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Introduction Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@ed17bee Children: Item: Title: 1.1. AD pathogenesis in DS Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@2a33fae0 Item: Title: 1.2. Opportunities for AD trials in DS Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@707f7052 Item: Title: 1.3. Challenges to conducting AD trials in DS Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@11028347 Item: Title: 1.4. The Horizon21 European Down Syndrome Consortium Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@14899482 Item: Title: 1.5. DS trial registry and cohorts with run-in data Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@21588809 Item: Title: 1.6. Genetic analyses to refine estimates of age at onset in DS Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@2aae9190 Item: Title: 1.7. Developing cognitive outcome measures for AD trials in DS Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@2f333739 Item: Title: 1.8. Patient stratification for clinical trials Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@77468bd9 Item: Title: 1.9. Surrogate markers of efficacy and safety Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@12bb4df8 Item: Title: 2. Conclusions Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4cc77c2e Item: Title: Acknowledgments Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7a7b0070 Item: Title: References Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@39a054a5 Info: Title: Alzheimer's disease in Down syndrome: An overlooked population for prevention trials Author: André Strydom Subject: Alzheimer's & Dementia: Translational Research & Clinical Interventions, 4 (2018) 703-713. doi:10.1016/j.trci.2018.10.006 Creator: Elsevier Producer: Acrobat Distiller 8.1.0 (Windows) CreationDate: Wed Jan 02 07:21:49 CET 2019 ModDate: Wed Jan 02 07:22:26 CET 2019 ID: 0x1dd1e98896bb79730ed6731811fdc52e, 0xd3fe517cc9a0464b9ffecbca81664cbe Filters: FilterPipeline: FlateDecode FilterPipeline: DCTDecode Images: Image: NisoImageMetadata: CompressionScheme: JPEG ImageWidth: 251 ImageHeight: 276 BitsPerSample: 8 BitsPerSampleUnit: integer ColorSpace: Separation Image: NisoImageMetadata: CompressionScheme: JPEG ImageWidth: 1544 ImageHeight: 1467 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: CompressionScheme: JPEG ImageWidth: 1544 ImageHeight: 2265 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: CompressionScheme: JPEG ImageWidth: 1550 ImageHeight: 2267 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: CompressionScheme: JPEG ImageWidth: 1542 ImageHeight: 1451 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Fonts: Type1: Font: BaseFont: BBCOGI+AdvP4C4E59 FontSubset: true FirstChar: 1 LastChar: 160 FontDescriptor: FontName: BBCOGI+AdvP4C4E59 Flags: Symbolic FontBBox: -31, -250, 1000, 750 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: BBCOML+AdvPS3F4C13 FontSubset: true FirstChar: 98 LastChar: 98 FontDescriptor: FontName: BBCOML+AdvPS3F4C13 Flags: Nonsymbolic FontBBox: 0, -291, 875, 697 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: BBCOGJ+AdvPSA88C FontSubset: true FirstChar: 38 LastChar: 245 FontDescriptor: FontName: BBCOGJ+AdvPSA88C Flags: Serif, Nonsymbolic FontBBox: -166, -208, 1010, 781 FontFile3: true Encoding: MacRomanEncoding Font: BaseFont: BBCONM+AdvPS3FDD77 FontSubset: true FirstChar: 46 LastChar: 119 FontDescriptor: FontName: BBCONM+AdvPS3FDD77 Flags: Nonsymbolic FontBBox: 0, -208, 1145, 864 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: BBCOGK+AdvPSA88B FontSubset: true FirstChar: 46 LastChar: 119 FontDescriptor: FontName: BBCOGK+AdvPSA88B Flags: Nonsymbolic FontBBox: -166, -208, 1000, 781 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: BBDAKC+AdvOTd877c31c+03 FontSubset: true FirstChar: 1 LastChar: 1 FontDescriptor: FontName: BBDAKC+AdvOTd877c31c+03 Flags: Symbolic FontBBox: 24, -10, 407, 460 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: BBCOHL+AdvPSSym FontSubset: true FirstChar: 1 LastChar: 1 FontDescriptor: FontName: BBCOHL+AdvPSSym Flags: Symbolic FontBBox: -177, -291, 1083, 1010 FontFile3: true EncodingDictionary: Differences: true Font: BaseFont: BBCOGH+AdvPSA88A FontSubset: true FirstChar: 30 LastChar: 151 FontDescriptor: FontName: BBCOGH+AdvPSA88A Flags: Serif, Nonsymbolic FontBBox: -166, -208, 1000, 781 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: BBCOHM+AdvPS586B FontSubset: true FirstChar: 49 LastChar: 49 FontDescriptor: FontName: BBCOHM+AdvPS586B Flags: Nonsymbolic FontBBox: -20, -229, 1010, 812 FontFile3: true Encoding: WinAnsiEncoding XMP: application/pdf doi:10.1016/j.trci.2018.10.006 Alzheimer's disease in Down syndrome: An overlooked population for prevention trials André Strydom Antonia Coppus Rafael Blesa Adrian Danek Juan Fortea John Hardy Johannes Levin Georg Nuebling Anne-Sophie Rebillat Craig Ritchie Cornelia van Duijn Shahid Zaman Henrik Zetterberg Alzheimer's disease Down syndrome Trisomy 21 Randomized controlled trials Prevention Dementia APP Amyloid Biomarkers Alzheimer's & Dementia: Translational Research & Clinical Interventions, 4 (2018) 703-713. doi:10.1016/j.trci.2018.10.006 Elsevier Inc. journal Alzheimer's & Dementia: Translational Research & Clinical Interventions © 2018 The Authors. 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400, 425 Annotation: Subtype: Link Rect: 317, 407, 539, 415 Annotation: Subtype: Link Rect: 317, 397, 539, 405 Annotation: Subtype: Link Rect: 317, 387, 539, 395 Annotation: Subtype: Link Rect: 317, 377, 434, 385 Annotation: Subtype: Link Rect: 317, 367, 539, 375 Annotation: Subtype: Link Rect: 317, 357, 539, 365 Annotation: Subtype: Link Rect: 317, 347, 491, 355 Annotation: Subtype: Link Rect: 317, 337, 475, 345 Annotation: Subtype: Link Rect: 478, 337, 539, 345 Annotation: Subtype: Link Rect: 317, 327, 539, 335 Annotation: Subtype: Link Rect: 317, 317, 539, 325 Annotation: Subtype: Link Rect: 317, 307, 434, 315 Annotation: Subtype: Link Rect: 317, 297, 539, 305 Annotation: Subtype: Link Rect: 317, 287, 539, 295 Annotation: Subtype: Link Rect: 317, 277, 539, 285 Annotation: Subtype: Link Rect: 317, 267, 539, 275 Annotation: Subtype: Link Rect: 317, 257, 365, 265 Annotation: Subtype: Link Rect: 317, 247, 539, 255 Annotation: Subtype: Link Rect: 317, 237, 539, 245 Annotation: Subtype: Link Rect: 317, 227, 447, 235 Annotation: Subtype: Link Rect: 317, 217, 334, 225 Annotation: Subtype: Link Rect: 337, 217, 539, 225 Annotation: Subtype: Link Rect: 317, 207, 539, 215 Annotation: Subtype: Link Rect: 317, 197, 539, 205 Annotation: Subtype: Link Rect: 317, 187, 484, 195 Annotation: Subtype: Link Rect: 317, 178, 539, 186 Annotation: Subtype: Link Rect: 317, 168, 539, 176 Annotation: Subtype: Link Rect: 317, 158, 539, 166 Annotation: Subtype: Link Rect: 317, 148, 539, 156 Annotation: Subtype: Link Rect: 317, 138, 335, 146 Checksum: 7274ee7e Type: CRC32 Checksum: 73da9855c0c4b34fda20121f8583a1b5 Type: MD5 Checksum: a2e596652228c0ffec0ac747f776744ff367b045 Type: SHA-1