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Producer: Aspose.Pdf for .NET 10.1.0; modified using iTextSharp™ 5.4.0 ©2000-2012 1T3XT BVBA (AGPL-version) CreationDate: Thu Feb 22 04:27:20 2018 CET ModDate: Mon Mar 12 13:17:16 2018 CET Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 9 Encrypted: no Page size: 599.981 x 799.994 pts Page rot: 0 File size: 766133 bytes Optimized: no PDF version: 1.4 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- MinionPro-Regular CID Type 0C Identity-H yes no yes 269 0 AMJNIO+MinionProIt Type 1C WinAnsi yes yes no 32 0 AMJNIP+Minion-Black Type 1C WinAnsi yes yes no 31 0 AMJNMP+MinionProBold Type 1C WinAnsi yes yes no 270 0 AMJOCN+MinionProIt+20 Type 1C WinAnsi yes yes no 271 0 AMJOCO+MinionProRegular Type 1C WinAnsi yes yes no 29 0 AMJOCP+MinionProRegular+fb Type 1C Custom yes yes yes 30 0 AMJODA+MinionMath-Regular Type 1C WinAnsi yes yes no 33 0 AMJOEB+MinionProRegular+20 Type 1C WinAnsi yes yes no 35 0 AMJOEC+MinionMathItalic Type 1C WinAnsi yes yes no 59 0 AMJOEE+MinionMath-Regular+22 Type 1C Custom yes yes yes 34 0 TMJOZQ+MinionPro-Regular CID TrueType Identity-H yes yes yes 1 0 AMJOKD+MinionScUnic Type 1C WinAnsi yes yes no 68 0 AMJPEA+MinionPro-Regular2 Type 1C Custom yes yes yes 110 0 AMJPEB+MinionMath-Regular-Graphic Type 1C WinAnsi yes yes no 111 0 Jhove (Rel. 1.6, 2011-01-04) Date: 2019-02-14 17:22:14 CET RepresentationInformation: pmc_29682579.pdf ReportingModule: PDF-hul, Rel. 1.8 (2009-05-22) LastModified: 2018-04-30 03:47:27 CEST Size: 766133 Format: PDF Version: 1.4 Status: Well-Formed, but not valid SignatureMatches: PDF-hul ErrorMessage: Invalid destination object Offset: 168356 ErrorMessage: Invalid destination object Offset: 168356 ErrorMessage: Invalid destination object Offset: 168356 ErrorMessage: Invalid destination object Offset: 168356 ErrorMessage: Invalid destination object Offset: 168356 ErrorMessage: Invalid destination object Offset: 168356 ErrorMessage: Invalid destination object Offset: 168356 ErrorMessage: Invalid destination object Offset: 168356 ErrorMessage: Invalid destination object Offset: 168356 ErrorMessage: Invalid destination object Offset: 168356 ErrorMessage: Invalid destination object Offset: 168356 ErrorMessage: Invalid destination object Offset: 168356 ErrorMessage: Invalid destination object Offset: 168356 ErrorMessage: Invalid destination object Offset: 168356 ErrorMessage: Invalid destination object Offset: 168356 ErrorMessage: Invalid destination object Offset: 168356 ErrorMessage: Invalid destination object Offset: 168356 ErrorMessage: Invalid destination object Offset: 168356 ErrorMessage: Invalid destination object Offset: 168356 ErrorMessage: Invalid destination object Offset: 168356 ErrorMessage: Invalid destination object Offset: 168356 ErrorMessage: Invalid destination object Offset: 168356 ErrorMessage: Invalid destination object Offset: 168356 ErrorMessage: Invalid destination object Offset: 168356 ErrorMessage: Invalid destination object Offset: 168356 ErrorMessage: Invalid destination object Offset: 168356 ErrorMessage: Invalid destination object Offset: 168356 ErrorMessage: Invalid destination object Offset: 168356 ErrorMessage: Invalid destination object Offset: 168356 ErrorMessage: Invalid destination object Offset: 168356 ErrorMessage: Invalid destination object Offset: 168356 ErrorMessage: Invalid destination object Offset: 168356 ErrorMessage: Invalid destination object Offset: 168356 ErrorMessage: Invalid destination object Offset: 168356 ErrorMessage: Invalid destination object Offset: 168356 ErrorMessage: Invalid destination object Offset: 168356 ErrorMessage: Invalid destination object Offset: 168356 ErrorMessage: Invalid destination object Offset: 168356 ErrorMessage: Invalid destination object Offset: 168356 ErrorMessage: Invalid destination object Offset: 168356 ErrorMessage: Invalid destination object Offset: 168356 ErrorMessage: Invalid destination object Offset: 168356 ErrorMessage: Invalid destination object Offset: 168356 ErrorMessage: Invalid destination object Offset: 168356 MIMEtype: application/pdf PDFMetadata: Objects: 311 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseNone Outlines: Item: Title: Glomerular Filtration Rate and/or Ratio of Urine Albumin to Creatinine as Markers for Diabetic Retinopathy: A Ten-Year Follow-Up Study Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@16f65612 Item: Title: 1. Introduction Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@311d617d Item: Title: 2. Materials and Methods Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7c53a9eb Children: Item: Title: 2.1. Setting Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@ed17bee Item: Title: 2.2. Design and Sample Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@2a33fae0 Item: Title: 2.3. Power of the Study Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@707f7052 Item: Title: 2.4. Method Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@11028347 Item: Title: 2.5. Inclusion Criteria Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@14899482 Item: Title: 2.6. Exclusion Criteria Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@21588809 Item: Title: 2.7. Ethical Adherence Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@2aae9190 Item: Title: 2.8. Statistical Methods Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@2f333739 Item: Title: 3. Results Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@77468bd9 Children: Item: Title: 3.1. Demographic Variables of Sample Size Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@12bb4df8 Item: Title: 3.2. Study of Incidence of Diabetic Retinopathy Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4cc77c2e Item: Title: 3.3. Study of Incidence of Nephropathy Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7a7b0070 Item: Title: 3.4. Statistical Analysis of any Diabetic Retinopathy Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@39a054a5 Item: Title: 3.5. Statistical Analysis of Severe Diabetic Retinopathy Forms Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@71bc1ae4 Item: Title: 3.6. Study of Survival Analysis Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6ed3ef1 Item: Title: 4. Discussion Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@2437c6dc Item: Title: 5. Conclusions Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1f89ab83 Item: Title: Disclosure Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@e73f9ac Item: Title: Conflicts of Interest Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@61064425 Item: Title: Acknowledgments Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7b1d7fff Info: Title: HDJDR_5637130 1..9 Creator: Aspose Ltd. Producer: Aspose.Pdf for .NET 10.1.0; modified using iTextSharp™ 5.4.0 ©2000-2012 1T3XT BVBA (AGPL-version) CreationDate: Thu Feb 22 04:27:20 CET 2018 ModDate: Mon Mar 12 13:17:16 CET 2018 ID: 0x2cdaab7cbb82d1484d04b12f82a44795, 0xc381948842abd4655cba277287557218 Filters: FilterPipeline: FlateDecode Fonts: Type0: Font: BaseFont: TMJOZQ+MinionPro-Regular Encoding: Identity-H ToUnicode: true Font: BaseFont: MinionPro-Regular Encoding: Identity-H ToUnicode: true Type1: Font: BaseFont: AMJNIO+MinionProIt FontSubset: true FirstChar: 38 LastChar: 243 FontDescriptor: FontName: AMJNIO+MinionProIt Flags: Serif, Nonsymbolic FontBBox: -135, -250, 1000, 854 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: AMJODA+MinionMath-Regular FontSubset: true FirstChar: 48 LastChar: 215 FontDescriptor: FontName: AMJODA+MinionMath-Regular Flags: Nonsymbolic FontBBox: -20, -427, 1541, 1072 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: AMJOEE+MinionMath-Regular+22 FontSubset: true FirstChar: 1 LastChar: 138 FontDescriptor: FontName: AMJOEE+MinionMath-Regular+22 Flags: Symbolic FontBBox: -135, -385, 1333, 895 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: AMJOEB+MinionProRegular+20 FontSubset: true FirstChar: 134 LastChar: 150 FontDescriptor: FontName: AMJOEB+MinionProRegular+20 Flags: Nonsymbolic FontBBox: -1187, -260, 1333, 833 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: AMJOKD+MinionScUnic FontSubset: true FirstChar: 70 LastChar: 117 FontDescriptor: FontName: AMJOKD+MinionScUnic Flags: Serif, Nonsymbolic FontBBox: -218, -250, 937, 802 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: AMJNMP+MinionProBold FontSubset: true FirstChar: 49 LastChar: 53 FontDescriptor: FontName: AMJNMP+MinionProBold Flags: Nonsymbolic FontBBox: -20, -239, 968, 854 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: AMJPEA+MinionPro-Regular2 FontSubset: true FirstChar: 2 LastChar: 121 FontDescriptor: FontName: AMJPEA+MinionPro-Regular2 Flags: Serif, Symbolic FontBBox: -290, -360, 1684, 989 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: AMJOCN+MinionProIt+20 FontSubset: true FirstChar: 146 LastChar: 146 FontDescriptor: FontName: AMJOCN+MinionProIt+20 Flags: Nonsymbolic FontBBox: -1187, -260, 1312, 822 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: AMJPEB+MinionMath-Regular-Graphic FontSubset: true FirstChar: 120 LastChar: 121 FontDescriptor: FontName: AMJPEB+MinionMath-Regular-Graphic Flags: Nonsymbolic FontBBox: 16, -261, 556, 448 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: AMJOEC+MinionMathItalic FontSubset: true FirstChar: 70 LastChar: 112 FontDescriptor: FontName: AMJOEC+MinionMathItalic Flags: Nonsymbolic, Italic FontBBox: -333, -260, 1000, 854 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: AMJOCO+MinionProRegular FontSubset: true FirstChar: 37 LastChar: 248 FontDescriptor: FontName: AMJOCO+MinionProRegular Flags: Serif, Nonsymbolic FontBBox: -20, -250, 947, 854 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: AMJOCP+MinionProRegular+fb FontSubset: true FirstChar: 1 LastChar: 5 FontDescriptor: FontName: AMJOCP+MinionProRegular+fb Flags: Symbolic FontBBox: 0, -10, 781, 708 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: AMJNIP+Minion-Black FontSubset: true FirstChar: 44 LastChar: 122 FontDescriptor: FontName: AMJNIP+Minion-Black Flags: Serif, Nonsymbolic, ForceBold FontBBox: -133, -250, 1120, 827 FontFile3: true Encoding: WinAnsiEncoding CIDFontType0: Font: BaseFont: MinionPro-Regular CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: MinionPro-Regular Flags: Nonsymbolic FontBBox: -290, -360, 1684, 989 FontFile3: true CIDFontType2: Font: BaseFont: TMJOZQ+MinionPro-Regular CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: TMJOZQ+MinionPro-Regular Flags: Nonsymbolic FontBBox: -289, -360, 1684, 917 FontFile2: true XMP: application/pdfGlomerular Filtration Rate and/or Ratio of Urine Albumin to Creatinine as Markers for Diabetic Retinopathy: A Ten-Year Follow-Up StudyRomero-Aroca, PedroBaget-Bernaldiz, MarcNavarro-Gil, RaulMoreno-Ribas, AntonioValls-Mateu, AidaSagarra-Alamo, RamonBarrot-De La Puente, Joan F.Mundet-Tuduri, XavierAims. To determine the relationship between diabetic nephropathy and diabetic retinopathy on a population of type 2 diabetes mellitus patients. Methods. A prospective ten-year follow-up population-based study. We determined differences between estimated glomerular filtration rate (eGFR) using the chronic kidney disease epidemiology collaboration equation and urine albumin to creatinine ratio. Results. Annual incidence of any-DR was 8.21 ± 0.60% (7.06%–8.92%), sight-threatening diabetic retinopathy (STDR) was 2.65 ± 0.14% (2.48%–2.88%), and diabetic macular edema (DME) was 2.21 ± 0.18% (2%–2.49%). Renal study results were as follows: UACR > 30 mg/g had an annual incidence of 7.02 ± 0.05% (6.97%–7.09%), eGFR < 60 ml/min/1.73 m2 incidence was 5.89 ± 0.12% (5.70%–6.13%). Cox’s proportional regression analysis of DR incidence shows that renal function studied by eGFR < 60 ml/min/1.73 m2 was less significant (p=0.04, HR 1.223, 1.098–1.201) than UACR ≥ 300 mg/g (p<0.001, HR 1.485, 1.103–1.548). The study of STDR shows that eGFR < 60 ml/min/1.73 m2 was significant (p=0.02, HR 1.890, 1.267–2.820), UACR ≥ 300 mg/g (p<0.001, HR 2.448, 1.595–3.757), and DME shows that eGFR < 60 ml/min/1.73 m2 was significant (p=0.02, HR 1.920, 1.287–2.864) and UACR ≥ 300 mg/g (p<0.001, HR 2.432, 1.584–3.732). Conclusions. The UACR has a better association with diabetic retinopathy than the eGFR, although both are important risk factors for diabetic retinopathy.Journal of Diabetes ResearchHindawi2018/02/26Research articledoi:10.1155/2018/5637130en Pages: Page: Label: 1 Annotations: Annotation: Subtype: Link Rect: 195, 537, 205, 547 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 204, 523, 214, 533 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 314, 523, 325, 533 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 312, 111, 317, 122 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 322, 111, 327, 122 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 497, 100, 501, 110 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 50, 705, 168, 713 Page: Label: 2 Annotations: Annotation: Subtype: Link Rect: 140, 716, 145, 726 Flags: 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