4cc2e417fa1be5034225e2d2841ce95a optlimdet_a2019v19n17.pdf 2c7398819baed599a6f645453687e97433118009 optlimdet_a2019v19n17.pdf efec45b4ab82d46799cf0c0d6e0579831a4bacb354eddfb0cf9e86cd3b789968 optlimdet_a2019v19n17.pdf Title: Optimizing the Limit of Detection of Waveguide-Based Interferometric Biosensor Devices Subject: Waveguide-based photonic sensors provide a unique combination of high sensitivity, compact size and label-free, multiplexed operation. Interferometric configurations furthermore enable a simple, fixed-wavelength read-out making them particularly suitable for low-cost diagnostic and monitoring devices. Their limit of detection, i.e. the lowest analyte concentration that can be reliably observed, mainly depends on the sensors response to small refractive index changes, and the noise in the read-out system. While enhancements in the sensors response have been extensively studied, noise optimization has received much less attention. Here we show that order-of-magnitude enhancements in the limit of detection can be achieved through systematic noise reduction, and demonstrate a limit of detection of 10-8RIU with a silicon nitride sensor operating at telecom wavelengths. Keywords: limit of detection; coherent detection; silicon photonics; interferometer; biosensors Author: Jonas Leuermann, Adrián Fernández-Gavela, Antonia Torres-Cubillo, Sergio Postigo, Alejandro Sánchez-Postigo, Laura M. Lechuga, Robert Halir and Íñigo Molina-Fernández Creator: LaTeX with hyperref package Producer: pdfTeX-1.40.18 CreationDate: Wed Aug 21 06:17:59 2019 CEST ModDate: Mon Dec 9 10:19:23 2019 CET Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 13 Encrypted: no Page size: 595.276 x 841.89 pts (A4) Page rot: 0 File size: 1513944 bytes Optimized: yes PDF version: 1.5 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- YLRSBX+URWPalladioL-Ital Type 1 Custom yes yes no 540 0 NUOBIU+URWPalladioL-Bold Type 1 Custom yes yes no 543 0 RHOZOO+URWPalladioL-Roma Type 1 Custom yes yes no 546 0 DUTHLI+CMSY10 Type 1 Builtin yes yes no 549 0 RVSEMT+TimesNewRomanPS-BoldItalicMT Type 1C WinAnsi yes yes no 553 0 SOSTRQ+CMR10 Type 1 Builtin yes yes no 317 0 DFKAXP+PazoMath-Italic Type 1 Builtin yes yes no 318 0 BCDEEE+Calibri TrueType WinAnsi yes yes no 117 0 Helvetica Type 1 Standard no no no 121 0 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Lechuga, Robert Halir and Íñigo Molina-Fernández Waveguide-based photonic sensors provide a unique combination of high sensitivity, compact size and label-free, multiplexed operation. Interferometric configurations furthermore enable a simple, fixed-wavelength read-out making them particularly suitable for low-cost diagnostic and monitoring devices. Their limit of detection, i.e. the lowest analyte concentration that can be reliably observed, mainly depends on the sensors response to small refractive index changes, and the noise in the read-out system. While enhancements in the sensors response have been extensively studied, noise optimization has received much less attention. Here we show that order-of-magnitude enhancements in the limit of detection can be achieved through systematic noise reduction, and demonstrate a limit of detection of 10-8RIU with a silicon nitride sensor operating at telecom wavelengths. 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