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edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@74ad1f1f Item: Title: Cell proliferation assay Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6a1aab78 Item: Title: Liposome-mediated transient cell transfection Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@462d5aee Item: Title: Lentivirus cell transduction Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@69b0fd6f Item: Title: RNA isolation and quantitative real-time PCR analysis Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@757942a1 Item: Title: Immunoblot analysis Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4a87761d Item: Title: Immunoprecipitation assay Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@66d1af89 Item: Title: Apoptosis assay Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@8646db9 Item: Title: Analysis of intracellular ROS Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@37374a5e Item: Title: Mitochondrial membrane potential determination Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4671e53b Item: Title: Mitochondrial DNA damage analysis Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@2db7a79b Item: Title: MitoTracker and MitoSox colocalization analysis Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6950e31 Item: Title: Glutathione content quantification Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@b7dd107 Item: Title: Chronic lymphocytic leukemia (CLL) patients Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@42eca56e Item: Title: CLL cell preparation Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@52f759d7 Item: Title: Genetic analysis Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7cbd213e Item: Title: Reduced thiols Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@192d3247 Item: Title: Statistical analysis Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@3ecd23d9 Item: Title: Results Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@569cfc36 Children: Item: Title: Mutant p53 increases mitochondrial ROS production Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@43bd930a Item: Title: The induction of ROS is functionally involved in the oncogenic effects of mutant p53 Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@33723e30 Item: Title: Mutant p53 downregulates UCP2 expression through the inhibition of PGC-1α Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@64f6106c Item: Title: UCP2 inhibition by mutant p53 increases ΔΨm without damaging mtDNA Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@553a3d88 Item: Title: Mutant p53-dependent downregulation of the PGC-1α/UCP2 axis is mediated by the blockage of SESN1/AMPK signaling Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7a30d1e6 Item: Title: UCP2 blockage has a major role on the pro-oxidant and oncogenic effect of mutant p53 Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@5891e32e Item: Title: PGC-1α/UCP2 axis is not regulated by the endogenous basal level of wild-type p53 Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@cb0ed20 Item: Title: Chemotherapy stimulates UCP2 through wtp53 activation Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@8e24743 Item: Title: Discussion Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@74a10858 Item: Title: Acknowledgements Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@23fe1d71 Item: Title: Author contributions Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@28ac3dc3 Item: Title: Competing interests Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@32eebfca Item: Title: ACKNOWLEDGMENTS Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4e718207 Info: Title: Mutant p53 blocks SESN1/AMPK/PGC-1α/UCP2 axis increasing mitochondrial O2ˉ· production in cancer cells Author: Marco Cordani Subject: British Journal of Cancer, doi:10.1038/s41416-018-0288-2 Keywords: Creator: Springer CreationDate: Mon Oct 22 14:52:45 CEST 2018 ModDate: Mon Oct 22 14:53:54 CEST 2018 ID: 0xbc436cf3076911b937181b5eb4c2989b, 0xb5ac3717ef75e7419fc687911876c645 Filters: FilterPipeline: FlateDecode FilterPipeline: DCTDecode Images: Image: NisoImageMetadata: FormatName: image/png ImageWidth: 96 ImageHeight: 96 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 1492 ImageHeight: 1908 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 1284 ImageHeight: 1880 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FontSubset: true FirstChar: 146 LastChar: 150 FontDescriptor: FontName: NFGPFJ+AdvOT46dcae81+20 Flags: Nonsymbolic FontBBox: 0, -197, 1125, 864 FontFile3: true Encoding: WinAnsiEncoding XMP: application/pdf doi:10.1038/s41416-018-0288-2 Mutant p53 blocks SESN1/AMPK/PGC-1α/UCP2 axis increasing mitochondrial O2ˉ· production in cancer cells Marco Cordani Giovanna Butera Ilaria Dando Margalida Torrens-Mas Elena Butturini Raffaella Pacchiana Elisa Oppici Chiara Cavallini Sara Gasperini Nicola Tamassia Mercedes Nadal-Serrano Michela Coan Davide Rossi Gianluca Gaidano Michele Caraglia Sofia Mariotto Riccardo Spizzo Pilar Roca Jordi Oliver Maria Teresa Scupoli Massimo Donadelli Springer US British Journal of Cancer, doi:10.1038/s41416-018-0288-2 10.1038/s41416-018-0288-2 http://dx.doi.org/10.1038/s41416-018-0288-2 journal British Journal of Cancer © 2018, Cancer Research UK 1532-1827 10.1038/s41416-018-0288-2 springer.com springerlink.com 2010-04-23 True 10.1038/s41416-018-0288-2 springer.com springerlink.com Springer 2018-10-22T17:53:54+05:30 2018-10-22T17:52:45+05:30 2018-10-22T17:53:54+05:30 True VoR uuid:76d9db48-3413-485a-bd86-dfd7348cdcda uuid:08a1ea2b-20b9-41a2-9ebd-2c7c1cc63710 default 1 converted uuid:b7b80c3e-2a10-486d-be0d-f9302c0b03c4 converted to PDF/A-2b pdfToolbox 2018-10-22T17:53:53+05:30 2 B http://ns.adobe.com/pdf/1.3/ pdf Adobe PDF Schema internal A name object indicating whether the document has been modified to include trapping information Trapped Text http://ns.adobe.com/pdfx/1.3/ pdfx pdfx internal ID of PDF/X standard GTS_PDFXVersion Text internal Conformance level of PDF/X standard GTS_PDFXConformance Text internal Company creating the PDF Company Text internal Date when document was last modified SourceModified Text external Mirrors crossmark:CrosMarkDomains CrossMarkDomains Seq Text internal Mirrors crossmark:DOI doi Text http://ns.adobe.com/xap/1.0/mm/ xmpMM XMP Media Management Schema internal UUID based identifier for specific incarnation of a document InstanceID URI internal The common identifier for all versions and renditions of a document. OriginalDocumentID URI http://www.aiim.org/pdfa/ns/id/ pdfaid PDF/A ID Schema internal Part of PDF/A standard part Integer internal Amendment of PDF/A standard amd Text internal Conformance level of PDF/A standard conformance Text http://crossref.org/crossmark/1.0/ crossmark crossmark internal CrossMarkDomains CrossMarkDomains Seq Text internal CrossmarkDomainExclusive CrossmarkDomainExclusive Text internal Usual same as prism:doi DOI Text external The date when a publication was published. MajorVersionDate Text http://prismstandard.org/namespaces/basic/2.0/ prism Prism external The aggregation type specifies the unit of aggregation for a content collection. Comment PRISM recommends that the PRISM Aggregation Type Controlled Vocabulary be used to provide values for this element. Note: PRISM recommends against the use of the #other value currently allowed in this controlled vocabulary. In lieu of using #other please reach out to the PRISM group at info@prismstandard.org to request addition of your term to the Aggregation Type Controlled Vocabulary. aggregationType Text external Copyright copyright Text external The Digital Object Identifier for the article. The DOI may also be used as the dc:identifier. If used as a dc:identifier, the URI form should be captured, and the bare identifier should also be captured using prism:doi. If an alternate unique identifier is used as the required dc:identifier, then the DOI should be specified as a bare identifier within prism:doi only. If the URL associated with a DOI is to be specified, then prism:url may be used in conjunction with prism:doi in order to provide the service endpoint (i.e. the URL). doi Text external ISSN for an electronic version of the issue in which the resource occurs. Permits publishers to include a second ISSN, identifying an electronic version of the issue in which the resource occurs (therefore e(lectronic)Issn. If used, prism:eIssn MUST contain the ISSN of the electronic version. See prism:issn. issn Text external Title of the magazine, or other publication, in which a resource was/will be published. Typically this will be used to provide the name of the magazine an article appeared in as metadata for the article, along with information such as the article title, the publisher, volume, number, and cover date. Note: Publication name can be used to differentiate between a print magazine and the online version if the names are different such as “magazine” and “magazine.com.” publicationName Text external This element provides the url for an article or unit of content. The attribute platform is optionally allowed for situations in which multiple URLs must be specified. PRISM recommends that a subset of the PCV platform values, namely “mobile” and “web”, be used in conjunction with this element. NOTE: PRISM recommends against the use of the #other value allowed in the PRISM Platform controlled vocabulary. In lieu of using #other please reach out to the PRISM group at prism-wg@yahoogroups.com to request addition of your term to the Platform Controlled Vocabulary. url Text http://www.niso.org/schemas/jav/1.0/ jav NISO external Values for Journal Article Version are one of the following: AO = Author’s Original SMUR = Submitted Manuscript Under Review AM = Accepted Manuscript P = Proof VoR = Version of Record CVoR = Corrected Version of Record EVoR = Enhanced Version of Record journal_article_version Closed Choice of Text Pages: Page: Label: 994 Sequence: 1 Annotations: Annotation: Subtype: Link Rect: 533, 704, 535, 736 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 533, 709, 553, 740 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 553, 695, 559, 705 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 553, 695, 559, 705 Flags: Print AppearanceDictionary: true 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