: 688 ImageHeight: 126 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: ImageWidth: 1420 ImageHeight: 1764 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: Perceptual Image: NisoImageMetadata: ImageWidth: 896 ImageHeight: 1839 ColorSpace: black is zero BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: ImageWidth: 1183 ImageHeight: 2389 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: Perceptual Image: NisoImageMetadata: ImageWidth: 896 ImageHeight: 1217 ColorSpace: black is zero BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: ImageWidth: 1100 ImageHeight: 90 ColorSpace: black is zero BitsPerSample: 1 BitsPerSampleUnit: integer Filter: FlateDecode Fonts: Type1: Font: BaseFont: DEKEIM+JjylxmAdvTTaf7f9f4f.B FontSubset: true FirstChar: 32 LastChar: 117 FontDescriptor: FontName: DEKEIM+JjylxmAdvTTaf7f9f4f.B Flags: Nonsymbolic FontBBox: -218, -250, 875, 895 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: DEKEMM+CrxkrrAdvTTe45e47d2 FontSubset: true FirstChar: 32 LastChar: 122 FontDescriptor: FontName: DEKEMM+CrxkrrAdvTTe45e47d2 Flags: Nonsymbolic FontBBox: -218, -250, 833, 875 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: MyriadPro-Regular FirstChar: 1 LastChar: 255 FontDescriptor: FontName: MyriadPro-Regular Flags: Nonsymbolic FontBBox: -46, -250, 1126, 879 FontFile: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: DEKGAM+WmvrbrAdvTT7329fd89.I FontSubset: true FirstChar: 32 LastChar: 121 FontDescriptor: FontName: DEKGAM+WmvrbrAdvTT7329fd89.I Flags: Nonsymbolic FontBBox: -218, -250, 885, 864 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: DEKFAN+LmfvlvAdvTT99c4c969 FontSubset: true FirstChar: 32 LastChar: 121 FontDescriptor: FontName: DEKFAN+LmfvlvAdvTT99c4c969 Flags: Nonsymbolic FontBBox: -41, -250, 854, 885 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: DEKFCB+DwxtltAdvTT8861b38f.I FontSubset: true FirstChar: 32 LastChar: 121 FontDescriptor: FontName: DEKFCB+DwxtltAdvTT8861b38f.I Flags: Nonsymbolic FontBBox: -187, -239, 1062, 875 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: CydkjgOpenSans-Extrabold FirstChar: 32 LastChar: 149 FontDescriptor: FontName: CydkjgOpenSans-Extrabold Flags: Nonsymbolic FontBBox: -728, -293, 1407, 1124 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: DEKFCA+MvlmrvAdvTT86d47313+20 FontSubset: true FirstChar: 2 LastChar: 151 FontDescriptor: FontName: DEKFCA+MvlmrvAdvTT86d47313+20 Flags: Symbolic FontBBox: -218, -218, 1291, 812 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: DENLFN+JkvtqkAdvTTaf7f9f4f.B+20 FontSubset: true FirstChar: 32 LastChar: 146 FontDescriptor: FontName: DENLFN+JkvtqkAdvTTaf7f9f4f.B+20 Flags: Nonsymbolic FontBBox: -468, -197, 1656, 864 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: NdqmjnOpenSans-Light FirstChar: 32 LastChar: 222 FontDescriptor: FontName: NdqmjnOpenSans-Light Flags: Nonsymbolic FontBBox: -521, -269, 1140, 1048 FontFile3: true Encoding: MacRomanEncoding Font: BaseFont: DEKGEN+HnwsjxAdvTT86d47313+03 FontSubset: true FirstChar: 1 LastChar: 4 FontDescriptor: FontName: DEKGEN+HnwsjxAdvTT86d47313+03 Flags: Symbolic FontBBox: -281, -250, 906, 885 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: DENLEM+WmhqwkAdvTT99c4c969+20 FontSubset: true FirstChar: 32 LastChar: 146 FontDescriptor: FontName: DENLEM+WmhqwkAdvTT99c4c969+20 Flags: Nonsymbolic FontBBox: -447, -197, 1583, 864 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: BtwwnqOregonLDOBook FirstChar: 0 LastChar: 255 FontDescriptor: FontName: BtwwnqOregonLDOBook Flags: Serif, Nonsymbolic FontBBox: 1, -308, 1045, 922 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: DEKFAP+PqgxrrAdvTT86d47313 FontSubset: true FirstChar: 32 LastChar: 215 FontDescriptor: FontName: DEKFAP+PqgxrrAdvTT86d47313 Flags: Serif, Nonsymbolic FontBBox: -218, -239, 1020, 875 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: DEKGJP+FxymfhAdvTT83913201.I FontSubset: true FirstChar: 32 LastChar: 121 FontDescriptor: FontName: DEKGJP+FxymfhAdvTT83913201.I Flags: Nonsymbolic FontBBox: -93, -250, 906, 875 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: DEKEMN+YpvsltAdvTTb5929f4c FontSubset: true FirstChar: 32 LastChar: 243 FontDescriptor: FontName: DEKEMN+YpvsltAdvTTb5929f4c Flags: Nonsymbolic FontBBox: -41, -250, 812, 864 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: DEKEMO+XmwprgAdvTTb5929f4c+20 FontSubset: true FirstChar: 2 LastChar: 143 FontDescriptor: FontName: DEKEMO+XmwprgAdvTTb5929f4c+20 Flags: Symbolic FontBBox: -447, -208, 1375, 864 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: DEKFAO+SpldqnAdvTT1b53b5fb.I FontSubset: true FirstChar: 32 LastChar: 121 FontDescriptor: FontName: DEKFAO+SpldqnAdvTT1b53b5fb.I Flags: Nonsymbolic FontBBox: -114, -250, 864, 854 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: DEKGHO+VmlxmnAdvTTb5929f4c+21 FontSubset: true FirstChar: 1 LastChar: 2 FontDescriptor: FontName: DEKGHO+VmlxmnAdvTTb5929f4c+21 Flags: Symbolic FontBBox: -20, -208, 1208, 895 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: DEKGHP+DrtyqhAdvTT1b53b5fb.I+03 FontSubset: true FirstChar: 1 LastChar: 2 FontDescriptor: FontName: DEKGHP+DrtyqhAdvTT1b53b5fb.I+03 Flags: Symbolic FontBBox: -572, -260, 947, 968 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: DEKGGN+BbyscyAdvTT8861b38f.I+03 FontSubset: true FirstChar: 1 LastChar: 2 FontDescriptor: FontName: DEKGGN+BbyscyAdvTT8861b38f.I+03 Flags: Symbolic FontBBox: -291, -239, 937, 885 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: DENLML+GtgmvpAdvTTb5929f4c+22 FontSubset: true FirstChar: 21 LastChar: 22 FontDescriptor: FontName: DENLML+GtgmvpAdvTTb5929f4c+22 Flags: Nonsymbolic FontBBox: -10, -218, 1083, 906 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true XMP: Acrobat Distiller 10.1.5 (Windows); modified using iText® 5.3.5 ©2000-2012 1T3XT BVBA (AGPL-version) application/pdf 10.1186/s13287-018-0843-z Stem Cell Research & Therapy Stem Cell Research & Therapy, 2018, doi:10.1186/s13287-018-0843-z Intramuscular transplantation of bone marrow cells prolongs the lifespan of SOD1G93A mice and modulates expression of prognosis biomarkers of the disease Amaya Rando Diego Pastor Mari Carmen Viso-León Anna Martínez Raquel Manzano Xavier Navarro Rosario Osta Salvador Martínez 2018-04-06T16:05:36+02:00 2018-03-30T05:43:44+08:00 Arbortext Advanced Print Publisher 9.1.440/W Unicode 2018-04-06T16:05:36+02:00 uuid:808dee17-fd0e-478e-9931-017c103251a0 uuid:c65af77a-c503-4a26-a96e-0ac28da24914 default 1 converted uuid:38da55df-b201-4d2d-a7e1-f17c9b8d0829 converted to PDF/A-2b pdfToolbox 2018-03-30T05:51:18+08:00 2 B Diego Pastor http://orcid.org/0000-0002-2884-6580 Springer Nature ORCID Schema http://springernature.com/ns/xmpExtensions/2.0/ sn authorInfo Bag AuthorInformation external Author information: contains the name of each author and his/her ORCID (ORCiD: Open Researcher and Contributor ID). An ORCID is a persistent identifier (a non-proprietary alphanumeric code) to uniquely identify scientific and other academic authors. editorInfo Bag EditorInformation external Editor information: contains the name of each editor and his/her ORCID identifier. seriesEditorInfo Bag SeriesEditorInformation external Series editor information: contains the name of each series editor and his/her ORCID identifier. AuthorInformation http://springernature.com/ns/xmpExtensions/2.0/authorInfo/ author Specifies the types of author information: name and ORCID of an author. name Text Gives the name of an author. orcid URI Gives the ORCID of an author. EditorInformation http://springernature.com/ns/xmpExtensions/2.0/editorInfo/ editor Specifies the types of editor information: name and ORCID of an editor. name Text Gives the name of an editor. orcid URI Gives the ORCID of an editor. SeriesEditorInformation http://springernature.com/ns/xmpExtensions/2.0/seriesEditorInfo/ seriesEditor Specifies the types of series editor information: name and ORCID of a series editor. name Text Gives the name of a series editor. orcid URI Gives the ORCID of a series editor. http://ns.adobe.com/pdf/1.3/ pdf Adobe PDF Schema internal A name object indicating whether the document has been modified to include trapping information Trapped Text http://ns.adobe.com/xap/1.0/mm/ xmpMM XMP Media Management Schema internal UUID based identifier for specific incarnation of a document InstanceID URI internal The common identifier for all versions and renditions of a document. OriginalDocumentID URI internal A reference to the original document from which this one is derived. It is a minimal reference; missing components can be assumed to be unchanged. For example, a new version might only need to specify the instance ID and version number of the previous version, or a rendition might only need to specify the instance ID and rendition class of the original. DerivedFrom ResourceRef Identifies a portion of a document. This can be a position at which the document has been changed since the most recent event history (stEvt:changed). For a resource within an xmpMM:Ingredients list, the ResourceRef uses this type to identify both the portion of the containing document that refers to the resource, and the portion of the referenced resource that is referenced. http://ns.adobe.com/xap/1.0/sType/Part# stPart Part http://ns.adobe.com/xap/1.0/t/pg/ xmpTPg XMP Paged-Text internal A structure containing the characteristics of a font used in a document Fonts Bag Font internal XMP08 Spec: An ordered array of plate names that are needed to print the document (including any in contained documents). PlateNames Seq Text A structure containing the characteristics of a font used in a document. http://ns.adobe.com/xap/1.0/sType/Font# stFnt Font http://ns.adobe.com/pdfx/1.3/ pdfx PDF/X ID Schema internal ID of PDF/X standard GTS_PDFXVersion Text internal Conformance level of PDF/X standard GTS_PDFXConformance Text internal Company creating the PDF Company Text internal Date when document was last modified SourceModified Text http://www.aiim.org/pdfa/ns/id/ pdfaid PDF/A ID Schema internal Part of PDF/A standard part Integer internal Amendment of PDF/A standard amd Text internal Conformance level of PDF/A standard conformance Text Pages: Page: Sequence: 1 Annotations: Annotation: Subtype: Link Rect: 484, 657, 538, 679 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 196, 547, 205, 556 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 251, 232, 256, 242 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 261, 232, 266, 242 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 228, 220, 233, 230 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 109, 184, 114, 194 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 453, 280, 458, 290 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 359, 268, 364, 278 Flags: Print AppearanceDictionary: true Destination: 267 Annotation: Subtype: Link Rect: 482, 208, 487, 218 Flags: Print AppearanceDictionary: true Destination: 267 Annotation: Subtype: Link Rect: 493, 208, 498, 218 Flags: Print AppearanceDictionary: true Destination: 267 Annotation: Subtype: Link Rect: 497, 160, 507, 170 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 472, 124, 481, 134 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 487, 124, 497, 134 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 307, 100, 317, 110 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 324, 100, 334, 110 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 114, 144, 164, 152 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 239, 65, 357, 72 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 182, 41, 321, 48 Flags: Print AppearanceDictionary: true Thumb: true Page: Sequence: 2 Annotations: Annotation: Subtype: Link Rect: 260, 693, 270, 702 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 275, 693, 285, 702 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 154, 657, 164, 666 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 239, 645, 249, 654 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 255, 645, 264, 654 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 194, 633, 203, 642 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 209, 633, 218, 642 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 218, 609, 228, 618 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 81, 525, 90, 534 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 97, 525, 106, 534 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 275, 489, 285, 498 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 205, 453, 214, 462 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 219, 453, 228, 462 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 210, 417, 219, 426 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 225, 417, 234, 426 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 140, 105, 145, 114 Flags: Print AppearanceDictionary: true Destination: 267 Annotation: Subtype: Link Rect: 427, 573, 437, 582 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 508, 381, 518, 390 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 458, 297, 468, 306 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 473, 297, 483, 306 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 307, 141, 317, 150 Flags: Print AppearanceDictionary: true Destination: null Thumb: true Page: Sequence: 3 Annotations: Annotation: Subtype: Link Rect: 185, 537, 194, 546 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 185, 69, 194, 78 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 341, 633, 350, 642 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 388, 621, 393, 630 Flags: Print AppearanceDictionary: true Destination: 55 Annotation: Subtype: Link Rect: 416, 621, 420, 630 Flags: Print AppearanceDictionary: true Destination: 84 Annotation: Subtype: Link Rect: 405, 597, 414, 606 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 387, 573, 396, 582 Flags: Print AppearanceDictionary: true Destination: null Thumb: true Page: Sequence: 4 Annotations: Annotation: Subtype: Link Rect: 304, 657, 313, 666 Flags: Print AppearanceDictionary: true Destination: 110 Annotation: Subtype: Link Rect: 523, 633, 533, 642 Flags: Print AppearanceDictionary: true Destination: 110 Annotation: Subtype: Link Rect: 437, 573, 447, 582 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 488, 477, 507, 486 Flags: Print AppearanceDictionary: true Destination: 110 Annotation: Subtype: Link Rect: 451, 453, 471, 462 Flags: Print AppearanceDictionary: true Destination: 110 Annotation: Subtype: Link Rect: 351, 405, 369, 414 Flags: Print AppearanceDictionary: true Destination: 110 Annotation: Subtype: Link Rect: 524, 333, 532, 342 Flags: Print AppearanceDictionary: true Destination: 110 Annotation: Subtype: Link Rect: 405, 297, 414, 306 Flags: Print AppearanceDictionary: true Destination: 110 Annotation: Subtype: Link Rect: 307, 225, 317, 234 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 343, 225, 352, 234 Flags: Print AppearanceDictionary: true Destination: 126 Annotation: Subtype: Link Rect: 391, 189, 400, 198 Flags: Print AppearanceDictionary: true Destination: 126 Annotation: Subtype: Link Rect: 450, 117, 459, 126 Flags: Print AppearanceDictionary: true Destination: 126 Thumb: true Page: Sequence: 5 Annotations: Annotation: Subtype: Link Rect: 91, 165, 100, 174 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 185, 141, 194, 150 Flags: Print AppearanceDictionary: true Destination: 126 Annotation: Subtype: Link Rect: 276, 69, 285, 78 Flags: Print AppearanceDictionary: true Destination: 126 Annotation: Subtype: Link Rect: 491, 165, 500, 174 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 485, 129, 494, 138 Flags: Print AppearanceDictionary: true Destination: 126 Thumb: true Page: Sequence: 6 Annotations: Annotation: Subtype: Link Rect: 59, 141, 68, 150 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 201, 117, 209, 126 Flags: Print AppearanceDictionary: true Destination: 126 Annotation: Subtype: Link Rect: 208, 93, 217, 102 Flags: Print AppearanceDictionary: true Destination: 126 Annotation: Subtype: Link Rect: 432, 508, 440, 517 Flags: Print AppearanceDictionary: true Destination: 154 Annotation: Subtype: Link Rect: 496, 448, 505, 457 Flags: Print AppearanceDictionary: true Destination: 154 Annotation: Subtype: Link Rect: 379, 400, 388, 409 Flags: Print AppearanceDictionary: true Destination: 154 Annotation: Subtype: Link Rect: 483, 340, 492, 349 Flags: Print AppearanceDictionary: true Destination: 154 Annotation: Subtype: Link Rect: 307, 189, 317, 198 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 322, 189, 331, 198 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 337, 153, 347, 162 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 351, 153, 361, 162 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 459, 129, 468, 138 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 474, 129, 483, 138 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 402, 93, 412, 102 Flags: Print AppearanceDictionary: true Destination: 154 Thumb: true Page: Sequence: 7 Thumb: true Page: Sequence: 8 Annotations: Annotation: Subtype: Link Rect: 129, 645, 139, 654 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 227, 585, 237, 594 Flags: Print AppearanceDictionary: true Destination: 158 Annotation: Subtype: Link Rect: 143, 561, 153, 570 Flags: Print AppearanceDictionary: true Destination: 158 Annotation: Subtype: Link Rect: 203, 537, 213, 546 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 263, 513, 273, 522 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 224, 441, 233, 450 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 239, 441, 249, 450 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 227, 357, 237, 366 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 241, 357, 251, 366 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 93, 297, 102, 306 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 108, 297, 117, 306 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 103, 285, 113, 294 Flags: Print AppearanceDictionary: true Destination: 291 Annotation: Subtype: Link Rect: 118, 285, 128, 294 Flags: Print AppearanceDictionary: true Destination: 291 Annotation: Subtype: Link Rect: 245, 201, 254, 210 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 161, 165, 171, 174 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 176, 165, 186, 174 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 192, 165, 201, 174 Flags: Print AppearanceDictionary: true Destination: 291 Annotation: Subtype: Link Rect: 263, 141, 272, 150 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 278, 141, 288, 150 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 56, 129, 66, 138 Flags: Print AppearanceDictionary: true Destination: 291 Annotation: Subtype: Link Rect: 155, 117, 164, 126 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 169, 117, 179, 126 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 184, 117, 193, 126 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 227, 81, 236, 90 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 307, 177, 317, 186 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 307, 105, 317, 114 Flags: Print AppearanceDictionary: true Destination: 291 Annotation: Subtype: Link Rect: 329, 69, 338, 78 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 464, 57, 474, 66 Flags: Print AppearanceDictionary: true Destination: 291 Thumb: true Page: Sequence: 9 Annotations: Annotation: Subtype: Link Rect: 108, 573, 118, 582 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 247, 537, 256, 546 Flags: Print AppearanceDictionary: true Destination: 291 Annotation: Subtype: Link Rect: 275, 501, 285, 510 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 227, 441, 237, 450 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 243, 441, 253, 450 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 259, 441, 268, 450 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 148, 333, 158, 342 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 96, 177, 105, 186 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 111, 177, 120, 186 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 86, 129, 96, 138 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 143, 117, 153, 126 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 221, 117, 230, 126 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 237, 117, 246, 126 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 197, 105, 207, 114 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 213, 105, 222, 114 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 265, 57, 270, 66 Flags: Print AppearanceDictionary: true Destination: 267 Annotation: Subtype: Link Rect: 275, 57, 285, 66 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 478, 681, 488, 690 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 517, 561, 527, 570 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 388, 513, 397, 522 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 404, 513, 413, 522 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 420, 513, 429, 522 Flags: Print AppearanceDictionary: true Destination: 291 Annotation: Subtype: Link Rect: 436, 513, 445, 522 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 338, 501, 348, 510 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 353, 501, 362, 510 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 367, 501, 376, 510 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 489, 489, 499, 498 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 508, 489, 517, 498 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 373, 465, 382, 474 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 389, 465, 398, 474 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 346, 453, 355, 462 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 362, 453, 372, 462 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 338, 441, 347, 450 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 353, 441, 362, 450 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 451, 393, 460, 402 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 446, 345, 455, 354 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 503, 333, 513, 342 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 527, 273, 536, 282 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 304, 261, 314, 270 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 345, 237, 355, 246 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 341, 129, 351, 138 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 466, 129, 476, 138 Flags: Print AppearanceDictionary: true Destination: null Thumb: true Page: Sequence: 10 Annotations: Annotation: Subtype: Link Rect: 213, 120, 289, 128 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 56, 111, 256, 119 Flags: Print AppearanceDictionary: true Thumb: true Page: Sequence: 11 Thumb: true Page: Sequence: 12 Annotations: Annotation: Subtype: Link Rect: 88, 194, 207, 201 Flags: Print AppearanceDictionary: true Thumb: true Checksum: 5413b40c Type: CRC32 Checksum: 4921f633dd17ca533e69e7c29718c3d3 Type: MD5 Checksum: 1600dc1bf398af92277dec2e73649263c5178064 Type: SHA-1