429c163a237b04c5018b351913932c82 NATCO_a2019v10p1124.pdf 5f78f104492b476135a9f6949422be82656767c2 NATCO_a2019v10p1124.pdf a9706b8a4835d06573804654f7b0a2381bddb0dedbcba19fb1499868b3090ee7 NATCO_a2019v10p1124.pdf Title: Global monitoring of antimicrobial resistance based on metagenomics analyses of urban sewage Subject: Nature Communications, doi:10.1038/s41467-019-08853-3 Keywords: Author: Rene S. 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distribution of AMR genes Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1b26f7b2 Item: Title: Global diversity and clustering of AMR genes Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@491cc5c9 Item: Title: AMR genes and drug use association Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@74ad1f1f Item: Title: Prediction of AMR based on population-level health data Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6a1aab78 Item: Title: Discussion Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@462d5aee Item: Title: Methods Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@69b0fd6f Children: Item: Title: Ethics Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@757942a1 Item: Title: Collection of urban sewage samples Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4a87761d Item: Title: Sample handling and DNA extraction Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@66d1af89 Item: Title: Whole-community sequencing Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@8646db9 Item: Title: Trimming and mapping of sequencing reads Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@37374a5e Item: Title: Bacterial and AMR gene distribution Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4671e53b Item: Title: Within-site reproducibility Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@2db7a79b Item: Title: Within-country representativeness Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6950e31 Item: Title: Sample composition comparison Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@b7dd107 Item: Title: Sample dissimilarities Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@42eca56e Item: Title: Heat maps Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@52f759d7 Item: Title: Sample ordination Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7cbd213e Item: Title: Testing of sample dissimilarities Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@192d3247 Item: Title: Alpha diversity Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@3ecd23d9 Item: Title: Procrustes analysis Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@569cfc36 Item: Title: Graphics and statistics Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@43bd930a Item: Title: Correlation between AMU and external explanatory variables Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@33723e30 Item: Title: Resistance prediction Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@64f6106c Item: Title: Creation of global figures and maps Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@553a3d88 Item: Title: Analysis of tetracyclines, sulfonamides, macrolides, and quinolone Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7a30d1e6 Item: Title: Analysis of aminoglycosides Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@5891e32e Item: Title: Analysis of β-lactams Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@cb0ed20 Item: Title: Calculation of defined daily dosages (DDDs) based on residues Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@8e24743 Item: Title: References Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@74a10858 Item: Title: References Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@23fe1d71 Item: Title: Acknowledgements Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@28ac3dc3 Item: Title: Author contributions Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@32eebfca Item: Title: Competing interests Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4e718207 Item: Title: ACKNOWLEDGEMENTS Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1d371b2d Info: Title: Global monitoring of antimicrobial resistance based on metagenomics analyses of urban sewage Author: Rene S. 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FontBBox: -10, -250, 968, 1010 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true XMP: application/pdf doi:10.1038/s41467-019-08853-3 Global monitoring of antimicrobial resistance based on metagenomics analyses of urban sewage Rene S. Hendriksen Patrick Munk Patrick Njage Bram Bunnik Luke McNally Oksana Lukjancenko Timo Röder David Nieuwenhuijse Susanne Karlsmose Pedersen Jette Kjeldgaard Rolf S. Kaas Philip Thomas Lanken Conradsen Clausen Josef Korbinian Vogt Pimlapas Leekitcharoenphon Milou G. M. Schans Tina Zuidema Ana Maria Roda Husman Simon Rasmussen Bent Petersen Artan Bego Catherine Rees Susan Cassar Kris Coventry Peter Collignon Franz Allerberger Teddie O. Rahube Guilherme Oliveira Ivan Ivanov Yith Vuthy Thet Sopheak Christopher K. Yost Changwen Ke Huanying Zheng Li Baisheng Xiaoyang Jiao Pilar Donado-Godoy Kalpy Julien Coulibaly Matijana Jergović Jasna Hrenovic Renáta Karpíšková Jose Eduardo Villacis Mengistu Legesse Tadesse Eguale Annamari Heikinheimo Lile Malania Andreas Nitsche Annika Brinkmann Courage Kosi Setsoafia Saba Bela Kocsis Norbert Solymosi Thorunn R. Thorsteinsdottir Abdulla Mohamed Hatha Masoud Alebouyeh Dearbhaile Morris Martin Cormican Louise O’Connor Jacob Moran-Gilad Patricia Alba Antonio Battisti Zeinegul Shakenova Ciira Kiiyukia Eric Ng’eno Lul Raka Jeļena Avsejenko Aivars Bērziņš Vadims Bartkevics Christian Penny Heraa Rajandas Sivachandran Parimannan Malcolm Vella Haber Pushkar Pal Gert-Jan Jeunen Neil Gemmell Kayode Fashae Rune Holmstad Rumina Hasan Sadia Shakoor Maria Luz Zamudio Rojas Dariusz Wasyl Golubinka Bosevska Mihail Kochubovski Cojocaru Radu Amy Gassama Vladimir Radosavljevic Stefan Wuertz Rogelio Zuniga-Montanez Moon Y. F. Tay Dagmar Gavačová Katarina Pastuchova Peter Truska Marija Trkov Kerneels Esterhuyse Karen Keddy Marta Cerdà-Cuéllar Sujatha Pathirage Leif Norrgren Stefan Örn D. G. Joakim Larsson Tanja Van der Heijden Happiness Houka Kumburu Bakary Sanneh Pawou Bidjada Berthe-Marie Njanpop-Lafourcade Somtinda Christelle Nikiema-Pessinaba Belkis Levent John Scott Meschke Nicola Koren Beck Chinh Dang Van Nguyen Do Phuc Doan Minh Nguyen Tran Geoffrey Kwenda Djim-adjim Tabo Astrid Louise Wester Sara Cuadros-Orellana Clara Amid Guy Cochrane Thomas Sicheritz-Ponten Heike Schmitt Jorge Raul Matheu Alvarez Awa Aidara-Kane Sünje J. Pamp Ole Lund Tine Hald Mark Woolhouse Marion P. Koopmans Håkan Vigre Thomas Nordahl Petersen Frank M. Aarestrup Springer US Nature Communications, doi:10.1038/s41467-019-08853-3 10.1038/s41467-019-08853-3 http://dx.doi.org/10.1038/s41467-019-08853-3 journal Nature Communications © 2019, The Author(s) 2041-1723 10.1038/s41467-019-08853-3 springer.com springerlink.com 2010-04-23 True 10.1038/s41467-019-08853-3 springer.com springerlink.com Springer 2019-03-04T12:04:03+01:00 2019-03-02T10:13:38+05:30 2019-03-04T12:04:03+01:00 True iText® 5.3.5 ©2000-2012 1T3XT BVBA (AGPL-version) VoR uuid:34acf68b-b886-4d0b-bedc-e5bd83e95385 uuid:50080f98-45e9-4a94-a435-d86575a4ba6c default 1 converted uuid:f6ad8e5a-7e82-4fc0-a646-c0fb0b6093e1 converted to PDF/A-2b pdfToolbox 2019-03-02T10:14:31+05:30 2 B Patrick Munk http://orcid.org/0000-0001-8813-4019 Bram Bunnik http://orcid.org/0000-0003-2177-7073 Simon Rasmussen http://orcid.org/0000-0001-6323-9041 Frank M. Aarestrup http://orcid.org/0000-0002-7116-2723 http://ns.adobe.com/pdf/1.3/ pdf Adobe PDF Schema internal A name object indicating whether the document has been modified to include trapping information Trapped Text http://ns.adobe.com/pdfx/1.3/ pdfx pdfx internal ID of PDF/X standard GTS_PDFXVersion Text internal Conformance level of PDF/X standard GTS_PDFXConformance Text internal Company creating the PDF Company Text internal Date when document was last modified SourceModified Text external Mirrors crossmark:CrosMarkDomains CrossMarkDomains Seq Text internal Mirrors crossmark:DOI doi Text http://ns.adobe.com/xap/1.0/mm/ xmpMM XMP Media Management Schema internal UUID based identifier for specific incarnation of a document InstanceID URI internal The common identifier for all versions and renditions of a document. 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