6c773a59dfe4dc0adcad54f278bd22a3 pmc_30305635.pdf db5bd3763b592e0b06745ba984ac9694d82e76cf pmc_30305635.pdf 1c6b62912051f5788c3f86763226001021e087ab928fbed32be2276a839b2956 pmc_30305635.pdf Title: Shu complex SWS1-SWSAP1 promotes early steps in mouse meiotic recombination Subject: Nature Communications, doi:10.1038/s41467-018-06384-x Keywords: Author: Carla M. Abreu Creator: Springer Producer: iText® 5.3.5 ©2000-2012 1T3XT BVBA (AGPL-version) CreationDate: Thu Oct 4 07:53:22 2018 CEST ModDate: Thu Oct 4 14:37:24 2018 CEST Tagged: no UserProperties: no Suspects: no Form: AcroForm JavaScript: no Pages: 13 Encrypted: no Page size: 595.276 x 782.362 pts Page rot: 0 File size: 6968655 bytes Optimized: no PDF version: 1.4 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- LMDHLK+AdvOTea1a7398 Type 1C WinAnsi yes yes no 103 0 LMDJAD+AdvOTea1a7398+fb Type 1C Custom yes yes yes 190 0 LMDJAE+AdvOT9bd21c25.I Type 1C WinAnsi yes yes no 191 0 LMDJAF+AdvOTcb88df00 Type 1C WinAnsi yes yes no 105 0 Arial-BoldMT Type 1C WinAnsi yes no no 739 0 LMDJEF+AdvOTf23bb480 Type 1C WinAnsi yes yes no 740 0 LMDJFG+AdvTTda6f6cb8.B Type 1C WinAnsi yes yes no 112 0 LMDJKH+AdvOT1ef757c0+fb Type 1C Custom yes yes yes 104 0 LMDJKI+AdvOT1ef757c0+20 Type 1C WinAnsi yes yes no 106 0 LMDJMK+AdvOTb65e897d.B Type 1C WinAnsi yes yes no 107 0 LMDJKG+AdvOT1ef757c0 Type 1C WinAnsi yes yes no 108 0 LMDJML+AdvOT7d6df7ab.I+22 Type 1C Custom yes yes yes 109 0 LMDJJF+AdvOT125c650c Type 1C WinAnsi yes yes no 110 0 LMDJLJ+AdvOT1ef757c0+22 Type 1C Custom yes yes yes 111 0 LMDJLK+AdvOT7d6df7ab.I Type 1C WinAnsi yes yes no 113 0 LMDJMM+AdvTTab7e17fd+22 Type 1C Custom yes yes no 114 0 LMDNIJ+Symbol Type 1C Custom yes yes yes 135 0 LMDNGI+Helvetica Type 1C WinAnsi yes yes no 136 0 LMDNGJ+Helvetica-Oblique Type 1C WinAnsi yes yes no 137 0 LMDNEI+Helvetica-Bold Type 1C WinAnsi yes yes no 138 0 LMDOMD+AdvOT1ef757c0+03 Type 1C Custom yes yes yes 192 0 LMDOME+AdvOT45bf69de.BI Type 1C WinAnsi yes yes no 193 0 LMDONF+AdvTTab7e17fd Type 1C WinAnsi yes yes no 194 0 LMDONG+AdvTT2876772e+22 Type 1C Custom yes yes yes 195 0 LMDONH+AdvOT8608a8d1+22 Type 1C Custom yes yes yes 196 0 LMDONI+AdvOTea1a7398+20 Type 1C WinAnsi yes yes no 197 0 LMDONJ+AdvOT8608a8d1+03 Type 1C Custom yes yes yes 198 0 Helvetica2 Type 1C WinAnsi yes no no 225 0 LMEKBH+AdvOT8608a8d1 Type 1C WinAnsi yes yes no 276 0 LMEJPG+AdvOT7d6df7ab.I+03 Type 1C Custom yes yes yes 277 0 Helvetica-Bold2 Type 1C WinAnsi yes no no 300 0 Helvetica-Oblique2 Type 1C WinAnsi yes no no 301 0 LMFMAL+AdvOT8608a8d1+20 Type 1C Custom yes yes yes 381 0 LMGHEI+AdvOTcb88df00+fb Type 1C Custom yes yes yes 414 0 LMGHDI+AdvOT8b40f9c2.B+20 Type 1C Custom yes yes yes 415 0 Arial-ItalicMT Type 1C Custom yes no yes 443 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2024-01-19 06:00:11 CET RepresentationInformation: pmc_30305635.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2020-03-09 03:38:44 CET Size: 6968655 Format: PDF Version: 1.4 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 816 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseOutlines Language: EN Outlines: Item: Title: Shu complex SWS1-SWSAP1 promotes early steps in mouse meiotic recombination Destination: title_link Children: Item: Title: Results Destination: A1 Children: Item: Title: Sws1 and Swsap1 mutant mice are viable but infertile Destination: B1 Item: Title: Meiotic RAD51 and DMC1 focus assembly requires SWS1-SWSAP1 Destination: B2 Item: Title: Resected DNA intermediates increase with SWS1-SWSAP1 loss Destination: B3 Item: Title: Crossovers in Sws1 and Swsap1 meiocytes that progress Destination: B4 Item: Title: Sws1 Chk2 and Swsap1 Chk2 double mutant females are fertile Destination: B5 Item: Title: BRCA2 C terminus promotes Swsap1 spermatocyte progression Destination: B6 Item: Title: Discussion Destination: A2 Item: Title: Methods Destination: A3 Children: Item: Title: Mouse care Destination: B7 Item: Title: Generation and genotyping of Shu mutant mice Destination: B8 Item: Title: RT-PCR Destination: B9 Item: Title: Primer sequences Destination: B10 Item: Title: Histology Destination: B11 Item: Title: Testis extracts and western blotting Destination: B12 Item: Title: Spermatocyte chromosome spreads and immunofluorescence Destination: B13 Item: Title: Oocyte chromosome spreads Destination: B14 Item: Title: Statistical analysis Destination: B15 Item: Title: References Destination: A4 Item: Title: References Destination: A5 Item: Title: Acknowledgements Destination: A6 Item: Title: Author contributions Destination: A7 Item: Title: Competing interests Destination: A8 Item: Title: ACKNOWLEDGEMENTS Destination: M1 Info: Title: Shu complex SWS1-SWSAP1 promotes early steps in mouse meiotic recombination Author: Carla M. Abreu Subject: Nature Communications, doi:10.1038/s41467-018-06384-x Keywords: Creator: Springer Producer: iText® 5.3.5 ©2000-2012 1T3XT BVBA (AGPL-version) CreationDate: Thu Oct 04 08:23:22 CEST 2018 ModDate: Thu Oct 04 14:37:24 CEST 2018 ID: 0x5ab41e2ef07b998b922cca1847232a83, 0xb453401f1a01b91833c795bdeff744ed Filters: FilterPipeline: FlateDecode FilterPipeline: DCTDecode Images: Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 815 ImageHeight: 1226 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Intent: Perceptual Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 404 ImageHeight: 1224 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Intent: Perceptual Image: NisoImageMetadata: FormatName: image/png ImageWidth: 701 ImageHeight: 700 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: Perceptual Image: NisoImageMetadata: FormatName: image/png ImageWidth: 927 ImageHeight: 465 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: Perceptual Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 702 ImageHeight: 700 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Intent: Perceptual Image: NisoImageMetadata: FormatName: image/png ImageWidth: 927 ImageHeight: 230 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: Perceptual Image: NisoImageMetadata: FormatName: image/png ImageWidth: 732 ImageHeight: 241 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: Perceptual Image: NisoImageMetadata: FormatName: image/png ImageWidth: 731 ImageHeight: 974 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: Perceptual Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 731 ImageHeight: 241 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Intent: Perceptual Image: NisoImageMetadata: FormatName: image/png ImageWidth: 34 ImageHeight: 34 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 731 ImageHeight: 731 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: Perceptual Image: NisoImageMetadata: FormatName: image/png ImageWidth: 31 ImageHeight: 41 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 34 ImageHeight: 34 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 31 ImageHeight: 41 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 31 ImageHeight: 41 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 1256 ImageHeight: 732 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: Perceptual Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1301 ImageHeight: 561 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Intent: Perceptual Image: NisoImageMetadata: FormatName: image/png ImageWidth: 1166 ImageHeight: 577 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: Perceptual Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 468 ImageHeight: 645 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Intent: Perceptual Image: NisoImageMetadata: FormatName: image/png ImageWidth: 856 ImageHeight: 212 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: Perceptual Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 856 ImageHeight: 426 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Intent: Perceptual Image: NisoImageMetadata: FormatName: image/png ImageWidth: 1100 ImageHeight: 90 ColorSpace: black is zero BitsPerSample: 1 BitsPerSampleUnit: integer Filter: FlateDecode Fonts: Type1: Font: BaseFont: LMDOMD+AdvOT1ef757c0+03 FontSubset: true FirstChar: 1 LastChar: 3 FontDescriptor: FontName: LMDOMD+AdvOT1ef757c0+03 Flags: Symbolic FontBBox: -125, -270, 854, 791 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: LMDOME+AdvOT45bf69de.BI FontSubset: true FirstChar: 49 LastChar: 119 FontDescriptor: FontName: LMDOME+AdvOT45bf69de.BI Flags: Nonsymbolic FontBBox: -135, -250, 1010, 864 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: LMDONF+AdvTTab7e17fd FontSubset: true FirstChar: 43 LastChar: 61 FontDescriptor: FontName: LMDONF+AdvTTab7e17fd Flags: Nonsymbolic FontBBox: -156, -250, 1072, 947 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: LMDONG+AdvTT2876772e+22 FontSubset: true FirstChar: 1 LastChar: 1 FontDescriptor: FontName: LMDONG+AdvTT2876772e+22 Flags: Symbolic FontBBox: -218, -260, 1291, 1020 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: LMDONH+AdvOT8608a8d1+22 FontSubset: true FirstChar: 1 LastChar: 3 FontDescriptor: FontName: LMDONH+AdvOT8608a8d1+22 Flags: Symbolic FontBBox: 0, -322, 1218, 968 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: LMDONI+AdvOTea1a7398+20 FontSubset: true FirstChar: 146 LastChar: 150 FontDescriptor: FontName: LMDONI+AdvOTea1a7398+20 Flags: Nonsymbolic FontBBox: -93, -197, 843, 791 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: LMDONJ+AdvOT8608a8d1+03 FontSubset: true FirstChar: 1 LastChar: 1 FontDescriptor: FontName: LMDONJ+AdvOT8608a8d1+03 Flags: Symbolic FontBBox: -479, -364, 854, 927 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: LMDNIJ+Symbol FontSubset: true FirstChar: 1 LastChar: 3 FontDescriptor: FontName: LMDNIJ+Symbol Flags: Symbolic FontBBox: -180, -293, 1090, 1010 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: LMDNGI+Helvetica FontSubset: true FirstChar: 32 LastChar: 150 FontDescriptor: FontName: LMDNGI+Helvetica Flags: Nonsymbolic FontBBox: -166, -225, 1000, 931 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: LMDNGJ+Helvetica-Oblique FontSubset: true FirstChar: 32 LastChar: 150 FontDescriptor: FontName: LMDNGJ+Helvetica-Oblique Flags: Nonsymbolic, Italic FontBBox: -170, -225, 1116, 931 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: LMDNEI+Helvetica-Bold FontSubset: true FirstChar: 97 LastChar: 105 FontDescriptor: FontName: LMDNEI+Helvetica-Bold Flags: Nonsymbolic, ForceBold FontBBox: -170, -228, 1003, 962 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: LMEKBH+AdvOT8608a8d1 FontSubset: true FirstChar: 181 LastChar: 181 FontDescriptor: FontName: LMEKBH+AdvOT8608a8d1 Flags: Nonsymbolic FontBBox: -62, -208, 927, 958 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: LMEJPG+AdvOT7d6df7ab.I+03 FontSubset: true FirstChar: 1 LastChar: 1 FontDescriptor: FontName: LMEJPG+AdvOT7d6df7ab.I+03 Flags: Symbolic FontBBox: -62, -270, 906, 781 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: LMGHEI+AdvOTcb88df00+fb FontSubset: true FirstChar: 1 LastChar: 1 FontDescriptor: FontName: LMGHEI+AdvOTcb88df00+fb Flags: Symbolic FontBBox: 0, -197, 895, 791 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: LMGHDI+AdvOT8b40f9c2.B+20 FontSubset: true FirstChar: 1 LastChar: 1 FontDescriptor: FontName: LMGHDI+AdvOT8b40f9c2.B+20 Flags: Symbolic FontBBox: -989, -375, 2000, 1052 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: Helvetica2 FirstChar: 32 LastChar: 150 FontDescriptor: FontName: Helvetica2 Flags: Nonsymbolic FontBBox: -166, -225, 1000, 931 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: Arial-BoldMT FirstChar: 0 LastChar: 255 FontDescriptor: FontName: Arial-BoldMT Flags: Nonsymbolic FontBBox: -628, -376, 2000, 1010 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: LMDJEF+AdvOTf23bb480 FontSubset: true FirstChar: 40 LastChar: 242 FontDescriptor: FontName: LMDJEF+AdvOTf23bb480 Flags: Nonsymbolic FontBBox: -31, -197, 968, 916 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: LMDHLK+AdvOTea1a7398 FontSubset: true FirstChar: 37 LastChar: 177 FontDescriptor: FontName: LMDHLK+AdvOTea1a7398 Flags: Nonsymbolic FontBBox: -31, -197, 979, 906 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: LMDJKH+AdvOT1ef757c0+fb FontSubset: true FirstChar: 1 LastChar: 3 FontDescriptor: FontName: LMDJKH+AdvOT1ef757c0+fb Flags: Symbolic FontBBox: 0, -10, 781, 708 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: LMDJAF+AdvOTcb88df00 FontSubset: true FirstChar: 45 LastChar: 121 FontDescriptor: FontName: LMDJAF+AdvOTcb88df00 Flags: Nonsymbolic FontBBox: -41, -197, 968, 906 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: LMDJKI+AdvOT1ef757c0+20 FontSubset: true FirstChar: 146 LastChar: 150 FontDescriptor: FontName: LMDJKI+AdvOT1ef757c0+20 Flags: Nonsymbolic FontBBox: -135, -187, 1010, 833 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: LMDJMK+AdvOTb65e897d.B FontSubset: true FirstChar: 39 LastChar: 121 FontDescriptor: FontName: LMDJMK+AdvOTb65e897d.B Flags: Serif, Nonsymbolic FontBBox: -20, -250, 968, 854 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: LMDJKG+AdvOT1ef757c0 FontSubset: true FirstChar: 37 LastChar: 215 FontDescriptor: FontName: LMDJKG+AdvOT1ef757c0 Flags: Serif, Nonsymbolic FontBBox: -20, -250, 947, 854 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: Helvetica-Bold2 FirstChar: 97 LastChar: 105 FontDescriptor: FontName: Helvetica-Bold2 Flags: Nonsymbolic, ForceBold FontBBox: -170, -228, 1003, 962 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: LMDJML+AdvOT7d6df7ab.I+22 FontSubset: true FirstChar: 1 LastChar: 1 FontDescriptor: FontName: LMDJML+AdvOT7d6df7ab.I+22 Flags: Symbolic FontBBox: -156, -166, 750, 916 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: Helvetica-Oblique2 FirstChar: 0 LastChar: 255 FontDescriptor: FontName: Helvetica-Oblique2 Flags: Nonsymbolic, Italic FontBBox: -170, -225, 1116, 931 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: LMDJJF+AdvOT125c650c FontSubset: true FirstChar: 77 LastChar: 77 FontDescriptor: FontName: LMDJJF+AdvOT125c650c Flags: Nonsymbolic FontBBox: -31, -197, 979, 906 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: LMDJLJ+AdvOT1ef757c0+22 FontSubset: true FirstChar: 1 LastChar: 3 FontDescriptor: FontName: LMDJLJ+AdvOT1ef757c0+22 Flags: Symbolic FontBBox: -135, -166, 697, 916 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: LMDJFG+AdvTTda6f6cb8.B FontSubset: true FirstChar: 48 LastChar: 57 FontDescriptor: FontName: LMDJFG+AdvTTda6f6cb8.B Flags: Nonsymbolic FontBBox: -72, -218, 895, 927 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: LMDJLK+AdvOT7d6df7ab.I FontSubset: true FirstChar: 40 LastChar: 121 FontDescriptor: FontName: LMDJLK+AdvOT7d6df7ab.I Flags: Nonsymbolic FontBBox: -135, -250, 1000, 854 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: LMDJMM+AdvTTab7e17fd+22 FontSubset: true FirstChar: 21 LastChar: 21 FontDescriptor: FontName: LMDJMM+AdvTTab7e17fd+22 Flags: Nonsymbolic FontBBox: -156, -218, 937, 947 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: Arial-ItalicMT FirstChar: 0 LastChar: 255 FontDescriptor: FontName: Arial-ItalicMT Flags: Symbolic, Italic FontBBox: -517, -325, 1359, 998 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: LMFMAL+AdvOT8608a8d1+20 FontSubset: true FirstChar: 1 LastChar: 1 FontDescriptor: FontName: LMFMAL+AdvOT8608a8d1+20 Flags: Symbolic FontBBox: -968, -333, 2000, 1020 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: LMDJAD+AdvOTea1a7398+fb FontSubset: true FirstChar: 1 LastChar: 1 FontDescriptor: FontName: LMDJAD+AdvOTea1a7398+fb Flags: Symbolic FontBBox: 0, -197, 750, 791 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: LMDJAE+AdvOT9bd21c25.I FontSubset: true FirstChar: 40 LastChar: 119 FontDescriptor: FontName: LMDJAE+AdvOT9bd21c25.I Flags: Nonsymbolic FontBBox: -83, -197, 1010, 906 FontFile3: true Encoding: WinAnsiEncoding XMP: application/pdf doi:10.1038/s41467-018-06384-x Shu complex SWS1-SWSAP1 promotes early steps in mouse meiotic recombination Carla M. Abreu Rohit Prakash Peter J. Romanienko Ignasi Roig Scott Keeney Maria Jasin Springer US Nature Communications, doi:10.1038/s41467-018-06384-x 10.1038/s41467-018-06384-x http://dx.doi.org/10.1038/s41467-018-06384-x journal Nature Communications © 2018, The Author(s) 2041-1723 10.1038/s41467-018-06384-x springer.com springerlink.com 2010-04-23 True 10.1038/s41467-018-06384-x springer.com springerlink.com Springer 2018-10-04T14:37:24+02:00 2018-10-04T11:23:22+05:30 2018-10-04T14:37:24+02:00 True iText® 5.3.5 ©2000-2012 1T3XT BVBA (AGPL-version) VoR uuid:09d4b68f-b9be-4522-a321-46387945b5d4 uuid:92a8bb3f-a033-4365-90c0-fab12263e3a2 default 1 converted uuid:bd13bcb6-6ad7-42a5-b020-9a84bebcd41b converted to PDF/A-2b pdfToolbox 2018-10-04T11:24:18+05:30 2 B Carla M. Abreu http://orcid.org/0000-0002-8070-8388 Rohit Prakash http://orcid.org/0000-0001-5981-8980 Ignasi Roig http://orcid.org/0000-0003-0313-3581 Scott Keeney http://orcid.org/0000-0002-1283-6417 Maria Jasin http://orcid.org/0000-0002-7976-2379 http://ns.adobe.com/pdf/1.3/ pdf Adobe PDF Schema internal A name object indicating whether the document has been modified to include trapping information Trapped Text http://ns.adobe.com/pdfx/1.3/ pdfx pdfx internal ID of PDF/X standard GTS_PDFXVersion Text internal Conformance level of PDF/X standard GTS_PDFXConformance Text internal Company creating the PDF Company Text internal Date when document was last modified SourceModified Text external Mirrors crossmark:CrosMarkDomains CrossMarkDomains Seq Text internal Mirrors crossmark:DOI doi Text http://ns.adobe.com/xap/1.0/mm/ xmpMM XMP Media Management Schema internal UUID based identifier for specific incarnation of a document InstanceID URI internal The common identifier for all versions and renditions of a document. OriginalDocumentID URI http://www.aiim.org/pdfa/ns/id/ pdfaid PDF/A ID Schema internal Part of PDF/A standard part Integer internal Amendment of PDF/A standard amd Text internal Conformance level of PDF/A standard conformance Text http://crossref.org/crossmark/1.0/ crossmark crossmark internal CrossMarkDomains CrossMarkDomains Seq Text internal CrossmarkDomainExclusive CrossmarkDomainExclusive Text internal Usual same as prism:doi DOI Text external The date when a publication was published. MajorVersionDate Text http://prismstandard.org/namespaces/basic/2.0/ prism Prism external The aggregation type specifies the unit of aggregation for a content collection. Comment PRISM recommends that the PRISM Aggregation Type Controlled Vocabulary be used to provide values for this element. Note: PRISM recommends against the use of the #other value currently allowed in this controlled vocabulary. In lieu of using #other please reach out to the PRISM group at info@prismstandard.org to request addition of your term to the Aggregation Type Controlled Vocabulary. aggregationType Text external Copyright copyright Text external The Digital Object Identifier for the article. The DOI may also be used as the dc:identifier. If used as a dc:identifier, the URI form should be captured, and the bare identifier should also be captured using prism:doi. If an alternate unique identifier is used as the required dc:identifier, then the DOI should be specified as a bare identifier within prism:doi only. If the URL associated with a DOI is to be specified, then prism:url may be used in conjunction with prism:doi in order to provide the service endpoint (i.e. the URL). doi Text external ISSN for an electronic version of the issue in which the resource occurs. Permits publishers to include a second ISSN, identifying an electronic version of the issue in which the resource occurs (therefore e(lectronic)Issn. If used, prism:eIssn MUST contain the ISSN of the electronic version. See prism:issn. issn Text external Title of the magazine, or other publication, in which a resource was/will be published. Typically this will be used to provide the name of the magazine an article appeared in as metadata for the article, along with information such as the article title, the publisher, volume, number, and cover date. Note: Publication name can be used to differentiate between a print magazine and the online version if the names are different such as “magazine” and “magazine.com.” publicationName Text external This element provides the url for an article or unit of content. The attribute platform is optionally allowed for situations in which multiple URLs must be specified. PRISM recommends that a subset of the PCV platform values, namely “mobile” and “web”, be used in conjunction with this element. NOTE: PRISM recommends against the use of the #other value allowed in the PRISM Platform controlled vocabulary. In lieu of using #other please reach out to the PRISM group at prism-wg@yahoogroups.com to request addition of your term to the Platform Controlled Vocabulary. url Text http://springernature.com/ns/xmpExtensions/2.0/ sn Springer Nature ORCID Schema external Author information: contains the name of each author and his/her ORCID (ORCiD: Open Researcher and Contributor ID). An ORCID is a persistent identifier (a non-proprietary alphanumeric code) to uniquely identify scientific and other academic authors. authorInfo Bag AuthorInformation Specifies the types of author information: name and ORCID of an author. http://springernature.com/ns/xmpExtensions/2.0/authorInfo/ author AuthorInformation Gives the name of an author. name Text Gives the ORCID of an author. orcid URI http://www.niso.org/schemas/jav/1.0/ jav NISO external Values for Journal Article Version are one of the following: AO = Author’s Original SMUR = Submitted Manuscript Under Review AM = Accepted Manuscript P = Proof VoR = Version of Record CVoR = Corrected Version of Record EVoR = Enhanced Version of Record journal_article_version Closed Choice of Text Pages: Page: Label: 1 Annotations: Annotation: Subtype: Link Rect: 114, 539, 114, 550 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 114, 539, 114, 550 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 122, 539, 123, 550 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 113, 539, 123, 550 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 123, 539, 126, 550 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 197, 539, 198, 550 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 197, 539, 198, 550 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 206, 539, 207, 550 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 196, 539, 207, 550 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 207, 539, 209, 550 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 370, 539, 371, 550 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 370, 539, 371, 550 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 379, 539, 380, 550 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 369, 539, 380, 550 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 380, 539, 382, 550 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 452, 539, 453, 550 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 452, 539, 453, 550 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 461, 539, 462, 550 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 452, 539, 462, 550 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 462, 539, 465, 550 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 536, 539, 537, 550 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 536, 539, 537, 550 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 544, 539, 545, 550 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 535, 539, 545, 550 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 545, 539, 548, 550 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 474, 43, 548, 51 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 282, 23, 398, 30 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 547, 23, 551, 30 Flags: Print AppearanceDictionary: true Thumb: true Page: Label: 2 Annotations: Annotation: Subtype: Link Rect: 280, 694, 284, 702 Flags: Print AppearanceDictionary: true Destination: 452 Annotation: Subtype: Link Rect: 285, 694, 289, 702 Flags: Print AppearanceDictionary: true Destination: 452 Annotation: Subtype: Link Rect: 168, 652, 171, 660 Flags: Print AppearanceDictionary: true Destination: 452 Annotation: Subtype: Link Rect: 173, 652, 176, 660 Flags: Print AppearanceDictionary: true Destination: 452 Annotation: Subtype: Link Rect: 84, 621, 87, 629 Flags: Print AppearanceDictionary: true Destination: 452 Annotation: Subtype: Link Rect: 89, 621, 92, 629 Flags: Print AppearanceDictionary: true Destination: 452 Annotation: Subtype: Link Rect: 96, 621, 100, 629 Flags: Print AppearanceDictionary: true Destination: 452 Annotation: Subtype: Link Rect: 193, 611, 196, 618 Flags: Print AppearanceDictionary: true Destination: 452 Annotation: Subtype: Link Rect: 92, 579, 96, 587 Flags: Print AppearanceDictionary: true Destination: 452 Annotation: Subtype: Link Rect: 269, 558, 273, 566 Flags: Print AppearanceDictionary: true Destination: 452 Annotation: Subtype: Link Rect: 172, 496, 179, 503 Flags: Print AppearanceDictionary: true Destination: 452 Annotation: Subtype: Link Rect: 183, 496, 190, 503 Flags: Print AppearanceDictionary: true Destination: 452 Annotation: Subtype: Link Rect: 135, 464, 142, 472 Flags: Print AppearanceDictionary: true Destination: 452 Annotation: Subtype: Link Rect: 144, 464, 151, 472 Flags: Print AppearanceDictionary: true Destination: 452 Annotation: Subtype: Link Rect: 222, 422, 230, 430 Flags: Print AppearanceDictionary: true Destination: 452 Annotation: Subtype: Link Rect: 69, 381, 76, 388 Flags: Print AppearanceDictionary: true Destination: 452 Annotation: Subtype: Link Rect: 78, 381, 85, 388 Flags: Print AppearanceDictionary: true Destination: 452 Annotation: Subtype: Link Rect: 87, 381, 94, 388 Flags: Print AppearanceDictionary: true Destination: 452 Annotation: Subtype: Link Rect: 98, 381, 105, 388 Flags: Print AppearanceDictionary: true Destination: 452 Annotation: Subtype: Link Rect: 273, 360, 280, 367 Flags: Print AppearanceDictionary: true Destination: 452 Annotation: Subtype: Link Rect: 282, 360, 289, 367 Flags: Print AppearanceDictionary: true Destination: 452 Annotation: Subtype: Link Rect: 282, 349, 289, 357 Flags: Print AppearanceDictionary: true Destination: 452 Annotation: Subtype: Link Rect: 265, 339, 272, 346 Flags: Print AppearanceDictionary: true Destination: 452 Annotation: Subtype: Link Rect: 282, 276, 289, 283 Flags: Print AppearanceDictionary: true Destination: 452 Annotation: Subtype: Link Rect: 73, 245, 81, 252 Flags: Print AppearanceDictionary: true Destination: 452 Annotation: Subtype: Link Rect: 82, 245, 89, 252 Flags: Print AppearanceDictionary: true Destination: 452 Annotation: Subtype: Link Rect: 145, 234, 152, 242 Flags: Print AppearanceDictionary: true Destination: 452 Annotation: Subtype: Link Rect: 156, 234, 163, 242 Flags: Print AppearanceDictionary: true Destination: 452 Annotation: Subtype: Link Rect: 165, 234, 172, 242 Flags: Print AppearanceDictionary: true Destination: 452 Annotation: Subtype: Link Rect: 140, 213, 147, 221 Flags: Print AppearanceDictionary: true Destination: 452 Annotation: Subtype: Link Rect: 122, 192, 129, 200 Flags: Print AppearanceDictionary: true Destination: 452 Annotation: Subtype: Link Rect: 131, 192, 138, 200 Flags: Print AppearanceDictionary: true Destination: 452 Annotation: Subtype: Link Rect: 410, 670, 414, 679 Flags: Print AppearanceDictionary: true Destination: 143 Annotation: Subtype: Link Rect: 326, 639, 330, 648 Flags: Print AppearanceDictionary: true Destination: 143 Annotation: Subtype: Link Rect: 530, 482, 535, 491 Flags: Print AppearanceDictionary: true Destination: 143 Annotation: Subtype: Link Rect: 482, 450, 487, 460 Flags: Print AppearanceDictionary: true Destination: 143 Annotation: Subtype: Link Rect: 423, 419, 428, 428 Flags: Print AppearanceDictionary: true Destination: 143 Annotation: Subtype: Link Rect: 484, 401, 491, 409 Flags: Print AppearanceDictionary: true Destination: 452 Annotation: Subtype: Link Rect: 348, 335, 353, 345 Flags: Print AppearanceDictionary: true Destination: 143 Annotation: Subtype: Link Rect: 377, 224, 385, 231 Flags: Print AppearanceDictionary: true Destination: 452 Annotation: Subtype: Link Rect: 388, 224, 396, 231 Flags: Print AppearanceDictionary: true Destination: 475 Annotation: Subtype: Link Rect: 375, 171, 379, 179 Flags: Print AppearanceDictionary: true Destination: 452 Annotation: Subtype: Link Rect: 447, 150, 455, 158 Flags: Print AppearanceDictionary: true Destination: 475 Annotation: Subtype: Link Rect: 323, 115, 327, 125 Flags: Print AppearanceDictionary: true Destination: 232 Annotation: Subtype: Link Rect: 342, 98, 350, 106 Flags: Print AppearanceDictionary: true Destination: 475 Annotation: Subtype: Link Rect: 436, 23, 551, 30 Flags: Print AppearanceDictionary: true Thumb: true Page: Label: 3 Annotations: Annotation: Subtype: Link Rect: 108, 90, 113, 100 Flags: Print AppearanceDictionary: true Destination: 232 Annotation: Subtype: Link Rect: 454, 111, 458, 121 Flags: Print AppearanceDictionary: true Destination: 232 Annotation: Subtype: Link Rect: 470, 94, 477, 102 Flags: Print AppearanceDictionary: true Destination: 452 Annotation: Subtype: Link Rect: 479, 94, 486, 102 Flags: Print AppearanceDictionary: true Destination: 475 Annotation: Subtype: Link Rect: 282, 23, 398, 30 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 547, 23, 551, 30 Flags: Print AppearanceDictionary: true Thumb: true Page: Label: 4 Annotations: Annotation: Subtype: Link Rect: 260, 561, 264, 571 Flags: Print AppearanceDictionary: true Destination: 232 Annotation: Subtype: Link Rect: 95, 502, 102, 509 Flags: Print AppearanceDictionary: true Destination: 452 Annotation: Subtype: Link Rect: 104, 502, 111, 509 Flags: Print AppearanceDictionary: true Destination: 452 Annotation: Subtype: Link Rect: 152, 477, 156, 487 Flags: Print AppearanceDictionary: true Destination: 232 Annotation: Subtype: Link Rect: 250, 331, 257, 339 Flags: Print AppearanceDictionary: true Destination: 475 Annotation: Subtype: Link Rect: 72, 300, 79, 308 Flags: Print AppearanceDictionary: true Destination: 475 Annotation: Subtype: Link Rect: 260, 289, 267, 297 Flags: Print AppearanceDictionary: true Destination: 475 Annotation: Subtype: Link Rect: 269, 289, 276, 297 Flags: Print AppearanceDictionary: true Destination: 475 Annotation: Subtype: Link Rect: 219, 234, 223, 243 Flags: Print AppearanceDictionary: true Destination: 318 Annotation: Subtype: Link Rect: 387, 585, 394, 593 Flags: Print AppearanceDictionary: true Destination: 475 Annotation: Subtype: Link Rect: 449, 470, 456, 478 Flags: Print AppearanceDictionary: true Destination: 475 Annotation: Subtype: Link Rect: 342, 408, 346, 415 Flags: Print AppearanceDictionary: true Destination: 452 Annotation: Subtype: Link Rect: 347, 408, 355, 415 Flags: Print AppearanceDictionary: true Destination: 475 Annotation: Subtype: Link Rect: 356, 408, 364, 415 Flags: Print AppearanceDictionary: true Destination: 475 Annotation: Subtype: Link Rect: 324, 373, 329, 382 Flags: Print AppearanceDictionary: true Destination: 318 Annotation: Subtype: Link Rect: 528, 341, 533, 351 Flags: Print AppearanceDictionary: true Destination: 318 Annotation: Subtype: Link Rect: 383, 247, 388, 257 Flags: Print AppearanceDictionary: true Destination: 318 Annotation: Subtype: Link Rect: 444, 161, 452, 168 Flags: Print AppearanceDictionary: true Destination: 475 Annotation: Subtype: Link Rect: 429, 119, 437, 127 Flags: Print AppearanceDictionary: true Destination: 475 Annotation: Subtype: Link Rect: 345, 74, 350, 83 Flags: Print AppearanceDictionary: true Destination: 388 Annotation: Subtype: Link Rect: 436, 23, 551, 30 Flags: Print AppearanceDictionary: true Thumb: true Page: Label: 5 Annotations: Annotation: Subtype: Link Rect: 125, 107, 132, 115 Flags: Print AppearanceDictionary: true Destination: 475 Annotation: Subtype: Link Rect: 61, 72, 66, 82 Flags: Print AppearanceDictionary: true Destination: 388 Annotation: Subtype: Link Rect: 62, 51, 67, 61 Flags: Print AppearanceDictionary: true Destination: 388 Annotation: Subtype: Link Rect: 263, 51, 267, 61 Flags: Print AppearanceDictionary: true Destination: 388 Annotation: Subtype: Link Rect: 428, 51, 432, 61 Flags: Print AppearanceDictionary: true Destination: 388 Annotation: Subtype: Link Rect: 282, 23, 398, 30 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 547, 23, 551, 30 Flags: Print AppearanceDictionary: true Thumb: true Page: Label: 6 Annotations: Annotation: Subtype: Link Rect: 141, 320, 146, 330 Flags: Print AppearanceDictionary: true Destination: 388 Annotation: Subtype: Link Rect: 207, 300, 212, 309 Flags: Print AppearanceDictionary: true Destination: 388 Annotation: Subtype: Link Rect: 180, 279, 185, 288 Flags: Print AppearanceDictionary: true Destination: 388 Annotation: Subtype: Link Rect: 263, 268, 267, 278 Flags: Print AppearanceDictionary: true Destination: 388 Annotation: Subtype: Link Rect: 263, 240, 270, 248 Flags: Print AppearanceDictionary: true Destination: 475 Annotation: Subtype: Link Rect: 161, 134, 165, 142 Flags: Print AppearanceDictionary: true Destination: 452 Annotation: Subtype: Link Rect: 244, 124, 252, 131 Flags: Print AppearanceDictionary: true Destination: 475 Annotation: Subtype: Link Rect: 146, 113, 154, 121 Flags: Print AppearanceDictionary: true Destination: 475 Annotation: Subtype: Link Rect: 148, 89, 153, 98 Flags: Print AppearanceDictionary: true Destination: 452 Annotation: Subtype: Link Rect: 87, 71, 91, 79 Flags: Print AppearanceDictionary: true Destination: 452 Annotation: Subtype: Link Rect: 95, 71, 98, 79 Flags: Print AppearanceDictionary: true Destination: 452 Annotation: Subtype: Link Rect: 282, 61, 286, 69 Flags: Print AppearanceDictionary: true Destination: 452 Annotation: Subtype: Link Rect: 288, 61, 291, 69 Flags: Print AppearanceDictionary: true Destination: 452 Annotation: Subtype: Link Rect: 65, 47, 70, 56 Flags: Print AppearanceDictionary: true Destination: 452 Annotation: Subtype: Link Rect: 528, 436, 533, 445 Flags: Print AppearanceDictionary: true Destination: 452 Annotation: Subtype: Link Rect: 507, 383, 511, 393 Flags: Print AppearanceDictionary: true Destination: 452 Annotation: Subtype: Link Rect: 432, 331, 436, 340 Flags: Print AppearanceDictionary: true Destination: 452 Annotation: Subtype: Link Rect: 497, 320, 502, 330 Flags: Print AppearanceDictionary: true Destination: 452 Annotation: Subtype: Link Rect: 384, 203, 388, 210 Flags: Print AppearanceDictionary: true Destination: 452 Annotation: Subtype: Link Rect: 436, 23, 551, 30 Flags: Print AppearanceDictionary: true Thumb: true Page: Label: 7 Annotations: Annotation: Subtype: Link Rect: 258, 78, 265, 85 Flags: Print AppearanceDictionary: true Destination: 475 Annotation: Subtype: Link Rect: 282, 23, 398, 30 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 547, 23, 551, 30 Flags: Print AppearanceDictionary: true Thumb: true Page: Label: 8 Annotations: Annotation: Subtype: Link Rect: 66, 360, 73, 367 Flags: Print AppearanceDictionary: true Destination: 475 Annotation: Subtype: Link Rect: 214, 349, 221, 357 Flags: Print AppearanceDictionary: true Destination: 475 Annotation: Subtype: Link Rect: 66, 287, 73, 294 Flags: Print AppearanceDictionary: true Destination: 452 Annotation: Subtype: Link Rect: 221, 241, 225, 251 Flags: Print AppearanceDictionary: true Destination: 452 Annotation: Subtype: Link Rect: 217, 224, 224, 231 Flags: Print AppearanceDictionary: true Destination: 452 Annotation: Subtype: Link Rect: 226, 224, 233, 231 Flags: Print AppearanceDictionary: true Destination: 452 Annotation: Subtype: Link Rect: 235, 224, 242, 231 Flags: Print AppearanceDictionary: true Destination: 475 Annotation: Subtype: Link Rect: 213, 203, 217, 211 Flags: Print AppearanceDictionary: true Destination: 452 Annotation: Subtype: Link Rect: 227, 192, 230, 200 Flags: Print AppearanceDictionary: true Destination: 452 Annotation: Subtype: Link Rect: 232, 192, 236, 200 Flags: Print AppearanceDictionary: true Destination: 452 Annotation: Subtype: Link Rect: 114, 161, 118, 169 Flags: Print AppearanceDictionary: true Destination: 452 Annotation: Subtype: Link Rect: 119, 161, 123, 169 Flags: Print AppearanceDictionary: true Destination: 452 Annotation: Subtype: Link Rect: 399, 482, 404, 491 Flags: Print AppearanceDictionary: true Destination: 318 Annotation: Subtype: Link Rect: 535, 412, 542, 420 Flags: Print AppearanceDictionary: true Destination: 475 Annotation: Subtype: Link Rect: 544, 412, 551, 420 Flags: Print AppearanceDictionary: true Destination: 475 Annotation: Subtype: Link Rect: 495, 339, 503, 346 Flags: Print AppearanceDictionary: true Destination: 475 Annotation: Subtype: Link Rect: 480, 318, 488, 326 Flags: Print AppearanceDictionary: true Destination: 475 Annotation: Subtype: Link Rect: 489, 318, 497, 326 Flags: Print AppearanceDictionary: true Destination: 475 Annotation: Subtype: Link Rect: 407, 266, 415, 273 Flags: Print AppearanceDictionary: true Destination: 475 Annotation: Subtype: Link Rect: 436, 23, 551, 30 Flags: Print AppearanceDictionary: true Thumb: true Page: Label: 9 Annotations: Annotation: Subtype: Link Rect: 219, 119, 225, 125 Flags: Print AppearanceDictionary: true Destination: 475 Annotation: Subtype: Link Rect: 226, 119, 232, 125 Flags: Print AppearanceDictionary: true Destination: 475 Annotation: Subtype: Link Rect: 282, 23, 398, 30 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 547, 23, 551, 30 Flags: Print AppearanceDictionary: true Thumb: true Page: Label: 10 Annotations: Annotation: Subtype: Link Rect: 87, 519, 93, 524 Flags: Print AppearanceDictionary: true Destination: 475 Annotation: Subtype: Link Rect: 94, 519, 100, 524 Flags: Print AppearanceDictionary: true Destination: 475 Annotation: Subtype: Link Rect: 163, 519, 168, 524 Flags: Print AppearanceDictionary: true Destination: 475 Annotation: Subtype: Link Rect: 170, 519, 175, 524 Flags: Print AppearanceDictionary: true Destination: 475 Annotation: Subtype: Link Rect: 126, 168, 132, 174 Flags: Print AppearanceDictionary: true Destination: 452 Annotation: Subtype: Link Rect: 535, 410, 541, 416 Flags: Print AppearanceDictionary: true Destination: 475 Annotation: Subtype: Link Rect: 503, 178, 506, 186 Flags: Print AppearanceDictionary: true Destination: 232 Annotation: Subtype: Link Rect: 510, 178, 514, 186 Flags: Print AppearanceDictionary: true Destination: 452 Annotation: Subtype: Link Rect: 184, 618, 188, 626 Flags: Print AppearanceDictionary: true Destination: 318 Annotation: Subtype: Link Rect: 225, 587, 230, 595 Flags: Print AppearanceDictionary: true Destination: 232 Annotation: Subtype: Link Rect: 436, 23, 551, 30 Flags: Print AppearanceDictionary: true Thumb: true Page: Label: 11 Annotations: Annotation: Subtype: Link Rect: 477, 111, 482, 117 Flags: Print AppearanceDictionary: true Destination: 475 Annotation: Subtype: Link Rect: 282, 23, 398, 30 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 543, 23, 551, 30 Flags: Print AppearanceDictionary: true Thumb: true Page: Label: 12 Annotations: Annotation: Subtype: Link Rect: 419, 712, 423, 720 Flags: Print AppearanceDictionary: true Destination: 232 Annotation: Subtype: Link Rect: 116, 628, 120, 636 Flags: Print AppearanceDictionary: true Destination: 318 Annotation: Subtype: Link Rect: 298, 628, 302, 636 Flags: Print AppearanceDictionary: true Destination: 232 Annotation: Subtype: Link Rect: 427, 597, 431, 605 Flags: Print AppearanceDictionary: true Destination: 318 Annotation: Subtype: Link Rect: 448, 587, 452, 595 Flags: Print AppearanceDictionary: true Destination: 318 Annotation: Subtype: Link Rect: 436, 23, 551, 30 Flags: Print AppearanceDictionary: true Thumb: true Page: Label: 13 Annotations: Annotation: Subtype: Link Rect: 463, 400, 551, 407 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 303, 392, 338, 399 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 475, 357, 538, 364 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 303, 348, 371, 355 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 472, 206, 551, 213 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 303, 197, 346, 204 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 282, 23, 398, 30 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 543, 23, 551, 30 Flags: Print AppearanceDictionary: true Thumb: true Checksum: 8090672e Type: CRC32 Checksum: 6c773a59dfe4dc0adcad54f278bd22a3 Type: MD5 Checksum: db5bd3763b592e0b06745ba984ac9694d82e76cf Type: SHA-1 Checksum: 1c6b62912051f5788c3f86763226001021e087ab928fbed32be2276a839b2956 Type: SHA-256