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Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf Profile: Linearized PDF PDFMetadata: Objects: 1362 FreeObjects: 1 IncrementalUpdates: 1 DocumentCatalog: PageLayout: SinglePage PageMode: UseOutlines Outlines: Item: Title: Urgent challenges in quantification and interpretation of brain grey matter atrophy in individual MS patients using MRI Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@eafc191 Children: Item: Title: Introduction Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@612fc6eb Item: Title: Review of measurement techniques Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1060b431 Children: Item: Title: Cortical atrophy measurement techniques Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@612679d6 Item: Title: Deep GM atrophy measurement techniques Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@11758f2a Item: Title: Group-level analysis methods Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@e720b71 Item: Title: Challenges of pathology, physiology and treatment effects Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1b26f7b2 Children: Item: Title: Unclear pathological substrate Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@491cc5c9 Item: Title: Evolution of GM atrophy Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@74ad1f1f Item: Title: Influence of physiological variability Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6a1aab78 Item: Title: Evaluation of treatment response Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@462d5aee Item: Title: Measurement challenges Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@69b0fd6f Children: Item: Title: Influence of WM lesions Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@757942a1 Item: Title: Influence of atrophy itself Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4a87761d Item: Title: Influence of other pathology Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@66d1af89 Item: Title: Technical variability Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@8646db9 Item: Title: Conclusions Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@37374a5e Item: Title: Acknowledgements Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4671e53b Item: Title: References Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@2db7a79b Info: Title: Urgent challenges in quantification and interpretation of brain grey matter atrophy in individual MS patients using MRI Author: Houshang Amiri Subject: NeuroImage: Clinical, 19 (2018) 466-475. doi:10.1016/j.nicl.2018.04.023 Keywords: Multiple sclerosis; Brain atrophy; Grey matter; Magnetic resonance imaging; Creator: Elsevier CreationDate: Thu Aug 16 16:06:29 CEST 2018 ModDate: Thu Aug 16 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FontSubset: true FirstChar: 38 LastChar: 242 FontDescriptor: FontName: KJLEFI+AdvOT7fb33346.I Flags: Serif, Nonsymbolic FontBBox: -160, -257, 1000, 980 FontFile3: true Encoding: WinAnsiEncoding CIDFontType0: Font: BaseFont: PFVQMO+CharisSIL-Italic CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: PFVQMO+CharisSIL-Italic Flags: Serif, Symbolic, Italic FontBBox: -716, -533, 3058, 1270 FontFile3: true Font: BaseFont: FDXICI+CharisSIL CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: FDXICI+CharisSIL Flags: Serif, Symbolic FontBBox: -692, -533, 3000, 1270 FontFile3: true XMP: application/pdf doi:10.1016/j.nicl.2018.04.023 Urgent challenges in quantification and interpretation of brain grey matter atrophy in individual MS patients using MRI Houshang Amiri Alexandra de Sitter Kerstin Bendfeldt Marco Battaglini Claudia A.M. Gandini Wheeler-Kingshott Massimiliano Calabrese Jeroen J.G. Geurts Maria A. Rocca Jaume Sastre-Garriga Christian Enzinger Nicola de Stefano Massimo Filippi Álex Rovira Frederik Barkhof Hugo Vrenken MAGNIMS Study Group Multiple sclerosis Brain atrophy Grey matter Magnetic resonance imaging Elsevier NeuroImage: Clinical, 19 (2018) 466-475. doi:10.1016/j.nicl.2018.04.023 journal NeuroImage: Clinical © 2018 The Authors. 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Sequence: 10 Annotations: Annotation: Subtype: Link Rect: 37, 726, 288, 733 Annotation: Subtype: Link Rect: 49, 719, 288, 725 Annotation: Subtype: Link Rect: 49, 711, 74, 717 Annotation: Subtype: Link Rect: 37, 703, 288, 709 Annotation: Subtype: Link Rect: 49, 695, 288, 701 Annotation: Subtype: Link Rect: 49, 687, 288, 693 Annotation: Subtype: Link Rect: 49, 679, 157, 685 Annotation: Subtype: Link Rect: 37, 671, 288, 677 Annotation: Subtype: Link Rect: 49, 663, 278, 669 Annotation: Subtype: Link Rect: 49, 655, 286, 661 Annotation: Subtype: Link Rect: 49, 647, 170, 653 Annotation: Subtype: Link Rect: 37, 639, 288, 645 Annotation: Subtype: Link Rect: 49, 631, 270, 637 Annotation: Subtype: Link Rect: 49, 623, 140, 629 Annotation: Subtype: Link Rect: 37, 615, 288, 621 Annotation: Subtype: Link Rect: 49, 607, 285, 613 Annotation: Subtype: Link Rect: 49, 599, 258, 605 Annotation: Subtype: Link Rect: 49, 591, 81, 597 Annotation: Subtype: Link Rect: 37, 583, 287, 589 Annotation: Subtype: Link Rect: 49, 575, 283, 581 Annotation: Subtype: Link Rect: 49, 567, 199, 573 Annotation: Subtype: Link Rect: 37, 559, 280, 566 Annotation: Subtype: Link Rect: 49, 551, 288, 558 Annotation: Subtype: Link Rect: 49, 543, 240, 550 Annotation: Subtype: Link Rect: 37, 535, 281, 542 Annotation: Subtype: Link Rect: 49, 527, 286, 534 Annotation: Subtype: Link Rect: 49, 519, 81, 526 Annotation: Subtype: Link Rect: 37, 511, 276, 518 Annotation: Subtype: Link Rect: 49, 503, 288, 510 Annotation: Subtype: Link Rect: 49, 495, 278, 502 Annotation: Subtype: Link Rect: 49, 487, 108, 494 Annotation: Subtype: Link Rect: 37, 479, 288, 486 Annotation: Subtype: Link Rect: 49, 471, 286, 478 Annotation: Subtype: Link Rect: 37, 463, 288, 470 Annotation: Subtype: Link Rect: 49, 455, 288, 462 Annotation: Subtype: Link Rect: 49, 448, 228, 454 Annotation: Subtype: Link Rect: 37, 440, 282, 446 Annotation: Subtype: Link Rect: 49, 432, 274, 438 Annotation: Subtype: Link Rect: 49, 424, 177, 430 Annotation: Subtype: Link Rect: 37, 416, 288, 422 Annotation: Subtype: Link Rect: 49, 408, 286, 414 Annotation: Subtype: Link Rect: 49, 400, 96, 406 Annotation: Subtype: Link Rect: 37, 392, 281, 398 Annotation: Subtype: Link Rect: 49, 384, 280, 390 Annotation: Subtype: Link Rect: 49, 376, 67, 382 Annotation: Subtype: Link Rect: 37, 368, 288, 374 Annotation: Subtype: Link Rect: 49, 360, 280, 366 Annotation: Subtype: Link Rect: 49, 352, 170, 358 Annotation: Subtype: Link Rect: 37, 344, 280, 350 Annotation: Subtype: Link Rect: 49, 336, 256, 342 Annotation: Subtype: Link Rect: 318, 726, 384, 733 Annotation: Subtype: Link Rect: 306, 719, 540, 725 Annotation: Subtype: Link Rect: 318, 711, 550, 717 Annotation: Subtype: Link Rect: 318, 703, 536, 709 Annotation: Subtype: Link Rect: 306, 695, 557, 701 Annotation: Subtype: Link Rect: 318, 687, 548, 693 Annotation: Subtype: Link Rect: 318, 679, 552, 685 Annotation: Subtype: Link Rect: 318, 671, 443, 677 Annotation: Subtype: Link Rect: 306, 663, 553, 669 Annotation: 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544, 510 Annotation: Subtype: Link Rect: 318, 495, 555, 502 Annotation: Subtype: Link Rect: 318, 487, 557, 494 Annotation: Subtype: Link Rect: 318, 479, 399, 486 Annotation: Subtype: Link Rect: 306, 471, 546, 478 Annotation: Subtype: Link Rect: 318, 463, 542, 470 Annotation: Subtype: Link Rect: 306, 455, 554, 462 Annotation: Subtype: Link Rect: 318, 448, 552, 454 Annotation: Subtype: Link Rect: 318, 440, 557, 446 Annotation: Subtype: Link Rect: 318, 432, 543, 438 Annotation: Subtype: Link Rect: 306, 424, 557, 430 Annotation: Subtype: Link Rect: 318, 416, 557, 422 Annotation: Subtype: Link Rect: 318, 408, 350, 414 Annotation: Subtype: Link Rect: 306, 400, 557, 406 Annotation: Subtype: Link Rect: 318, 392, 541, 398 Annotation: Subtype: Link Rect: 318, 384, 550, 390 Annotation: Subtype: Link Rect: 318, 376, 544, 382 Annotation: Subtype: Link Rect: 306, 368, 557, 374 Annotation: Subtype: Link Rect: 318, 360, 545, 366 Annotation: Subtype: Link Rect: 318, 352, 544, 358 Annotation: Subtype: Link Rect: 318, 344, 415, 350 Checksum: 67f7f054 Type: CRC32 Checksum: 16d3f6647ff55669ef7657fd69500aaa Type: MD5 Checksum: 5278536947ea52fe338dbd92598ec3b739198f4b Type: SHA-1