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Conclusions Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@eafc191 Item: Title: Background Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@612fc6eb Item: Title: Methods Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1060b431 Children: Item: Title: Development of the clustering framework Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@612679d6 Item: Title: Development of the reference on regulatory basis for approval of OMP Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@11758f2a Item: Title: Results Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@e720b71 Children: Item: Title: Clustering of medical conditions Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1b26f7b2 Item: Title: Regulatory standard Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@491cc5c9 Item: Title: Discussion Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@74ad1f1f Children: Item: Title: Summary of findings Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6a1aab78 Item: Title: Quality of scientific evidence Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@462d5aee Item: Title: Findings in clusters of medical conditions Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@69b0fd6f Item: Title: Study limitations Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@757942a1 Item: Title: Conclusions Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4a87761d Item: Title: Additional file Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@66d1af89 Item: Title: Abbreviations Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@8646db9 Item: Title: Acknowledgements Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@37374a5e Item: Title: Funding Destination: 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regulatory-decision making on orphan medicinal products authorisation in Europe: methodological uncertainties Author: Caridad Pontes Subject: Orphanet Journal of Rare Diseases, 2018, doi:10.1186/s13023-018-0926-z Keywords: Orphan drug production,Rare diseases,Research design/methods,Research design/standards,Clinical trials as topic,Drug approval Creator: Arbortext Advanced Print Publisher 9.1.440/W Unicode Producer: Acrobat Distiller 10.1.5 (Windows); modified using iText® 5.3.5 ©2000-2012 1T3XT BVBA (AGPL-version) CreationDate: Wed Nov 14 08:01:56 CET 2018 ModDate: Thu Nov 15 14:56:47 CET 2018 ID: 0xa1e6c6ab6828bbc3259f80d49c61422a, 0xf57828231c4ff8b22d6714307574c51d Filters: FilterPipeline: FlateDecode FilterPipeline: DCTDecode Images: Image: NisoImageMetadata: FormatName: image/png ImageWidth: 688 ImageHeight: 126 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 95 ImageHeight: 91 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supporting regulatory-decision making on orphan medicinal products authorisation in Europe: methodological uncertainties Caridad Pontes Juan Manuel Fontanet Roser Vives Aranzazu Sancho Mònica Gómez-Valent José Ríos Rosa Morros Jorge Martinalbo Martin Posch Armin Koch Kit Roes Katrien Oude Rengerink Josep Torrent-Farnell Ferran Torres 2018-11-15T14:56:47+01:00 2018-11-14T15:01:56+08:00 Arbortext Advanced Print Publisher 9.1.440/W Unicode 2018-11-15T14:56:47+01:00 uuid:2b0b7a0a-f568-45ed-a1e0-6d1629f1dead uuid:49f76797-6308-4f26-916d-52dc4dbd2bdb default 1 converted uuid:45398806-df04-472e-87ec-0f764487649a converted to PDF/A-2b pdfToolbox 2018-11-14T15:48:43+08:00 2 B Caridad Pontes http://orcid.org/0000-0002-3274-6048 Springer Nature ORCID Schema http://springernature.com/ns/xmpExtensions/2.0/ sn authorInfo Bag AuthorInformation external Author information: contains the name of each author and his/her ORCID (ORCiD: Open Researcher and Contributor ID). 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