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Item: Title: Baseline Muscle MRI and muscle function analysis. Item: Title: One year muscle MRI and muscle function analysis. Item: Title: Discussion Item: Title: Methods Children: Item: Title: Study design and participants. Item: Title: Muscle imaging. Item: Title: Statistics. Item: Title: Acknowledgements Item: Title: Figure 1 Analysis of fat fraction in thigh and trunk muscles in LOPD patients at baseline. Item: Title: Figure 2 Yearly progression in thigh muscle fat replacement in symptomatic LOPD patients. Item: Title: Figure 3 Yearly progression of fat replacement in individual muscles of symptomatic patients. Item: Title: Table 1 Clinical characteristics of the cohort of LOPD patients participating in the study. Item: Title: Table 2 Demographic and clinical data of symptomatic and asymptomatic Pompe patients included in the study. Item: Title: Table 3 Correlation between Thigh fat fraction and muscle function tests, spirometry results and patient-reported outcomes at baseline visit. Item: Title: Table 4 Change between baseline and year 1 evaluation in muscle function tests, spirometry, quantitative muscle MRI and patient reported outcome measures in symptomatic and asymptomatic LOPD patients. Item: Title: Table 5 Fat fraction progression in every thigh and trunk muscle after one year of follow-up in symptomatic and asymptomatic patients. 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FontDescriptor: FontName: ESPERG+STIXGeneral-Regular Flags: Serif, Symbolic FontBBox: -995, -455, 2000, 1055 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true CIDFontType2: Font: BaseFont: PVDXPK+Corbel-Bold CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: PVDXPK+Corbel-Bold Flags: Symbolic FontBBox: -556, -239, 1155, 952 FontFile2: true Font: BaseFont: KVUYXU+Corbel CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: KVUYXU+Corbel Flags: Symbolic FontBBox: -553, -239, 1110, 952 FontFile2: true XMP: application/pdf doi:10.1038/s41598-018-29170-7 Springer US Scientific Reports, doi:10.1038/s41598-018-29170-7 Quantitative muscle MRI to follow up late onset Pompe patients: a prospective study 10.1038/s41598-018-29170-7 http://dx.doi.org/10.1038/s41598-018-29170-7 journal Scientific Reports © 2018, The Author(s) 2045-2322 10.1038/s41598-018-29170-7 Springer 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