5bbe0408f63d7957692ada89ce6b2ee3 pmc_30030554.pdf e066f404bd54fe8b83cc2ce2d96c91816799dff1 pmc_30030554.pdf ae813ad743096e080d114cc11608fae20ced80753834ed5c75d600e8aa47ef82 pmc_30030554.pdf Title: Neurodegeneration in diabetic retinopathy: does it really matter? Subject: Diabetologia, doi:10.1007/s00125-018-4692-1 Keywords: Diabetic retinopathy,Microvascular impairment,Neurodegeneration,Neuroprotection,Neurovascular unit,Personalised medicine,Review Author: Rafael Simó Creator: Arbortext Advanced Print Publisher 9.1.440/W Unicode Producer: Acrobat Distiller 9.0.0 (Windows) CreationDate: Wed Jul 25 05:30:52 2018 CEST ModDate: Wed Jul 25 11:38:22 2018 CEST Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 11 Encrypted: no Page size: 595.276 x 790.866 pts Page rot: 0 File size: 2027125 bytes Optimized: yes PDF version: 1.4 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- DIAEOE+GdnstkAdvTT99c4c969 Type 1C WinAnsi yes yes no 529 0 DIAIBB+KnksfpAdvTT577c760c Type 1C WinAnsi yes yes no 540 0 IHIAPM+JftgnxDpqdbmAdvPi3 Type 1C WinAnsi yes yes no 541 0 IHIAPL+QjlvypVvmswhAdvTTc488b0e6 Type 1C WinAnsi yes yes no 542 0 DIAIBC+KmqpghAdvP0005 Type 1C WinAnsi yes yes no 543 0 DIAIBD+CdfdnbAdvTTc488b0e6 Type 1C WinAnsi yes yes no 544 0 DIAIBF+NrbdrxAdvTTaf7f9f4f.B Type 1C WinAnsi yes yes no 545 0 DIAIBG+FmbfyfAdvTT3713a231 Type 1C WinAnsi yes yes no 546 0 DIAICH+KbyrgvAdvTT3713a231+20 Type 1C WinAnsi yes yes no 547 0 DIAIDH+YslbgmAdvTTb8864ccf.B Type 1C WinAnsi yes yes no 537 0 DIAIDI+WkcqjvAdvTT4ff65459 Type 1C WinAnsi yes yes no 538 0 DIAIEJ+PkjgvpAdvTTc488b0e6+20 Type 1C WinAnsi yes yes no 539 0 DIAJLB+KtqstqAdvTTa351d857.B Type 1C WinAnsi yes yes no 212 0 DIAJLC+TxxphsAdvTTa351d857.B+20 Type 1C WinAnsi yes yes no 211 0 DIAJND+QsxwkhAdvTT3713a231+03 Type 1C Custom yes yes yes 248 0 DmltwrHelvetica Type 1C WinAnsi yes no no 245 0 GcpjmyArial Type 1C Custom yes no yes 244 0 GncvwlArialBold Type 1C WinAnsi yes no no 243 0 IHIBAO+WrkbdcHcxfbwAdvTT3713a231 Type 1C WinAnsi yes yes no 290 0 IHIBCP+QdfyngTmjmxgAdvTTb8864ccf.B Type 1C WinAnsi yes yes no 289 0 TPQENF+TqqfngSymbol Type 1C Custom yes yes no 288 0 PrstkrHelvetica-Bold Type 1C WinAnsi yes no no 285 0 IHIAPJ+TysmrjNpnhpsAdvTT577c760c Type 1C WinAnsi yes yes no 284 0 OQUGOP+RhqsygHelvetica-Oblique Type 1C WinAnsi yes yes no 323 0 DIBEFJ+NgtfgxAdvTT50a2f13e.I Type 1C WinAnsi yes yes no 320 0 DIBEFK+ShyshmAdvTTb8864ccf.B+20 Type 1C WinAnsi yes yes no 319 0 VIYPQY+VypqykArialMT Type 1C Custom yes yes yes 348 0 Jhove (Rel. 1.22.1, 2019-04-17) Date: 2020-12-23 06:05:07 CET RepresentationInformation: pmc_30030554.pdf ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17) LastModified: 2020-07-06 04:18:01 CEST Size: 2027125 Format: PDF Version: 1.4 Status: Well-Formed, but not valid SignatureMatches: PDF-hul ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - 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Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@462d5aee Children: Item: Title: Abstract Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@69b0fd6f Item: Title: Introduction Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@757942a1 Item: Title: Epidemiology and the associated economic burden Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4a87761d Item: Title: The key role of the NVU in retinal physiology Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@66d1af89 Item: Title: Is microvascular disease a primary pathogenic event in the development of diabetic retinopathy? Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@8646db9 Children: Item: Title: Blood–retinal barrier dysfunction in diabetes Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@37374a5e Item: Title: Imaging early stages of microvascular disease: the role of optical coherence tomography angiography Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4671e53b Item: Title: Is neurodegeneration the primary event in the pathogenesis of diabetic retinopathy? Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@2db7a79b Children: Item: Title: Mechanisms linking retinal neurodegeneration and early microvascular impairment Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6950e31 Item: Title: How do we integrate the microvascular and neural components? Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@b7dd107 Item: Title: Retinal neurodegeneration is a biomarker of neurodegenerative diseases Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@42eca56e Item: Title: Where do we go from here? Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@52f759d7 Item: Title: References Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7cbd213e Info: Title: Neurodegeneration in diabetic retinopathy: does it really matter? Author: Rafael Simó Subject: Diabetologia, doi:10.1007/s00125-018-4692-1 Keywords: Diabetic retinopathy,Microvascular impairment,Neurodegeneration,Neuroprotection,Neurovascular unit,Personalised medicine,Review Creator: Arbortext Advanced Print Publisher 9.1.440/W Unicode Producer: Acrobat Distiller 9.0.0 (Windows) CreationDate: Wed Jul 25 05:30:52 CEST 2018 ModDate: Wed Jul 25 11:38:22 CEST 2018 ID: 0x39f84b459c3fc274da4a21fd2d7191e1, 0x977c9e4515b23c4da3bf67dbdfed1ea8 Filters: FilterPipeline: FlateDecode FilterPipeline: DCTDecode Images: Image: NisoImageMetadata: FormatName: image/png ImageWidth: 3 ImageHeight: 3 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: Perceptual Image: NisoImageMetadata: FormatName: image/png ImageWidth: 2 ImageHeight: 2 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: Perceptual Image: NisoImageMetadata: FormatName: image/png ImageWidth: 3 ImageHeight: 3 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: 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unit,Personalised medicine,Review Acrobat Distiller 9.0.0 (Windows) application/pdf 10.1007/s00125-018-4692-1 Diabetologia Diabetologia, doi:10.1007/s00125-018-4692-1 Diabetic retinopathy Microvascular impairment Neurodegeneration Neuroprotection Neurovascular unit Personalised medicine Review Neurodegeneration in diabetic retinopathy: does it really matter? 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