03f77103cbd18d99f672dfe719b13a29 pmc_30086772.pdf 13c85956525fa83ad223ac1b0a4b868dcd445257 pmc_30086772.pdf 2d69ec9e8a743bb5247560b384075ac57fb43ef3a46ea6c4a5e5cf140feb6ee5 pmc_30086772.pdf Title: Effects of differently shaped TiO2NPs (nanospheres, nanorods and nanowires) on the in vitro model (Caco-2/HT29) of the intestinal barrier Subject: Particle and Fibre Toxicology, 2018, doi:10.1186/s12989-018-0269-x Keywords: TiO2NPs nanospheres,TiO2NPs nanorods,TiO2NPs nanowires,Intestinal barrier,In vitro Author: Alba García-Rodríguez Creator: Arbortext Advanced Print Publisher 9.1.440/W Unicode Producer: Acrobat Distiller 10.1.5 (Windows); modified using iText® 5.3.5 ©2000-2012 1T3XT BVBA (AGPL-version) CreationDate: Tue Aug 7 04:16:23 2018 CEST ModDate: Tue Aug 7 15:20:27 2018 CEST Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 16 Encrypted: no Page size: 595.276 x 790.866 pts Page rot: 0 File size: 2382216 bytes Optimized: no PDF version: 1.4 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- MyriadPro-Regular Type 1 Custom yes no no 8 0 BBDDDH+KhfrpsAdvTTb5929f4c Type 1C WinAnsi yes yes no 82 0 BBDDDF+QpprrwAdvTTe45e47d2 Type 1C WinAnsi yes yes no 16 0 BBDDGH+KwrcsdAdvTT99c4c969 Type 1C WinAnsi yes yes no 13 0 BBDDDG+SykdslAdvTT7329fd89.I Type 1C WinAnsi yes yes no 17 0 BBDDHH+MfhbhnAdvTT1b53b5fb.I Type 1C WinAnsi yes yes no 83 0 BBDDHI+VbjcfcAdvTTb5929f4c+20 Type 1C WinAnsi yes yes no 92 0 BBDCPF+JvcrfhAdvTTaf7f9f4f.B Type 1C WinAnsi yes yes no 11 0 BBDDHJ+FvpwlhAdvTT86d47313 Type 1C WinAnsi yes yes no 15 0 BBDDHK+SxvblsAdvTT86d47313+20 Type 1C WinAnsi yes yes no 10 0 BBDEIH+GydxskAdvTT86d47313+03 Type 1C Custom yes yes yes 9 0 BBDEHG+WynnfbAdvTT8861b38f.I Type 1C WinAnsi yes yes no 12 0 BBDEJI+WhgpbyAdvTT83913201.I Type 1C WinAnsi yes yes no 14 0 BBDEMH+JmnqxcAdvTT86d47313+22 Type 1C Custom yes yes no 51 0 BBDEMI+WdnlkrAdvTT99c4c969+20 Type 1C WinAnsi yes yes no 52 0 BBDENJ+CpmrqcAdvTT8861b38f.I+21 Type 1C WinAnsi yes yes no 53 0 BBDFAJ+CrhqbpAdvTT8861b38f.I+03 Type 1C Custom yes yes yes 63 0 BBDIJE+CdbwrwAdvTTb5929f4c+03 Type 1C Custom yes yes yes 84 0 BBDKNH+PvhjwhHelvetica-Bold Type 1C WinAnsi yes yes no 134 0 BBEFDJ+CkxhrpAdvTTb5929f4c+22 Type 1C Custom yes yes no 216 0 BBEGBE+NbjyknAdvTTaf7f9f4f.B+20 Type 1C WinAnsi yes yes no 294 0 Jhove (Rel. 1.22.1, 2019-04-17) Date: 2022-02-25 02:30:09 CET RepresentationInformation: pmc_30086772.pdf ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17) LastModified: 2020-02-05 11:45:22 CET Size: 2382216 Format: PDF Version: 1.4 Status: Well-Formed, but not valid SignatureMatches: PDF-hul ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR1' cannot be found Offset: 2097573 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR2' cannot be found Offset: 2097573 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR3' cannot be found Offset: 2097573 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR4' cannot be found Offset: 2097573 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR5' cannot be found Offset: 2097573 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR6' cannot be found Offset: 2097573 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR7' cannot be found Offset: 2097573 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR9' cannot be found Offset: 2097573 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR10' cannot be found Offset: 2097573 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR11' cannot be found Offset: 2097573 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR12' cannot be found Offset: 2097573 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR13' cannot be found Offset: 2097573 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR15' cannot be found Offset: 2097573 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR16' cannot be found Offset: 2097573 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR17' cannot be found Offset: 2097573 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR18' cannot be found Offset: 2097573 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR19' cannot be found Offset: 2097573 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR20' cannot be found Offset: 2097573 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR21' cannot be found Offset: 2097573 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR22' cannot be found Offset: 2097573 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR22' cannot be found Offset: 2097573 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR23' cannot be found Offset: 2097573 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR24' cannot be found Offset: 2097573 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR25' cannot be found Offset: 2097573 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR26' cannot be found Offset: 2097573 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR27' cannot be found Offset: 2097573 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR6' cannot be found Offset: 2097573 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR28' cannot be found Offset: 2097573 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR29' cannot be found Offset: 2097573 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR30' cannot be found Offset: 2097573 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR31' cannot be found Offset: 2097573 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR32' cannot be found Offset: 2097573 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR33' cannot be found Offset: 2097573 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR34' cannot be found Offset: 2097573 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR35' cannot be found Offset: 2097573 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR33' cannot be found Offset: 2097573 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR36' cannot be found Offset: 2097573 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR37' cannot be found Offset: 2097573 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR38' cannot be found Offset: 2097573 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR38' cannot be found Offset: 2097573 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR39' cannot be found Offset: 2097573 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR22' cannot be found Offset: 2097573 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR38' cannot be found Offset: 2097573 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR39' cannot be found Offset: 2097573 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR39' cannot be found Offset: 2097573 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR40' cannot be found Offset: 2097573 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR41' cannot be found Offset: 2097573 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR42' cannot be found Offset: 2097573 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR43' cannot be found Offset: 2097573 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR12' cannot be found Offset: 2097573 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR41' cannot be found Offset: 2097573 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR44' cannot be found Offset: 2097573 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR12' cannot be found Offset: 2097573 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR39' cannot be found Offset: 2097573 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR45' cannot be found Offset: 2097573 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR44' cannot be found Offset: 2097573 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR46' cannot be found Offset: 2097573 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR15' cannot be found Offset: 2097573 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR39' cannot be found Offset: 2097573 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR47' cannot be found Offset: 2097573 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR45' cannot be found Offset: 2097573 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR48' cannot be found Offset: 2097573 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR49' cannot be found Offset: 2097573 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR24' cannot be found Offset: 2097573 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR11' cannot be found Offset: 2097573 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR50' cannot be found Offset: 2097573 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR51' cannot be found Offset: 2097573 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR12' cannot be found Offset: 2097573 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR44' cannot be found Offset: 2097573 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR52' cannot be found Offset: 2097573 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR38' cannot be found Offset: 2097573 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR53' cannot be found Offset: 2097573 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR54' cannot be found Offset: 2097573 MIMEtype: application/pdf PDFMetadata: Objects: 617 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseOutlines Language: EN Outlines: Item: Title: Abstract Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@612fc6eb Children: Item: Title: Background Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1060b431 Item: Title: Methods Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@612679d6 Item: Title: Results Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@11758f2a Item: Title: Conclusions Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@e720b71 Item: Title: Background Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1b26f7b2 Item: Title: Methods Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@491cc5c9 Children: Item: Title: Nanomaterial dispersion and characterization Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@74ad1f1f Item: Title: Cell culture and the in vitro coculture model Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6a1aab78 Item: Title: Viability studies Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@462d5aee Item: Title: Evaluation of the barrier’s integrity in the in vitro coculture model Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@69b0fd6f Item: Title: Paracellular transport through the coculture barrier Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@757942a1 Item: Title: TiO2NPs localization by confocal microscopy Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4a87761d Item: Title: TiO2NPs transport across the Caco-2/HT29 coculture barrier Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@66d1af89 Item: Title: RNA extraction and gene expression by real-time qPCR Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@8646db9 Item: Title: Genotoxic and oxidative DNA damage quantification Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@37374a5e Item: Title: Statistical analysis Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4671e53b Item: Title: Results Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@2db7a79b Children: Item: Title: Nanoparticles characterization Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6950e31 Item: Title: Cytotoxic effects of the Caco-2/HT29 coculture barrier exposed to TiO2NPs Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@b7dd107 Item: Title: Evaluation of the barrier’s integrity after TiO2NPs’ exposure Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@42eca56e Item: Title: Assessing detrimental effects of TiO2NPs exposure by gene expression Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@52f759d7 Item: Title: Caco-2/HT29 barrier uptake of TiO2NPs Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7cbd213e Item: Title: Nanoparticles translocation through the Caco-2/HT29 barrier Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@192d3247 Item: Title: Genotoxic and oxidative damage. The comet assay Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@3ecd23d9 Item: Title: Discussion Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@569cfc36 Item: Title: Conclusions Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@43bd930a Item: Title: Additional file Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@33723e30 Item: Title: Acknowledgements Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@64f6106c Item: Title: Funding Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@553a3d88 Item: Title: Availability of data and materials Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7a30d1e6 Item: Title: Authors’ contributions Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@5891e32e Item: Title: Ethics approval and consent to participate Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@cb0ed20 Item: Title: Consent for publication Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@8e24743 Item: Title: Competing interests Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@74a10858 Item: Title: Publisher’s Note Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@23fe1d71 Item: Title: Author details Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@28ac3dc3 Item: Title: References Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@32eebfca Info: Title: Effects of differently shaped TiO2NPs (nanospheres, nanorods and nanowires) on the in vitro model (Caco-2/HT29) of the intestinal barrier Author: Alba García-Rodríguez Subject: Particle and Fibre Toxicology, 2018, doi:10.1186/s12989-018-0269-x Keywords: TiO2NPs nanospheres,TiO2NPs nanorods,TiO2NPs nanowires,Intestinal barrier,In vitro Creator: Arbortext Advanced Print Publisher 9.1.440/W Unicode Producer: Acrobat Distiller 10.1.5 (Windows); modified using iText® 5.3.5 ©2000-2012 1T3XT BVBA (AGPL-version) CreationDate: Tue Aug 07 04:16:23 CEST 2018 ModDate: Tue Aug 07 15:20:27 CEST 2018 ID: 0x3b04a9cd625a5b0492d489b76aa3ed09, 0x8d847f147bd13e8c3727cf221be894b0 Filters: FilterPipeline: FlateDecode FilterPipeline: DCTDecode Images: Image: NisoImageMetadata: FormatName: image/png ImageWidth: 688 ImageHeight: 126 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 95 ImageHeight: 91 BitsPerSample: 8 BitsPerSampleUnit: integer Intent: Perceptual Image: NisoImageMetadata: FormatName: image/png ImageWidth: 54 ImageHeight: 103 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 176 ImageHeight: 182 BitsPerSample: 8 BitsPerSampleUnit: integer Intent: Perceptual Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1949 ImageHeight: 2157 ColorSpace: black is zero BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1420 ImageHeight: 892 BitsPerSample: 8 BitsPerSampleUnit: integer Intent: Perceptual Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1420 ImageHeight: 760 BitsPerSample: 8 BitsPerSampleUnit: integer Intent: Perceptual Image: NisoImageMetadata: FormatName: image/png ImageWidth: 1100 ImageHeight: 90 ColorSpace: black is zero BitsPerSample: 1 BitsPerSampleUnit: integer Filter: FlateDecode Fonts: Type1: Font: BaseFont: BBDKNH+PvhjwhHelvetica-Bold FontSubset: true FirstChar: 32 LastChar: 68 FontDescriptor: FontName: BBDKNH+PvhjwhHelvetica-Bold Flags: Nonsymbolic, ForceBold FontBBox: -170, -228, 1003, 962 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: BBEGBE+NbjyknAdvTTaf7f9f4f.B+20 FontSubset: true FirstChar: 32 LastChar: 146 FontDescriptor: FontName: BBEGBE+NbjyknAdvTTaf7f9f4f.B+20 Flags: Nonsymbolic FontBBox: -468, -197, 1656, 864 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: MyriadPro-Regular FirstChar: 1 LastChar: 255 FontDescriptor: FontName: MyriadPro-Regular Flags: Nonsymbolic FontBBox: -46, -250, 1126, 879 FontFile: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: BBDEIH+GydxskAdvTT86d47313+03 FontSubset: true FirstChar: 1 LastChar: 6 FontDescriptor: FontName: BBDEIH+GydxskAdvTT86d47313+03 Flags: Symbolic FontBBox: -281, -250, 906, 885 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: BBDDHK+SxvblsAdvTT86d47313+20 FontSubset: true FirstChar: 32 LastChar: 150 FontDescriptor: FontName: BBDDHK+SxvblsAdvTT86d47313+20 Flags: Nonsymbolic FontBBox: -218, -218, 1291, 812 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: BBDCPF+JvcrfhAdvTTaf7f9f4f.B FontSubset: true FirstChar: 32 LastChar: 117 FontDescriptor: FontName: BBDCPF+JvcrfhAdvTTaf7f9f4f.B Flags: Nonsymbolic FontBBox: -218, -250, 875, 895 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: BBDEHG+WynnfbAdvTT8861b38f.I FontSubset: true FirstChar: 32 LastChar: 224 FontDescriptor: FontName: BBDEHG+WynnfbAdvTT8861b38f.I Flags: Nonsymbolic FontBBox: -187, -239, 1062, 875 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: BBDDGH+KwrcsdAdvTT99c4c969 FontSubset: true FirstChar: 32 LastChar: 122 FontDescriptor: FontName: BBDDGH+KwrcsdAdvTT99c4c969 Flags: Nonsymbolic FontBBox: -41, -250, 854, 885 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: BBDEJI+WhgpbyAdvTT83913201.I FontSubset: true FirstChar: 32 LastChar: 118 FontDescriptor: FontName: BBDEJI+WhgpbyAdvTT83913201.I Flags: Nonsymbolic FontBBox: -93, -250, 906, 875 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: BBDDHJ+FvpwlhAdvTT86d47313 FontSubset: true FirstChar: 32 LastChar: 215 FontDescriptor: FontName: BBDDHJ+FvpwlhAdvTT86d47313 Flags: Serif, Nonsymbolic FontBBox: -218, -239, 1020, 875 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: BBDDDF+QpprrwAdvTTe45e47d2 FontSubset: true FirstChar: 32 LastChar: 237 FontDescriptor: FontName: BBDDDF+QpprrwAdvTTe45e47d2 Flags: Nonsymbolic FontBBox: -218, -250, 833, 875 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: BBDDDG+SykdslAdvTT7329fd89.I FontSubset: true FirstChar: 32 LastChar: 121 FontDescriptor: FontName: BBDDDG+SykdslAdvTT7329fd89.I Flags: Nonsymbolic FontBBox: -218, -250, 885, 864 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: BBDDDH+KhfrpsAdvTTb5929f4c FontSubset: true FirstChar: 32 LastChar: 250 FontDescriptor: FontName: BBDDDH+KhfrpsAdvTTb5929f4c Flags: Nonsymbolic FontBBox: -41, -250, 812, 864 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: BBDDHH+MfhbhnAdvTT1b53b5fb.I FontSubset: true FirstChar: 32 LastChar: 242 FontDescriptor: FontName: BBDDHH+MfhbhnAdvTT1b53b5fb.I Flags: Nonsymbolic FontBBox: -114, -250, 864, 854 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: BBDEMH+JmnqxcAdvTT86d47313+22 FontSubset: true FirstChar: 21 LastChar: 22 FontDescriptor: FontName: BBDEMH+JmnqxcAdvTT86d47313+22 Flags: Nonsymbolic FontBBox: -166, -260, 1031, 906 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: BBDEMI+WdnlkrAdvTT99c4c969+20 FontSubset: true FirstChar: 32 LastChar: 146 FontDescriptor: FontName: BBDEMI+WdnlkrAdvTT99c4c969+20 Flags: Nonsymbolic FontBBox: -447, -197, 1583, 864 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: BBDIJE+CdbwrwAdvTTb5929f4c+03 FontSubset: true FirstChar: 1 LastChar: 2 FontDescriptor: FontName: BBDIJE+CdbwrwAdvTTb5929f4c+03 Flags: Symbolic FontBBox: -531, -260, 802, 968 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: BBDENJ+CpmrqcAdvTT8861b38f.I+21 FontSubset: true FirstChar: 32 LastChar: 153 FontDescriptor: FontName: BBDENJ+CpmrqcAdvTT8861b38f.I+21 Flags: Nonsymbolic FontBBox: -62, -208, 1375, 802 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: BBEFDJ+CkxhrpAdvTTb5929f4c+22 FontSubset: true FirstChar: 21 LastChar: 22 FontDescriptor: FontName: BBEFDJ+CkxhrpAdvTTb5929f4c+22 Flags: Nonsymbolic FontBBox: -10, -218, 1083, 906 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: BBDDHI+VbjcfcAdvTTb5929f4c+20 FontSubset: true FirstChar: 32 LastChar: 150 FontDescriptor: FontName: BBDDHI+VbjcfcAdvTTb5929f4c+20 Flags: Nonsymbolic FontBBox: -447, -208, 1375, 864 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: BBDFAJ+CrhqbpAdvTT8861b38f.I+03 FontSubset: true FirstChar: 1 LastChar: 2 FontDescriptor: FontName: BBDFAJ+CrhqbpAdvTT8861b38f.I+03 Flags: Symbolic FontBBox: -291, -239, 937, 885 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true XMP: TiO2NPs nanospheres,TiO2NPs nanorods,TiO2NPs nanowires,Intestinal barrier,In vitro Acrobat Distiller 10.1.5 (Windows); modified using iText® 5.3.5 ©2000-2012 1T3XT BVBA (AGPL-version) application/pdf 10.1186/s12989-018-0269-x Particle and Fibre Toxicology Particle and Fibre Toxicology, 2018, doi:10.1186/s12989-018-0269-x TiO2NPs nanospheres TiO2NPs nanorods TiO2NPs nanowires Intestinal barrier In vitro Effects of differently shaped TiO2NPs (nanospheres, nanorods and nanowires) on the in vitro model (Caco-2/HT29) of the intestinal barrier Alba García-Rodríguez Laura Vila Constanza Cortés Alba Hernández Ricard Marcos 2018-08-07T15:20:27+02:00 2018-08-07T10:16:23+08:00 Arbortext Advanced Print Publisher 9.1.440/W Unicode 2018-08-07T15:20:27+02:00 uuid:ca2474d8-17f5-4ffd-88bc-a446ebd5776c uuid:4b68d6f9-1f33-4f63-ba4c-e0e6765a0963 default 1 converted uuid:831b7cb6-64e7-4153-a76a-ad1fcd6a9478 converted to PDF/A-2b pdfToolbox 2018-08-07T10:27:56+08:00 2 B Ricard Marcos http://orcid.org/0000-0001-7891-357X Springer Nature ORCID Schema http://springernature.com/ns/xmpExtensions/2.0/ sn authorInfo Bag AuthorInformation external Author information: contains the name of each author and his/her ORCID (ORCiD: Open Researcher and Contributor ID). An ORCID is a persistent identifier (a non-proprietary alphanumeric code) to uniquely identify scientific and other academic authors. editorInfo Bag EditorInformation external Editor information: contains the name of each editor and his/her ORCID identifier. seriesEditorInfo Bag SeriesEditorInformation external Series editor information: contains the name of each series editor and his/her ORCID identifier. AuthorInformation http://springernature.com/ns/xmpExtensions/2.0/authorInfo/ author Specifies the types of author information: name and ORCID of an author. name Text Gives the name of an author. orcid URI Gives the ORCID of an author. EditorInformation http://springernature.com/ns/xmpExtensions/2.0/editorInfo/ editor Specifies the types of editor information: name and ORCID of an editor. name Text Gives the name of an editor. orcid URI Gives the ORCID of an editor. SeriesEditorInformation http://springernature.com/ns/xmpExtensions/2.0/seriesEditorInfo/ seriesEditor Specifies the types of series editor information: name and ORCID of a series editor. name Text Gives the name of a series editor. orcid URI Gives the ORCID of a series editor. http://ns.adobe.com/pdf/1.3/ pdf Adobe PDF Schema internal A name object indicating whether the document has been modified to include trapping information Trapped Text http://ns.adobe.com/xap/1.0/mm/ xmpMM XMP Media Management Schema internal UUID based identifier for specific incarnation of a document InstanceID URI internal The common identifier for all versions and renditions of a document. OriginalDocumentID URI internal A reference to the original document from which this one is derived. It is a minimal reference; missing components can be assumed to be unchanged. For example, a new version might only need to specify the instance ID and version number of the previous version, or a rendition might only need to specify the instance ID and rendition class of the original. DerivedFrom ResourceRef Identifies a portion of a document. This can be a position at which the document has been changed since the most recent event history (stEvt:changed). For a resource within an xmpMM:Ingredients list, the ResourceRef uses this type to identify both the portion of the containing document that refers to the resource, and the portion of the referenced resource that is referenced. http://ns.adobe.com/xap/1.0/sType/Part# stPart Part http://ns.adobe.com/xap/1.0/t/pg/ xmpTPg XMP Paged-Text internal A structure containing the characteristics of a font used in a document Fonts Bag Font internal XMP08 Spec: An ordered array of plate names that are needed to print the document (including any in contained documents). PlateNames Seq Text A structure containing the characteristics of a font used in a document. http://ns.adobe.com/xap/1.0/sType/Font# stFnt Font http://ns.adobe.com/pdfx/1.3/ pdfx PDF/X ID Schema internal ID of PDF/X standard GTS_PDFXVersion Text internal Conformance level of PDF/X standard GTS_PDFXConformance Text internal Company creating the PDF Company Text internal Date when document was last modified SourceModified Text http://www.aiim.org/pdfa/ns/id/ pdfaid PDF/A ID Schema internal Part of PDF/A standard part Integer internal Amendment of PDF/A standard amd Text internal Conformance level of PDF/A standard conformance Text Pages: Page: Label: 1 Annotations: Annotation: Subtype: Link Rect: 484, 657, 538, 679 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 458, 547, 467, 556 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 196, 241, 201, 251 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 118, 205, 123, 215 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 191, 157, 196, 167 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 202, 157, 207, 167 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 477, 229, 482, 239 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 382, 181, 387, 191 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 114, 126, 184, 134 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 187, 126, 251, 134 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 239, 65, 357, 72 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 182, 41, 321, 48 Flags: Print AppearanceDictionary: true Thumb: true Page: Label: 2 Annotations: Annotation: Subtype: Link Rect: 123, 633, 128, 642 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 134, 633, 139, 642 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 86, 597, 96, 606 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 183, 585, 192, 594 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 130, 561, 140, 570 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 183, 525, 192, 534 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 198, 525, 207, 534 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 203, 357, 213, 366 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 218, 357, 228, 366 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 166, 309, 176, 318 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 105, 273, 114, 282 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 119, 273, 129, 282 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 119, 237, 128, 246 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 82, 165, 91, 174 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 123, 129, 133, 138 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 275, 105, 285, 114 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 524, 357, 533, 366 Flags: Print AppearanceDictionary: true Destination: null Thumb: true Page: Label: 3 Annotations: Annotation: Subtype: Link Rect: 189, 465, 193, 474 Flags: Print AppearanceDictionary: true Destination: 291 Annotation: Subtype: Link Rect: 502, 393, 511, 402 Flags: Print AppearanceDictionary: true Destination: null Thumb: true Page: Label: 4 Annotations: Annotation: Subtype: Link Rect: 234, 345, 238, 354 Flags: Print AppearanceDictionary: true Destination: 291 Annotation: Subtype: Link Rect: 333, 285, 439, 294 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 431, 201, 436, 210 Flags: Print AppearanceDictionary: true Destination: 77 Annotation: Subtype: Link Rect: 416, 141, 425, 150 Flags: Print AppearanceDictionary: true Destination: 77 Thumb: true Page: Label: 5 Annotations: Annotation: Subtype: Link Rect: 100, 105, 105, 114 Flags: Print AppearanceDictionary: true Destination: 291 Thumb: true Page: Label: 6 Annotations: Annotation: Subtype: Link Rect: 122, 669, 131, 678 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 113, 549, 122, 558 Flags: Print AppearanceDictionary: true Destination: 77 Annotation: Subtype: Link Rect: 209, 453, 214, 462 Flags: Print AppearanceDictionary: true Destination: 291 Annotation: Subtype: Link Rect: 256, 429, 265, 438 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 213, 417, 218, 426 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 264, 405, 268, 414 Flags: Print AppearanceDictionary: true Destination: 88 Annotation: Subtype: Link Rect: 206, 177, 215, 186 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 194, 129, 203, 138 Flags: Print AppearanceDictionary: true Destination: 123 Annotation: Subtype: Link Rect: 77, 93, 86, 102 Flags: Print AppearanceDictionary: true Destination: 123 Annotation: Subtype: Link Rect: 184, 93, 193, 102 Flags: Print AppearanceDictionary: true Destination: 123 Annotation: Subtype: Link Rect: 439, 165, 459, 174 Flags: Print AppearanceDictionary: true Destination: 123 Annotation: Subtype: Link Rect: 479, 165, 482, 174 Flags: Print AppearanceDictionary: true Destination: 123 Annotation: Subtype: Link Rect: 419, 57, 424, 66 Flags: Print AppearanceDictionary: true Destination: 132 Thumb: true Page: Label: 7 Annotations: Annotation: Subtype: Link Rect: 113, 117, 122, 126 Flags: Print AppearanceDictionary: true Destination: 132 Thumb: true Page: Label: 8 Annotations: Annotation: Subtype: Link Rect: 261, 405, 266, 414 Flags: Print AppearanceDictionary: true Destination: 132 Annotation: Subtype: Link Rect: 213, 369, 222, 378 Flags: Print AppearanceDictionary: true Destination: 153 Annotation: Subtype: Link Rect: 102, 321, 111, 330 Flags: Print AppearanceDictionary: true Destination: 153 Annotation: Subtype: Link Rect: 202, 297, 211, 306 Flags: Print AppearanceDictionary: true Destination: 153 Annotation: Subtype: Link Rect: 429, 417, 439, 426 Flags: Print AppearanceDictionary: true Destination: 153 Annotation: Subtype: Link Rect: 509, 393, 519, 402 Flags: Print AppearanceDictionary: true Destination: 153 Annotation: Subtype: Link Rect: 439, 345, 446, 354 Flags: Print AppearanceDictionary: true Destination: 153 Thumb: true Page: Label: 9 Annotations: Annotation: Subtype: Link Rect: 84, 105, 89, 114 Flags: Print AppearanceDictionary: true Destination: 166 Annotation: Subtype: Link Rect: 386, 129, 396, 138 Flags: Print AppearanceDictionary: true Destination: 166 Annotation: Subtype: Link Rect: 416, 129, 420, 138 Flags: Print AppearanceDictionary: true Destination: 166 Thumb: true Page: Label: 10 Annotations: Annotation: Subtype: Link Rect: 207, 453, 212, 462 Flags: Print AppearanceDictionary: true Destination: 166 Annotation: Subtype: Link Rect: 201, 345, 206, 354 Flags: Print AppearanceDictionary: true Destination: 166 Annotation: Subtype: Link Rect: 359, 369, 369, 378 Flags: Print AppearanceDictionary: true Destination: 166 Annotation: Subtype: Link Rect: 501, 357, 511, 366 Flags: Print AppearanceDictionary: true Destination: 166 Annotation: Subtype: Link Rect: 426, 345, 430, 354 Flags: Print AppearanceDictionary: true Destination: 291 Annotation: Subtype: Link Rect: 381, 93, 385, 101 Flags: Print AppearanceDictionary: true Destination: 166 Thumb: true Page: Label: 11 Annotations: Annotation: Subtype: Link Rect: 217, 669, 227, 678 Flags: Print AppearanceDictionary: true Destination: 166 Annotation: Subtype: Link Rect: 56, 657, 64, 666 Flags: Print AppearanceDictionary: true Destination: 166 Annotation: Subtype: Link Rect: 233, 453, 237, 462 Flags: Print AppearanceDictionary: true Destination: 291 Annotation: Subtype: Link Rect: 88, 417, 93, 426 Flags: Print AppearanceDictionary: true Destination: 182 Annotation: Subtype: Link Rect: 375, 669, 380, 678 Flags: Print AppearanceDictionary: true Destination: 214 Annotation: Subtype: Link Rect: 482, 645, 491, 654 Flags: Print AppearanceDictionary: true Destination: 214 Annotation: Subtype: Link Rect: 442, 609, 451, 618 Flags: Print AppearanceDictionary: true Destination: 214 Annotation: Subtype: Link Rect: 400, 573, 409, 582 Flags: Print AppearanceDictionary: true Destination: 182 Annotation: Subtype: Link Rect: 428, 573, 433, 582 Flags: Print AppearanceDictionary: true Destination: 182 Annotation: Subtype: Link Rect: 340, 465, 350, 474 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 355, 465, 364, 474 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 390, 345, 400, 354 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 429, 261, 439, 270 Flags: Print AppearanceDictionary: true Destination: null Thumb: true Page: Label: 12 Annotations: Annotation: Subtype: Link Rect: 235, 177, 244, 186 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 250, 177, 259, 186 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 108, 129, 118, 138 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 411, 177, 420, 186 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 425, 177, 434, 186 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 410, 81, 420, 90 Flags: Print AppearanceDictionary: true Destination: null Thumb: true Page: Label: 13 Annotations: Annotation: Subtype: Link Rect: 140, 669, 150, 678 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 173, 585, 183, 594 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 189, 585, 198, 594 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 159, 465, 168, 474 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 259, 465, 268, 474 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 104, 453, 114, 462 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 195, 189, 204, 198 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 232, 117, 242, 126 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 248, 117, 257, 126 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 159, 93, 168, 102 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 433, 645, 443, 654 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 488, 501, 497, 510 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 506, 381, 516, 390 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 524, 381, 533, 390 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 393, 333, 402, 342 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 407, 333, 417, 342 Flags: Print AppearanceDictionary: true Destination: null Thumb: true Page: Label: 14 Annotations: Annotation: Subtype: Link Rect: 135, 693, 144, 702 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 180, 609, 190, 618 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 194, 609, 204, 618 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 59, 573, 69, 582 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 149, 417, 159, 426 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 168, 249, 178, 258 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 59, 237, 69, 246 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 85, 165, 95, 174 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 243, 141, 253, 150 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 225, 117, 234, 126 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 59, 69, 69, 78 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 74, 69, 84, 78 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 89, 69, 99, 78 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 83, 57, 93, 66 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 364, 681, 374, 690 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 408, 633, 418, 642 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 477, 585, 487, 594 Flags: Print AppearanceDictionary: true Destination: null Thumb: true Page: Label: 15 Annotations: Annotation: Subtype: Link Rect: 112, 669, 122, 678 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 59, 597, 69, 606 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 61, 523, 118, 530 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 509, 592, 530, 599 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 319, 583, 503, 590 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 414, 565, 534, 572 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 319, 556, 347, 563 Flags: Print AppearanceDictionary: true Thumb: true Page: Label: 16 Annotations: Annotation: Subtype: Link Rect: 127, 620, 265, 628 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 71, 611, 207, 619 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 71, 602, 165, 610 Flags: Print AppearanceDictionary: true Thumb: true Checksum: 8eaf984e Type: CRC32 Checksum: 03f77103cbd18d99f672dfe719b13a29 Type: MD5 Checksum: 13c85956525fa83ad223ac1b0a4b868dcd445257 Type: SHA-1