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Title:          A Rift Valley fever virus Gn ectodomain-based DNA vaccine induces a partial protection not improved by APC targeting
Subject:        npj Vaccines, doi:10.1038/s41541-018-0052-x
Keywords:       
Author:         Tiphany Chrun
Creator:        Springer
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      Title: A Rift Valley fever virus Gn ectodomain-based DNA vaccine induces a partial protection not improved by APC targeting
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        Title: Introduction
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        Title: Results
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          Title: Generation and validation of scFvs for targeting RVFV eGn to ovine DEC205 and CD11c receptors
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          Title: Construction, characterization and expression of anti-DEC205 and anti-CD11c scFvs fused to RVFV eGn
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         Item: 
          Title: Immunization with pscDEC-eGn promotes the eGn-specific IFNγ T-cell responses
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         Item: 
          Title: Immunization with peGn promotes the anti-eGn IgG responses in sheep sera
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         Item: 
          Title: peGn and to a lesser extent pscDEC-eGn induce partial protection against infectious RVFV challenge in sheep
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          Title: The anti-eGn IgG levels at challenge correlate with virological and clinical protection
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        Title: Discussion
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        Title: Materials and methods
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          Title: Cell lines
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          Title: RVFV strains
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          Title: Construction and production of plasmids
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          Title: Plasmid transfection in’vitro
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          Title: Cell lysate and supernatant preparation
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          Title: Western blots and dot blots
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          Title: Lymph duct cannulation and low-density lymph cell collection
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          Title: Assessment of plasmid transfection efficacy in sheep skin
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          Title: Immunizations and RVFV challenge
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          Title: Low-density lymph cells and PBMC isolation
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          Title: Staining of lymph dendritic cell and flow cytometry analysis
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          Title: Evaluation of eGn-specific T-cell responses by ELISPOT
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          Title: Evaluation of anti-eGn, anti-N and anti-RVFV responses by ELISA
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         Item: 
          Title: RNA extraction from serum and transfected skin samples
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          Title: Gn RNA quantification by qRT-PCR
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          Title: Virus titration by plaque assay
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          Title: Plaque reduction assay
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          Title: Statistical and correlation analysis
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          Title: Data availability
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        Title: Acknowledgements
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        Title: Author contributions
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        Title: Competing interests
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        Title: ACKNOWLEDGMENTS
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               <rdf:li xml:lang="x-default">A Rift Valley fever virus Gn ectodomain-based DNA vaccine induces a partial protection not improved by APC targeting</rdf:li>
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               <rdf:li>Luc Jouneau</rdf:li>
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               <rdf:li>Enric Vidal</rdf:li>
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                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
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                           <pdfaProperty:description>The aggregation type specifies the unit of aggregation for a content collection. 
Comment 
PRISM recommends that the PRISM Aggregation Type Controlled Vocabulary be used to provide values for this element. 
Note: PRISM recommends against the use of the #other value currently allowed in this controlled vocabulary. In lieu of using #other please reach out to the PRISM group at info@prismstandard.org to request addition of your term to the Aggregation Type Controlled Vocabulary. 

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                           <pdfaProperty:description>Copyright </pdfaProperty:description>
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                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
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                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>The Digital Object Identifier for the article.
The DOI may also be used as the dc:identifier. If used as a dc:identifier, the URI form should be captured, and the bare identifier should also be captured using prism:doi. If an alternate unique identifier is used as the required dc:identifier, then the DOI should be specified as a bare identifier within prism:doi only. 
If the URL associated with a DOI is to be specified, then prism:url may be used in conjunction with prism:doi in order to provide the service endpoint (i.e. the URL). 
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                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
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                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>ISSN for an electronic version of the issue in which the resource occurs. 
Permits publishers to include a second ISSN, identifying an electronic version of the issue in which the resource occurs (therefore e(lectronic)Issn. If used, prism:eIssn MUST contain the ISSN of the electronic version. See prism:issn. 
</pdfaProperty:description>
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                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
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                        <rdf:li rdf:parseType="Resource">
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                           <pdfaProperty:description>Title of the magazine, or other publication, in which a resource was/will be published. 
Typically this will be used to provide the name of the magazine an article appeared in as metadata for the article, along with information such as the article title, the publisher, volume, number, and cover date. 

Note: Publication name can be used to differentiate between a print magazine and the online version if the names are different such as “magazine” and “magazine.com.” 
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                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
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                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>This element provides the url for an article or unit of content. 
The attribute platform is optionally allowed for situations in which multiple URLs must be specified. PRISM recommends that a subset of the PCV platform values, namely “mobile” and “web”, be used in conjunction with this element. 
NOTE: PRISM recommends against the use of the #other value allowed in the PRISM Platform controlled vocabulary. In lieu of using #other please reach out to the PRISM group at prism-wg@yahoogroups.com to request addition of your term to the Platform Controlled Vocabulary. 
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                  <pdfaSchema:schema>NISO</pdfaSchema:schema>
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                           <pdfaProperty:description>Values for Journal Article Version are one of the following:
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SMUR = Submitted Manuscript Under Review
AM = Accepted Manuscript
P = Proof
VoR = Version of Record
CVoR = Corrected Version of Record
EVoR = Enhanced Version of Record</pdfaProperty:description>
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