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Introduction Destination: section1 Item: Title: 2. Methods Destination: section2 Children: Item: Title: 2.1. Protocol Registration Destination: section3 Item: Title: 2.2. Eligibility Criteria, Information Sources, and Search Strategy Destination: section4 Item: Title: 2.3. Study Selection Destination: section5 Item: Title: 2.4. Data Extraction Destination: section6 Item: Title: 2.5. Assessment of Risk of Bias Destination: section7 Item: Title: 2.6. Data Analysis Destination: section8 Item: Title: 3. Results Destination: section9 Children: Item: Title: 3.1. Study Selection and Study Characteristics Destination: section10 Item: Title: 3.2. Total Osteocalcin among Gestational Diabetes Mellitus Destination: section11 Item: Title: 3.3. Subgroup Analysis for tOC Destination: section12 Item: Title: 3.4. Metaregressions for tOC Destination: section13 Item: Title: 3.5. Undercarboxylated Osteocalcin among Gestational Diabetes Mellitus Destination: section14 Item: Title: 3.6. Subgroup Analysis for ucOC Destination: section15 Item: Title: 4. Discussion Destination: section16 Children: Item: Title: 4.1. Main Findings Destination: section17 Item: Title: 4.2. Clinical Implications Destination: section18 Item: Title: 4.3. Strengths and Limitations Destination: section19 Item: Title: 4.4. Osteocalcin as a Predictive Protein for Gestational Diabetes Mellitus Destination: section20 Item: Title: 5. Conclusions and Implications Destination: section21 Item: Title: Additional Points Destination: section22 Item: Title: Conflicts of Interest Destination: section23 Item: Title: Authors’ Contributions Destination: section24 Item: Title: Acknowledgments Destination: section25 Item: Title: Supplementary Materials Destination: section26 Info: Title: HDJDR_4986735 1..15 Creator: Aspose Ltd. 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Mellitus and Their Intrinsic and Extrinsic Determinants: Systematic Review and Meta-AnalysisMartinez-Portilla, Raigam J.Villafan-Bernal, Jose R.Lip-Sosa, Diana L.Meler, EvaClotet, JordiSerna-Vela, Francisco J.Velazquez-Garcia, SergioSerrano-Diaz, Leopoldo C.Figueras, FrancescBackground. Undercarboxylated osteocalcin (ucOC) increases insulin release and insulin resistance in mice. In humans, evidence is scarce but a correlation of ucOC and total osteocalcin (tOC) with glycemic status markers has been demonstrated. The relationship of ucOC and tOC with gestational diabetes mellitus (GDM) has been even less characterized. Objective. To assess the mean difference of tOC and ucOC serum concentrations among nondiabetic pregnant women and women diagnosed as GDM in the second trimester of pregnancy and to determine the possible intrinsic and extrinsic contributors to this difference. Methods. A systematic search was performed to identify relevant studies published in English and Spanish using PubMed, SCOPUS, ISI Web of Knowledge, and PROSPERO database for meta-analysis. Observational studies measuring mean serum levels of osteocalcin among GDM, with at least 10 subjects analyzed in each group were selected. Mean difference (MD) by random effects model was used. Heterogeneity between studies was assessed using Cochran’s Q, H, and I2 statistics. Results. From 38 selected studies, 5 were retained for analysis for a total of 1119 pregnant women. Serum concentrations of tOC were not significantly different among women with GDM and nondiabetic pregnant controls (MD: 1.56; 95% CI: −0.70 to 3.82; p=0.175). Meanwhile, ucOC serum levels were significantly higher among women with GDM (MD: 1.17; 95% CI: 0.24 to 2.11; p=0.013). The only factor influencing tOC was the UV index, showing a reduction in mean difference between GDM and controls when exposed to higher concentrations of UV rays. Conclusions. This meta-analysis provides evidence to support the use of ucOC as a potential marker for GDM rather than tOC, yielding very little variability among studies and no difference among methods or brands used for its analysis.Journal of Diabetes ResearchHindawi2018/12/30Research articledoi:10.1155/2018/4986735en Pages: Page: Label: 1 Annotations: Annotation: Subtype: Link Rect: 227, 537, 237, 547 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 200, 509, 210, 519 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 478, 310, 549, 320 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 86, 299, 156, 309 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 50, 705, 168, 713 Page: Label: 2 Annotations: Annotation: Subtype: Link Rect: 99, 672, 104, 682 Flags: Print AppearanceDictionary: true Destination: 266 Annotation: Subtype: Link Rect: 224, 649, 229, 659 Flags: Print AppearanceDictionary: true Destination: 266 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