a186c46047e41e3a42b19627ecba3a74 pmc_30002380.pdf 73834a1866d7d285461f47bea8fdc137fd94d187 pmc_30002380.pdf 26217a94434b8733478144c43cc48715925796968fc7f1ceee0784a0a41e29ef pmc_30002380.pdf Title: Effect of Transportation on Cultured Limbal Epithelial Sheets for Worldwide Treatment of Limbal Stem Cell Deficiency Subject: Scientific Reports, doi:10.1038/s41598-018-28553-0 Keywords: Author: O. A. Utheim Creator: Springer Producer: iText® 5.3.5 ©2000-2012 1T3XT BVBA (AGPL-version) CreationDate: Thu Jul 5 19:41:58 2018 CEST ModDate: Fri Jul 6 11:46:36 2018 CEST Tagged: no UserProperties: no Suspects: no Form: AcroForm JavaScript: no Pages: 12 Encrypted: no Page size: 595.276 x 782.362 pts Page rot: 0 File size: 1868701 bytes Optimized: no PDF version: 1.4 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- QCCHAM+Corbel CID TrueType Identity-H yes yes yes 485 0 MinionPro-It Type 1C Custom yes no yes 37 0 ICSDSC+TimesNewRomanPSMT Type 1C WinAnsi yes yes yes 486 0 BLHCAW+Corbel2 Type 1C WinAnsi yes yes yes 39 0 IGXGSC+Corbel-Bold CID TrueType Identity-H yes yes yes 40 0 MinionPro-Regular Type 1C Custom yes no yes 41 0 SCWBAL+Corbel-Bold2 Type 1C WinAnsi yes yes yes 403 0 BLHCAW+Corbel2 Type 1C WinAnsi yes yes yes 404 0 QCCHAM+Corbel CID TrueType Identity-H yes yes yes 519 0 MyriadPro-It Type 1C WinAnsi yes no yes 419 0 EuclidSymbol Type 1C Custom yes no yes 36 0 MinionPro-Bold Type 1C WinAnsi yes no yes 38 0 BLHCAW+Corbel2 Type 1C WinAnsi yes yes yes 396 0 QCCHAM+Corbel CID TrueType Identity-H yes yes yes 405 0 MyriadPro-It Type 1C WinAnsi yes no yes 406 0 EuclidSymbol-Italic Type 1C Custom yes no yes 55 0 QCCHAM+Corbel CID TrueType Identity-H yes yes yes 414 0 HXRTEE+STIXGeneral-Regular Type 1C Custom yes yes yes 73 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2024-01-19 06:55:27 CET RepresentationInformation: pmc_30002380.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2020-03-02 03:41:38 CET Size: 1868701 Format: PDF Version: 1.4 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 581 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: ViewerPreferences: HideToolbar: false HideMenubar: false HideWindowUI: false FitWindow: false CenterWindow: false DisplayDocTitle: false NonFullScreenPageMode: UseNone Direction: L2R ViewArea: CropBox ViewClip: CropBox PrintArea: CropBox PageClip: CropBox PageLayout: SinglePage PageMode: UseOutlines Language: EN Outlines: Item: Title: Effect of Transportation on Cultured Limbal Epithelial Sheets for Worldwide Treatment of Limbal Stem Cell Deficiency Children: Item: Title: Results Children: Item: Title: Donor Characteristics of Cultured Cells. Item: Title: Effect of Transportation on Viability of LEC Sheets. Item: Title: Effect of Transportation on Morphology of Cells in LEC Sheets. Item: Title: Effect of Transportation on Inter- and Intracellular Adherence of Cells. Item: Title: Effect of Transportation on Phenotype, Proliferation and Apoptosis of LEC Cell Sheets based on Immunohistochemical Analyses ... Item: Title: Effect of Transportation on Metabolic Status of the Medium. Item: Title: Discussion Item: Title: Conclusions Item: Title: Methods Children: Item: Title: Harvesting of Limbal Donors and Ethics Statement. Item: Title: Preparation and Culture of Limbal Epithelial Cells. Item: Title: Storage and Transport Simulation. Item: Title: Cell Viability Analysis. Item: Title: TEM Analysis. Item: Title: Histological Analysis. Item: Title: Immunohistochemical Analyses. Item: Title: Metabolic Analyses. Item: Title: Statistical Analyses. Item: Title: Image processing. Item: Title: Data Availability. Item: Title: Acknowledgements Item: Title: Figure 1 Viability of LECs after Transport Simulation and/or Storage. Item: Title: Figure 2 H&E-sections of LECs after Transport Simulation and/or Storage. Item: Title: Figure 3 Desmosome and hemidesmosome imaging and analysis. Item: Title: Figure 4  Expression of Immunohistochemical Markers for LECs after Transport Simulation and/or Storage. Item: Title: Figure 5 Metabolic Changes in the Storage/Transport Medium. Item: Title: Table 1 Antibodies Used in the Study. Info: Title: Effect of Transportation on Cultured Limbal Epithelial Sheets for Worldwide Treatment of Limbal Stem Cell Deficiency Author: O. A. Utheim Subject: Scientific Reports, doi:10.1038/s41598-018-28553-0 Keywords: Creator: Springer Producer: iText® 5.3.5 ©2000-2012 1T3XT BVBA (AGPL-version) CreationDate: Thu Jul 05 20:11:58 CEST 2018 ModDate: Fri Jul 06 11:46:36 CEST 2018 ID: 0x5d0bd617e12476a79d5d48bce76492f9, 0xb8e50310c5f877247b523630e3b568e0 Filters: FilterPipeline: FlateDecode FilterPipeline: DCTDecode Images: Image: NisoImageMetadata: FormatName: image/png ImageWidth: 1100 ImageHeight: 90 ColorSpace: black is zero BitsPerSample: 1 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric Name: X Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 850 ImageHeight: 993 BitsPerSample: 8 BitsPerSampleUnit: integer Intent: RelativeColorimetric Name: X Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1350 ImageHeight: 1563 BitsPerSample: 8 BitsPerSampleUnit: integer Intent: RelativeColorimetric Name: X Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1650 ImageHeight: 1399 ColorSpace: black is zero BitsPerSample: 8 BitsPerSampleUnit: integer Intent: RelativeColorimetric Name: X Image: NisoImageMetadata: FormatName: image/png ImageWidth: 1400 ImageHeight: 2065 ColorSpace: black is zero BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric Name: X Image: NisoImageMetadata: FormatName: image/png ImageWidth: 1400 ImageHeight: 2265 ColorSpace: black is zero BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric Name: X Fonts: Type0: Font: BaseFont: QCCHAM+Corbel Encoding: Identity-H ToUnicode: true Font: BaseFont: IGXGSC+Corbel-Bold Encoding: Identity-H ToUnicode: true Type1: Font: BaseFont: EuclidSymbol FirstChar: 0 LastChar: 255 FontDescriptor: FontName: EuclidSymbol Flags: Symbolic FontBBox: -166, -253, 1090, 950 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: MinionPro-It FirstChar: 0 LastChar: 255 FontDescriptor: FontName: MinionPro-It Flags: Serif, Nonsymbolic, Italic FontBBox: -201, -360, 1684, 1002 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: ICSDSC+TimesNewRomanPSMT FontSubset: true FirstChar: 32 LastChar: 120 FontDescriptor: FontName: ICSDSC+TimesNewRomanPSMT Flags: Serif, Nonsymbolic FontBBox: -568, -307, 2000, 1007 FontFile3: true Encoding: WinAnsiEncoding ToUnicode: true Font: BaseFont: MinionPro-Bold FirstChar: 0 LastChar: 255 FontDescriptor: FontName: MinionPro-Bold Flags: Serif, Nonsymbolic FontBBox: -319, -360, 1684, 1024 FontFile3: true Encoding: WinAnsiEncoding ToUnicode: true Font: BaseFont: BLHCAW+Corbel2 FontSubset: true FirstChar: 0 LastChar: 255 FontDescriptor: FontName: BLHCAW+Corbel2 Flags: Nonsymbolic FontBBox: -553, -239, 1110, 952 FontFile3: true Encoding: WinAnsiEncoding ToUnicode: true Font: BaseFont: EuclidSymbol-Italic FirstChar: 0 LastChar: 255 FontDescriptor: FontName: EuclidSymbol-Italic Flags: Symbolic, Italic FontBBox: -166, -276, 1162, 950 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: MinionPro-Regular FirstChar: 0 LastChar: 255 FontDescriptor: FontName: MinionPro-Regular Flags: Serif, Nonsymbolic FontBBox: -290, -360, 1684, 989 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: HXRTEE+STIXGeneral-Regular FontSubset: true FirstChar: 29 LastChar: 31 FontDescriptor: FontName: HXRTEE+STIXGeneral-Regular Flags: Serif, Symbolic FontBBox: -995, -455, 2000, 1055 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true CIDFontType2: Font: BaseFont: QCCHAM+Corbel CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: QCCHAM+Corbel Flags: Symbolic FontBBox: -553, -239, 1110, 952 FontFile2: true Font: BaseFont: IGXGSC+Corbel-Bold CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: IGXGSC+Corbel-Bold Flags: Symbolic FontBBox: -556, -239, 1155, 952 FontFile2: true XMP: application/pdf doi:10.1038/s41598-018-28553-0 Springer US Scientific Reports, doi:10.1038/s41598-018-28553-0 Effect of Transportation on Cultured Limbal Epithelial Sheets for Worldwide Treatment of Limbal Stem Cell Deficiency O. A. Utheim T. Lyberg J. R. Eidet S. Raeder A. Sehic B. Roald E. Messelt M. F. de la Paz D. A. Dartt T. P. Utheim 10.1038/s41598-018-28553-0 http://dx.doi.org/10.1038/s41598-018-28553-0 journal Scientific Reports © 2018, The Author(s) 2045-2322 10.1038/s41598-018-28553-0 Springer 2018-07-06T11:46:36+02:00 2018-07-05T23:11:58+05:30 2018-07-06T11:46:36+02:00 True iText® 5.3.5 ©2000-2012 1T3XT BVBA (AGPL-version) VoR uuid:e29e5709-ec2a-4dd1-af40-45e8ab6ef069 uuid:4b0a7408-9a2a-40da-a048-5e7424222107 default 1 converted uuid:56c68640-cf51-4b57-bd06-840da0b5acdd converted to PDF/A-2b pdfToolbox 2018-07-05T23:12:39+05:30 2 B http://ns.adobe.com/xap/1.0/mm/ xmpMM XMP Media Management Schema internal UUID based identifier for specific incarnation of a document InstanceID URI internal The common identifier for all versions and renditions of a document. OriginalDocumentID URI internal A reference to the original document from which this one is derived. It is a minimal reference; missing components can be assumed to be unchanged. For example, a new version might only need to specify the instance ID and version number of the previous version, or a rendition might only need to specify the instance ID and rendition class of the original. DerivedFrom ResourceRef Identifies a portion of a document. This can be a position at which the document has been changed since the most recent event history (stEvt:changed). For a resource within an xmpMM:Ingredients list, the ResourceRef uses this type to identify both the portion of the containing document that refers to the resource, and the portion of the referenced resource that is referenced. http://ns.adobe.com/xap/1.0/sType/Part# stPart Part http://ns.adobe.com/pdf/1.3/ pdf Adobe PDF Schema internal A name object indicating whether the document has been modified to include trapping information Trapped Text http://ns.adobe.com/pdfx/1.3/ pdfx pdfx internal ID of PDF/X standard GTS_PDFXVersion Text internal Conformance level of PDF/X standard GTS_PDFXConformance Text internal Company creating the PDF Company Text internal Date when document was last modified SourceModified Text internal Mirrors crossmark:DOI doi Text http://www.aiim.org/pdfa/ns/id/ pdfaid PDF/A ID Schema internal Part of PDF/A standard part Integer internal Amendment of PDF/A standard amd Text internal Conformance level of PDF/A standard conformance Text http://prismstandard.org/namespaces/basic/2.0/ prism Prism external The aggregation type specifies the unit of aggregation for a content collection. Comment PRISM recommends that the PRISM Aggregation Type Controlled Vocabulary be used to provide values for this element. Note: PRISM recommends against the use of the #other value currently allowed in this controlled vocabulary. In lieu of using #other please reach out to the PRISM group at info@prismstandard.org to request addition of your term to the Aggregation Type Controlled Vocabulary. aggregationType Text external Copyright copyright Text external The Digital Object Identifier for the article. The DOI may also be used as the dc:identifier. If used as a dc:identifier, the URI form should be captured, and the bare identifier should also be captured using prism:doi. If an alternate unique identifier is used as the required dc:identifier, then the DOI should be specified as a bare identifier within prism:doi only. If the URL associated with a DOI is to be specified, then prism:url may be used in conjunction with prism:doi in order to provide the service endpoint (i.e. the URL). doi Text external ISSN for an electronic version of the issue in which the resource occurs. Permits publishers to include a second ISSN, identifying an electronic version of the issue in which the resource occurs (therefore e(lectronic)Issn. If used, prism:eIssn MUST contain the ISSN of the electronic version. See prism:issn. issn Text external Title of the magazine, or other publication, in which a resource was/will be published. Typically this will be used to provide the name of the magazine an article appeared in as metadata for the article, along with information such as the article title, the publisher, volume, number, and cover date. Note: Publication name can be used to differentiate between a print magazine and the online version if the names are different such as “magazine” and “magazine.com.” publicationName Text external This element provides the url for an article or unit of content. The attribute platform is optionally allowed for situations in which multiple URLs must be specified. PRISM recommends that a subset of the PCV platform values, namely “mobile” and “web”, be used in conjunction with this element. NOTE: PRISM recommends against the use of the #other value allowed in the PRISM Platform controlled vocabulary. In lieu of using #other please reach out to the PRISM group at prism-wg@yahoogroups.com to request addition of your term to the Platform Controlled Vocabulary. url Text http://www.niso.org/schemas/jav/1.0/ jav NISO external Values for Journal Article Version are one of the following: AO = Author’s Original SMUR = Submitted Manuscript Under Review AM = Accepted Manuscript P = Proof VoR = Version of Record CVoR = Corrected Version of Record EVoR = Enhanced Version of Record journal_article_version Closed Choice of Text Pages: Page: Sequence: 1 Annotations: Annotation: Subtype: Link Rect: 319, 508, 328, 496 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 308, 281, 311, 269 Flags: Print AppearanceDictionary: true Destination: 306 Annotation: Subtype: Link Rect: 313, 281, 315, 269 Flags: Print AppearanceDictionary: true Destination: 306 Annotation: Subtype: Link Rect: 452, 251, 454, 239 Flags: Print AppearanceDictionary: true Destination: 306 Annotation: Subtype: Link Rect: 343, 241, 346, 229 Flags: Print AppearanceDictionary: true Destination: 306 Annotation: Subtype: Link Rect: 212, 231, 214, 219 Flags: Print AppearanceDictionary: true Destination: 306 Annotation: Subtype: Link Rect: 499, 231, 502, 219 Flags: Print AppearanceDictionary: true Destination: 306 Annotation: Subtype: Link Rect: 319, 221, 322, 209 Flags: Print AppearanceDictionary: true Destination: 306 Annotation: Subtype: Link Rect: 446, 181, 448, 169 Flags: Print AppearanceDictionary: true Destination: 306 Annotation: Subtype: Link Rect: 252, 53, 327, 43 Flags: Print AppearanceDictionary: true Thumb: true Page: Sequence: 2 Annotations: Annotation: Subtype: Link Rect: 472, 388, 475, 376 Flags: Print AppearanceDictionary: true Destination: 306 Annotation: Subtype: Link Rect: 476, 388, 479, 376 Flags: Print AppearanceDictionary: true Destination: 306 Annotation: Subtype: Link Rect: 482, 388, 488, 376 Flags: Print AppearanceDictionary: true Destination: 306 Annotation: Subtype: Link Rect: 235, 348, 240, 336 Flags: Print AppearanceDictionary: true Destination: 306 Annotation: Subtype: Link Rect: 263, 338, 269, 326 Flags: Print AppearanceDictionary: true Destination: 306 Annotation: Subtype: Link Rect: 188, 268, 191, 256 Flags: Print AppearanceDictionary: true Destination: 306 Annotation: Subtype: Link Rect: 498, 258, 501, 246 Flags: Print AppearanceDictionary: true Destination: 306 Annotation: Subtype: Link Rect: 475, 124, 495, 112 Flags: Print AppearanceDictionary: true Destination: 3 Annotation: Subtype: Link Rect: 448, 114, 456, 102 Flags: Print AppearanceDictionary: true Destination: 3 Annotation: Subtype: Link Rect: 206, 54, 210, 42 Flags: Print AppearanceDictionary: true Destination: 3 Thumb: true Page: Sequence: 3 Annotations: Annotation: Subtype: Link Rect: 280, 211, 284, 199 Flags: Print AppearanceDictionary: true Destination: 43 Annotation: Subtype: Link Rect: 519, 161, 523, 149 Flags: Print AppearanceDictionary: true Destination: 43 Thumb: true Page: Sequence: 4 Annotations: Annotation: Subtype: Link Rect: 305, 214, 340, 202 Flags: Print AppearanceDictionary: true Destination: 57 Annotation: Subtype: Link Rect: 423, 194, 434, 182 Flags: Print AppearanceDictionary: true Destination: 57 Annotation: Subtype: Link Rect: 538, 184, 549, 172 Flags: Print AppearanceDictionary: true Destination: 57 Annotation: Subtype: Link Rect: 194, 134, 206, 122 Flags: Print AppearanceDictionary: true Destination: 57 Annotation: Subtype: Link Rect: 193, 114, 204, 102 Flags: Print AppearanceDictionary: true Destination: 57 Thumb: true Page: Sequence: 5 Annotations: Annotation: Subtype: Link Rect: 328, 74, 332, 62 Flags: Print AppearanceDictionary: true Destination: 75 Thumb: true Page: Sequence: 6 Annotations: Annotation: Subtype: Link Rect: 495, 714, 500, 702 Flags: Print AppearanceDictionary: true Destination: 306 Annotation: Subtype: Link Rect: 502, 714, 508, 702 Flags: Print AppearanceDictionary: true Destination: 354 Annotation: Subtype: Link Rect: 470, 694, 481, 682 Flags: Print AppearanceDictionary: true Destination: 75 Annotation: Subtype: Link Rect: 214, 674, 225, 662 Flags: Print AppearanceDictionary: true Destination: 75 Annotation: Subtype: Link Rect: 540, 665, 545, 651 Flags: Print AppearanceDictionary: true Destination: 306 Annotation: Subtype: Link Rect: 546, 665, 552, 651 Flags: Print AppearanceDictionary: true Destination: 354 Annotation: Subtype: Link Rect: 238, 635, 247, 621 Flags: Print AppearanceDictionary: true Destination: 75 Annotation: Subtype: Link Rect: 377, 624, 386, 612 Flags: Print AppearanceDictionary: true Destination: 75 Annotation: Subtype: Link Rect: 285, 574, 295, 562 Flags: Print AppearanceDictionary: true Destination: 75 Annotation: Subtype: Link Rect: 446, 565, 457, 551 Flags: Print AppearanceDictionary: true Destination: 75 Annotation: Subtype: Link Rect: 226, 544, 232, 532 Flags: Print AppearanceDictionary: true Destination: 306 Annotation: Subtype: Link Rect: 516, 534, 526, 522 Flags: Print AppearanceDictionary: true Destination: 75 Annotation: Subtype: Link Rect: 261, 514, 272, 502 Flags: Print AppearanceDictionary: true Destination: 75 Annotation: Subtype: Link Rect: 202, 494, 207, 482 Flags: Print AppearanceDictionary: true Destination: 306 Annotation: Subtype: Link Rect: 407, 454, 416, 442 Flags: Print AppearanceDictionary: true Destination: 75 Annotation: Subtype: Link Rect: 536, 444, 545, 432 Flags: Print AppearanceDictionary: true Destination: 75 Annotation: Subtype: Link Rect: 221, 424, 227, 412 Flags: Print AppearanceDictionary: true Destination: 354 Annotation: Subtype: Link Rect: 444, 404, 453, 392 Flags: Print AppearanceDictionary: true Destination: 75 Annotation: Subtype: Link Rect: 188, 384, 197, 372 Flags: Print AppearanceDictionary: true Destination: 75 Annotation: Subtype: Link Rect: 435, 374, 438, 362 Flags: Print AppearanceDictionary: true Destination: 306 Annotation: Subtype: Link Rect: 365, 334, 376, 322 Flags: Print AppearanceDictionary: true Destination: 75 Annotation: Subtype: Link Rect: 483, 324, 494, 312 Flags: Print AppearanceDictionary: true Destination: 75 Annotation: Subtype: Link Rect: 335, 314, 341, 302 Flags: Print AppearanceDictionary: true Destination: 354 Annotation: Subtype: Link Rect: 308, 294, 319, 282 Flags: Print AppearanceDictionary: true Destination: 75 Annotation: Subtype: Link Rect: 431, 284, 443, 272 Flags: Print AppearanceDictionary: true Destination: 75 Annotation: Subtype: Link Rect: 379, 274, 385, 262 Flags: Print AppearanceDictionary: true Destination: 354 Annotation: Subtype: Link Rect: 386, 274, 392, 262 Flags: Print AppearanceDictionary: true Destination: 354 Annotation: Subtype: Link Rect: 307, 254, 314, 242 Flags: Print AppearanceDictionary: true Destination: 75 Annotation: Subtype: Link Rect: 438, 244, 445, 232 Flags: Print AppearanceDictionary: true Destination: 75 Annotation: Subtype: Link Rect: 441, 234, 446, 222 Flags: Print AppearanceDictionary: true Destination: 354 Annotation: Subtype: Link Rect: 269, 224, 272, 212 Flags: Print AppearanceDictionary: true Destination: 306 Annotation: Subtype: Link Rect: 542, 214, 549, 202 Flags: Print AppearanceDictionary: true Destination: 75 Annotation: Subtype: Link Rect: 288, 194, 295, 182 Flags: Print AppearanceDictionary: true Destination: 75 Annotation: Subtype: Link Rect: 314, 104, 318, 92 Flags: Print AppearanceDictionary: true Destination: 166 Annotation: Subtype: Link Rect: 399, 84, 410, 72 Flags: Print AppearanceDictionary: true Destination: 166 Annotation: Subtype: Link Rect: 174, 64, 184, 52 Flags: Print AppearanceDictionary: true Destination: 166 Annotation: Subtype: Link Rect: 466, 64, 472, 52 Flags: Print AppearanceDictionary: true Destination: 354 Annotation: Subtype: Link Rect: 294, 54, 299, 42 Flags: Print AppearanceDictionary: true Destination: 354 Thumb: true Page: Sequence: 7 Annotations: Annotation: Subtype: Link Rect: 436, 115, 446, 103 Flags: Print AppearanceDictionary: true Destination: 166 Annotation: Subtype: Link Rect: 461, 105, 471, 93 Flags: Print AppearanceDictionary: true Destination: 166 Annotation: Subtype: Link Rect: 529, 95, 535, 83 Flags: Print AppearanceDictionary: true Destination: 354 Annotation: Subtype: Link Rect: 404, 85, 415, 73 Flags: Print AppearanceDictionary: true Destination: 166 Annotation: Subtype: Link Rect: 174, 65, 184, 53 Flags: Print AppearanceDictionary: true Destination: 166 Annotation: Subtype: Link Rect: 477, 65, 482, 53 Flags: Print AppearanceDictionary: true Destination: 354 Thumb: true Page: Sequence: 8 Annotations: Annotation: Subtype: Link Rect: 430, 734, 442, 722 Flags: Print AppearanceDictionary: true Destination: 166 Annotation: Subtype: Link Rect: 395, 724, 401, 712 Flags: Print AppearanceDictionary: true Destination: 354 Annotation: Subtype: Link Rect: 481, 704, 492, 692 Flags: Print AppearanceDictionary: true Destination: 166 Annotation: Subtype: Link Rect: 428, 694, 437, 682 Flags: Print AppearanceDictionary: true Destination: 166 Annotation: Subtype: Link Rect: 388, 684, 394, 672 Flags: Print AppearanceDictionary: true Destination: 354 Annotation: Subtype: Link Rect: 449, 664, 458, 652 Flags: Print AppearanceDictionary: true Destination: 166 Annotation: Subtype: Link Rect: 428, 654, 437, 642 Flags: Print AppearanceDictionary: true Destination: 166 Annotation: Subtype: Link Rect: 386, 644, 391, 632 Flags: Print AppearanceDictionary: true Destination: 354 Annotation: Subtype: Link Rect: 471, 624, 480, 612 Flags: Print AppearanceDictionary: true Destination: 166 Annotation: Subtype: Link Rect: 413, 614, 423, 602 Flags: Print AppearanceDictionary: true Destination: 166 Annotation: Subtype: Link Rect: 357, 604, 363, 592 Flags: Print AppearanceDictionary: true Destination: 354 Annotation: Subtype: Link Rect: 378, 584, 389, 572 Flags: Print AppearanceDictionary: true Destination: 166 Annotation: Subtype: Link Rect: 522, 574, 533, 562 Flags: Print AppearanceDictionary: true Destination: 166 Annotation: Subtype: Link Rect: 523, 564, 534, 552 Flags: Print AppearanceDictionary: true Destination: 166 Annotation: Subtype: Link Rect: 475, 554, 481, 542 Flags: Print AppearanceDictionary: true Destination: 354 Annotation: Subtype: Link Rect: 267, 464, 269, 452 Flags: Print AppearanceDictionary: true Destination: 306 Annotation: Subtype: Link Rect: 472, 434, 475, 422 Flags: Print AppearanceDictionary: true Destination: 306 Annotation: Subtype: Link Rect: 385, 414, 388, 402 Flags: Print AppearanceDictionary: true Destination: 306 Annotation: Subtype: Link Rect: 374, 404, 377, 392 Flags: Print AppearanceDictionary: true Destination: 306 Annotation: Subtype: Link Rect: 413, 364, 416, 352 Flags: Print AppearanceDictionary: true Destination: 306 Annotation: Subtype: Link Rect: 184, 284, 187, 272 Flags: Print AppearanceDictionary: true Destination: 306 Annotation: Subtype: Link Rect: 365, 274, 371, 262 Flags: Print AppearanceDictionary: true Destination: 354 Annotation: Subtype: Link Rect: 172, 264, 177, 252 Flags: Print AppearanceDictionary: true Destination: 306 Annotation: Subtype: Link Rect: 178, 264, 184, 252 Flags: Print AppearanceDictionary: true Destination: 306 Annotation: Subtype: Link Rect: 185, 264, 191, 252 Flags: Print AppearanceDictionary: true Destination: 354 Annotation: Subtype: Link Rect: 192, 264, 198, 252 Flags: Print AppearanceDictionary: true Destination: 354 Annotation: Subtype: Link Rect: 421, 254, 424, 242 Flags: Print AppearanceDictionary: true Destination: 306 Annotation: Subtype: Link Rect: 281, 174, 284, 162 Flags: Print AppearanceDictionary: true Destination: 306 Annotation: Subtype: Link Rect: 476, 154, 482, 142 Flags: Print AppearanceDictionary: true Destination: 306 Annotation: Subtype: Link Rect: 432, 144, 437, 132 Flags: Print AppearanceDictionary: true Destination: 306 Annotation: Subtype: Link Rect: 192, 104, 197, 92 Flags: Print AppearanceDictionary: true Destination: 306 Annotation: Subtype: Link Rect: 197, 94, 203, 82 Flags: Print AppearanceDictionary: true Destination: 306 Annotation: Subtype: Link Rect: 442, 94, 448, 82 Flags: Print AppearanceDictionary: true Destination: 306 Annotation: Subtype: Link Rect: 449, 94, 454, 82 Flags: Print AppearanceDictionary: true Destination: 306 Annotation: Subtype: Link Rect: 511, 94, 514, 82 Flags: Print AppearanceDictionary: true Destination: 306 Annotation: Subtype: Link Rect: 459, 74, 464, 62 Flags: Print AppearanceDictionary: true Destination: 306 Annotation: Subtype: Link Rect: 336, 54, 341, 42 Flags: Print AppearanceDictionary: true Destination: 306 Thumb: true Page: Sequence: 9 Annotations: Annotation: Subtype: Link Rect: 203, 674, 208, 662 Flags: Print AppearanceDictionary: true Destination: 306 Annotation: Subtype: Link Rect: 358, 644, 361, 632 Flags: Print AppearanceDictionary: true Destination: 306 Annotation: Subtype: Link Rect: 206, 624, 211, 612 Flags: Print AppearanceDictionary: true Destination: 306 Annotation: Subtype: Link Rect: 301, 624, 307, 612 Flags: Print AppearanceDictionary: true Destination: 354 Annotation: Subtype: Link Rect: 494, 624, 499, 612 Flags: Print AppearanceDictionary: true Destination: 306 Annotation: Subtype: Link Rect: 273, 574, 278, 562 Flags: Print AppearanceDictionary: true Destination: 354 Annotation: Subtype: Link Rect: 188, 564, 194, 552 Flags: Print AppearanceDictionary: true Destination: 354 Annotation: Subtype: Link Rect: 282, 564, 288, 552 Flags: Print AppearanceDictionary: true Destination: 306 Annotation: Subtype: Link Rect: 223, 544, 228, 532 Flags: Print AppearanceDictionary: true Destination: 354 Annotation: Subtype: Link Rect: 448, 118, 454, 106 Flags: Print AppearanceDictionary: true Destination: 354 Annotation: Subtype: Link Rect: 225, 108, 231, 96 Flags: Print AppearanceDictionary: true Destination: 354 Thumb: true Page: Sequence: 10 Annotations: Annotation: Subtype: Link Rect: 453, 672, 456, 660 Flags: Print AppearanceDictionary: true Destination: 306 Annotation: Subtype: Link Rect: 470, 470, 476, 458 Flags: Print AppearanceDictionary: true Destination: 354 Annotation: Subtype: Link Rect: 536, 369, 542, 356 Flags: Print AppearanceDictionary: true Destination: 306 Annotation: Subtype: Link Rect: 496, 124, 501, 112 Flags: Print AppearanceDictionary: true Destination: 306 Annotation: Subtype: Link Rect: 546, 64, 552, 52 Flags: Print AppearanceDictionary: true Destination: 354 Thumb: true Page: Sequence: 11 Annotations: Annotation: Subtype: Link Rect: 267, 323, 409, 313 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 519, 314, 554, 304 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 167, 306, 270, 296 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 167, 289, 304, 279 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 261, 255, 360, 245 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 167, 212, 310, 202 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 324, 178, 421, 168 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 326, 161, 435, 151 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 520, 153, 554, 143 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 167, 144, 254, 134 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 247, 127, 367, 117 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 521, 110, 554, 100 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 167, 102, 260, 92 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 196, 85, 324, 75 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 203, 68, 317, 58 Flags: Print AppearanceDictionary: true Thumb: true Page: Sequence: 12 Annotations: Annotation: Subtype: Link Rect: 245, 726, 368, 716 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 478, 658, 554, 648 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 167, 649, 218, 639 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 279, 590, 403, 580 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 196, 573, 293, 563 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 520, 539, 554, 529 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 167, 530, 260, 520 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 483, 522, 554, 512 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 167, 513, 218, 503 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 356, 291, 515, 279 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 344, 167, 504, 155 Flags: Print AppearanceDictionary: true Thumb: true Checksum: 87950c14 Type: CRC32 Checksum: a186c46047e41e3a42b19627ecba3a74 Type: MD5 Checksum: 73834a1866d7d285461f47bea8fdc137fd94d187 Type: SHA-1 Checksum: 26217a94434b8733478144c43cc48715925796968fc7f1ceee0784a0a41e29ef Type: SHA-256