68f9f5617b75e26b7841be70c457be9d pmc_30478379.pdf fd24c0d954ccf2dbe0bce887565c6ce193c6967d pmc_30478379.pdf 49dc226081a2208ff6a0b5a549481e39bd34453b5427485af65bcd14e4ed891c pmc_30478379.pdf Title: Variations in the immune and metabolic response of proactive and reactive Sparus aurata under stimulation with Vibrio anguillarum vaccine Subject: Scientific Reports, doi:10.1038/s41598-018-35863-w Keywords: Author: R. Vargas Creator: Springer Producer: iText® 5.3.5 ©2000-2012 1T3XT BVBA (AGPL-version) CreationDate: Fri Nov 16 21:49:28 2018 CET ModDate: Tue Nov 20 12:50:58 2018 CET Tagged: no UserProperties: no Suspects: no Form: AcroForm JavaScript: no Pages: 9 Encrypted: no Page size: 595.276 x 782.362 pts Page rot: 0 File size: 1675677 bytes Optimized: no PDF version: 1.4 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- PQVUKZ+Corbel-BoldItalic CID TrueType Identity-H yes yes yes 283 0 SEOWAT+Corbel CID TrueType Identity-H yes yes yes 284 0 ADNYAE+Corbel-BoldItalic2 Type 1C WinAnsi yes yes yes 285 0 MinionPro-Regular Type 1C Custom yes no yes 42 0 BVYXYD+Corbel-Bold2 Type 1C WinAnsi yes yes yes 38 0 MinionPro-It Type 1C Custom yes no yes 37 0 YWJNTE+Corbel2 Type 1C WinAnsi yes yes yes 41 0 HBVDCP+Corbel-Bold CID TrueType Identity-H yes yes yes 65 0 EuclidSymbol-BoldItalic Type 1C Custom yes no yes 286 0 BHJBWB+TimesNewRomanPSMT Type 1C WinAnsi yes yes yes 287 0 BVYXYD+Corbel-Bold2 Type 1C WinAnsi yes yes yes 186 0 YWJNTE+Corbel2 Type 1C WinAnsi yes yes yes 187 0 SEOWAT+Corbel CID TrueType Identity-H yes yes yes 331 0 MyriadPro-It Type 1C WinAnsi yes no yes 189 0 EuclidSymbol-Italic Type 1C Custom yes no yes 36 0 MinionPro-Bold Type 1C WinAnsi yes no yes 39 0 EuclidSymbol Type 1C Custom yes no yes 40 0 YWJNTE+Corbel2 Type 1C WinAnsi yes yes yes 195 0 SEOWAT+Corbel CID TrueType Identity-H yes yes yes 188 0 OXLCWB+STIXGeneral-Regular Type 1C Custom yes yes yes 64 0 BVYXYD+Corbel-Bold2 Type 1C WinAnsi yes yes yes 206 0 YWJNTE+Corbel2 Type 1C WinAnsi yes yes yes 207 0 SEOWAT+Corbel CID TrueType Identity-H yes yes yes 208 0 MyriadPro-It Type 1C WinAnsi yes no yes 209 0 Jhove (Rel. 1.22.1, 2019-04-17) Date: 2022-11-29 02:35:38 CET RepresentationInformation: pmc_30478379.pdf ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17) LastModified: 2019-08-12 03:39:48 CEST Size: 1675677 Format: PDF Version: 1.4 Status: Well-Formed, but not valid SignatureMatches: PDF-hul ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'SpringerNature_SciRep_35863.indd: 15. Silva, P. I. M. et al. Individual differences in cortisol levels and behaviour of Senegalese sole (Solea senegalensis) juveniles: Evidence for coping styles. Applied Animal Behaviour Science 124, 75–81 (2010). :39' cannot be found Offset: 1088391 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'SpringerNature_SciRep_35863.indd: 3. Sih, A., Bell, A. & Johnson, J. C. Behavioral syndromes: an ecological and evolutionary overview. Trends Ecol. Evol. (Amst.) 19, 372–378 (2004). :41' cannot be found Offset: 1088391 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'SpringerNature_SciRep_35863.indd:Figure 1. Outline of behavioural tests and behavioural screening for proactive and reactive phenotypes in S. aurata.:44' cannot be found Offset: 1088391 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'SpringerNature_SciRep_35863.indd:Figure 1. Outline of behavioural tests and behavioural screening for proactive and reactive phenotypes in S. aurata.:45' cannot be found Offset: 1088391 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'SpringerNature_SciRep_35863.indd:Figure 1. Outline of behavioural tests and behavioural screening for proactive and reactive phenotypes in S. aurata.:47' cannot be found Offset: 1088391 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'SpringerNature_SciRep_35863.indd:Figure 2. Gill responses of proactive and reactive fish exposed to Vibrio anguillarum bacterin at 1, 3 and 7 days post-vaccination (A) Expression profiles of immune- (il1β, tnfα and igm) and oxidative stress-related (gpx1, sod and :50' cannot be found Offset: 1088391 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'SpringerNature_SciRep_35863.indd:Figure 2. Gill responses of proactive and reactive fish exposed to Vibrio anguillarum bacterin at 1, 3 and 7 days post-vaccination (A) Expression profiles of immune- (il1β, tnfα and igm) and oxidative stress-related (gpx1, sod and:51' cannot be found Offset: 1088391 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'SpringerNature_SciRep_35863.indd:Figure 3. Liver responses of proactive and reactive fish exposed to Vibrio anguillarum bacterin at 1, 3 and 7 days post-vaccination (A) Expression profiles of immune- (il1β, tnfα and igm), oxidative stress- (gpx1, sod and cat) an:52' cannot be found Offset: 1088391 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'SpringerNature_SciRep_35863.indd:Figure 3. Liver responses of proactive and reactive fish exposed to Vibrio anguillarum bacterin at 1, 3 and 7 days post-vaccination (A) Expression profiles of immune- (il1β, tnfα and igm), oxidative stress- (gpx1, sod and cat) a:53' cannot be found Offset: 1088391 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'SpringerNature_SciRep_35863.indd:Figure 4. Plasma cortisol and glucose dynamics of proactive and reactive fish exposed to Vibrio anguillarum bacterin at 1, 3 and 7 days post-vaccination. *indicates significant differences between proactive and reactive fish (p⁜琀㰠　⸀　㔀⸀‥됀 椀渀搀椀㨀㔀㐩⽂潲摥牛〠〠そ⽓畢瑹灥⽌楮欯䉓㰼⽗‰⽔祰支䉯牤敲⽓⽓㸾⽒散瑛㐹㜮㌳㔠㈲〮㈶㌠㔰ㄮ㜴㌠㈰㠮ㄲ㉝⽈⽎⽁值㰯丠㜷‰⁒㸾㸾੥湤潢樊㜳‰扪਼㰯䘠㐯呹灥⽁湮潴⽄敳琨SpringerNature_SciRep_35863.indd:Figure 4. Plasma cortisol and glucose dynamics of proactive and reactive fish exposed to Vibrio anguillarum bacterin at 1, 3 and 7 days post-vaccination. *indicates significant differences between proactive and reactive fish (p⁜琀㰠　⸀　㔀⸀‥됀 椀渀搀㨀㔀㔩⽂潲摥牛〠〠そ⽓畢瑹灥⽌楮欯䉓㰼⽗‰⽔祰支䉯牤敲⽓⽓㸾⽒散瑛㔳㌮㠹㌠ㄷ〮㈶㌠㔳㠮㈱㌠ㄵ㠮ㄲ㉝⽈⽎⽁值㰯丠㜸‰⁒㸾㸾੥湤潢樊㜴‰扪਼㰯䘠㐯呹灥⽁湮潴⽄敳琨SpringerNature_SciRep_35863.indd: 20. Mikkelsen, H., Lund, V., Martinsen, L.-C., Gravningen, K. & Schrøder, M. B. Variability among Vibrio anguillarum O2 isolates from Atlantic cod (Gadus morhua L.): Characterisation and vaccination studies. Aquaculture 266, 16–25 (2007:56' cannot be found Offset: 1088391 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'SpringerNature_SciRep_35863.indd:Figure 4. Plasma cortisol and glucose dynamics of proactive and reactive fish exposed to Vibrio anguillarum bacterin at 1, 3 and 7 days post-vaccination. *indicates significant differences between proactive and reactive fish (p⁜琀㰠　⸀　㔀⸀‥됀 椀渀搀㨀㔀㔩⽂潲摥牛〠〠そ⽓畢瑹灥⽌楮欯䉓㰼⽗‰⽔祰支䉯牤敲⽓⽓㸾⽒散瑛㔳㌮㠹㌠ㄷ〮㈶㌠㔳㠮㈱㌠ㄵ㠮ㄲ㉝⽈⽎⽁值㰯丠㜸‰⁒㸾㸾੥湤潢樊㜴‰扪਼㰯䘠㐯呹灥⽁湮潴⽄敳琨SpringerNature_SciRep_35863.indd: 20. Mikkelsen, H., Lund, V., Martinsen, L.-C., Gravningen, K. & Schrøder, M. B. Variability among Vibrio anguillarum O2 isolates from Atlantic cod (Gadus morhua L.): Characterisation and vaccination studies. Aquaculture 266, 16–25 (2007:56' cannot be found Offset: 1088391 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'SpringerNature_SciRep_35863.indd: 19. Hickey, M. E. & Lee, J.-L. A comprehensive review of Vibrio (Listonella) anguillarum: ecology, pathology and prevention. Reviews in Aquaculture 10, 585–610 (2018). :57' cannot be found Offset: 1088391 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'SpringerNature_SciRep_35863.indd: 27. Tort, L. Stress and immune modulation in fish. Developmental & Comparative Immunology 35, 1366–1375 (2011). :67' cannot be found Offset: 1088391 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'SpringerNature_SciRep_35863.indd: 38. Oliveira, M. et al. Can non-invasive methods be used to assess effects of nanoparticles in fish? Ecological Indicators, https://doi.org/10.1016/j.ecolind.2017.06.023 (2017). :82' cannot be found Offset: 1088391 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'SpringerNature_SciRep_35863.indd: 38. Oliveira, M. et al. Can non-invasive methods be used to assess effects of nanoparticles in fish? Ecological Indicators, https://doi.org/10.1016/j.ecolind.2017.06.023 (2017). :84' cannot be found Offset: 1088391 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'SpringerNature_SciRep_35863.indd: 40. Erel, O. A new automated colorimetric method for measuring total oxidant status. Clin. Biochem. 38, 1103–1111 (2005). :85' cannot be found Offset: 1088391 MIMEtype: application/pdf PDFMetadata: Objects: 377 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: ViewerPreferences: HideToolbar: false HideMenubar: false HideWindowUI: false FitWindow: false CenterWindow: false DisplayDocTitle: false NonFullScreenPageMode: UseNone Direction: L2R ViewArea: CropBox ViewClip: CropBox PrintArea: CropBox PageClip: CropBox PageLayout: SinglePage PageMode: UseOutlines Language: EN Outlines: Item: Title: Variations in the immune and metabolic response of proactive and reactive Sparus aurata under stimulation with Vibrio angui ... Children: Item: Title: Results Children: Item: Title: Behavioural screening. Item: Title: Gene expression and biochemical endpoints in gills. Item: Title: Gene expression and biochemical endpoints in liver. Item: Title: Plasma cortisol and glucose. Item: Title: Discussion Item: Title: Methods Children: Item: Title: Fish husbandry. Item: Title: Behavioural screening. Item: Title: Fish vaccination. Item: Title: Transcriptional analysis. Item: Title: Biochemical analysis in liver and gills. Item: Title: Cortisol and glucose analysis in plasma. Item: Title: Statistical analysis. Item: Title: Acknowledgements Item: Title: Figure 1 Outline of behavioural tests and behavioural screening for proactive and reactive phenotypes in S. Item: Title: Figure 2 Gill responses of proactive and reactive fish exposed to Vibrio anguillarum bacterin at 1, 3 and 7 days post-vaccination (A) Expression profiles of immune- (il1β, tnfα and igm) and oxidative stress-related (gpx1, sod and cat) gene transcripts. Item: Title: Figure 3 Liver responses of proactive and reactive fish exposed to Vibrio anguillarum bacterin at 1, 3 and 7 days post-vaccination (A) Expression profiles of immune- (il1β, tnfα and igm), oxidative stress- (gpx1, sod and cat) and metabolic-related (lpl, g Item: Title: Figure 4 Plasma cortisol and glucose dynamics of proactive and reactive fish exposed to Vibrio anguillarum bacterin at 1, 3 and 7 days post-vaccination. Item: Title: Table 1 Primers used for gene expression analysis in S. Info: Title: Variations in the immune and metabolic response of proactive and reactive Sparus aurata under stimulation with Vibrio anguillarum vaccine Author: R. 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FontName: HBVDCP+Corbel-Bold Flags: Symbolic FontBBox: -556, -239, 1155, 952 FontFile2: true XMP: application/pdf doi:10.1038/s41598-018-35863-w Springer US Scientific Reports, doi:10.1038/s41598-018-35863-w Variations in the immune and metabolic response of proactive and reactive Sparus aurata under stimulation with Vibrio anguillarum vaccine R. Vargas J. C. Balasch I. Brandts F. Reyes-Lamp#x000F3;pez L. Tort M. Teles 10.1038/s41598-018-35863-w http://dx.doi.org/10.1038/s41598-018-35863-w journal Scientific Reports © 2018, The Author(s) 2045-2322 10.1038/s41598-018-35863-w Springer 2018-11-20T12:50:58+01:00 2018-11-17T02:19:28+05:30 2018-11-20T12:50:58+01:00 True iText® 5.3.5 ©2000-2012 1T3XT BVBA (AGPL-version) VoR uuid:9699484f-e26f-4f4a-834e-03d71aefe12a uuid:bd99c523-ccf3-41d2-a78a-3c502158e4e1 default 1 converted uuid:0c96fba9-d75d-44fa-9aea-6cde89d48fea converted to PDF/A-2b pdfToolbox 2018-11-17T02:20:15+05:30 2 B http://ns.adobe.com/xap/1.0/mm/ xmpMM XMP Media Management Schema internal UUID based identifier for specific incarnation of a document InstanceID URI internal The common identifier for all versions and renditions of a document. OriginalDocumentID URI internal A reference to the original document from which this one is derived. It is a minimal reference; missing components can be assumed to be unchanged. 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