969c3fdc9ebc678d214bae20341cfb43 intjoumolsci_a2019v20p4734.pdf 54bd35af293c12afd5fef904eac85b9c74ca0034 intjoumolsci_a2019v20p4734.pdf 19d9a415d89c201bc4eda029e5883600f8f43e430cde77a39fb32058c62cd99d intjoumolsci_a2019v20p4734.pdf Title: Extracellular Albumin Covalently Sequesters Selenocompounds and Determines Cytotoxicity Subject: Selenocompounds (SeCs) are well-known nutrients and promising candidates for cancer therapy; however, treatment efficacy is very heterogeneous and the mechanism of action is not fully understood. Several SeCs have been reported to have albumin-binding ability, which is an important factor in determining the treatment efficacy of drugs. In the present investigation, we hypothesized that extracellular albumin might orchestrate SeCs efficacy. Four SeCs representing distinct categories were selected to investigate their cytotoxicity, cellular uptake, and species transformation. Concomitant treatment of albumin greatly decreased cytotoxicity and cellular uptake of SeCs. Using both X-ray absorption spectroscopy and hyphenated mass spectrometry, we confirmed the formation of macromolecular conjugates between SeCs and albumin. Although the conjugate was still internalized, possibly via albumin scavenger receptors expressed on the cell surface, the uptake was strongly inhibited by excess albumin. In summary, the present investigation established the importance of extracellular albumin binding in determining SeCs cytotoxicity. Due to the fact that albumin content is higher in humans and animals than in cell cultures, and varies among many patient categories, our results are believed to have high translational impact and clinical implications. Keywords: selenium; albumin; cytotoxicity; cellular uptake; X-ray absorption spectroscopy Author: Wenyi Zheng, Roberto Boada, Rui He, Tingting Xiao, Fei Ye, Laura Simonelli, Manuel Valiente, Ying Zhao and Moustapha Hassan Creator: LaTeX with hyperref package Producer: pdfTeX-1.40.18 CreationDate: Tue Sep 24 11:00:40 2019 CEST ModDate: Tue Sep 24 11:00:40 2019 CEST Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 13 Encrypted: no Page size: 595.276 x 841.89 pts (A4) Page rot: 0 File size: 1862880 bytes Optimized: no PDF version: 1.5 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- VUMHJQ+URWPalladioL-Ital Type 1 Custom yes yes no 125 0 SHRJFI+URWPalladioL-Bold Type 1 Custom yes yes no 126 0 CRTEHM+URWPalladioL-Roma Type 1 Custom yes yes no 127 0 ASICFG+Rpxr Type 1 Builtin yes yes no 128 0 CKUPDE+TimesNewRomanPS-BoldItalicMT Type 1C WinAnsi yes yes no 133 0 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TrueType WinAnsi yes yes no 431 0 JKDFGG+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 432 0 JKDFHH+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 433 0 JKDGFD+Calibri CID TrueType Identity-H yes yes yes 434 0 JKDJFD+CambriaMath CID TrueType Identity-H yes yes yes 435 0 RYQMUY+VnURWPalladioL Type 1 Custom yes yes no 540 0 VSHNAE+Rpcxr Type 1 Builtin yes yes no 554 0 Jhove (Rel. 1.22.1, 2019-04-17) Date: 2020-02-19 05:29:45 CET RepresentationInformation: intjoumolsci_a2019v20p4734.pdf ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17) LastModified: 2020-01-13 12:35:24 CET Size: 1862880 Format: PDF Version: 1.5 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 0 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: ViewerPreferences: HideToolbar: false HideMenubar: false HideWindowUI: false FitWindow: true CenterWindow: false DisplayDocTitle: false NonFullScreenPageMode: UseNone Direction: L2R ViewArea: CropBox ViewClip: CropBox PrintArea: CropBox PageClip: CropBox PageLayout: SinglePage PageMode: UseNone Outlines: Item: Title: ぉのぴひはつふっぴどはのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸲ Item: Title: げづびふぬぴびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮ㄩ‾㸊⡜㌷㙜㌷㝜〰ぃはのっはねどぴちのぴぜ〴ぜ〰ごひづちぴねづのぴぜ〴ぜ〰ぷどぴとぜ〴ぜ〰ぁぬぢふねどのぜ〴ぜ〰いづっひづちびづつぜ〴ぜ〰こづぬづのはっはねばはふのつぜ〴ぜ〰ぃべぴはぴはへどっどぴべぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㈩‾㸊⡜㌷㙜㌷㝜〰げづつふっづつぜ〴ぜ〰ぃづぬぬふぬちひぜ〴ぜ〰さばぴちにづぜ〴ぜ〰はてぜ〴ぜ〰こづぬづのはっはねばはふのつびぜ〴ぜ〰さのつづひぬどのづつぜ〴ぜ〰ぴとづぜ〴ぜ〰いどねどのどびとづつぜ〴ぜ〰ぃべぴはぴはへどっどぴべぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㌩‾㸊⡜㌷㙜㌷㝜〰こづぬづのはっはねばはふのつびぜ〴ぜ〰ぃはぶちぬづのぴぬべぜ〴ぜ〰あどのつぜ〴ぜ〰ぴはぜ〴ぜ〰ぅへぴひちっづぬぬふぬちひぜ〴ぜ〰ぁぬぢふねどのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㐩‾㸊⡜㌷㙜㌷㝜〰ごとづぜ〴ぜ〰げはぬづぜ〴ぜ〰はてぜ〴ぜ〰ぁぬぢふねどのぜ〴ぜ〰ちのつぜ〴ぜ〰こねちぬぬぜ〴ぜ〰きはぬづっふぬちひぜ〴ぜ〰ごとどはぬびぜ〴ぜ〰どのぜ〴ぜ〰こづぬづのはっはねばはふのつぜ〴ぜ〰ごひちのびてはひねちぴどはのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㔩‾㸊⡜㌷㙜㌷㝜〰ぁぬぢふねどのぜ〴ぜ〰ぷちびぜ〴ぜ〰ぁっぴどぶづぬべぜ〴ぜ〰ぅのつはっべぴはびづつぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸳ Children: Item: Title: ぃはのっはねどぴちのぴぜ〴ぜ〰ごひづちぴねづのぴぜ〴ぜ〰ぷどぴとぜ〴ぜ〰ぁぬぢふねどのぜ〴ぜ〰いづっひづちびづつぜ〴ぜ〰こづぬづのはっはねばはふのつぜ〴ぜ〰ぃべぴはぴはへどっどぴべぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㈩‾㸊⡜㌷㙜㌷㝜〰げづつふっづつぜ〴ぜ〰ぃづぬぬふぬちひぜ〴ぜ〰さばぴちにづぜ〴ぜ〰はてぜ〴ぜ〰こづぬづのはっはねばはふのつびぜ〴ぜ〰さのつづひぬどのづつぜ〴ぜ〰ぴとづぜ〴ぜ〰いどねどのどびとづつぜ〴ぜ〰ぃべぴはぴはへどっどぴべぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㌩‾㸊⡜㌷㙜㌷㝜〰こづぬづのはっはねばはふのつびぜ〴ぜ〰ぃはぶちぬづのぴぬべぜ〴ぜ〰あどのつぜ〴ぜ〰ぴはぜ〴ぜ〰ぅへぴひちっづぬぬふぬちひぜ〴ぜ〰ぁぬぢふねどのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㐩‾㸊⡜㌷㙜㌷㝜〰ごとづぜ〴ぜ〰げはぬづぜ〴ぜ〰はてぜ〴ぜ〰ぁぬぢふねどのぜ〴ぜ〰ちのつぜ〴ぜ〰こねちぬぬぜ〴ぜ〰きはぬづっふぬちひぜ〴ぜ〰ごとどはぬびぜ〴ぜ〰どのぜ〴ぜ〰こづぬづのはっはねばはふのつぜ〴ぜ〰ごひちのびてはひねちぴどはのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㔩‾㸊⡜㌷㙜㌷㝜〰ぁぬぢふねどのぜ〴ぜ〰ぷちびぜ〴ぜ〰ぁっぴどぶづぬべぜ〴ぜ〰ぅのつはっべぴはびづつぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸳ Item: Title: げづつふっづつぜ〴ぜ〰ぃづぬぬふぬちひぜ〴ぜ〰さばぴちにづぜ〴ぜ〰はてぜ〴ぜ〰こづぬづのはっはねばはふのつびぜ〴ぜ〰さのつづひぬどのづつぜ〴ぜ〰ぴとづぜ〴ぜ〰いどねどのどびとづつぜ〴ぜ〰ぃべぴはぴはへどっどぴべぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㌩‾㸊⡜㌷㙜㌷㝜〰こづぬづのはっはねばはふのつびぜ〴ぜ〰ぃはぶちぬづのぴぬべぜ〴ぜ〰あどのつぜ〴ぜ〰ぴはぜ〴ぜ〰ぅへぴひちっづぬぬふぬちひぜ〴ぜ〰ぁぬぢふねどのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㐩‾㸊⡜㌷㙜㌷㝜〰ごとづぜ〴ぜ〰げはぬづぜ〴ぜ〰はてぜ〴ぜ〰ぁぬぢふねどのぜ〴ぜ〰ちのつぜ〴ぜ〰こねちぬぬぜ〴ぜ〰きはぬづっふぬちひぜ〴ぜ〰ごとどはぬびぜ〴ぜ〰どのぜ〴ぜ〰こづぬづのはっはねばはふのつぜ〴ぜ〰ごひちのびてはひねちぴどはのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㔩‾㸊⡜㌷㙜㌷㝜〰ぁぬぢふねどのぜ〴ぜ〰ぷちびぜ〴ぜ〰ぁっぴどぶづぬべぜ〴ぜ〰ぅのつはっべぴはびづつぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸳ Item: Title: こづぬづのはっはねばはふのつびぜ〴ぜ〰ぃはぶちぬづのぴぬべぜ〴ぜ〰あどのつぜ〴ぜ〰ぴはぜ〴ぜ〰ぅへぴひちっづぬぬふぬちひぜ〴ぜ〰ぁぬぢふねどのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㐩‾㸊⡜㌷㙜㌷㝜〰ごとづぜ〴ぜ〰げはぬづぜ〴ぜ〰はてぜ〴ぜ〰ぁぬぢふねどのぜ〴ぜ〰ちのつぜ〴ぜ〰こねちぬぬぜ〴ぜ〰きはぬづっふぬちひぜ〴ぜ〰ごとどはぬびぜ〴ぜ〰どのぜ〴ぜ〰こづぬづのはっはねばはふのつぜ〴ぜ〰ごひちのびてはひねちぴどはのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㔩‾㸊⡜㌷㙜㌷㝜〰ぁぬぢふねどのぜ〴ぜ〰ぷちびぜ〴ぜ〰ぁっぴどぶづぬべぜ〴ぜ〰ぅのつはっべぴはびづつぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸳ Item: Title: ごとづぜ〴ぜ〰げはぬづぜ〴ぜ〰はてぜ〴ぜ〰ぁぬぢふねどのぜ〴ぜ〰ちのつぜ〴ぜ〰こねちぬぬぜ〴ぜ〰きはぬづっふぬちひぜ〴ぜ〰ごとどはぬびぜ〴ぜ〰どのぜ〴ぜ〰こづぬづのはっはねばはふのつぜ〴ぜ〰ごひちのびてはひねちぴどはのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㔩‾㸊⡜㌷㙜㌷㝜〰ぁぬぢふねどのぜ〴ぜ〰ぷちびぜ〴ぜ〰ぁっぴどぶづぬべぜ〴ぜ〰ぅのつはっべぴはびづつぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸳ Item: Title: ぁぬぢふねどのぜ〴ぜ〰ぷちびぜ〴ぜ〰ぁっぴどぶづぬべぜ〴ぜ〰ぅのつはっべぴはびづつぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸳ Item: Title: いどびっふびびどはのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸴ Item: Title: きちぴづひどちぬびぜ〴ぜ〰ちのつぜ〴ぜ〰きづぴとはつびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮ㄩ‾㸊⡜㌷㙜㌷㝜〰ぃとづねどっちぬびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㈩‾㸊⡜㌷㙜㌷㝜〰ぃづぬぬぜ〴ぜ〰ぃふぬぴふひづぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㌩‾㸊⡜㌷㙜㌷㝜〰ぐひづばちひちぴどはのぜ〴ぜ〰はてぜ〴ぜ〰こづぬづのはっはねばはふのつぜ〴ぜ〰こぴはっにぜ〴ぜ〰こはぬふぴどはのびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㐩‾㸊⡜㌷㙜㌷㝜〰ぁびびづびびねづのぴぜ〴ぜ〰はてぜ〴ぜ〰ぃづぬぬぜ〴ぜ〰ざどちぢどぬどぴべぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㔩‾㸊⡜㌷㙜㌷㝜〰きづちびふひづねづのぴぜ〴ぜ〰はてぜ〴ぜ〰ぉのぴひちっづぬぬふぬちひぜ〴ぜ〰こづぬづのどふねぜ〴ぜ〰ぅぬづねづのぴぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㘩‾㸊⡜㌷㙜㌷㝜〰ぐひづばちひちぴどはのぜ〴ぜ〰はてぜ〴ぜ〰ぁぬぢふねどのぜ〴ぜ〰ぃはのなふでちぴづぜ〴ぜ〰ちのつぜ〴ぜ〰こづひふねぜ〴ぜ〰きどへぴふひづぜ〴ぜ〰はてぜ〴ぜ〰こづぬづのはっはねばはふのつびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㜩‾㸊⡜㌷㙜㌷㝜〰こづぬづのどふねぜ〴ぜ〰こばづっどちぴどはのぜ〴ぜ〰ぢべぜ〴ぜ〰じ〭げちべぜ〴ぜ〰ぁぢびはひぢちのっづぜ〴ぜ〰こばづっぴひはびっはばべぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㠩‾㸊⡜㌷㙜㌷㝜〰こばづっどちぴどはのぜ〴ぜ〰はてぜ〴ぜ〰ば〭じべぬづのづびづぬづのはっべちのちぴづぜ〴ぜ〰ぢべぜ〴ぜ〰がどぱふどつぜ〴ぜ〰ぃとひはねちぴはでひちばとべぜ〲㍜〰きちびびぜ〴ぜ〰こばづっぴひはねづぴひべぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㤩‾㸊⡜㌷㙜㌷㝜〰ぁびびづびびねづのぴぜ〴ぜ〰はてぜ〴ぜ〰ぃづぬぬふぬちひぜ〴ぜ〰さばぴちにづぜ〴ぜ〰はてぜ〴ぜ〰ぁぬぢふねどのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㄰ Children: Item: Title: ぃとづねどっちぬびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㈩‾㸊⡜㌷㙜㌷㝜〰ぃづぬぬぜ〴ぜ〰ぃふぬぴふひづぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㌩‾㸊⡜㌷㙜㌷㝜〰ぐひづばちひちぴどはのぜ〴ぜ〰はてぜ〴ぜ〰こづぬづのはっはねばはふのつぜ〴ぜ〰こぴはっにぜ〴ぜ〰こはぬふぴどはのびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㐩‾㸊⡜㌷㙜㌷㝜〰ぁびびづびびねづのぴぜ〴ぜ〰はてぜ〴ぜ〰ぃづぬぬぜ〴ぜ〰ざどちぢどぬどぴべぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㔩‾㸊⡜㌷㙜㌷㝜〰きづちびふひづねづのぴぜ〴ぜ〰はてぜ〴ぜ〰ぉのぴひちっづぬぬふぬちひぜ〴ぜ〰こづぬづのどふねぜ〴ぜ〰ぅぬづねづのぴぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㘩‾㸊⡜㌷㙜㌷㝜〰ぐひづばちひちぴどはのぜ〴ぜ〰はてぜ〴ぜ〰ぁぬぢふねどのぜ〴ぜ〰ぃはのなふでちぴづぜ〴ぜ〰ちのつぜ〴ぜ〰こづひふねぜ〴ぜ〰きどへぴふひづぜ〴ぜ〰はてぜ〴ぜ〰こづぬづのはっはねばはふのつびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㜩‾㸊⡜㌷㙜㌷㝜〰こづぬづのどふねぜ〴ぜ〰こばづっどちぴどはのぜ〴ぜ〰ぢべぜ〴ぜ〰じ〭げちべぜ〴ぜ〰ぁぢびはひぢちのっづぜ〴ぜ〰こばづっぴひはびっはばべぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㠩‾㸊⡜㌷㙜㌷㝜〰こばづっどちぴどはのぜ〴ぜ〰はてぜ〴ぜ〰ば〭じべぬづのづびづぬづのはっべちのちぴづぜ〴ぜ〰ぢべぜ〴ぜ〰がどぱふどつぜ〴ぜ〰ぃとひはねちぴはでひちばとべぜ〲㍜〰きちびびぜ〴ぜ〰こばづっぴひはねづぴひべぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㤩‾㸊⡜㌷㙜㌷㝜〰ぁびびづびびねづのぴぜ〴ぜ〰はてぜ〴ぜ〰ぃづぬぬふぬちひぜ〴ぜ〰さばぴちにづぜ〴ぜ〰はてぜ〴ぜ〰ぁぬぢふねどのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㄰ Item: Title: ぃづぬぬぜ〴ぜ〰ぃふぬぴふひづぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㌩‾㸊⡜㌷㙜㌷㝜〰ぐひづばちひちぴどはのぜ〴ぜ〰はてぜ〴ぜ〰こづぬづのはっはねばはふのつぜ〴ぜ〰こぴはっにぜ〴ぜ〰こはぬふぴどはのびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㐩‾㸊⡜㌷㙜㌷㝜〰ぁびびづびびねづのぴぜ〴ぜ〰はてぜ〴ぜ〰ぃづぬぬぜ〴ぜ〰ざどちぢどぬどぴべぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㔩‾㸊⡜㌷㙜㌷㝜〰きづちびふひづねづのぴぜ〴ぜ〰はてぜ〴ぜ〰ぉのぴひちっづぬぬふぬちひぜ〴ぜ〰こづぬづのどふねぜ〴ぜ〰ぅぬづねづのぴぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㘩‾㸊⡜㌷㙜㌷㝜〰ぐひづばちひちぴどはのぜ〴ぜ〰はてぜ〴ぜ〰ぁぬぢふねどのぜ〴ぜ〰ぃはのなふでちぴづぜ〴ぜ〰ちのつぜ〴ぜ〰こづひふねぜ〴ぜ〰きどへぴふひづぜ〴ぜ〰はてぜ〴ぜ〰こづぬづのはっはねばはふのつびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㜩‾㸊⡜㌷㙜㌷㝜〰こづぬづのどふねぜ〴ぜ〰こばづっどちぴどはのぜ〴ぜ〰ぢべぜ〴ぜ〰じ〭げちべぜ〴ぜ〰ぁぢびはひぢちのっづぜ〴ぜ〰こばづっぴひはびっはばべぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㠩‾㸊⡜㌷㙜㌷㝜〰こばづっどちぴどはのぜ〴ぜ〰はてぜ〴ぜ〰ば〭じべぬづのづびづぬづのはっべちのちぴづぜ〴ぜ〰ぢべぜ〴ぜ〰がどぱふどつぜ〴ぜ〰ぃとひはねちぴはでひちばとべぜ〲㍜〰きちびびぜ〴ぜ〰こばづっぴひはねづぴひべぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㤩‾㸊⡜㌷㙜㌷㝜〰ぁびびづびびねづのぴぜ〴ぜ〰はてぜ〴ぜ〰ぃづぬぬふぬちひぜ〴ぜ〰さばぴちにづぜ〴ぜ〰はてぜ〴ぜ〰ぁぬぢふねどのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㄰ Item: Title: ぐひづばちひちぴどはのぜ〴ぜ〰はてぜ〴ぜ〰こづぬづのはっはねばはふのつぜ〴ぜ〰こぴはっにぜ〴ぜ〰こはぬふぴどはのびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㐩‾㸊⡜㌷㙜㌷㝜〰ぁびびづびびねづのぴぜ〴ぜ〰はてぜ〴ぜ〰ぃづぬぬぜ〴ぜ〰ざどちぢどぬどぴべぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㔩‾㸊⡜㌷㙜㌷㝜〰きづちびふひづねづのぴぜ〴ぜ〰はてぜ〴ぜ〰ぉのぴひちっづぬぬふぬちひぜ〴ぜ〰こづぬづのどふねぜ〴ぜ〰ぅぬづねづのぴぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㘩‾㸊⡜㌷㙜㌷㝜〰ぐひづばちひちぴどはのぜ〴ぜ〰はてぜ〴ぜ〰ぁぬぢふねどのぜ〴ぜ〰ぃはのなふでちぴづぜ〴ぜ〰ちのつぜ〴ぜ〰こづひふねぜ〴ぜ〰きどへぴふひづぜ〴ぜ〰はてぜ〴ぜ〰こづぬづのはっはねばはふのつびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㜩‾㸊⡜㌷㙜㌷㝜〰こづぬづのどふねぜ〴ぜ〰こばづっどちぴどはのぜ〴ぜ〰ぢべぜ〴ぜ〰じ〭げちべぜ〴ぜ〰ぁぢびはひぢちのっづぜ〴ぜ〰こばづっぴひはびっはばべぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㠩‾㸊⡜㌷㙜㌷㝜〰こばづっどちぴどはのぜ〴ぜ〰はてぜ〴ぜ〰ば〭じべぬづのづびづぬづのはっべちのちぴづぜ〴ぜ〰ぢべぜ〴ぜ〰がどぱふどつぜ〴ぜ〰ぃとひはねちぴはでひちばとべぜ〲㍜〰きちびびぜ〴ぜ〰こばづっぴひはねづぴひべぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㤩‾㸊⡜㌷㙜㌷㝜〰ぁびびづびびねづのぴぜ〴ぜ〰はてぜ〴ぜ〰ぃづぬぬふぬちひぜ〴ぜ〰さばぴちにづぜ〴ぜ〰はてぜ〴ぜ〰ぁぬぢふねどのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㄰ Item: Title: ぁびびづびびねづのぴぜ〴ぜ〰はてぜ〴ぜ〰ぃづぬぬぜ〴ぜ〰ざどちぢどぬどぴべぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㔩‾㸊⡜㌷㙜㌷㝜〰きづちびふひづねづのぴぜ〴ぜ〰はてぜ〴ぜ〰ぉのぴひちっづぬぬふぬちひぜ〴ぜ〰こづぬづのどふねぜ〴ぜ〰ぅぬづねづのぴぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㘩‾㸊⡜㌷㙜㌷㝜〰ぐひづばちひちぴどはのぜ〴ぜ〰はてぜ〴ぜ〰ぁぬぢふねどのぜ〴ぜ〰ぃはのなふでちぴづぜ〴ぜ〰ちのつぜ〴ぜ〰こづひふねぜ〴ぜ〰きどへぴふひづぜ〴ぜ〰はてぜ〴ぜ〰こづぬづのはっはねばはふのつびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㜩‾㸊⡜㌷㙜㌷㝜〰こづぬづのどふねぜ〴ぜ〰こばづっどちぴどはのぜ〴ぜ〰ぢべぜ〴ぜ〰じ〭げちべぜ〴ぜ〰ぁぢびはひぢちのっづぜ〴ぜ〰こばづっぴひはびっはばべぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㠩‾㸊⡜㌷㙜㌷㝜〰こばづっどちぴどはのぜ〴ぜ〰はてぜ〴ぜ〰ば〭じべぬづのづびづぬづのはっべちのちぴづぜ〴ぜ〰ぢべぜ〴ぜ〰がどぱふどつぜ〴ぜ〰ぃとひはねちぴはでひちばとべぜ〲㍜〰きちびびぜ〴ぜ〰こばづっぴひはねづぴひべぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㤩‾㸊⡜㌷㙜㌷㝜〰ぁびびづびびねづのぴぜ〴ぜ〰はてぜ〴ぜ〰ぃづぬぬふぬちひぜ〴ぜ〰さばぴちにづぜ〴ぜ〰はてぜ〴ぜ〰ぁぬぢふねどのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㄰ Item: Title: きづちびふひづねづのぴぜ〴ぜ〰はてぜ〴ぜ〰ぉのぴひちっづぬぬふぬちひぜ〴ぜ〰こづぬづのどふねぜ〴ぜ〰ぅぬづねづのぴぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㘩‾㸊⡜㌷㙜㌷㝜〰ぐひづばちひちぴどはのぜ〴ぜ〰はてぜ〴ぜ〰ぁぬぢふねどのぜ〴ぜ〰ぃはのなふでちぴづぜ〴ぜ〰ちのつぜ〴ぜ〰こづひふねぜ〴ぜ〰きどへぴふひづぜ〴ぜ〰はてぜ〴ぜ〰こづぬづのはっはねばはふのつびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㜩‾㸊⡜㌷㙜㌷㝜〰こづぬづのどふねぜ〴ぜ〰こばづっどちぴどはのぜ〴ぜ〰ぢべぜ〴ぜ〰じ〭げちべぜ〴ぜ〰ぁぢびはひぢちのっづぜ〴ぜ〰こばづっぴひはびっはばべぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㠩‾㸊⡜㌷㙜㌷㝜〰こばづっどちぴどはのぜ〴ぜ〰はてぜ〴ぜ〰ば〭じべぬづのづびづぬづのはっべちのちぴづぜ〴ぜ〰ぢべぜ〴ぜ〰がどぱふどつぜ〴ぜ〰ぃとひはねちぴはでひちばとべぜ〲㍜〰きちびびぜ〴ぜ〰こばづっぴひはねづぴひべぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㤩‾㸊⡜㌷㙜㌷㝜〰ぁびびづびびねづのぴぜ〴ぜ〰はてぜ〴ぜ〰ぃづぬぬふぬちひぜ〴ぜ〰さばぴちにづぜ〴ぜ〰はてぜ〴ぜ〰ぁぬぢふねどのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㄰ Item: Title: ぐひづばちひちぴどはのぜ〴ぜ〰はてぜ〴ぜ〰ぁぬぢふねどのぜ〴ぜ〰ぃはのなふでちぴづぜ〴ぜ〰ちのつぜ〴ぜ〰こづひふねぜ〴ぜ〰きどへぴふひづぜ〴ぜ〰はてぜ〴ぜ〰こづぬづのはっはねばはふのつびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㜩‾㸊⡜㌷㙜㌷㝜〰こづぬづのどふねぜ〴ぜ〰こばづっどちぴどはのぜ〴ぜ〰ぢべぜ〴ぜ〰じ〭げちべぜ〴ぜ〰ぁぢびはひぢちのっづぜ〴ぜ〰こばづっぴひはびっはばべぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㠩‾㸊⡜㌷㙜㌷㝜〰こばづっどちぴどはのぜ〴ぜ〰はてぜ〴ぜ〰ば〭じべぬづのづびづぬづのはっべちのちぴづぜ〴ぜ〰ぢべぜ〴ぜ〰がどぱふどつぜ〴ぜ〰ぃとひはねちぴはでひちばとべぜ〲㍜〰きちびびぜ〴ぜ〰こばづっぴひはねづぴひべぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㤩‾㸊⡜㌷㙜㌷㝜〰ぁびびづびびねづのぴぜ〴ぜ〰はてぜ〴ぜ〰ぃづぬぬふぬちひぜ〴ぜ〰さばぴちにづぜ〴ぜ〰はてぜ〴ぜ〰ぁぬぢふねどのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㄰ Item: Title: こづぬづのどふねぜ〴ぜ〰こばづっどちぴどはのぜ〴ぜ〰ぢべぜ〴ぜ〰じ〭げちべぜ〴ぜ〰ぁぢびはひぢちのっづぜ〴ぜ〰こばづっぴひはびっはばべぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㠩‾㸊⡜㌷㙜㌷㝜〰こばづっどちぴどはのぜ〴ぜ〰はてぜ〴ぜ〰ば〭じべぬづのづびづぬづのはっべちのちぴづぜ〴ぜ〰ぢべぜ〴ぜ〰がどぱふどつぜ〴ぜ〰ぃとひはねちぴはでひちばとべぜ〲㍜〰きちびびぜ〴ぜ〰こばづっぴひはねづぴひべぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㤩‾㸊⡜㌷㙜㌷㝜〰ぁびびづびびねづのぴぜ〴ぜ〰はてぜ〴ぜ〰ぃづぬぬふぬちひぜ〴ぜ〰さばぴちにづぜ〴ぜ〰はてぜ〴ぜ〰ぁぬぢふねどのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㄰ Item: Title: こばづっどちぴどはのぜ〴ぜ〰はてぜ〴ぜ〰ば〭じべぬづのづびづぬづのはっべちのちぴづぜ〴ぜ〰ぢべぜ〴ぜ〰がどぱふどつぜ〴ぜ〰ぃとひはねちぴはでひちばとべぜ〲㍜〰きちびびぜ〴ぜ〰こばづっぴひはねづぴひべぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㤩‾㸊⡜㌷㙜㌷㝜〰ぁびびづびびねづのぴぜ〴ぜ〰はてぜ〴ぜ〰ぃづぬぬふぬちひぜ〴ぜ〰さばぴちにづぜ〴ぜ〰はてぜ〴ぜ〰ぁぬぢふねどのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㄰ Item: Title: ぁびびづびびねづのぴぜ〴ぜ〰はてぜ〴ぜ〰ぃづぬぬふぬちひぜ〴ぜ〰さばぴちにづぜ〴ぜ〰はてぜ〴ぜ〰ぁぬぢふねどのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㄰ Item: Title: こぴちぴどびぴどっびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸵ Item: Title: ぃはのっぬふびどはのびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸵ Item: Title: げづてづひづのっづび Filters: FilterPipeline: FlateDecode Fonts: Type1: Font: BaseFont: ASICFG+Rpxr FontSubset: true FirstChar: 11 LastChar: 47 FontDescriptor: FontName: ASICFG+Rpxr Flags: Symbolic FontBBox: -40, -283, 904, 728 FontFile: true Font: BaseFont: FVGOTS+EURB10 FontSubset: true FirstChar: 27 LastChar: 27 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