02355447f78bea288bb462757b4a956d jouclimed_a2019v8p1875.pdf c9a2837ded07e374c09c497a91fe935794b4c800 jouclimed_a2019v8p1875.pdf 2c237f8e343773a33b12bc9bb258be058b885266fc35031904c9b3758518bbde jouclimed_a2019v8p1875.pdf Title: Specific Nuclear Magnetic Resonance Lipoprotein Subclass Profiles and Central Arterial Stiffness in Type 1 Diabetes Mellitus: A Case Control Study Subject: Background: Dyslipidemia has been associated with vascular complications of type 1 diabetes mellitus (T1DM). We examined the proton nuclear magnetic resonance (NMR)-assessed lipoprotein subclass profiles in subjects with T1DM compared with those of healthy subjects and assessed the potential relationship of these profiles with arterial stiffness. Methods: Eighty-four participants with T1DM of at least 10 years duration and no clinical cardiovascular disease (age: 35–65 years; 50% men) and 42 healthy participants were evaluated for: (1) clinical and anthropometric data (including classical cardiovascular risk factors), (2) insulin sensitivity by estimated glucose disposal rate, (3) microvascular complications, (4) NMR-assessed lipoprotein subclass profile, and (5) arterial stiffness (aortic pulse wave velocity). Results: Participants with T1DM had an apparently better conventional lipid profile than healthy participants, but with significant differences in NMR-assessed lipoprotein profiles such as higher triglyceride content of low-density lipoprotein (LDL) and high-density lipoprotein (HDL). In healthy participants, arterial stiffness was associated with NMR-based LDL subclasses. By contrast, in T1DM participants, arterial stiffness was independently associated mainly with NMR-based very-low-density lipoprotein (VLDL) subclasses: positively with total VLDL particles (and subclasses) and VLDL triglyceride content, and negatively with LDL and HDL particle sizes. These results were maintained after adjustments for classical cardiovascular risk factors. Conclusions: Subjects with T1DM, while having an apparently better conventional lipid profile than healthy controls, presented significant alterations in their NMR-assessed lipoprotein profile. The association between arterial stiffness and NMR-assessed lipoprotein profiles also differed in both groups. These results support a potential role of the identified differences in the residual cardiovascular risk in T1DM. Keywords: type 1 diabetes mellitus; arterial stiffness; preclinical atherosclerosis; cardiovascular risk; nuclear magnetic resonance spectroscopy; lipoprotein subclass profiles Author: Gemma Llauradó, Núria Amigó, Albert Cano, Silvia Ballesta, Lara Albert, Isabel Mazarico, Sonia Fernández-Veledo, Juan Pedro-Botet, Joan Vendrell and José-Miguel González-Clemente Creator: LaTeX with hyperref package Producer: pdfTeX-1.40.18 CreationDate: Tue Nov 5 10:57:43 2019 CET ModDate: Tue Nov 5 10:57:43 2019 CET Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 17 Encrypted: no Page size: 595.276 x 841.89 pts (A4) Page rot: 0 File size: 1994367 bytes Optimized: no PDF version: 1.5 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- CLJGKZ+URWPalladioL-Ital Type 1 Custom yes yes no 99 0 CNINRR+URWPalladioL-Bold Type 1 Custom yes yes no 100 0 PQOKRE+Rpxb Type 1 Builtin yes yes no 101 0 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GBLQZB+Rpxi Type 1 Builtin yes yes no 269 0 HDMJJF+PalatinoLinotype CID TrueType Identity-H yes yes yes 275 0 HDMJLF+PalatinoLinotype TrueType WinAnsi yes yes no 276 0 HDMJPF+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 277 0 HDMKAH+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 278 0 HDMKBI+TimesNewRoman CID TrueType Identity-H yes yes yes 279 0 HDMJLF+PalatinoLinotype TrueType WinAnsi yes yes no 313 0 HDMJPF+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 314 0 HDMKAH+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 315 0 HDMKBI+TimesNewRoman CID TrueType Identity-H yes yes yes 316 0 Jhove (Rel. 1.22.1, 2019-04-17) Date: 2020-01-17 05:26:57 CET RepresentationInformation: jouclimed_a2019v8p1875.pdf ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17) LastModified: 2020-01-16 12:42:50 CET Size: 1994367 Format: PDF Version: 1.5 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 0 FreeObjects: 1 IncrementalUpdates: 0 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