e1726ccec4c9359e5c6a9e7337d085ac  nucacires_a2019m1v47nD1pD1128-D1136.pdf
6a6055bc159f0f2d4483d0750b5c1f7fc031038c  nucacires_a2019m1v47nD1pD1128-D1136.pdf
20f8f42bbe989c192c699d20927e919477e532bc56ac2a3391874f2fe0aaeb16  nucacires_a2019m1v47nD1pD1128-D1136.pdf

Title:          
Subject:        
Keywords:       
Author:         
Creator:        XMLPublish v.3.0 Copyright 1991-2017 Aptara Inc.
Producer:       Acrobat Distiller 19.0 (Windows); modified using iTextSharp 5.5.10 ©2000-2016 iText Group NV (AGPL-version)
CreationDate:   Sat Dec 29 20:55:24 2018 CET
ModDate:        Fri Feb  7 19:40:41 2020 CET
Tagged:         no
UserProperties: no
Suspects:       no
Form:           none
JavaScript:     no
Pages:          9
Encrypted:      no
Page size:      612.284 x 790.866 pts
Page rot:       0
File size:      5156011 bytes
Optimized:      yes
PDF version:    1.4

name                                 type              encoding         emb sub uni object ID
------------------------------------ ----------------- ---------------- --- --- --- ---------
LIKBIP+TimesNewRomanMTStd            Type 1C           Custom           yes yes yes    306  0
LIKBJP+TimesNewRomanMTStd-BoldIt     Type 1C           Custom           yes yes yes    286  0
LIKBKA+TimesNewRomanMTStd-Italic     Type 1C           Custom           yes yes yes    287  0
LIKBKB+Helvetica-Bold                Type 1C           MacRoman         yes yes no     288  0
LIKBNB+Helvetica                     Type 1C           WinAnsi          yes yes no     301  0
LIKCAB+MTSYB                         Type 1C           Custom           yes yes no     307  0
LIKCAC+RMTMIB                        Type 1C           Custom           yes yes yes    308  0
ZLZYKT+ArialMT                       TrueType          WinAnsi          yes yes no     309  0
LIKCAD+RMTMI                         Type 1C           Custom           yes yes yes    125  0
LIKCDD+TimesNewRomanMTStd-Bold       Type 1C           Custom           yes yes yes    126  0
LIKKCD+MTSY                          Type 1C           Custom           yes yes yes    131  0

Jhove (Rel. 1.22.1, 2019-04-17)
 Date: 2020-02-08 05:38:58 CET
 RepresentationInformation: nucacires_a2019m1v47nD1pD1128-D1136.pdf
  ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17)
  LastModified: 2020-02-07 20:08:19 CET
  Size: 5156011
  Format: PDF
  Version: 1.4
  Status: Well-Formed and valid
  SignatureMatches:
   PDF-hul
  MIMEtype: application/pdf
  Profile: Linearized PDF, ISO PDF/A-1, Level B
  PDFMetadata: 
   Objects: 337
   FreeObjects: 1
   IncrementalUpdates: 1
   DocumentCatalog: 
    PageLayout: SinglePage
    PageMode: UseThumbs
   Info: 
    Title: 
    Author: 
    Subject: 
    Keywords: 
    Creator: XMLPublish v.3.0 Copyright 1991-2017 Aptara Inc.
    Producer: Acrobat Distiller 19.0 (Windows); modified using iTextSharp 5.5.10 ©2000-2016 iText Group NV (AGPL-version)
    CreationDate: Sat Dec 29 21:25:24 CET 2018
    ModDate: Fri Feb 07 19:40:41 CET 2020
   ID: 0x8190b2da7981072589ceb6aca8cf750a, 0x73a3431244339847beb5e293859aa4db
   Filters: 
    FilterPipeline: FlateDecode
    FilterPipeline: DCTDecode
   Images: 
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 2173
      ImageHeight: 2677
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 2740
      ImageHeight: 1618
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 2709
      ImageHeight: 2899
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
   Fonts: 
    Type1: 
     Font: 
      BaseFont: LIKBKB+Helvetica-Bold
      FontSubset: true
      FirstChar: 40
      LastChar: 222
      FontDescriptor: 
       FontName: LIKBKB+Helvetica-Bold
       Flags: Nonsymbolic, ForceBold
       FontBBox: -170, -228, 1003, 962
       FontFile3: true
      Encoding: MacRomanEncoding
     Font: 
      BaseFont: LIKBIP+TimesNewRomanMTStd
      FontSubset: true
      FirstChar: 2
      LastChar: 180
      FontDescriptor: 
       FontName: LIKBIP+TimesNewRomanMTStd
       Flags: Serif, Symbolic
       FontBBox: -94, -241, 1006, 916
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: LIKCAB+MTSYB
      FontSubset: true
      FirstChar: 2
      LastChar: 2
      FontDescriptor: 
       FontName: LIKCAB+MTSYB
       Flags: Symbolic, ForceBold
       FontBBox: -16, -935, 1043, 896
       FontFile3: true
      EncodingDictionary: 
       Differences: true
     Font: 
      BaseFont: LIKKCD+MTSY
      FontSubset: true
      FirstChar: 2
      LastChar: 2
      FontDescriptor: 
       FontName: LIKKCD+MTSY
       Flags: Symbolic
       FontBBox: 0, -954, 1043, 796
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: LIKCAC+RMTMIB
      FontSubset: true
      FirstChar: 47
      LastChar: 47
      FontDescriptor: 
       FontName: LIKCAC+RMTMIB
       Flags: Symbolic, Italic, ForceBold
       FontBBox: 0, -208, 994, 706
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: LIKBNB+Helvetica
      FontSubset: true
      FirstChar: 40
      LastChar: 122
      FontDescriptor: 
       FontName: LIKBNB+Helvetica
       Flags: Nonsymbolic
       FontBBox: -166, -225, 1000, 931
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: LIKCAD+RMTMI
      FontSubset: true
      FirstChar: 47
      LastChar: 62
      FontDescriptor: 
       FontName: LIKCAD+RMTMI
       Flags: Symbolic, Italic
       FontBBox: 0, -213, 987, 680
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: LIKBJP+TimesNewRomanMTStd-BoldIt
      FontSubset: true
      FirstChar: 48
      LastChar: 133
      FontDescriptor: 
       FontName: LIKBJP+TimesNewRomanMTStd-BoldIt
       Flags: Serif, Symbolic, Italic, ForceBold
       FontBBox: -266, -259, 1076, 942
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: LIKCDD+TimesNewRomanMTStd-Bold
      FontSubset: true
      FirstChar: 2
      LastChar: 121
      FontDescriptor: 
       FontName: LIKCDD+TimesNewRomanMTStd-Bold
       Flags: Serif, Symbolic, ForceBold
       FontBBox: -191, -241, 1065, 957
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: LIKBKA+TimesNewRomanMTStd-Italic
      FontSubset: true
      FirstChar: 2
      LastChar: 121
      FontDescriptor: 
       FontName: LIKBKA+TimesNewRomanMTStd-Italic
       Flags: Serif, Symbolic, Italic
       FontBBox: -271, -246, 1100, 904
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
    TrueType: 
     Font: 
      BaseFont: ZLZYKT+ArialMT
      FontSubset: true
      FirstChar: 32
      LastChar: 121
      FontDescriptor: 
       FontName: ZLZYKT+ArialMT
       Flags: Nonsymbolic
       FontBBox: -664, -324, 2000, 1039
       FontFile2: true
      Encoding: WinAnsiEncoding
   XMP: <x:xmpmeta xmlns:x="adobe:ns:meta/" x:xmptk="Adobe XMP Core 5.6-c016 91.163616, 2018/10/29-16:58:49        ">
   <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
      <rdf:Description rdf:about=""
            xmlns:dc="http://purl.org/dc/elements/1.1/"
            xmlns:prism="http://prismstandard.org/namespaces/basic/3.0/"
            xmlns:jav="http://www.niso.org/schemas/jav/1.0/"
            xmlns:pdf="http://ns.adobe.com/pdf/1.3/"
            xmlns:xmp="http://ns.adobe.com/xap/1.0/"
            xmlns:xmpMM="http://ns.adobe.com/xap/1.0/mm/">
         <dc:format>xml</dc:format>
         <dc:identifier>doi:10.1093/nar/gky944</dc:identifier>
         <dc:title>
            <rdf:Alt>
               <rdf:li xml:lang="x-default"/>
            </rdf:Alt>
         </dc:title>
         <dc:creator>
            <rdf:Seq>
               <rdf:li/>
               <rdf:li>Shan Wu</rdf:li>
               <rdf:li>Yang Bai</rdf:li>
               <rdf:li>Honghe Sun</rdf:li>
               <rdf:li>Chen Jiao</rdf:li>
               <rdf:li>Shaogui Guo</rdf:li>
               <rdf:li>Kun Zhao</rdf:li>
               <rdf:li>Jose Blanca</rdf:li>
               <rdf:li>Zhonghua Zhang</rdf:li>
               <rdf:li>Sanwen Huang</rdf:li>
               <rdf:li>Yong Xu</rdf:li>
               <rdf:li>Yiqun Weng</rdf:li>
               <rdf:li>Michael Mazourek</rdf:li>
               <rdf:li>Umesh K. Reddy</rdf:li>
               <rdf:li>Kaori Ando</rdf:li>
               <rdf:li>James D McCreight</rdf:li>
               <rdf:li>Arthur A Schaffer</rdf:li>
               <rdf:li>Joseph Burger</rdf:li>
               <rdf:li>Yaakov Tadmor</rdf:li>
               <rdf:li>Nurit Katzir</rdf:li>
               <rdf:li>Xuemei Tang</rdf:li>
               <rdf:li>Yang Liu</rdf:li>
               <rdf:li>James J Giovannoni</rdf:li>
               <rdf:li>Kai-Shu Ling</rdf:li>
               <rdf:li>W Patrick Wechter</rdf:li>
               <rdf:li>Amnon Levi</rdf:li>
               <rdf:li>Jordi Garcia-Mas</rdf:li>
               <rdf:li>Rebecca Grumet</rdf:li>
               <rdf:li>Zhangjun Fei</rdf:li>
            </rdf:Seq>
         </dc:creator>
         <dc:description>
            <rdf:Alt>
               <rdf:li xml:lang="x-default"/>
            </rdf:Alt>
         </dc:description>
         <dc:publisher>
            <rdf:Bag>
               <rdf:li>Oxford University Press</rdf:li>
            </rdf:Bag>
         </dc:publisher>
         <prism:aggregationType>journal</prism:aggregationType>
         <prism:publicationName>Nucleic Acids Research</prism:publicationName>
         <prism:issn>1362-4962</prism:issn>
         <prism:doi>10.1093/nar/gky944</prism:doi>
         <prism:url>http://dx.doi.org/10.1093/nar/gky944</prism:url>
         <jav:journal_article_version>VoR</jav:journal_article_version>
         <pdf:Producer>Acrobat Distiller 19.0 (Windows); modified using iTextSharp 5.5.10 ©2000-2016 iText Group NV (AGPL-version)</pdf:Producer>
         <pdf:Keywords/>
         <xmp:ModifyDate>2020-02-07T19:40:41+01:00</xmp:ModifyDate>
         <xmp:MetadataDate>2020-02-07T19:40:41+01:00</xmp:MetadataDate>
         <xmp:CreateDate>2018-12-30T01:25:24+05:30</xmp:CreateDate>
         <xmp:CreatorTool>XMLPublish v.3.0 Copyright 1991-2017 Aptara Inc.</xmp:CreatorTool>
         <xmpMM:DocumentID>uuid:dedffdc5-375b-4877-823c-f66adec1af3b</xmpMM:DocumentID>
         <xmpMM:InstanceID>uuid:de3880cf-ea6c-4d19-9bc2-c5fb068cc28d</xmpMM:InstanceID>
      </rdf:Description>
   </rdf:RDF>
</x:xmpmeta>
   Pages: 
    Page: 
     Label: 1128
     Sequence: 1
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 112, 614, 122, 628
      Annotation: 
       Subtype: Link
       Rect: 374, 550, 384, 565
      Annotation: 
       Subtype: Link
       Rect: 367, 204, 501, 217
    Page: 
     Label: 1129
     Sequence: 2
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 124, 470, 214, 482
      Annotation: 
       Subtype: Link
       Rect: 105, 437, 112, 449
       Destination: 113
      Annotation: 
       Subtype: Link
       Rect: 92, 393, 99, 406
       Destination: 113
      Annotation: 
       Subtype: Link
       Rect: 211, 371, 218, 384
       Destination: 113
      Annotation: 
       Subtype: Link
       Rect: 57, 360, 64, 373
       Destination: 113
      Annotation: 
       Subtype: Link
       Rect: 187, 360, 194, 373
       Destination: 113
      Annotation: 
       Subtype: Link
       Rect: 230, 338, 237, 351
       Destination: 113
      Annotation: 
       Subtype: Link
       Rect: 275, 305, 297, 318
       Destination: 113
      Annotation: 
       Subtype: Link
       Rect: 157, 218, 297, 230
      Annotation: 
       Subtype: Link
       Rect: 173, 207, 297, 219
      Annotation: 
       Subtype: Link
       Rect: 125, 196, 221, 208
      Annotation: 
       Subtype: Link
       Rect: 57, 185, 171, 197
      Annotation: 
       Subtype: Link
       Rect: 57, 174, 166, 186
      Annotation: 
       Subtype: Link
       Rect: 178, 174, 189, 186
       Destination: 113
      Annotation: 
       Subtype: Link
       Rect: 54, 75, 173, 88
      Annotation: 
       Subtype: Link
       Rect: 493, 689, 505, 701
       Destination: 113
      Annotation: 
       Subtype: Link
       Rect: 555, 667, 567, 680
       Destination: 113
      Annotation: 
       Subtype: Link
       Rect: 378, 656, 481, 669
      Annotation: 
       Subtype: Link
       Rect: 463, 623, 475, 636
       Destination: 113
      Annotation: 
       Subtype: Link
       Rect: 536, 623, 548, 636
       Destination: 113
      Annotation: 
       Subtype: Link
       Rect: 414, 612, 426, 625
       Destination: 113
      Annotation: 
       Subtype: Link
       Rect: 342, 360, 363, 373
       Destination: 113
      Annotation: 
       Subtype: Link
       Rect: 320, 315, 571, 341
      Annotation: 
       Subtype: Link
       Rect: 422, 316, 546, 329
      Annotation: 
       Subtype: Link
       Rect: 380, 305, 491, 318
      Annotation: 
       Subtype: Link
       Rect: 542, 64, 554, 77
       Destination: 113
    Page: 
     Label: 1130
     Sequence: 3
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 217, 700, 229, 712
       Destination: 113
      Annotation: 
       Subtype: Link
       Rect: 40, 655, 291, 681
      Annotation: 
       Subtype: Link
       Rect: 120, 601, 132, 614
       Destination: 113
      Annotation: 
       Subtype: Link
       Rect: 263, 546, 270, 559
       Destination: 54
      Annotation: 
       Subtype: Link
       Rect: 252, 415, 264, 427
       Destination: 113
      Annotation: 
       Subtype: Link
       Rect: 213, 382, 220, 395
       Destination: 54
      Annotation: 
       Subtype: Link
       Rect: 40, 195, 291, 220
      Annotation: 
       Subtype: Link
       Rect: 40, 173, 291, 198
      Annotation: 
       Subtype: Link
       Rect: 44, 141, 56, 153
       Destination: 113
      Annotation: 
       Subtype: Link
       Rect: 139, 97, 151, 110
       Destination: 113
      Annotation: 
       Subtype: Link
       Rect: 457, 539, 469, 552
       Destination: 113
      Annotation: 
       Subtype: Link
       Rect: 381, 506, 393, 519
       Destination: 113
      Annotation: 
       Subtype: Link
       Rect: 488, 506, 500, 519
       Destination: 113
      Annotation: 
       Subtype: Link
       Rect: 444, 473, 455, 486
       Destination: 113
      Annotation: 
       Subtype: Link
       Rect: 367, 408, 374, 420
       Destination: 54
      Annotation: 
       Subtype: Link
       Rect: 519, 386, 526, 398
       Destination: 54
      Annotation: 
       Subtype: Link
       Rect: 539, 148, 551, 161
       Destination: 113
      Annotation: 
       Subtype: Link
       Rect: 307, 114, 558, 140
      Annotation: 
       Subtype: Link
       Rect: 404, 64, 416, 77
       Destination: 113
    Page: 
     Label: 1131
     Sequence: 4
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 241, 94, 253, 106
       Destination: 113
      Annotation: 
       Subtype: Link
       Rect: 387, 126, 511, 139
    Page: 
     Label: 1132
     Sequence: 5
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 40, 622, 291, 648
      Annotation: 
       Subtype: Link
       Rect: 44, 601, 56, 614
       Destination: 113
      Annotation: 
       Subtype: Link
       Rect: 68, 546, 80, 559
       Destination: 113
      Annotation: 
       Subtype: Link
       Rect: 96, 488, 108, 501
       Destination: 113
      Annotation: 
       Subtype: Link
       Rect: 137, 423, 144, 435
       Destination: 54
      Annotation: 
       Subtype: Link
       Rect: 60, 288, 72, 300
       Destination: 113
      Annotation: 
       Subtype: Link
       Rect: 426, 634, 438, 647
       Destination: 113
      Annotation: 
       Subtype: Link
       Rect: 482, 612, 494, 625
       Destination: 113
      Annotation: 
       Subtype: Link
       Rect: 307, 502, 558, 527
      Annotation: 
       Subtype: Link
       Rect: 380, 372, 387, 384
       Destination: 83
      Annotation: 
       Subtype: Link
       Rect: 308, 328, 315, 340
       Destination: 83
      Annotation: 
       Subtype: Link
       Rect: 356, 196, 463, 209
      Annotation: 
       Subtype: Link
       Rect: 307, 184, 558, 210
      Annotation: 
       Subtype: Link
       Rect: 307, 173, 558, 199
      Annotation: 
       Subtype: Link
       Rect: 353, 163, 520, 176
    Page: 
     Label: 1133
     Sequence: 6
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 161, 332, 173, 345
       Destination: 117
      Annotation: 
       Subtype: Link
       Rect: 230, 332, 242, 345
       Destination: 117
      Annotation: 
       Subtype: Link
       Rect: 241, 135, 248, 148
       Destination: 54
      Annotation: 
       Subtype: Link
       Rect: 201, 102, 256, 115
      Annotation: 
       Subtype: Link
       Rect: 247, 91, 254, 104
       Destination: 98
      Annotation: 
       Subtype: Link
       Rect: 97, 80, 108, 93
       Destination: 113
      Annotation: 
       Subtype: Link
       Rect: 252, 69, 259, 82
       Destination: 98
    Page: 
     Label: 1134
     Sequence: 7
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 191, 130, 267, 143
      Annotation: 
       Subtype: Link
       Rect: 272, 108, 284, 121
       Destination: 117
      Annotation: 
       Subtype: Link
       Rect: 307, 53, 558, 78
    Page: 
     Label: 1135
     Sequence: 8
    Page: 
     Label: 1136
     Sequence: 9
  Checksum: 282e3fee
   Type: CRC32
  Checksum: e1726ccec4c9359e5c6a9e7337d085ac
   Type: MD5
  Checksum: 6a6055bc159f0f2d4483d0750b5c1f7fc031038c
   Type: SHA-1