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Background Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1060b431 Item: Title: 2. Methods Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@612679d6 Children: Item: Title: 2.1. Study population Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@11758f2a Item: Title: 2.2. CSF analyses Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@e720b71 Item: Title: 2.3. Magnetic resonance imaging Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1b26f7b2 Children: Item: Title: 2.3.1. MRI acquisition and processing Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@491cc5c9 Item: Title: 2.3.2. Adjusted hippocampal volumes Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@74ad1f1f Item: Title: 2.3.3. Cortical signature of Alzheimer's disease Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6a1aab78 Item: Title: 2.4. Positron emission tomography Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@462d5aee Item: Title: 2.5. Definition of the AD state and stages in the AD continuum Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@69b0fd6f Item: Title: 2.6. Statistical methods Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@757942a1 Item: Title: 3. Results Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4a87761d Children: Item: Title: 3.1. Demographics and patients' characteristics Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@66d1af89 Item: Title: 3.2. Consistency of biomarker combinations across A/T/N categories at the individual level Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@8646db9 Item: Title: 3.3. Agreement and correlation between amyloid biomarkers Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@37374a5e Item: Title: 3.4. Agreement and correlation between neurodegeneration biomarkers Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4671e53b Item: Title: 3.5. Agreement and correlation between biomarkers of different pathophysiological categories Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@2db7a79b Item: Title: 4. Discussion Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6950e31 Item: Title: Acknowledgments Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@b7dd107 Item: Title: Supplementary data Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@42eca56e Item: Title: References Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@52f759d7 Info: Title: Challenges associated with biomarker-based classification systems for Alzheimer's disease Author: Ignacio Illán-Gala Subject: Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring, 10 (2018) 346-357. doi:10.1016/j.dadm.2018.03.004 Creator: Elsevier Producer: Acrobat Distiller 8.1.0 (Windows) CreationDate: Mon Dec 24 19:05:01 CET 2018 ModDate: Mon Dec 24 19:05:40 CET 2018 ID: 0x0eaf995c1275de3c612332ccb11d17ba, 0xfcf174da31c0d648a7ea82e02a56e041 Filters: FilterPipeline: FlateDecode FilterPipeline: DCTDecode Images: Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 251 ImageHeight: 276 BitsPerSample: 8 BitsPerSampleUnit: integer ColorSpace: Separation Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1922 ImageHeight: 2075 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1989 ImageHeight: 1748 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1998 ImageHeight: 1014 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1550 ImageHeight: 584 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1550 ImageHeight: 702 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Fonts: Type1: Font: BaseFont: FMIHMM+AdvPS586B FontSubset: true FirstChar: 44 LastChar: 54 FontDescriptor: FontName: FMIHMM+AdvPS586B Flags: Nonsymbolic FontBBox: -20, -229, 1010, 812 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: FMJDEJ+AdvPS7DED FontSubset: true FirstChar: 50 LastChar: 50 FontDescriptor: FontName: FMJDEJ+AdvPS7DED Flags: Nonsymbolic FontBBox: -20, -229, 927, 770 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: FMIIBL+AdvPS3F4C13 FontSubset: true FirstChar: 97 LastChar: 98 FontDescriptor: FontName: FMIIBL+AdvPS3F4C13 Flags: Nonsymbolic FontBBox: 0, -291, 875, 697 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: FMIHMK+AdvPSA88B FontSubset: true FirstChar: 42 LastChar: 121 FontDescriptor: FontName: FMIHMK+AdvPSA88B Flags: Serif, Nonsymbolic FontBBox: -166, -208, 1000, 781 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: FMIICM+AdvOTd877c31c+03 FontSubset: true FirstChar: 1 LastChar: 1 FontDescriptor: FontName: FMIICM+AdvOTd877c31c+03 Flags: Symbolic FontBBox: 24, -10, 407, 460 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: FMIHLI+AdvPSA88A FontSubset: true FirstChar: 37 LastChar: 245 FontDescriptor: FontName: FMIHLI+AdvPSA88A Flags: Serif, Nonsymbolic FontBBox: -166, -208, 1000, 781 FontFile3: true Encoding: MacRomanEncoding Font: BaseFont: FMIHML+AdvPSSym FontSubset: true FirstChar: 1 LastChar: 1 FontDescriptor: FontName: FMIHML+AdvPSSym Flags: Symbolic FontBBox: -177, -291, 1083, 1010 FontFile3: true EncodingDictionary: Differences: true Font: BaseFont: FMIHLJ+AdvP4C4E59 FontSubset: true FirstChar: 1 LastChar: 160 FontDescriptor: FontName: FMIHLJ+AdvP4C4E59 Flags: Symbolic FontBBox: -31, -250, 1000, 750 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: FMIHLK+AdvPSA88C FontSubset: true FirstChar: 38 LastChar: 245 FontDescriptor: FontName: FMIHLK+AdvPSA88C Flags: Serif, Nonsymbolic FontBBox: -166, -208, 1010, 781 FontFile3: true Encoding: MacRomanEncoding XMP: application/pdf doi:10.1016/j.dadm.2018.03.004 Challenges associated with biomarker-based classification systems for Alzheimer's disease Ignacio Illán-Gala Jordi Pegueroles Victor Montal Eduard Vilaplana María Carmona-Iragui Daniel Alcolea Bradford C. Dickerson Raquel Sánchez-Valle Mony J. de Leon Rafael Blesa Alberto Lleó Juan Fortea Alzheimer's Disease Neuroimaging Initiative1 Alzheimer's disease Biomarkers Magnetic resonance Positron emission tomography Classification systems Diagnosis Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring, 10 (2018) 346-357. doi:10.1016/j.dadm.2018.03.004 Elsevier Inc. journal Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring © 2018 The Authors. 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