59d877d260381f6515dcd15cbdaf58fe  gen_a2019m4v10n4p258.pdf
a1c704e787d2d95787512df84eb77a50a1c92bd7  gen_a2019m4v10n4p258.pdf
94ec6224bd91b8dde017ad293c14d2dfe377048c76afe285bf312c4d0914489a  gen_a2019m4v10n4p258.pdf

Title:          On the Importance to Acknowledge Transposable Elements in Epigenomic Analyses
Subject:        Eukaryotic genomes comprise a large proportion of repeated sequences, an important fraction of which are transposable elements (TEs). TEs are mobile elements that have a significant impact on genome evolution and on gene functioning. Although some TE insertions could provide adaptive advantages to species, transposition is a highly mutagenic event that has to be tightly controlled to ensure its viability. Genomes have evolved sophisticated mechanisms to control TE activity, the most important being epigenetic silencing. However, the epigenetic control of TEs can also affect genes located nearby that can become epigenetically regulated. It has been proposed that the combination of TE mobilization and the induced changes in the epigenetic landscape could allow a rapid phenotypic adaptation to global environmental changes. In this review, we argue the crucial need to take into account the repeated part of genomes when studying the global impact of epigenetic modifications on an organism. We emphasize more particularly why it is important to carefully consider TEs and what bioinformatic tools can be used to do so.
Keywords:       transposable element; epigenomics; bioinformatic tools
Author:         Emmanuelle Lerat, Josep Casacuberta, Cristian Chaparro and Cristina Vieira
Creator:        LaTeX with hyperref package
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CreationDate:   Sun Mar 31 08:59:02 2019 CEST
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Jhove (Rel. 1.6, 2011-01-04)
 Date: 2019-07-24 05:09:05 CEST
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