df784ccdafa1ae22230d33814ae4566b biology_a2019v8p85.pdf 5bdbbe24a024c9ac138389cc7df53deb8442dc63 biology_a2019v8p85.pdf 5e7ac572bef97101493513bcdae60638286e985f6ccaa35903e25b3570e773a5 biology_a2019v8p85.pdf Title: Cryotolerance of Stallion Spermatozoa Relies on Aquaglyceroporins rather than Orthodox Aquaporins Subject: Aquaporins (AQPs), a family of ubiquitous water channels divided into orthodox AQPs, aquaglyceroporins (GLPs), and superAQPs, are present in stallion spermatozoa. The aim of this study was to elucidate the functional relevance of each group of AQPs during stallion sperm cryopreservation through the use of three different inhibitors: acetazolamide (AC), phloretin (PHL) and propanediol (PDO). Sperm quality and function parameters were evaluated in the presence or absence of each inhibitor in fresh and frozen–thawed samples. In the presence of AC, different parameters were altered (p < 0.05), but not in a concentration- or time-depending manner. PHL was found to decrease sperm motility, viability, acrosome integrity, and the percentages of spermatozoa with low membrane lipid disorder, high mitochondrial membrane potential (MMP) and high intracellular levels of calcium and superoxides (p < 0.05). Finally, the sperm motility, viability, acrosome integrity, the percentages of spermatozoa with low membrane lipid disorder, high MMP and high intracellular calcium levels were higher (p < 0.05) in PDO treatments than in the control. The sperm response to AC, PHL and PDO indicates that GLPs, rather than orthodox AQPs, play a crucial role during stallion sperm cryopreservation. Furthermore, post-thaw sperm quality was higher in PDO treatments than in the control, suggesting that this molecule is a potential permeable cryoprotectant. Keywords: acetazolamide; aquaporins; phloretin; propanediol; sperm; stallion Author: Ariadna Delgado-Bermúdez, Federico Noto, Sebastián Bonilla-Correal, Estela Garcia-Bonavila, Jaime Catalán, Marion Papas, Sergi Bonet, Jordi Miró and Marc Yeste Creator: LaTeX with hyperref package Producer: pdfTeX-1.40.18 CreationDate: Tue Nov 12 11:01:13 2019 CET ModDate: Tue Nov 12 11:01:13 2019 CET Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 18 Encrypted: no Page size: 595.276 x 841.89 pts (A4) Page rot: 0 File size: 1682803 bytes Optimized: no PDF version: 1.5 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- VJQIIV+URWPalladioL-Ital Type 1 Custom yes yes no 150 0 CKUFDC+URWPalladioL-Bold Type 1 Custom yes yes no 151 0 FLAGDG+VnURWPalladioL-Bold Type 1 Custom yes yes no 152 0 QTLELQ+Pxbsy Type 1 Builtin yes yes no 153 0 MSAIRX+URWPalladioL-Roma Type 1 Custom yes yes no 154 0 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yes yes no 343 0 CMGDHA+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 344 0 CMGCPO+PalatinoLinotype CID TrueType Identity-H yes yes yes 372 0 CMGCPP+PalatinoLinotype TrueType WinAnsi yes yes no 373 0 CMGDFP+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 374 0 CMGDHA+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 375 0 CMGCPO+PalatinoLinotype CID TrueType Identity-H yes yes yes 402 0 CMGCPP+PalatinoLinotype TrueType WinAnsi yes yes no 403 0 CMGDFO+PalatinoLinotype,Italic CID TrueType Identity-H yes yes yes 404 0 CMGDFP+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 405 0 CMGDHA+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 406 0 CMGCPO+PalatinoLinotype CID TrueType Identity-H yes yes yes 444 0 CMGCPP+PalatinoLinotype TrueType WinAnsi yes yes no 445 0 CMGDFP+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 446 0 CMGDHA+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 447 0 Jhove (Rel. 1.22.1, 2019-04-17) Date: 2020-01-29 05:28:26 CET RepresentationInformation: biology_a2019v8p85.pdf ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17) LastModified: 2020-01-14 10:51:01 CET Size: 1682803 Format: PDF Version: 1.5 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 0 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: ViewerPreferences: HideToolbar: false HideMenubar: false HideWindowUI: false FitWindow: true CenterWindow: false DisplayDocTitle: false NonFullScreenPageMode: UseNone Direction: L2R ViewArea: CropBox ViewClip: CropBox PrintArea: CropBox PageClip: CropBox PageLayout: SinglePage PageMode: UseNone Outlines: Item: Title: ぉのぴひはつふっぴどはのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸲ Item: Title: きちぴづひどちぬびぜ〴ぜ〰ちのつぜ〴ぜ〰きづぴとはつびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮ㄩ‾㸊⡜㌷㙜㌷㝜〰こぴちぬぬどはのびぜ〴ぜ〰ちのつぜ〴ぜ〰ぅなちっふぬちぴづびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㈩‾㸊⡜㌷㙜㌷㝜〰ぁけぐぜ〴ぜ〰ぉのとどぢどぴはひびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㌩‾㸊⡜㌷㙜㌷㝜〰こぴちぬぬどはのぜ〴ぜ〰こばづひねぜ〴ぜ〰ぃひべはばひづびづひぶちぴどはのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㐩‾㸊⡜㌷㙜㌷㝜〰こばづひねぜ〴ぜ〰きはぴどぬどぴべぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㔩‾㸊⡜㌷㙜㌷㝜〰うぬはぷぜ〴ぜ〰ぃべぴはねづぴひべぜ〴ぜ〰ぁのちぬべびづびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獵扳散瑩潮⸲⸵⸱ Children: Item: Title: こぴちぬぬどはのびぜ〴ぜ〰ちのつぜ〴ぜ〰ぅなちっふぬちぴづびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㈩‾㸊⡜㌷㙜㌷㝜〰ぁけぐぜ〴ぜ〰ぉのとどぢどぴはひびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㌩‾㸊⡜㌷㙜㌷㝜〰こぴちぬぬどはのぜ〴ぜ〰こばづひねぜ〴ぜ〰ぃひべはばひづびづひぶちぴどはのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㐩‾㸊⡜㌷㙜㌷㝜〰こばづひねぜ〴ぜ〰きはぴどぬどぴべぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㔩‾㸊⡜㌷㙜㌷㝜〰うぬはぷぜ〴ぜ〰ぃべぴはねづぴひべぜ〴ぜ〰ぁのちぬべびづびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獵扳散瑩潮⸲⸵⸱ Item: Title: ぁけぐぜ〴ぜ〰ぉのとどぢどぴはひびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㌩‾㸊⡜㌷㙜㌷㝜〰こぴちぬぬどはのぜ〴ぜ〰こばづひねぜ〴ぜ〰ぃひべはばひづびづひぶちぴどはのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㐩‾㸊⡜㌷㙜㌷㝜〰こばづひねぜ〴ぜ〰きはぴどぬどぴべぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㔩‾㸊⡜㌷㙜㌷㝜〰うぬはぷぜ〴ぜ〰ぃべぴはねづぴひべぜ〴ぜ〰ぁのちぬべびづびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獵扳散瑩潮⸲⸵⸱ Item: Title: こぴちぬぬどはのぜ〴ぜ〰こばづひねぜ〴ぜ〰ぃひべはばひづびづひぶちぴどはのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㐩‾㸊⡜㌷㙜㌷㝜〰こばづひねぜ〴ぜ〰きはぴどぬどぴべぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㔩‾㸊⡜㌷㙜㌷㝜〰うぬはぷぜ〴ぜ〰ぃべぴはねづぴひべぜ〴ぜ〰ぁのちぬべびづびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獵扳散瑩潮⸲⸵⸱ Item: Title: こばづひねぜ〴ぜ〰きはぴどぬどぴべぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㔩‾㸊⡜㌷㙜㌷㝜〰うぬはぷぜ〴ぜ〰ぃべぴはねづぴひべぜ〴ぜ〰ぁのちぬべびづびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獵扳散瑩潮⸲⸵⸱ Item: Title: うぬはぷぜ〴ぜ〰ぃべぴはねづぴひべぜ〴ぜ〰ぁのちぬべびづびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獵扳散瑩潮⸲⸵⸱ Children: Item: Title: ぐぬちびねちぜ〴ぜ〰きづねぢひちのづぜ〴ぜ〰ちのつぜ〴ぜ〰ぁっひはびはねづぜ〴ぜ〰ぉのぴづでひどぴべぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獵扳散瑩潮⸲⸵⸲ Item: Title: こばづひねぜ〴ぜ〰きづねぢひちのづぜ〴ぜ〰がどばどつぜ〴ぜ〰いどびはひつづひぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獵扳散瑩潮⸲⸵⸳ Item: Title: きどぴはっとはのつひどちぬぜ〴ぜ〰きづねぢひちのづぜ〴ぜ〰ぐはぴづのぴどちぬぜ〴ぜ〰ぜ〵ぜ〰ききぐぜ〵ㅜ〰ぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獵扳散瑩潮⸲⸵⸴ Item: Title: ぉのぴひちっづぬぬふぬちひぜ〴ぜ〰ぃちぬっどふねぜ〴ぜ〰がづぶづぬびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獵扳散瑩潮⸲⸵⸵ Item: Title: ぉのぴひちっづぬぬふぬちひぜ〴ぜ〰こふばづひはへどつづぜ〴ぜ〰がづぶづぬびぜ〴ぜ〰ぜ〵ぜ〰く〲〭ぜ〵ㅜ〰ぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獵扳散瑩潮⸲⸵⸶ Item: Title: ぉのぴひちっづぬぬふぬちひぜ〴ぜ〰えべつひはでづのぜ〴ぜ〰ぐづひはへどつづぜ〴ぜ〰がづぶづぬびぜ〴ぜ〰ぜ〵ぜ〰え〲く〲ぜ〵ㅜ〰ぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㘩‾㸊⡜㌷㙜㌷㝜〰こぴちぴどびぴどっちぬぜ〴ぜ〰ぁのちぬべびづびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸳ Item: Title: こぴちぴどびぴどっちぬぜ〴ぜ〰ぁのちぬべびづびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸳ Item: Title: げづびふぬぴびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮ㄩ‾㸊⡜㌷㙜㌷㝜〰こばづひねぜ〴ぜ〰きはぴどぬどぴべぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㈩‾㸊⡜㌷㙜㌷㝜〰こばづひねぜ〴ぜ〰ざどちぢどぬどぴべ〺ぜ〴ぜ〰こすあげ〱〴〯ぐぉぜ〴ぜ〰ごづびぴぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㌩‾㸊⡜㌷㙜㌷㝜〰ぁっひはびはねづぜ〴ぜ〰ぉのぴづでひどぴべ〺ぜ〴ぜ〰ぐぎぁ〭うぉごぃ〯ぐぉぜ〴ぜ〰ごづびぴぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㐩‾㸊⡜㌷㙜㌷㝜〰きづねぢひちのづぜ〴ぜ〰がどばどつぜ〴ぜ〰いどびはひつづひ〺ぜ〴ぜ〰き〵〴〰〯すく〭ぐげく〭〱ぜ〴ぜ〰ごづびぴぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㔩‾㸊⡜㌷㙜㌷㝜〰きどぴはっとはのつひどちぬぜ〴ぜ〰きづねぢひちのづぜ〴ぜ〰ぐはぴづのぴどちぬぜ〴ぜ〰ぜ〵ぜ〰ききぐぜ〵ㅜ〰〺ぜ〴ぜ〰おぃ〱ぜ〴ぜ〰ごづびぴぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㘩‾㸊⡜㌷㙜㌷㝜〰ぉのぴひちっづぬぬふぬちひぜ〴ぜ〰ぃちぬっどふねぜ〴ぜ〰はてぜ〴ぜ〰こばづひねちぴはぺはち〺ぜ〴ぜ〰うぬふは〳〯ぐぉぜ〴ぜ〰ごづびぴぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㜩‾㸊⡜㌷㙜㌷㝜〰ぉのぴひちっづぬぬふぬちひぜ〴ぜ〰ぃちぬっどふねぜ〴ぜ〰はてぜ〴ぜ〰こばづひねちぴはぺはち〺ぜ〴ぜ〰げとはつ〵〯すく〭ぐげく〭〱ぜ〴ぜ〰ごづびぴぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㠩‾㸊⡜㌷㙜㌷㝜〰ぉのぴひちっづぬぬふぬちひぜ〴ぜ〰こふばづひはへどつづぜ〴ぜ〰がづぶづぬびぜ〴ぜ〰ぜ〵ぜ〰く〲〭ぜ〵ㅜ〰〺ぜ〴ぜ〰えぅ〯すく〭ぐげく〭〱ぜ〴ぜ〰ごづびぴぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㤩‾㸊⡜㌷㙜㌷㝜〰ぉのぴひちっづぬぬふぬちひぜ〴ぜ〰ぐづひはへどつづぜ〴ぜ〰がづぶづぬびぜ〴ぜ〰ぜ〵ぜ〰え〲く〲ぜ〵ㅜ〰〺ぜ〴ぜ〰え〲いぃういぁ〯ぐぉぜ〴ぜ〰ごづびぴぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸴ Children: Item: Title: こばづひねぜ〴ぜ〰きはぴどぬどぴべぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㈩‾㸊⡜㌷㙜㌷㝜〰こばづひねぜ〴ぜ〰ざどちぢどぬどぴべ〺ぜ〴ぜ〰こすあげ〱〴〯ぐぉぜ〴ぜ〰ごづびぴぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㌩‾㸊⡜㌷㙜㌷㝜〰ぁっひはびはねづぜ〴ぜ〰ぉのぴづでひどぴべ〺ぜ〴ぜ〰ぐぎぁ〭うぉごぃ〯ぐぉぜ〴ぜ〰ごづびぴぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㐩‾㸊⡜㌷㙜㌷㝜〰きづねぢひちのづぜ〴ぜ〰がどばどつぜ〴ぜ〰いどびはひつづひ〺ぜ〴ぜ〰き〵〴〰〯すく〭ぐげく〭〱ぜ〴ぜ〰ごづびぴぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㔩‾㸊⡜㌷㙜㌷㝜〰きどぴはっとはのつひどちぬぜ〴ぜ〰きづねぢひちのづぜ〴ぜ〰ぐはぴづのぴどちぬぜ〴ぜ〰ぜ〵ぜ〰ききぐぜ〵ㅜ〰〺ぜ〴ぜ〰おぃ〱ぜ〴ぜ〰ごづびぴぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㘩‾㸊⡜㌷㙜㌷㝜〰ぉのぴひちっづぬぬふぬちひぜ〴ぜ〰ぃちぬっどふねぜ〴ぜ〰はてぜ〴ぜ〰こばづひねちぴはぺはち〺ぜ〴ぜ〰うぬふは〳〯ぐぉぜ〴ぜ〰ごづびぴぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㜩‾㸊⡜㌷㙜㌷㝜〰ぉのぴひちっづぬぬふぬちひぜ〴ぜ〰ぃちぬっどふねぜ〴ぜ〰はてぜ〴ぜ〰こばづひねちぴはぺはち〺ぜ〴ぜ〰げとはつ〵〯すく〭ぐげく〭〱ぜ〴ぜ〰ごづびぴぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㠩‾㸊⡜㌷㙜㌷㝜〰ぉのぴひちっづぬぬふぬちひぜ〴ぜ〰こふばづひはへどつづぜ〴ぜ〰がづぶづぬびぜ〴ぜ〰ぜ〵ぜ〰く〲〭ぜ〵ㅜ〰〺ぜ〴ぜ〰えぅ〯すく〭ぐげく〭〱ぜ〴ぜ〰ごづびぴぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㤩‾㸊⡜㌷㙜㌷㝜〰ぉのぴひちっづぬぬふぬちひぜ〴ぜ〰ぐづひはへどつづぜ〴ぜ〰がづぶづぬびぜ〴ぜ〰ぜ〵ぜ〰え〲く〲ぜ〵ㅜ〰〺ぜ〴ぜ〰え〲いぃういぁ〯ぐぉぜ〴ぜ〰ごづびぴぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸴ Item: Title: こばづひねぜ〴ぜ〰ざどちぢどぬどぴべ〺ぜ〴ぜ〰こすあげ〱〴〯ぐぉぜ〴ぜ〰ごづびぴぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㌩‾㸊⡜㌷㙜㌷㝜〰ぁっひはびはねづぜ〴ぜ〰ぉのぴづでひどぴべ〺ぜ〴ぜ〰ぐぎぁ〭うぉごぃ〯ぐぉぜ〴ぜ〰ごづびぴぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㐩‾㸊⡜㌷㙜㌷㝜〰きづねぢひちのづぜ〴ぜ〰がどばどつぜ〴ぜ〰いどびはひつづひ〺ぜ〴ぜ〰き〵〴〰〯すく〭ぐげく〭〱ぜ〴ぜ〰ごづびぴぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㔩‾㸊⡜㌷㙜㌷㝜〰きどぴはっとはのつひどちぬぜ〴ぜ〰きづねぢひちのづぜ〴ぜ〰ぐはぴづのぴどちぬぜ〴ぜ〰ぜ〵ぜ〰ききぐぜ〵ㅜ〰〺ぜ〴ぜ〰おぃ〱ぜ〴ぜ〰ごづびぴぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㘩‾㸊⡜㌷㙜㌷㝜〰ぉのぴひちっづぬぬふぬちひぜ〴ぜ〰ぃちぬっどふねぜ〴ぜ〰はてぜ〴ぜ〰こばづひねちぴはぺはち〺ぜ〴ぜ〰うぬふは〳〯ぐぉぜ〴ぜ〰ごづびぴぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㜩‾㸊⡜㌷㙜㌷㝜〰ぉのぴひちっづぬぬふぬちひぜ〴ぜ〰ぃちぬっどふねぜ〴ぜ〰はてぜ〴ぜ〰こばづひねちぴはぺはち〺ぜ〴ぜ〰げとはつ〵〯すく〭ぐげく〭〱ぜ〴ぜ〰ごづびぴぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㠩‾㸊⡜㌷㙜㌷㝜〰ぉのぴひちっづぬぬふぬちひぜ〴ぜ〰こふばづひはへどつづぜ〴ぜ〰がづぶづぬびぜ〴ぜ〰ぜ〵ぜ〰く〲〭ぜ〵ㅜ〰〺ぜ〴ぜ〰えぅ〯すく〭ぐげく〭〱ぜ〴ぜ〰ごづびぴぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㤩‾㸊⡜㌷㙜㌷㝜〰ぉのぴひちっづぬぬふぬちひぜ〴ぜ〰ぐづひはへどつづぜ〴ぜ〰がづぶづぬびぜ〴ぜ〰ぜ〵ぜ〰え〲く〲ぜ〵ㅜ〰〺ぜ〴ぜ〰え〲いぃういぁ〯ぐぉぜ〴ぜ〰ごづびぴぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸴ Item: Title: ぁっひはびはねづぜ〴ぜ〰ぉのぴづでひどぴべ〺ぜ〴ぜ〰ぐぎぁ〭うぉごぃ〯ぐぉぜ〴ぜ〰ごづびぴぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㐩‾㸊⡜㌷㙜㌷㝜〰きづねぢひちのづぜ〴ぜ〰がどばどつぜ〴ぜ〰いどびはひつづひ〺ぜ〴ぜ〰き〵〴〰〯すく〭ぐげく〭〱ぜ〴ぜ〰ごづびぴぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㔩‾㸊⡜㌷㙜㌷㝜〰きどぴはっとはのつひどちぬぜ〴ぜ〰きづねぢひちのづぜ〴ぜ〰ぐはぴづのぴどちぬぜ〴ぜ〰ぜ〵ぜ〰ききぐぜ〵ㅜ〰〺ぜ〴ぜ〰おぃ〱ぜ〴ぜ〰ごづびぴぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㘩‾㸊⡜㌷㙜㌷㝜〰ぉのぴひちっづぬぬふぬちひぜ〴ぜ〰ぃちぬっどふねぜ〴ぜ〰はてぜ〴ぜ〰こばづひねちぴはぺはち〺ぜ〴ぜ〰うぬふは〳〯ぐぉぜ〴ぜ〰ごづびぴぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㜩‾㸊⡜㌷㙜㌷㝜〰ぉのぴひちっづぬぬふぬちひぜ〴ぜ〰ぃちぬっどふねぜ〴ぜ〰はてぜ〴ぜ〰こばづひねちぴはぺはち〺ぜ〴ぜ〰げとはつ〵〯すく〭ぐげく〭〱ぜ〴ぜ〰ごづびぴぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㠩‾㸊⡜㌷㙜㌷㝜〰ぉのぴひちっづぬぬふぬちひぜ〴ぜ〰こふばづひはへどつづぜ〴ぜ〰がづぶづぬびぜ〴ぜ〰ぜ〵ぜ〰く〲〭ぜ〵ㅜ〰〺ぜ〴ぜ〰えぅ〯すく〭ぐげく〭〱ぜ〴ぜ〰ごづびぴぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㤩‾㸊⡜㌷㙜㌷㝜〰ぉのぴひちっづぬぬふぬちひぜ〴ぜ〰ぐづひはへどつづぜ〴ぜ〰がづぶづぬびぜ〴ぜ〰ぜ〵ぜ〰え〲く〲ぜ〵ㅜ〰〺ぜ〴ぜ〰え〲いぃういぁ〯ぐぉぜ〴ぜ〰ごづびぴぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸴ Item: Title: きづねぢひちのづぜ〴ぜ〰がどばどつぜ〴ぜ〰いどびはひつづひ〺ぜ〴ぜ〰き〵〴〰〯すく〭ぐげく〭〱ぜ〴ぜ〰ごづびぴぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㔩‾㸊⡜㌷㙜㌷㝜〰きどぴはっとはのつひどちぬぜ〴ぜ〰きづねぢひちのづぜ〴ぜ〰ぐはぴづのぴどちぬぜ〴ぜ〰ぜ〵ぜ〰ききぐぜ〵ㅜ〰〺ぜ〴ぜ〰おぃ〱ぜ〴ぜ〰ごづびぴぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㘩‾㸊⡜㌷㙜㌷㝜〰ぉのぴひちっづぬぬふぬちひぜ〴ぜ〰ぃちぬっどふねぜ〴ぜ〰はてぜ〴ぜ〰こばづひねちぴはぺはち〺ぜ〴ぜ〰うぬふは〳〯ぐぉぜ〴ぜ〰ごづびぴぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㜩‾㸊⡜㌷㙜㌷㝜〰ぉのぴひちっづぬぬふぬちひぜ〴ぜ〰ぃちぬっどふねぜ〴ぜ〰はてぜ〴ぜ〰こばづひねちぴはぺはち〺ぜ〴ぜ〰げとはつ〵〯すく〭ぐげく〭〱ぜ〴ぜ〰ごづびぴぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㠩‾㸊⡜㌷㙜㌷㝜〰ぉのぴひちっづぬぬふぬちひぜ〴ぜ〰こふばづひはへどつづぜ〴ぜ〰がづぶづぬびぜ〴ぜ〰ぜ〵ぜ〰く〲〭ぜ〵ㅜ〰〺ぜ〴ぜ〰えぅ〯すく〭ぐげく〭〱ぜ〴ぜ〰ごづびぴぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㤩‾㸊⡜㌷㙜㌷㝜〰ぉのぴひちっづぬぬふぬちひぜ〴ぜ〰ぐづひはへどつづぜ〴ぜ〰がづぶづぬびぜ〴ぜ〰ぜ〵ぜ〰え〲く〲ぜ〵ㅜ〰〺ぜ〴ぜ〰え〲いぃういぁ〯ぐぉぜ〴ぜ〰ごづびぴぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸴ Item: Title: きどぴはっとはのつひどちぬぜ〴ぜ〰きづねぢひちのづぜ〴ぜ〰ぐはぴづのぴどちぬぜ〴ぜ〰ぜ〵ぜ〰ききぐぜ〵ㅜ〰〺ぜ〴ぜ〰おぃ〱ぜ〴ぜ〰ごづびぴぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㘩‾㸊⡜㌷㙜㌷㝜〰ぉのぴひちっづぬぬふぬちひぜ〴ぜ〰ぃちぬっどふねぜ〴ぜ〰はてぜ〴ぜ〰こばづひねちぴはぺはち〺ぜ〴ぜ〰うぬふは〳〯ぐぉぜ〴ぜ〰ごづびぴぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㜩‾㸊⡜㌷㙜㌷㝜〰ぉのぴひちっづぬぬふぬちひぜ〴ぜ〰ぃちぬっどふねぜ〴ぜ〰はてぜ〴ぜ〰こばづひねちぴはぺはち〺ぜ〴ぜ〰げとはつ〵〯すく〭ぐげく〭〱ぜ〴ぜ〰ごづびぴぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㠩‾㸊⡜㌷㙜㌷㝜〰ぉのぴひちっづぬぬふぬちひぜ〴ぜ〰こふばづひはへどつづぜ〴ぜ〰がづぶづぬびぜ〴ぜ〰ぜ〵ぜ〰く〲〭ぜ〵ㅜ〰〺ぜ〴ぜ〰えぅ〯すく〭ぐげく〭〱ぜ〴ぜ〰ごづびぴぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㤩‾㸊⡜㌷㙜㌷㝜〰ぉのぴひちっづぬぬふぬちひぜ〴ぜ〰ぐづひはへどつづぜ〴ぜ〰がづぶづぬびぜ〴ぜ〰ぜ〵ぜ〰え〲く〲ぜ〵ㅜ〰〺ぜ〴ぜ〰え〲いぃういぁ〯ぐぉぜ〴ぜ〰ごづびぴぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸴ Item: Title: ぉのぴひちっづぬぬふぬちひぜ〴ぜ〰ぃちぬっどふねぜ〴ぜ〰はてぜ〴ぜ〰こばづひねちぴはぺはち〺ぜ〴ぜ〰うぬふは〳〯ぐぉぜ〴ぜ〰ごづびぴぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㜩‾㸊⡜㌷㙜㌷㝜〰ぉのぴひちっづぬぬふぬちひぜ〴ぜ〰ぃちぬっどふねぜ〴ぜ〰はてぜ〴ぜ〰こばづひねちぴはぺはち〺ぜ〴ぜ〰げとはつ〵〯すく〭ぐげく〭〱ぜ〴ぜ〰ごづびぴぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㠩‾㸊⡜㌷㙜㌷㝜〰ぉのぴひちっづぬぬふぬちひぜ〴ぜ〰こふばづひはへどつづぜ〴ぜ〰がづぶづぬびぜ〴ぜ〰ぜ〵ぜ〰く〲〭ぜ〵ㅜ〰〺ぜ〴ぜ〰えぅ〯すく〭ぐげく〭〱ぜ〴ぜ〰ごづびぴぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㤩‾㸊⡜㌷㙜㌷㝜〰ぉのぴひちっづぬぬふぬちひぜ〴ぜ〰ぐづひはへどつづぜ〴ぜ〰がづぶづぬびぜ〴ぜ〰ぜ〵ぜ〰え〲く〲ぜ〵ㅜ〰〺ぜ〴ぜ〰え〲いぃういぁ〯ぐぉぜ〴ぜ〰ごづびぴぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸴ Item: Title: ぉのぴひちっづぬぬふぬちひぜ〴ぜ〰ぃちぬっどふねぜ〴ぜ〰はてぜ〴ぜ〰こばづひねちぴはぺはち〺ぜ〴ぜ〰げとはつ〵〯すく〭ぐげく〭〱ぜ〴ぜ〰ごづびぴぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㠩‾㸊⡜㌷㙜㌷㝜〰ぉのぴひちっづぬぬふぬちひぜ〴ぜ〰こふばづひはへどつづぜ〴ぜ〰がづぶづぬびぜ〴ぜ〰ぜ〵ぜ〰く〲〭ぜ〵ㅜ〰〺ぜ〴ぜ〰えぅ〯すく〭ぐげく〭〱ぜ〴ぜ〰ごづびぴぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㤩‾㸊⡜㌷㙜㌷㝜〰ぉのぴひちっづぬぬふぬちひぜ〴ぜ〰ぐづひはへどつづぜ〴ぜ〰がづぶづぬびぜ〴ぜ〰ぜ〵ぜ〰え〲く〲ぜ〵ㅜ〰〺ぜ〴ぜ〰え〲いぃういぁ〯ぐぉぜ〴ぜ〰ごづびぴぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸴ Item: Title: ぉのぴひちっづぬぬふぬちひぜ〴ぜ〰こふばづひはへどつづぜ〴ぜ〰がづぶづぬびぜ〴ぜ〰ぜ〵ぜ〰く〲〭ぜ〵ㅜ〰〺ぜ〴ぜ〰えぅ〯すく〭ぐげく〭〱ぜ〴ぜ〰ごづびぴぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㤩‾㸊⡜㌷㙜㌷㝜〰ぉのぴひちっづぬぬふぬちひぜ〴ぜ〰ぐづひはへどつづぜ〴ぜ〰がづぶづぬびぜ〴ぜ〰ぜ〵ぜ〰え〲く〲ぜ〵ㅜ〰〺ぜ〴ぜ〰え〲いぃういぁ〯ぐぉぜ〴ぜ〰ごづびぴぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸴ Item: Title: ぉのぴひちっづぬぬふぬちひぜ〴ぜ〰ぐづひはへどつづぜ〴ぜ〰がづぶづぬびぜ〴ぜ〰ぜ〵ぜ〰え〲く〲ぜ〵ㅜ〰〺ぜ〴ぜ〰え〲いぃういぁ〯ぐぉぜ〴ぜ〰ごづびぴぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸴ Item: Title: いどびっふびびどはのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸵ Item: Title: ぃはのっぬふびどはのびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸵ Item: Title: げづてづひづのっづび Filters: FilterPipeline: FlateDecode Fonts: Type1: Font: BaseFont: EUIVHG+Pxsyc FontSubset: true FirstChar: 8 LastChar: 8 FontDescriptor: FontName: EUIVHG+Pxsyc Flags: Symbolic FontBBox: -179, -347, 1406, 887 FontFile: true Font: BaseFont: VJQIIV+URWPalladioL-Ital FontSubset: true 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Link Rect: 234, 382, 407, 393 Checksum: 07181cc0 Type: CRC32 Checksum: df784ccdafa1ae22230d33814ae4566b Type: MD5 Checksum: 5bdbbe24a024c9ac138389cc7df53deb8442dc63 Type: SHA-1