f9fb2e492aea9c0fceffaa0819f2f3e1 pmc_29867542.pdf f7591c872602d1389204425a58c5f77a2bb471b8 pmc_29867542.pdf 18bc507b0de7e7c8cb1a5f63e605a11f86b518c6584987e9419ae9c7ac42f277 pmc_29867542.pdf Title: Detrimental Effects of Testosterone Addition to Estrogen Therapy Involve Cytochrome P-450-Induced 20-HETE Synthesis in Aorta of Ovariectomized Spontaneously Hypertensive Rat (SHR), a Model of Postmenopausal Hypertension Subject: Postmenopausal period has been associated to different symptoms such as hot flashes, vulvovaginal atrophy, hypoactive sexual desire disorder (HSDD) and others. Keywords: testosterone and estrogen treatment, spontaneously hypertensive rat (SHR), cardiovascular disease, vascular reactivity, ROS generation, cytochrome P-450 pathways, 20-HETE Author: Maria Helena C. Carvalho Creator: LaTeX with hyperref package Producer: pdfTeX-1.40.15 CreationDate: Fri May 4 12:43:05 2018 CEST ModDate: Fri May 4 14:58:05 2018 CEST Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 13 Encrypted: no Page size: 595.276 x 779.528 pts Page rot: 0 File size: 1935341 bytes Optimized: no PDF version: 1.5 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- YLTAEP+MinionPro-Regular Type 1 Custom yes yes no 39 0 OEZZWC+HelveticaNeueLTStd-Bd Type 1 Custom yes yes no 40 0 EHZWYZ+HelveticaNeueLTStd-Lt Type 1 Custom yes yes no 41 0 CCVXXJ+HelveticaNeueLTStd-BdIt Type 1 Custom yes yes no 42 0 MDXKUI+HelveticaNeueLTStd-LtIt Type 1 Custom yes yes no 43 0 OMBSDC+HelveticaNeueLTStd-MdIt Type 1 Custom yes yes no 45 0 ORBLUJ+MTGU Type 1 Builtin yes yes no 46 0 IRRGLI+MTSYN Type 1 Builtin yes yes no 47 0 JEDTZJ+MinionPro-It Type 1 Custom yes yes no 164 0 NIGJYF+RBLMI Type 1 Builtin yes yes no 245 0 MTZLGX+MinionPro-Bold Type 1 Custom yes yes no 295 0 XTKQHD+MTSYB Type 1 Builtin yes yes no 367 0 DCIUPS+HelveticaNeueLTStd-Roman Type 1 Custom yes yes no 368 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2024-01-19 06:58:43 CET RepresentationInformation: pmc_29867542.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2018-06-11 03:39:52 CEST Size: 1935341 Format: PDF Version: 1.5 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 957 FreeObjects: 3 IncrementalUpdates: 1 DocumentCatalog: PageLayout: SinglePage PageMode: UseOutlines Outlines: Item: Title: Detrimental Effects of Testosterone Addition to Estrogen Therapy Involve Cytochrome P-450-Induced 20-HETE Synthesis in Aorta of Ovariectomized Spontaneously Hypertensive Rat (SHR), a Model of Postmenopausal Hypertension Children: Item: Title: Introduction Item: Title: Materials and Methods Children: Item: Title: Animal Model Item: Title: Ovariectomy, Estrogen, and Testosterone Treatment Item: Title: Arterial Blood Pressure Measurement Item: Title: Vascular Reactivity Item: Title: Detection of Reactive Oxygen Species (ROS) Generation in Aortic Sections Item: Title: Immunoblot Analysis Item: Title: Quantitative Real-Time PCR (qPCR) Analysis Item: Title: Activity of CYP Enzymes and 20-HETE Concentration Item: Title: Statistical Analysis Item: Title: Results Children: Item: Title: Uterine Weight, Sex Steroid Hormone Levels and Arterial Blood Pressure Item: Title: Vascular Reactivity Item: Title: ROS Detection Item: Title: CYP4A1 and CYP4F3 Protein and mRNA Expression Item: Title: CYP4A1 and CYP4F3 Activity and 20-HETE Concentration in Rat Aorta Item: Title: Discussion Item: Title: Conclusion Item: Title: Author Contributions Item: Title: Funding Item: Title: Acknowledgments Item: Title: References Info: Title: Detrimental Effects of Testosterone Addition to Estrogen Therapy Involve Cytochrome P-450-Induced 20-HETE Synthesis in Aorta of Ovariectomized Spontaneously Hypertensive Rat (SHR), a Model of Postmenopausal Hypertension Author: Maria Helena C. Carvalho Subject: Postmenopausal period has been associated to different symptoms such as hot flashes, vulvovaginal atrophy, hypoactive sexual desire disorder (HSDD) and others. Keywords: testosterone and estrogen treatment, spontaneously hypertensive rat (SHR), cardiovascular disease, vascular reactivity, ROS generation, cytochrome P-450 pathways, 20-HETE Creator: LaTeX with hyperref package Producer: pdfTeX-1.40.15 CreationDate: Fri May 04 13:13:05 CEST 2018 ModDate: Fri May 04 15:28:05 CEST 2018 ID: 0x30ede68e7c921c97d8261a5333f273db, 0x9e611abd5cc6f54db6f8cc7825d54086 Filters: FilterPipeline: FlateDecode Fonts: Type1: Font: BaseFont: JEDTZJ+MinionPro-It FontSubset: true FirstChar: 40 LastChar: 243 FontDescriptor: FontName: JEDTZJ+MinionPro-It Flags: Symbolic FontBBox: -201, -360, 1684, 919 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: YLTAEP+MinionPro-Regular FontSubset: true FirstChar: 2 LastChar: 252 FontDescriptor: FontName: YLTAEP+MinionPro-Regular Flags: Symbolic FontBBox: -289, -360, 1684, 917 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: MTZLGX+MinionPro-Bold FontSubset: true FirstChar: 3 LastChar: 150 FontDescriptor: FontName: MTZLGX+MinionPro-Bold Flags: Symbolic FontBBox: -318, -360, 1684, 917 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: OEZZWC+HelveticaNeueLTStd-Bd FontSubset: true FirstChar: 40 LastChar: 124 FontDescriptor: FontName: OEZZWC+HelveticaNeueLTStd-Bd Flags: Symbolic FontBBox: -166, -218, 1078, 975 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: EHZWYZ+HelveticaNeueLTStd-Lt FontSubset: true FirstChar: 2 LastChar: 150 FontDescriptor: FontName: EHZWYZ+HelveticaNeueLTStd-Lt Flags: Symbolic FontBBox: -166, -214, 1050, 967 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: CCVXXJ+HelveticaNeueLTStd-BdIt FontSubset: true FirstChar: 42 LastChar: 121 FontDescriptor: FontName: CCVXXJ+HelveticaNeueLTStd-BdIt Flags: Symbolic FontBBox: -166, -218, 1129, 975 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: MDXKUI+HelveticaNeueLTStd-LtIt FontSubset: true FirstChar: 39 LastChar: 243 FontDescriptor: FontName: MDXKUI+HelveticaNeueLTStd-LtIt Flags: Symbolic FontBBox: -165, -214, 1099, 951 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: OMBSDC+HelveticaNeueLTStd-MdIt FontSubset: true FirstChar: 42 LastChar: 243 FontDescriptor: FontName: OMBSDC+HelveticaNeueLTStd-MdIt Flags: Symbolic FontBBox: -165, -218, 1125, 947 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: ORBLUJ+MTGU FontSubset: true FirstChar: 38 LastChar: 109 FontDescriptor: FontName: ORBLUJ+MTGU Flags: Symbolic FontBBox: 25, -213, 839, 683 FontFile: true Font: BaseFont: IRRGLI+MTSYN FontSubset: true FirstChar: 0 LastChar: 67 FontDescriptor: FontName: IRRGLI+MTSYN Flags: Symbolic FontBBox: 0, -954, 1043, 900 FontFile: true Font: BaseFont: XTKQHD+MTSYB FontSubset: true FirstChar: 67 LastChar: 67 FontDescriptor: FontName: XTKQHD+MTSYB Flags: Symbolic FontBBox: -16, -935, 1043, 896 FontFile: true Font: BaseFont: DCIUPS+HelveticaNeueLTStd-Roman FontSubset: true FirstChar: 35 LastChar: 35 FontDescriptor: FontName: DCIUPS+HelveticaNeueLTStd-Roman Flags: Symbolic FontBBox: -166, -214, 1076, 952 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: NIGJYF+RBLMI FontSubset: true FirstChar: 49 LastChar: 60 FontDescriptor: FontName: NIGJYF+RBLMI Flags: Symbolic FontBBox: -11, -230, 987, 750 FontFile: true XMP: application/pdf Maria Helena C. Carvalho Postmenopausal period has been associated to different symptoms such as hot flashes, vulvovaginal atrophy, hypoactive sexual desire disorder (HSDD) and others. Detrimental Effects of Testosterone Addition to Estrogen Therapy Involve Cytochrome P-450-Induced 20-HETE Synthesis in Aorta of Ovariectomized Spontaneously Hypertensive Rat (SHR), a Model of Postmenopausal Hypertension testosterone and estrogen treatment spontaneously hypertensive rat (SHR) cardiovascular disease vascular reactivity ROS generation cytochrome P-450 pathways 20-HETE 2018-05-04T16:13:05+05:30 LaTeX with hyperref package 2018-05-04T18:28:05+05:30 2018-05-04T18:28:05+05:30 testosterone and estrogen treatment, spontaneously hypertensive rat (SHR), cardiovascular disease, vascular reactivity, ROS generation, cytochrome P-450 pathways, 20-HETE pdfTeX-1.40.15 False This is MiKTeX-pdfTeX 2.9.5496 (1.40.15) uuid:1aa680f4-7c0a-491f-bac6-e5bf726fb40a uuid:a6833696-fa1a-4fac-bd11-87f0523e494c Pages: Page: Sequence: 1 Annotations: Annotation: Subtype: Link Rect: 43, 718, 147, 754 Annotation: Subtype: Link Rect: 474, 736, 551, 745 Annotation: Subtype: Link Rect: 476, 727, 551, 737 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