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     Item: 
      Title: Abstract
     Item: 
      Title: Subjects and methods
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       Item: 
        Title: Study design
       Item: 
        Title: Exclusion/inclusion criteria
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         Item: 
          Title: Inclusion criteria
         Item: 
          Title: Exclusion criteria
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        Title: Procedures and study medication
       Item: 
        Title: Randomisation and blinding
       Item: 
        Title: Assays
        Children: 
         Item: 
          Title: IGF-I, GH and IGFBP3
         Item: 
          Title: ALS
         Item: 
          Title: ALS
         Item: 
          Title: GHBP
         Item: 
          Title: GHBP
       Item: 
        Title: Statistical analysis
       Item: 
        Title: Data Safety Monitoring Board
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      Title: Results
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        Title: Participants
       Item: 
        Title: Efficacy
        Children: 
         Item: 
          Title: IGF-I
         Item: 
          Title: IGFBP3
         Item: 
          Title: ALS
         Item: 
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         Item: 
          Title: GH
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         Item: 
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        Title: Ring size
       Item: 
        Title: Signs and symptoms score
       Item: 
        Title: AcroQol
       Item: 
        Title: Safety
     Item: 
      Title: Discussion
     Item: 
      Title: Declaration of interest
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