9e2ec1f7995c7bfb87bc82c93df323bc biomolecules_a2019v9np-Final.pdf a11fc18eee697d0d182985d2058856a3113605d6 biomolecules_a2019v9np-Final.pdf fc481e78d9898b8712b9a77d2e5c38e89a4cc42527fd8cf5b1ed9f1fc48e3107 biomolecules_a2019v9np-Final.pdf Title: Beyond the Scavenging of Reactive Oxygen Species (ROS): Direct Effect of Cerium Oxide Nanoparticles in Reducing Fatty Acids Content in an In Vitro Model of Hepatocellular Steatosis Subject: Nonalcoholic fatty liver disease (NAFLD) is characterized by hepatic accumulation of lipids. Antisteatotic effects of cerium oxide nanoparticles (CeO2NPs) have recently been shown in animal models of liver disease. However, it is unclear whether the activity of CeO2NPs is related solely to the decrease in oxidative stress or, in addition, they directly decrease liver fatty acid accumulation. To address this question, in this work, we used an in vitro model of hepatocellular steatosis, exposing HepG2 cells to oleic and palmitic acid. Cell uptake of CeO2NPs and their effect on oxidative stress and viability of hepatic cells cultured with H2O2 were also evaluated. Results show that CeO2NPs were uptaken by HepG2 cells and reduced oxidative stress and improved cell viability. Treatment with oleic and palmitic acid increased lipogenesis and the content of different fatty acids. CeO2NPs reduced palmitic and stearic acid and most fatty acids consisting of more than 18 carbon atoms. These effects were associated with significant changes in elongase and desaturase activity. In conclusion, CeO2NPs directly protected HepG2 cells from cell injury in oxidative stress conditions and reduced fatty acid content in steatotic conditions by inducing specific changes in fatty acid metabolism, thus showing potential in the treatment of NAFLD. Keywords: nonalcoholic fatty liver disease; steatosis; liver; cerium oxide nanoparticles; oxidative stress Author: Marina Parra-Robert, Eudald Casals, Nuria Massana, Muling Zeng, Meritxell Perramón, Guillermo Fernández-Varo, Manuel Morales-Ruiz, Víctor Puntes, Wladimiro Jiménez and Gregori Casals Creator: LaTeX with hyperref package Producer: pdfTeX-1.40.18 CreationDate: Thu Aug 29 06:30:21 2019 CEST ModDate: Thu Aug 29 06:30:21 2019 CEST Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 16 Encrypted: no Page size: 595.276 x 841.89 pts (A4) Page rot: 0 File size: 3122637 bytes Optimized: no PDF version: 1.5 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- QNXTHB+URWPalladioL-Ital Type 1 Custom yes yes no 125 0 OFECFA+URWPalladioL-Bold Type 1 Custom yes yes no 126 0 LZDGTK+Rpxb Type 1 Builtin yes yes no 127 0 QTLELQ+Pxbsy Type 1 Builtin yes yes no 128 0 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BCDIEE+PalatinoLinotype-Roman CID TrueType Identity-H yes yes yes 425 0 BCDEEE+PalatinoLinotype-Roman TrueType WinAnsi yes yes no 457 0 BCDFEE+PalatinoLinotype-Italic TrueType WinAnsi yes yes no 458 0 BCDGEE+PalatinoLinotype-Bold TrueType WinAnsi yes yes no 459 0 BCDEEE+PalatinoLinotype-Roman TrueType WinAnsi yes yes no 475 0 BCDFEE+PalatinoLinotype-Italic TrueType WinAnsi yes yes no 476 0 BCDGEE+PalatinoLinotype-Bold TrueType WinAnsi yes yes no 477 0 BCDIEE+PalatinoLinotype-Roman CID TrueType Identity-H yes yes yes 478 0 VSHNAE+Rpcxr Type 1 Builtin yes yes no 679 0 Jhove (Rel. 1.22.1, 2019-04-17) Date: 2019-12-11 05:22:58 CET RepresentationInformation: biomolecules_a2019v9np-Final.pdf ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17) LastModified: 2019-12-10 10:55:20 CET Size: 3122637 Format: PDF Version: 1.5 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 0 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: ViewerPreferences: HideToolbar: false HideMenubar: false HideWindowUI: false FitWindow: true CenterWindow: false DisplayDocTitle: false NonFullScreenPageMode: UseNone Direction: L2R ViewArea: CropBox ViewClip: CropBox PrintArea: CropBox PageClip: CropBox PageLayout: SinglePage PageMode: UseNone Outlines: Item: Title: ぉのぴひはつふっぴどはのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸲ Item: Title: きちぴづひどちぬびぜ〴ぜ〰ちのつぜ〴ぜ〰きづぴとはつびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮ㄩ‾㸊⡜㌷㙜㌷㝜〰こべのぴとづびどびぜ〴ぜ〰ちのつぜ〴ぜ〰ぃとちひちっぴづひどぺちぴどはのぜ〴ぜ〰はてぜ〴ぜ〰ぃづく〲ぎぐびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獵扳散瑩潮⸲⸱⸱ Children: Item: Title: こべのぴとづびどびぜ〴ぜ〰ちのつぜ〴ぜ〰ぃとちひちっぴづひどぺちぴどはのぜ〴ぜ〰はてぜ〴ぜ〰ぃづく〲ぎぐびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獵扳散瑩潮⸲⸱⸱ Children: Item: Title: こべのぴとづびどびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獵扳散瑩潮⸲⸱⸲ Item: Title: ぁぬぢふねどのぜ〴ぜ〰ぃはのなふでちぴどはのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獵扳散瑩潮⸲⸱⸳ Item: Title: ぃとちひちっぴづひどぺちぴどはのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㈩‾㸊⡜㌷㙜㌷㝜〰ぃづぬぬぜ〴ぜ〰ぃふぬぴふひづぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㌩‾㸊⡜㌷㙜㌷㝜〰ぉのぴづひのちぬどぺちぴどはのぜ〴ぜ〰はてぜ〴ぜ〰ぃづく〲ぎぐびぜ〴ぜ〰どのぜ〴ぜ〰えづばぇ〲ぜ〴ぜ〰ぃづぬぬびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㐩‾㸊⡜㌷㙜㌷㝜〰ぃづぬぬぜ〴ぜ〰ざどちぢどぬどぴべぜ〴ぜ〰ぁのちぬべびどびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㔩‾㸊⡜㌷㙜㌷㝜〰げづちっぴどぶづぜ〴ぜ〰くへべでづのぜ〴ぜ〰こばづっどづびぜ〴ぜ〰きづちびふひづねづのぴぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㘩‾㸊⡜㌷㙜㌷㝜〰くへべびぴづひはぬびぜ〴ぜ〰きづちびふひづねづのぴびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㜩‾㸊⡜㌷㙜㌷㝜〰ぉのつふっぴどはのぜ〴ぜ〰はてぜ〴ぜ〰こぴづちぴはびどびぜ〴ぜ〰どのぜ〴ぜ〰えづばぇ〲ぜ〴ぜ〰ぃづぬぬびぜ〴ぜ〰ぷどぴとぜ〴ぜ〰くぬづどっぜ〴ぜ〰ちのつぜ〴ぜ〰ぐちぬねどぴどっぜ〴ぜ〰ぁっどつびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㠩‾㸊⡜㌷㙜㌷㝜〰ごはぴちぬぜ〴ぜ〰うぁぜ〴ぜ〰きづちびふひづねづのぴびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㤩‾㸊⡜㌷㙜㌷㝜〰こぴちぴどびぴどっちぬぜ〴ぜ〰ぁのちぬべびどびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸳ Item: Title: ぃづぬぬぜ〴ぜ〰ぃふぬぴふひづぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㌩‾㸊⡜㌷㙜㌷㝜〰ぉのぴづひのちぬどぺちぴどはのぜ〴ぜ〰はてぜ〴ぜ〰ぃづく〲ぎぐびぜ〴ぜ〰どのぜ〴ぜ〰えづばぇ〲ぜ〴ぜ〰ぃづぬぬびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㐩‾㸊⡜㌷㙜㌷㝜〰ぃづぬぬぜ〴ぜ〰ざどちぢどぬどぴべぜ〴ぜ〰ぁのちぬべびどびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㔩‾㸊⡜㌷㙜㌷㝜〰げづちっぴどぶづぜ〴ぜ〰くへべでづのぜ〴ぜ〰こばづっどづびぜ〴ぜ〰きづちびふひづねづのぴぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㘩‾㸊⡜㌷㙜㌷㝜〰くへべびぴづひはぬびぜ〴ぜ〰きづちびふひづねづのぴびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㜩‾㸊⡜㌷㙜㌷㝜〰ぉのつふっぴどはのぜ〴ぜ〰はてぜ〴ぜ〰こぴづちぴはびどびぜ〴ぜ〰どのぜ〴ぜ〰えづばぇ〲ぜ〴ぜ〰ぃづぬぬびぜ〴ぜ〰ぷどぴとぜ〴ぜ〰くぬづどっぜ〴ぜ〰ちのつぜ〴ぜ〰ぐちぬねどぴどっぜ〴ぜ〰ぁっどつびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㠩‾㸊⡜㌷㙜㌷㝜〰ごはぴちぬぜ〴ぜ〰うぁぜ〴ぜ〰きづちびふひづねづのぴびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㤩‾㸊⡜㌷㙜㌷㝜〰こぴちぴどびぴどっちぬぜ〴ぜ〰ぁのちぬべびどびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸳ Item: Title: ぉのぴづひのちぬどぺちぴどはのぜ〴ぜ〰はてぜ〴ぜ〰ぃづく〲ぎぐびぜ〴ぜ〰どのぜ〴ぜ〰えづばぇ〲ぜ〴ぜ〰ぃづぬぬびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㐩‾㸊⡜㌷㙜㌷㝜〰ぃづぬぬぜ〴ぜ〰ざどちぢどぬどぴべぜ〴ぜ〰ぁのちぬべびどびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㔩‾㸊⡜㌷㙜㌷㝜〰げづちっぴどぶづぜ〴ぜ〰くへべでづのぜ〴ぜ〰こばづっどづびぜ〴ぜ〰きづちびふひづねづのぴぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㘩‾㸊⡜㌷㙜㌷㝜〰くへべびぴづひはぬびぜ〴ぜ〰きづちびふひづねづのぴびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㜩‾㸊⡜㌷㙜㌷㝜〰ぉのつふっぴどはのぜ〴ぜ〰はてぜ〴ぜ〰こぴづちぴはびどびぜ〴ぜ〰どのぜ〴ぜ〰えづばぇ〲ぜ〴ぜ〰ぃづぬぬびぜ〴ぜ〰ぷどぴとぜ〴ぜ〰くぬづどっぜ〴ぜ〰ちのつぜ〴ぜ〰ぐちぬねどぴどっぜ〴ぜ〰ぁっどつびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㠩‾㸊⡜㌷㙜㌷㝜〰ごはぴちぬぜ〴ぜ〰うぁぜ〴ぜ〰きづちびふひづねづのぴびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㤩‾㸊⡜㌷㙜㌷㝜〰こぴちぴどびぴどっちぬぜ〴ぜ〰ぁのちぬべびどびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸳ Item: Title: ぃづぬぬぜ〴ぜ〰ざどちぢどぬどぴべぜ〴ぜ〰ぁのちぬべびどびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㔩‾㸊⡜㌷㙜㌷㝜〰げづちっぴどぶづぜ〴ぜ〰くへべでづのぜ〴ぜ〰こばづっどづびぜ〴ぜ〰きづちびふひづねづのぴぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㘩‾㸊⡜㌷㙜㌷㝜〰くへべびぴづひはぬびぜ〴ぜ〰きづちびふひづねづのぴびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㜩‾㸊⡜㌷㙜㌷㝜〰ぉのつふっぴどはのぜ〴ぜ〰はてぜ〴ぜ〰こぴづちぴはびどびぜ〴ぜ〰どのぜ〴ぜ〰えづばぇ〲ぜ〴ぜ〰ぃづぬぬびぜ〴ぜ〰ぷどぴとぜ〴ぜ〰くぬづどっぜ〴ぜ〰ちのつぜ〴ぜ〰ぐちぬねどぴどっぜ〴ぜ〰ぁっどつびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㠩‾㸊⡜㌷㙜㌷㝜〰ごはぴちぬぜ〴ぜ〰うぁぜ〴ぜ〰きづちびふひづねづのぴびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㤩‾㸊⡜㌷㙜㌷㝜〰こぴちぴどびぴどっちぬぜ〴ぜ〰ぁのちぬべびどびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸳ Item: Title: げづちっぴどぶづぜ〴ぜ〰くへべでづのぜ〴ぜ〰こばづっどづびぜ〴ぜ〰きづちびふひづねづのぴぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㘩‾㸊⡜㌷㙜㌷㝜〰くへべびぴづひはぬびぜ〴ぜ〰きづちびふひづねづのぴびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㜩‾㸊⡜㌷㙜㌷㝜〰ぉのつふっぴどはのぜ〴ぜ〰はてぜ〴ぜ〰こぴづちぴはびどびぜ〴ぜ〰どのぜ〴ぜ〰えづばぇ〲ぜ〴ぜ〰ぃづぬぬびぜ〴ぜ〰ぷどぴとぜ〴ぜ〰くぬづどっぜ〴ぜ〰ちのつぜ〴ぜ〰ぐちぬねどぴどっぜ〴ぜ〰ぁっどつびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㠩‾㸊⡜㌷㙜㌷㝜〰ごはぴちぬぜ〴ぜ〰うぁぜ〴ぜ〰きづちびふひづねづのぴびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㤩‾㸊⡜㌷㙜㌷㝜〰こぴちぴどびぴどっちぬぜ〴ぜ〰ぁのちぬべびどびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸳ Item: Title: くへべびぴづひはぬびぜ〴ぜ〰きづちびふひづねづのぴびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㜩‾㸊⡜㌷㙜㌷㝜〰ぉのつふっぴどはのぜ〴ぜ〰はてぜ〴ぜ〰こぴづちぴはびどびぜ〴ぜ〰どのぜ〴ぜ〰えづばぇ〲ぜ〴ぜ〰ぃづぬぬびぜ〴ぜ〰ぷどぴとぜ〴ぜ〰くぬづどっぜ〴ぜ〰ちのつぜ〴ぜ〰ぐちぬねどぴどっぜ〴ぜ〰ぁっどつびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㠩‾㸊⡜㌷㙜㌷㝜〰ごはぴちぬぜ〴ぜ〰うぁぜ〴ぜ〰きづちびふひづねづのぴびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㤩‾㸊⡜㌷㙜㌷㝜〰こぴちぴどびぴどっちぬぜ〴ぜ〰ぁのちぬべびどびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸳ Item: Title: ぉのつふっぴどはのぜ〴ぜ〰はてぜ〴ぜ〰こぴづちぴはびどびぜ〴ぜ〰どのぜ〴ぜ〰えづばぇ〲ぜ〴ぜ〰ぃづぬぬびぜ〴ぜ〰ぷどぴとぜ〴ぜ〰くぬづどっぜ〴ぜ〰ちのつぜ〴ぜ〰ぐちぬねどぴどっぜ〴ぜ〰ぁっどつびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㠩‾㸊⡜㌷㙜㌷㝜〰ごはぴちぬぜ〴ぜ〰うぁぜ〴ぜ〰きづちびふひづねづのぴびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㤩‾㸊⡜㌷㙜㌷㝜〰こぴちぴどびぴどっちぬぜ〴ぜ〰ぁのちぬべびどびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸳ Item: Title: ごはぴちぬぜ〴ぜ〰うぁぜ〴ぜ〰きづちびふひづねづのぴびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㤩‾㸊⡜㌷㙜㌷㝜〰こぴちぴどびぴどっちぬぜ〴ぜ〰ぁのちぬべびどびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸳ Item: Title: こぴちぴどびぴどっちぬぜ〴ぜ〰ぁのちぬべびどびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸳ Item: Title: げづびふぬぴびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮ㄩ‾㸊⡜㌷㙜㌷㝜〰ぃとちひちっぴづひどぺちぴどはのぜ〴ぜ〰はてぜ〴ぜ〰ぃづく〲ぎぐびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㈩‾㸊⡜㌷㙜㌷㝜〰ぃづぬぬふぬちひぜ〴ぜ〰さばぴちにづぜ〴ぜ〰はてぜ〴ぜ〰ぃづく〲ぎぐびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㌩‾㸊⡜㌷㙜㌷㝜〰ぅててづっぴぜ〴ぜ〰はてぜ〴ぜ〰ぃづく〲ぎぐびぜ〴ぜ〰どのぜ〴ぜ〰ぴとづぜ〴ぜ〰ざどちぢどぬどぴべぜ〴ぜ〰はてぜ〴ぜ〰えづばぇ〲ぜ〴ぜ〰ぉのっふぢちぴづつぜ〴ぜ〰ぷどぴとぜ〴ぜ〰え〲く〲ぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㐩‾㸊⡜㌷㙜㌷㝜〰ぅててづっぴぜ〴ぜ〰はてぜ〴ぜ〰ぃづく〲ぎぐびぜ〴ぜ〰どのぜ〴ぜ〰ぴとづぜ〴ぜ〰げくこぜ〴ぜ〰ぐひはつふっぴどはのぜ〴ぜ〰はてぜ〴ぜ〰えづばぇ〲ぜ〴ぜ〰ぉのっふぢちぴづつぜ〴ぜ〰ぷどぴとぜ〴ぜ〰え〲く〲ぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㔩‾㸊⡜㌷㙜㌷㝜〰ぅててづっぴぜ〴ぜ〰はてぜ〴ぜ〰ぃづく〲ぎぐびぜ〴ぜ〰どのぜ〴ぜ〰ぃとはぬづびぴづひはぬぜ〴ぜ〰ちのつぜ〴ぜ〰くへべびぴづひはぬびぜ〴ぜ〰ぃはのぴづのぴぜ〴ぜ〰はてぜ〴ぜ〰えづばぇ〲ぜ〴ぜ〰ぃづぬぬびぜ〴ぜ〰ごひづちぴづつぜ〴ぜ〰ぷどぴとぜ〴ぜ〰え〲く〲ぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㘩‾㸊⡜㌷㙜㌷㝜〰ぅててづっぴびぜ〴ぜ〰はてぜ〴ぜ〰ぃづく〲ぎぐびぜ〴ぜ〰どのぜ〴ぜ〰ごはぴちぬぜ〴ぜ〰うぁぜ〴ぜ〰ぃはのぴづのぴぜ〴ぜ〰はてぜ〴ぜ〰えづばぇ〲ぜ〴ぜ〰ぃづぬぬびぜ〴ぜ〰ごひづちぴづつぜ〴ぜ〰ぷどぴとぜ〴ぜ〰くぬづどっぜ〴ぜ〰ちのつぜ〴ぜ〰ぐちぬねどぴどっぜ〴ぜ〰ぁっどつぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㜩‾㸊⡜㌷㙜㌷㝜〰ぃづく〲ぎぐびぜ〴ぜ〰ぉのつふっづぜ〴ぜ〰こばづっどてどっぜ〴ぜ〰ぃとちのでづびぜ〴ぜ〰どのぜ〴ぜ〰ぴとづぜ〴ぜ〰うぁぜ〴ぜ〰きづぴちぢはぬどびねぜ〴ぜ〰はてぜ〴ぜ〰こぴづちぴはぴどっぜ〴ぜ〰えづばぇ〲ぜ〴ぜ〰ぃづぬぬびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸴ Children: Item: Title: ぃとちひちっぴづひどぺちぴどはのぜ〴ぜ〰はてぜ〴ぜ〰ぃづく〲ぎぐびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㈩‾㸊⡜㌷㙜㌷㝜〰ぃづぬぬふぬちひぜ〴ぜ〰さばぴちにづぜ〴ぜ〰はてぜ〴ぜ〰ぃづく〲ぎぐびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㌩‾㸊⡜㌷㙜㌷㝜〰ぅててづっぴぜ〴ぜ〰はてぜ〴ぜ〰ぃづく〲ぎぐびぜ〴ぜ〰どのぜ〴ぜ〰ぴとづぜ〴ぜ〰ざどちぢどぬどぴべぜ〴ぜ〰はてぜ〴ぜ〰えづばぇ〲ぜ〴ぜ〰ぉのっふぢちぴづつぜ〴ぜ〰ぷどぴとぜ〴ぜ〰え〲く〲ぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㐩‾㸊⡜㌷㙜㌷㝜〰ぅててづっぴぜ〴ぜ〰はてぜ〴ぜ〰ぃづく〲ぎぐびぜ〴ぜ〰どのぜ〴ぜ〰ぴとづぜ〴ぜ〰げくこぜ〴ぜ〰ぐひはつふっぴどはのぜ〴ぜ〰はてぜ〴ぜ〰えづばぇ〲ぜ〴ぜ〰ぉのっふぢちぴづつぜ〴ぜ〰ぷどぴとぜ〴ぜ〰え〲く〲ぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㔩‾㸊⡜㌷㙜㌷㝜〰ぅててづっぴぜ〴ぜ〰はてぜ〴ぜ〰ぃづく〲ぎぐびぜ〴ぜ〰どのぜ〴ぜ〰ぃとはぬづびぴづひはぬぜ〴ぜ〰ちのつぜ〴ぜ〰くへべびぴづひはぬびぜ〴ぜ〰ぃはのぴづのぴぜ〴ぜ〰はてぜ〴ぜ〰えづばぇ〲ぜ〴ぜ〰ぃづぬぬびぜ〴ぜ〰ごひづちぴづつぜ〴ぜ〰ぷどぴとぜ〴ぜ〰え〲く〲ぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㘩‾㸊⡜㌷㙜㌷㝜〰ぅててづっぴびぜ〴ぜ〰はてぜ〴ぜ〰ぃづく〲ぎぐびぜ〴ぜ〰どのぜ〴ぜ〰ごはぴちぬぜ〴ぜ〰うぁぜ〴ぜ〰ぃはのぴづのぴぜ〴ぜ〰はてぜ〴ぜ〰えづばぇ〲ぜ〴ぜ〰ぃづぬぬびぜ〴ぜ〰ごひづちぴづつぜ〴ぜ〰ぷどぴとぜ〴ぜ〰くぬづどっぜ〴ぜ〰ちのつぜ〴ぜ〰ぐちぬねどぴどっぜ〴ぜ〰ぁっどつぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㜩‾㸊⡜㌷㙜㌷㝜〰ぃづく〲ぎぐびぜ〴ぜ〰ぉのつふっづぜ〴ぜ〰こばづっどてどっぜ〴ぜ〰ぃとちのでづびぜ〴ぜ〰どのぜ〴ぜ〰ぴとづぜ〴ぜ〰うぁぜ〴ぜ〰きづぴちぢはぬどびねぜ〴ぜ〰はてぜ〴ぜ〰こぴづちぴはぴどっぜ〴ぜ〰えづばぇ〲ぜ〴ぜ〰ぃづぬぬびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸴ Item: Title: ぃづぬぬふぬちひぜ〴ぜ〰さばぴちにづぜ〴ぜ〰はてぜ〴ぜ〰ぃづく〲ぎぐびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㌩‾㸊⡜㌷㙜㌷㝜〰ぅててづっぴぜ〴ぜ〰はてぜ〴ぜ〰ぃづく〲ぎぐびぜ〴ぜ〰どのぜ〴ぜ〰ぴとづぜ〴ぜ〰ざどちぢどぬどぴべぜ〴ぜ〰はてぜ〴ぜ〰えづばぇ〲ぜ〴ぜ〰ぉのっふぢちぴづつぜ〴ぜ〰ぷどぴとぜ〴ぜ〰え〲く〲ぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㐩‾㸊⡜㌷㙜㌷㝜〰ぅててづっぴぜ〴ぜ〰はてぜ〴ぜ〰ぃづく〲ぎぐびぜ〴ぜ〰どのぜ〴ぜ〰ぴとづぜ〴ぜ〰げくこぜ〴ぜ〰ぐひはつふっぴどはのぜ〴ぜ〰はてぜ〴ぜ〰えづばぇ〲ぜ〴ぜ〰ぉのっふぢちぴづつぜ〴ぜ〰ぷどぴとぜ〴ぜ〰え〲く〲ぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㔩‾㸊⡜㌷㙜㌷㝜〰ぅててづっぴぜ〴ぜ〰はてぜ〴ぜ〰ぃづく〲ぎぐびぜ〴ぜ〰どのぜ〴ぜ〰ぃとはぬづびぴづひはぬぜ〴ぜ〰ちのつぜ〴ぜ〰くへべびぴづひはぬびぜ〴ぜ〰ぃはのぴづのぴぜ〴ぜ〰はてぜ〴ぜ〰えづばぇ〲ぜ〴ぜ〰ぃづぬぬびぜ〴ぜ〰ごひづちぴづつぜ〴ぜ〰ぷどぴとぜ〴ぜ〰え〲く〲ぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㘩‾㸊⡜㌷㙜㌷㝜〰ぅててづっぴびぜ〴ぜ〰はてぜ〴ぜ〰ぃづく〲ぎぐびぜ〴ぜ〰どのぜ〴ぜ〰ごはぴちぬぜ〴ぜ〰うぁぜ〴ぜ〰ぃはのぴづのぴぜ〴ぜ〰はてぜ〴ぜ〰えづばぇ〲ぜ〴ぜ〰ぃづぬぬびぜ〴ぜ〰ごひづちぴづつぜ〴ぜ〰ぷどぴとぜ〴ぜ〰くぬづどっぜ〴ぜ〰ちのつぜ〴ぜ〰ぐちぬねどぴどっぜ〴ぜ〰ぁっどつぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㜩‾㸊⡜㌷㙜㌷㝜〰ぃづく〲ぎぐびぜ〴ぜ〰ぉのつふっづぜ〴ぜ〰こばづっどてどっぜ〴ぜ〰ぃとちのでづびぜ〴ぜ〰どのぜ〴ぜ〰ぴとづぜ〴ぜ〰うぁぜ〴ぜ〰きづぴちぢはぬどびねぜ〴ぜ〰はてぜ〴ぜ〰こぴづちぴはぴどっぜ〴ぜ〰えづばぇ〲ぜ〴ぜ〰ぃづぬぬびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸴ Item: Title: ぅててづっぴぜ〴ぜ〰はてぜ〴ぜ〰ぃづく〲ぎぐびぜ〴ぜ〰どのぜ〴ぜ〰ぴとづぜ〴ぜ〰ざどちぢどぬどぴべぜ〴ぜ〰はてぜ〴ぜ〰えづばぇ〲ぜ〴ぜ〰ぉのっふぢちぴづつぜ〴ぜ〰ぷどぴとぜ〴ぜ〰え〲く〲ぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㐩‾㸊⡜㌷㙜㌷㝜〰ぅててづっぴぜ〴ぜ〰はてぜ〴ぜ〰ぃづく〲ぎぐびぜ〴ぜ〰どのぜ〴ぜ〰ぴとづぜ〴ぜ〰げくこぜ〴ぜ〰ぐひはつふっぴどはのぜ〴ぜ〰はてぜ〴ぜ〰えづばぇ〲ぜ〴ぜ〰ぉのっふぢちぴづつぜ〴ぜ〰ぷどぴとぜ〴ぜ〰え〲く〲ぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㔩‾㸊⡜㌷㙜㌷㝜〰ぅててづっぴぜ〴ぜ〰はてぜ〴ぜ〰ぃづく〲ぎぐびぜ〴ぜ〰どのぜ〴ぜ〰ぃとはぬづびぴづひはぬぜ〴ぜ〰ちのつぜ〴ぜ〰くへべびぴづひはぬびぜ〴ぜ〰ぃはのぴづのぴぜ〴ぜ〰はてぜ〴ぜ〰えづばぇ〲ぜ〴ぜ〰ぃづぬぬびぜ〴ぜ〰ごひづちぴづつぜ〴ぜ〰ぷどぴとぜ〴ぜ〰え〲く〲ぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㘩‾㸊⡜㌷㙜㌷㝜〰ぅててづっぴびぜ〴ぜ〰はてぜ〴ぜ〰ぃづく〲ぎぐびぜ〴ぜ〰どのぜ〴ぜ〰ごはぴちぬぜ〴ぜ〰うぁぜ〴ぜ〰ぃはのぴづのぴぜ〴ぜ〰はてぜ〴ぜ〰えづばぇ〲ぜ〴ぜ〰ぃづぬぬびぜ〴ぜ〰ごひづちぴづつぜ〴ぜ〰ぷどぴとぜ〴ぜ〰くぬづどっぜ〴ぜ〰ちのつぜ〴ぜ〰ぐちぬねどぴどっぜ〴ぜ〰ぁっどつぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㜩‾㸊⡜㌷㙜㌷㝜〰ぃづく〲ぎぐびぜ〴ぜ〰ぉのつふっづぜ〴ぜ〰こばづっどてどっぜ〴ぜ〰ぃとちのでづびぜ〴ぜ〰どのぜ〴ぜ〰ぴとづぜ〴ぜ〰うぁぜ〴ぜ〰きづぴちぢはぬどびねぜ〴ぜ〰はてぜ〴ぜ〰こぴづちぴはぴどっぜ〴ぜ〰えづばぇ〲ぜ〴ぜ〰ぃづぬぬびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸴ Item: Title: ぅててづっぴぜ〴ぜ〰はてぜ〴ぜ〰ぃづく〲ぎぐびぜ〴ぜ〰どのぜ〴ぜ〰ぴとづぜ〴ぜ〰げくこぜ〴ぜ〰ぐひはつふっぴどはのぜ〴ぜ〰はてぜ〴ぜ〰えづばぇ〲ぜ〴ぜ〰ぉのっふぢちぴづつぜ〴ぜ〰ぷどぴとぜ〴ぜ〰え〲く〲ぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㔩‾㸊⡜㌷㙜㌷㝜〰ぅててづっぴぜ〴ぜ〰はてぜ〴ぜ〰ぃづく〲ぎぐびぜ〴ぜ〰どのぜ〴ぜ〰ぃとはぬづびぴづひはぬぜ〴ぜ〰ちのつぜ〴ぜ〰くへべびぴづひはぬびぜ〴ぜ〰ぃはのぴづのぴぜ〴ぜ〰はてぜ〴ぜ〰えづばぇ〲ぜ〴ぜ〰ぃづぬぬびぜ〴ぜ〰ごひづちぴづつぜ〴ぜ〰ぷどぴとぜ〴ぜ〰え〲く〲ぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㘩‾㸊⡜㌷㙜㌷㝜〰ぅててづっぴびぜ〴ぜ〰はてぜ〴ぜ〰ぃづく〲ぎぐびぜ〴ぜ〰どのぜ〴ぜ〰ごはぴちぬぜ〴ぜ〰うぁぜ〴ぜ〰ぃはのぴづのぴぜ〴ぜ〰はてぜ〴ぜ〰えづばぇ〲ぜ〴ぜ〰ぃづぬぬびぜ〴ぜ〰ごひづちぴづつぜ〴ぜ〰ぷどぴとぜ〴ぜ〰くぬづどっぜ〴ぜ〰ちのつぜ〴ぜ〰ぐちぬねどぴどっぜ〴ぜ〰ぁっどつぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㜩‾㸊⡜㌷㙜㌷㝜〰ぃづく〲ぎぐびぜ〴ぜ〰ぉのつふっづぜ〴ぜ〰こばづっどてどっぜ〴ぜ〰ぃとちのでづびぜ〴ぜ〰どのぜ〴ぜ〰ぴとづぜ〴ぜ〰うぁぜ〴ぜ〰きづぴちぢはぬどびねぜ〴ぜ〰はてぜ〴ぜ〰こぴづちぴはぴどっぜ〴ぜ〰えづばぇ〲ぜ〴ぜ〰ぃづぬぬびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸴ Item: Title: ぅててづっぴぜ〴ぜ〰はてぜ〴ぜ〰ぃづく〲ぎぐびぜ〴ぜ〰どのぜ〴ぜ〰ぃとはぬづびぴづひはぬぜ〴ぜ〰ちのつぜ〴ぜ〰くへべびぴづひはぬびぜ〴ぜ〰ぃはのぴづのぴぜ〴ぜ〰はてぜ〴ぜ〰えづばぇ〲ぜ〴ぜ〰ぃづぬぬびぜ〴ぜ〰ごひづちぴづつぜ〴ぜ〰ぷどぴとぜ〴ぜ〰え〲く〲ぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㘩‾㸊⡜㌷㙜㌷㝜〰ぅててづっぴびぜ〴ぜ〰はてぜ〴ぜ〰ぃづく〲ぎぐびぜ〴ぜ〰どのぜ〴ぜ〰ごはぴちぬぜ〴ぜ〰うぁぜ〴ぜ〰ぃはのぴづのぴぜ〴ぜ〰はてぜ〴ぜ〰えづばぇ〲ぜ〴ぜ〰ぃづぬぬびぜ〴ぜ〰ごひづちぴづつぜ〴ぜ〰ぷどぴとぜ〴ぜ〰くぬづどっぜ〴ぜ〰ちのつぜ〴ぜ〰ぐちぬねどぴどっぜ〴ぜ〰ぁっどつぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㜩‾㸊⡜㌷㙜㌷㝜〰ぃづく〲ぎぐびぜ〴ぜ〰ぉのつふっづぜ〴ぜ〰こばづっどてどっぜ〴ぜ〰ぃとちのでづびぜ〴ぜ〰どのぜ〴ぜ〰ぴとづぜ〴ぜ〰うぁぜ〴ぜ〰きづぴちぢはぬどびねぜ〴ぜ〰はてぜ〴ぜ〰こぴづちぴはぴどっぜ〴ぜ〰えづばぇ〲ぜ〴ぜ〰ぃづぬぬびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸴ Item: Title: ぅててづっぴびぜ〴ぜ〰はてぜ〴ぜ〰ぃづく〲ぎぐびぜ〴ぜ〰どのぜ〴ぜ〰ごはぴちぬぜ〴ぜ〰うぁぜ〴ぜ〰ぃはのぴづのぴぜ〴ぜ〰はてぜ〴ぜ〰えづばぇ〲ぜ〴ぜ〰ぃづぬぬびぜ〴ぜ〰ごひづちぴづつぜ〴ぜ〰ぷどぴとぜ〴ぜ〰くぬづどっぜ〴ぜ〰ちのつぜ〴ぜ〰ぐちぬねどぴどっぜ〴ぜ〰ぁっどつぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㜩‾㸊⡜㌷㙜㌷㝜〰ぃづく〲ぎぐびぜ〴ぜ〰ぉのつふっづぜ〴ぜ〰こばづっどてどっぜ〴ぜ〰ぃとちのでづびぜ〴ぜ〰どのぜ〴ぜ〰ぴとづぜ〴ぜ〰うぁぜ〴ぜ〰きづぴちぢはぬどびねぜ〴ぜ〰はてぜ〴ぜ〰こぴづちぴはぴどっぜ〴ぜ〰えづばぇ〲ぜ〴ぜ〰ぃづぬぬびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸴ Item: Title: ぃづく〲ぎぐびぜ〴ぜ〰ぉのつふっづぜ〴ぜ〰こばづっどてどっぜ〴ぜ〰ぃとちのでづびぜ〴ぜ〰どのぜ〴ぜ〰ぴとづぜ〴ぜ〰うぁぜ〴ぜ〰きづぴちぢはぬどびねぜ〴ぜ〰はてぜ〴ぜ〰こぴづちぴはぴどっぜ〴ぜ〰えづばぇ〲ぜ〴ぜ〰ぃづぬぬびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸴ Item: Title: いどびっふびびどはのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸵ Item: Title: ぃはのっぬふびどはのびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸵ Item: Title: げづてづひづのっづび Filters: 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