e731c3af1f86d44dfff6e03b97d18f79 pmc_30023300.pdf 9fcd2f5d4f0fa2a8a816f1ddbc807101a273dd44 pmc_30023300.pdf f82f0a9601018cd66e3a0fd3f16acccc0c585f9297e0e5c97fed470eec70f2ba pmc_30023300.pdf Title: Elosulfase alfa for mucopolysaccharidosis type IVA_ Real-world experience in 7 patients from the Spanish Morquio-A early access program Subject: Molecular Genetics and Metabolism Reports, 15 (2018) 116-120. doi:10.1016/j.ymgmr.2018.03.009 Keywords: MPS IVA; Morquio A; Lysosomal storage disorder; Urinary GAGs; Elosulfase alfa; Quality of life Author: Guillem Pintos-Morell Creator: Elsevier CreationDate: Mon Apr 2 20:46:02 2018 CEST ModDate: Mon Apr 2 20:46:02 2018 CEST Tagged: no UserProperties: no Suspects: no Form: AcroForm JavaScript: no Pages: 5 Encrypted: no Page size: 595.276 x 793.701 pts Page rot: 0 File size: 256560 bytes Optimized: yes PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- RORTCL+CharisSIL CID Type 0C Identity-H yes yes yes 386 0 PPDOBG+AdvOT596495f2 Type 1C WinAnsi yes yes no 362 0 PPDOCH+AdvOT0de51fd2 Type 1C WinAnsi yes yes no 363 0 PPDOEH+AdvOT8608a8d1+20 Type 1C Custom yes yes yes 364 0 PPDOEI+AdvOT7fb33346.I Type 1C WinAnsi yes yes no 369 0 PPDOEJ+AdvOT596495f2+fb Type 1C Custom yes yes yes 372 0 PPDOEK+AdvOT596495f2+20 Type 1C WinAnsi yes yes no 378 0 PPDOEL+AdvOT1efcda3b.B Type 1C WinAnsi yes yes no 379 0 PPDOFM+AdvTT7b515deb Type 1C WinAnsi yes yes no 384 0 RORTCL+CharisSIL-Italic CID Type 0C Identity-H yes yes yes 150 0 PPDOIM+TimesNewRomanPSMT Type 1C WinAnsi yes yes no 159 0 PPDOJM+TimesNewRomanPS-BoldMT Type 1C WinAnsi yes yes no 158 0 PPDPEJ+AdvOT596495f2+22 Type 1C Custom yes yes yes 160 0 PPDPFK+AdvOT1efcda3b.B+fb Type 1C Custom yes yes yes 161 0 Jhove (Rel. 1.22.1, 2019-04-17) Date: 2020-12-18 06:10:36 CET RepresentationInformation: pmc_30023300.pdf ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17) LastModified: 2020-07-06 04:18:04 CEST Size: 256560 Format: PDF Version: 1.7 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf Profile: Linearized PDF PDFMetadata: Objects: 430 FreeObjects: 1 IncrementalUpdates: 1 DocumentCatalog: PageLayout: SinglePage PageMode: UseOutlines Outlines: Item: Title: Introduction Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@eafc191 Children: Item: Title: Introduction Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@612fc6eb Item: Title: Materials and methods Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1060b431 Item: Title: Results Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@612679d6 Item: Title: Discussion Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@11758f2a Item: Title: Acknowledgments Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@e720b71 Item: Title: Author contributions Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1b26f7b2 Item: Title: Conflicts of interest Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@491cc5c9 Item: Title: References Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@74ad1f1f Item: Title: Materials and methods Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6a1aab78 Item: Title: Results Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@462d5aee Item: Title: Discussion Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@69b0fd6f Item: Title: Acknowledgments Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@757942a1 Item: Title: Author contributions Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4a87761d Item: Title: Conflicts of interest Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@66d1af89 Item: Title: References Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@8646db9 Info: Title: Elosulfase alfa for mucopolysaccharidosis type IVA_ Real-world experience in 7 patients from the Spanish Morquio-A early access program Author: Guillem Pintos-Morell Subject: Molecular Genetics and Metabolism Reports, 15 (2018) 116-120. doi:10.1016/j.ymgmr.2018.03.009 Keywords: MPS IVA; Morquio A; Lysosomal storage disorder; Urinary GAGs; Elosulfase alfa; Quality of life Creator: Elsevier CreationDate: Mon Apr 02 20:46:02 CEST 2018 ModDate: Mon Apr 02 20:46:02 CEST 2018 ID: 0x8cfd06a6a798671e535288160a644fb9, 0xa67cb421545e304a8c241ab0923f6e92 Filters: FilterPipeline: FlateDecode FilterPipeline: DCTDecode Images: Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 236 ImageHeight: 298 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 248 ImageHeight: 272 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Fonts: Type0: Font: BaseFont: RORTCL+CharisSIL Encoding: Identity-H ToUnicode: true Font: BaseFont: RORTCL+CharisSIL-Italic Encoding: Identity-H ToUnicode: true Type1: Font: BaseFont: PPDOFM+AdvTT7b515deb FontSubset: true FirstChar: 174 LastChar: 174 FontDescriptor: FontName: PPDOFM+AdvTT7b515deb Flags: Nonsymbolic FontBBox: -97, -193, 859, 846 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: PPDPEJ+AdvOT596495f2+22 FontSubset: true FirstChar: 1 LastChar: 1 FontDescriptor: FontName: PPDPEJ+AdvOT596495f2+22 Flags: Symbolic FontBBox: 4, -257, 884, 878 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: PPDOEI+AdvOT7fb33346.I FontSubset: true FirstChar: 39 LastChar: 250 FontDescriptor: FontName: PPDOEI+AdvOT7fb33346.I Flags: Serif, Nonsymbolic FontBBox: -160, -257, 1000, 980 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: PPDPFK+AdvOT1efcda3b.B+fb FontSubset: true FirstChar: 1 LastChar: 1 FontDescriptor: FontName: PPDPFK+AdvOT1efcda3b.B+fb Flags: Symbolic FontBBox: 19, 0, 999, 878 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: PPDOEJ+AdvOT596495f2+fb FontSubset: true FirstChar: 1 LastChar: 5 FontDescriptor: FontName: PPDOEJ+AdvOT596495f2+fb Flags: Symbolic FontBBox: 27, 0, 921, 878 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: PPDOEK+AdvOT596495f2+20 FontSubset: true FirstChar: 150 LastChar: 150 FontDescriptor: FontName: PPDOEK+AdvOT596495f2+20 Flags: Nonsymbolic FontBBox: -477, -355, 1103, 878 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: PPDOBG+AdvOT596495f2 FontSubset: true FirstChar: 35 LastChar: 246 FontDescriptor: FontName: PPDOBG+AdvOT596495f2 Flags: Serif, Nonsymbolic FontBBox: -79, -257, 920, 984 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: PPDOEL+AdvOT1efcda3b.B FontSubset: true FirstChar: 46 LastChar: 119 FontDescriptor: FontName: PPDOEL+AdvOT1efcda3b.B Flags: Nonsymbolic FontBBox: -89, -257, 956, 998 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: PPDOCH+AdvOT0de51fd2 FontSubset: true FirstChar: 46 LastChar: 121 FontDescriptor: FontName: PPDOCH+AdvOT0de51fd2 Flags: Nonsymbolic FontBBox: -13, -250, 992, 947 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: PPDOEH+AdvOT8608a8d1+20 FontSubset: true FirstChar: 1 LastChar: 1 FontDescriptor: FontName: PPDOEH+AdvOT8608a8d1+20 Flags: Symbolic FontBBox: -970, -341, 2000, 1023 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: PPDOJM+TimesNewRomanPS-BoldMT FontSubset: true FirstChar: 32 LastChar: 116 FontDescriptor: FontName: PPDOJM+TimesNewRomanPS-BoldMT Flags: Nonsymbolic FontBBox: -558, -307, 2000, 1026 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: PPDOIM+TimesNewRomanPSMT FontSubset: true FirstChar: 32 LastChar: 116 FontDescriptor: FontName: PPDOIM+TimesNewRomanPSMT Flags: Nonsymbolic FontBBox: -568, -307, 2000, 1007 FontFile3: true Encoding: WinAnsiEncoding CIDFontType0: Font: BaseFont: RORTCL+CharisSIL-Italic CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: RORTCL+CharisSIL-Italic Flags: Serif, Symbolic, Italic FontBBox: -716, -533, 3058, 1270 FontFile3: true Font: BaseFont: RORTCL+CharisSIL CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: RORTCL+CharisSIL Flags: Serif, Symbolic FontBBox: -692, -533, 3000, 1270 FontFile3: true XMP: application/pdf doi:10.1016/j.ymgmr.2018.03.009 Elosulfase alfa for mucopolysaccharidosis type IVA_ Real-world experience in 7 patients from the Spanish Morquio-A early access program Guillem Pintos-Morell Javier Blasco-Alonso María L. Couce Luís G. Gutiérrez-Solana Encarna Guillén-Navarro Mar O'Callaghan Mireia del Toro MPS IVA Morquio A Lysosomal storage disorder Urinary GAGs Elosulfase alfa Quality of life Elsevier Molecular Genetics and Metabolism Reports, 15 (2018) 116-120. doi:10.1016/j.ymgmr.2018.03.009 journal Molecular Genetics and Metabolism Reports © 2018 The Authors. Published by Elsevier Inc. 2214-4269 15 116-120 116 120 10.1016/j.ymgmr.2018.03.009 https://doi.org/10.1016/j.ymgmr.2018.03.009 2010-04-23 true 10.1016/j.ymgmr.2018.03.009 elsevier.com sciencedirect.com 6.5 10.1016/j.ymgmr.2018.03.009 2010-04-23 true noindex elsevier.com sciencedirect.com VoR Elsevier 2018-04-02T18:46:02Z 2018-04-02T18:46:02Z 2018-04-02T18:46:02Z True MPS IVA; Morquio A; Lysosomal storage disorder; Urinary GAGs; Elosulfase alfa; Quality of life uuid:9077371f-a2ed-4485-b561-a7a61aa335ba uuid:cd7fae35-7159-4035-8704-99fb06151876 http://creativecommons.org/licenses/BY/4.0/ Pages: Page: Label: 116 Sequence: 1 Annotations: Annotation: Subtype: Link Rect: 322, 723, 369, 731 Annotation: Subtype: Link Rect: 271, 668, 407, 676 Annotation: Subtype: Link Rect: 37, 730, 37, 742 Annotation: Subtype: Link Rect: 140, 580, 144, 591 Destination: 334 Annotation: Subtype: Link Rect: 147, 581, 151, 592 Destination: 334 Annotation: Subtype: Link Rect: 153, 580, 157, 591 Destination: 334 Annotation: Subtype: Link Rect: 261, 580, 265, 591 Destination: 334 Annotation: Subtype: Link Rect: 343, 580, 347, 591 Destination: 334 Annotation: Subtype: Link Rect: 468, 580, 472, 591 Destination: 334 Annotation: Subtype: Link Rect: 154, 567, 158, 578 Destination: 334 Annotation: Subtype: Link Rect: 243, 567, 245, 578 Destination: 334 Annotation: Subtype: Link Rect: 325, 567, 329, 578 Destination: 334 Annotation: Subtype: Link Rect: 65, 205, 69, 213 Destination: 76 Annotation: Subtype: Link Rect: 115, 153, 128, 161 Destination: 76 Annotation: Subtype: Link Rect: 411, 247, 424, 255 Destination: 76 Annotation: Subtype: Link Rect: 505, 205, 509, 213 Destination: 76 Annotation: Subtype: Link Rect: 547, 195, 552, 203 Destination: 76 Annotation: Subtype: Link Rect: 484, 184, 506, 192 Destination: 76 Annotation: Subtype: Link Rect: 37, 72, 170, 79 Annotation: Subtype: Link Rect: 97, 106, 190, 113 Annotation: Subtype: Link Rect: 247, 106, 339, 113 Annotation: Subtype: Link Rect: 381, 106, 458, 113 Annotation: Subtype: Link Rect: 37, 98, 116, 104 Annotation: Subtype: Link Rect: 180, 98, 255, 104 Annotation: Subtype: Link Rect: 309, 98, 375, 104 Annotation: Subtype: Link Rect: 202, 748, 404, 759 Annotation: Subtype: Link Rect: 501, 608, 531, 622 Page: Label: 117 Sequence: 2 Page: Label: 118 Sequence: 3 Annotations: Annotation: Subtype: Link Rect: 262, 480, 271, 488 Destination: 76 Annotation: Subtype: Link Rect: 274, 480, 283, 488 Destination: 76 Annotation: Subtype: Link Rect: 111, 297, 120, 305 Destination: 76 Annotation: Subtype: Link Rect: 207, 245, 216, 253 Destination: 76 Annotation: Subtype: Link Rect: 126, 172, 135, 180 Destination: 76 Annotation: Subtype: Link Rect: 210, 172, 219, 180 Destination: 76 Annotation: Subtype: Link Rect: 96, 140, 105, 148 Destination: 76 Annotation: Subtype: Link Rect: 526, 726, 535, 734 Destination: 76 Annotation: Subtype: Link Rect: 337, 705, 346, 713 Destination: 76 Annotation: Subtype: Link Rect: 439, 684, 448, 692 Destination: 76 Annotation: Subtype: Link Rect: 457, 663, 466, 671 Destination: 76 Annotation: Subtype: Link Rect: 309, 632, 318, 640 Destination: 76 Annotation: Subtype: Link Rect: 406, 502, 434, 510 Destination: 1 Annotation: Subtype: Link Rect: 560, 491, 560, 499 Destination: 3 Annotation: Subtype: Link Rect: 306, 481, 351, 489 Destination: 3 Annotation: Subtype: Link Rect: 378, 460, 398, 468 Destination: 3 Annotation: Subtype: Link Rect: 343, 428, 364, 436 Destination: 3 Annotation: Subtype: Link Rect: 532, 376, 552, 384 Destination: 3 Annotation: Subtype: Link Rect: 437, 345, 465, 353 Destination: 1 Annotation: Subtype: Link Rect: 309, 313, 336, 321 Destination: 1 Annotation: Subtype: Link Rect: 309, 292, 336, 300 Destination: 1 Page: Label: 119 Sequence: 4 Annotations: Annotation: Subtype: Link Rect: 244, 705, 271, 713 Destination: 1 Annotation: Subtype: Link Rect: 58, 548, 67, 556 Destination: 76 Annotation: Subtype: Link Rect: 40, 506, 45, 514 Destination: 76 Annotation: Subtype: Link Rect: 47, 506, 52, 514 Destination: 76 Annotation: Subtype: Link Rect: 54, 506, 76, 514 Destination: 76 Annotation: Subtype: Link Rect: 40, 423, 49, 431 Destination: 76 Annotation: Subtype: Link Rect: 52, 423, 61, 431 Destination: 76 Annotation: Subtype: Link Rect: 135, 318, 144, 326 Destination: 76 Annotation: Subtype: Link Rect: 147, 318, 156, 326 Destination: 76 Annotation: Subtype: Link Rect: 106, 308, 111, 316 Destination: 76 Annotation: Subtype: Link Rect: 113, 308, 135, 316 Destination: 76 Annotation: Subtype: Link Rect: 196, 297, 205, 305 Destination: 76 Annotation: Subtype: Link Rect: 57, 245, 66, 253 Destination: 76 Annotation: Subtype: Link Rect: 211, 224, 220, 232 Destination: 76 Annotation: Subtype: Link Rect: 40, 172, 49, 180 Destination: 76 Annotation: Subtype: Link Rect: 52, 172, 61, 180 Destination: 76 Annotation: Subtype: Link Rect: 230, 119, 239, 127 Destination: 76 Annotation: Subtype: Link Rect: 441, 726, 450, 734 Destination: 76 Annotation: Subtype: Link Rect: 437, 674, 446, 682 Destination: 76 Annotation: Subtype: Link Rect: 449, 674, 458, 682 Destination: 76 Annotation: Subtype: Link Rect: 382, 559, 391, 567 Destination: 76 Annotation: Subtype: Link Rect: 349, 506, 358, 514 Destination: 76 Annotation: Subtype: Link Rect: 435, 485, 444, 493 Destination: 76 Annotation: Subtype: Link Rect: 543, 465, 552, 473 Destination: 76 Annotation: Subtype: Link Rect: 501, 391, 510, 399 Destination: 76 Annotation: Subtype: Link Rect: 414, 318, 423, 326 Destination: 76 Annotation: Subtype: Link Rect: 388, 297, 397, 305 Destination: 76 Annotation: Subtype: Link Rect: 469, 224, 473, 232 Destination: 76 Annotation: Subtype: Link Rect: 475, 224, 480, 232 Destination: 76 Annotation: Subtype: Link Rect: 471, 119, 480, 127 Destination: 76 Annotation: Subtype: Link Rect: 309, 109, 318, 117 Destination: 76 Page: Label: 120 Sequence: 5 Annotations: Annotation: Subtype: Link Rect: 191, 684, 200, 692 Destination: 76 Annotation: Subtype: Link Rect: 190, 394, 288, 401 Annotation: Subtype: Link Rect: 54, 386, 114, 393 Annotation: Subtype: Link Rect: 227, 362, 287, 369 Annotation: Subtype: Link Rect: 54, 354, 105, 361 Annotation: Subtype: Link Rect: 114, 330, 269, 337 Annotation: Subtype: Link Rect: 237, 315, 288, 321 Annotation: Subtype: Link Rect: 54, 307, 153, 313 Annotation: Subtype: Link Rect: 181, 283, 280, 289 Annotation: Subtype: Link Rect: 54, 275, 118, 281 Annotation: Subtype: Link Rect: 188, 251, 288, 257 Annotation: Subtype: Link Rect: 54, 243, 88, 249 Annotation: Subtype: Link Rect: 260, 219, 288, 225 Annotation: Subtype: Link Rect: 54, 211, 167, 217 Annotation: Subtype: Link Rect: 181, 187, 281, 193 Annotation: Subtype: Link Rect: 54, 179, 88, 185 Annotation: Subtype: Link Rect: 136, 155, 271, 162 Annotation: Subtype: Link Rect: 54, 147, 286, 154 Annotation: Subtype: Link Rect: 54, 139, 273, 146 Annotation: Subtype: Link Rect: 237, 123, 288, 130 Annotation: Subtype: Link Rect: 54, 115, 133, 122 Annotation: Subtype: Link Rect: 144, 99, 274, 106 Annotation: Subtype: Link Rect: 54, 91, 84, 98 Annotation: Subtype: Link Rect: 472, 726, 554, 733 Annotation: Subtype: Link Rect: 323, 719, 383, 725 Annotation: Subtype: Link Rect: 373, 695, 514, 701 Annotation: Subtype: Link Rect: 488, 679, 548, 685 Annotation: Subtype: Link Rect: 323, 671, 445, 677 Annotation: Subtype: Link Rect: 396, 647, 534, 653 Annotation: Subtype: Link Rect: 460, 607, 553, 613 Annotation: Subtype: Link Rect: 323, 599, 355, 605 Annotation: Subtype: Link Rect: 432, 575, 509, 581 Annotation: Subtype: Link Rect: 323, 559, 557, 566 Annotation: Subtype: Link Rect: 323, 551, 538, 558 Annotation: Subtype: Link Rect: 323, 543, 537, 550 Annotation: Subtype: Link Rect: 323, 535, 356, 542 Annotation: Subtype: Link Rect: 323, 511, 464, 518 Annotation: Subtype: Link Rect: 323, 495, 537, 502 Annotation: Subtype: Link Rect: 323, 487, 429, 494 Annotation: Subtype: Link Rect: 344, 463, 462, 470 Annotation: Subtype: Link Rect: 323, 455, 547, 462 Annotation: Subtype: Link Rect: 323, 448, 555, 454 Annotation: Subtype: Link Rect: 323, 440, 541, 446 Annotation: Subtype: Link Rect: 323, 432, 448, 438 Annotation: Subtype: Link Rect: 445, 408, 556, 414 Annotation: Subtype: Link Rect: 323, 400, 337, 406 Annotation: Subtype: Link Rect: 355, 376, 480, 382 Annotation: Subtype: Link Rect: 437, 352, 557, 358 Annotation: Subtype: Link Rect: 323, 344, 344, 350 Annotation: Subtype: Link Rect: 323, 336, 556, 342 Annotation: Subtype: Link Rect: 323, 328, 546, 334 Annotation: Subtype: Link Rect: 323, 320, 487, 326 Annotation: Subtype: Link Rect: 358, 296, 477, 302 Annotation: Subtype: Link Rect: 351, 272, 490, 279 Annotation: Subtype: Link Rect: 323, 248, 452, 255 Annotation: Subtype: Link Rect: 439, 232, 533, 239 Annotation: Subtype: Link Rect: 323, 224, 489, 231 Annotation: Subtype: Link Rect: 323, 216, 526, 223 Annotation: Subtype: Link Rect: 427, 185, 540, 191 Annotation: Subtype: Link Rect: 323, 177, 344, 183 Annotation: Subtype: Link Rect: 351, 153, 492, 159 Annotation: Subtype: Link Rect: 450, 137, 550, 143 Annotation: Subtype: Link Rect: 323, 129, 357, 135 Annotation: Subtype: Link Rect: 323, 121, 557, 127 Annotation: Subtype: Link Rect: 323, 113, 428, 119 Annotation: Subtype: Link Rect: 455, 97, 557, 103 Annotation: Subtype: Link Rect: 323, 89, 535, 95 Annotation: Subtype: Link Rect: 323, 81, 369, 87 Checksum: dc12b86a Type: CRC32 Checksum: e731c3af1f86d44dfff6e03b97d18f79 Type: MD5 Checksum: 9fcd2f5d4f0fa2a8a816f1ddbc807101a273dd44 Type: SHA-1